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Protein

Pre-mRNA-splicing factor SLU7

Gene

SLU7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 135CCHC-typeAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SLU7
Short name:
hSlu7
Gene namesi
Name:SLU7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164609.9
HGNCiHGNC:16939 SLU7
MIMi605974 gene
neXtProtiNX_O95391

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi116R → N: Abolishes nuclear localization. 1 Publication1
Mutagenesisi117K → N: Abolishes nuclear localization. 1 Publication1
Mutagenesisi120C → S: Induces a cytoplasmic localization; when associated with S-123; G-128 and S-133. 1 Publication1
Mutagenesisi123C → S: Induces a cytoplasmic localization; when associated with S-120; G-128 and S-133. 1 Publication1
Mutagenesisi125 – 126AM → VP: Does not affect nuclear localization. 1 Publication2
Mutagenesisi128H → G: Induces a cytoplasmic localization; when associated with S-120; S-123 and S-133. 1 Publication1
Mutagenesisi129K → N: Abolishes nuclear localization. 1 Publication1
Mutagenesisi133C → S: Induces a cytoplasmic localization; when associated with S-120; S-123 and G-128. 1 Publication1
Mutagenesisi136R → N: Abolishes nuclear localization. 1
Mutagenesisi166K → N: Abolishes nuclear localization. 1 Publication1

Organism-specific databases

DisGeNETi10569
OpenTargetsiENSG00000164609
PharmGKBiPA128394574

Polymorphism and mutation databases

BioMutaiSLU7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002891942 – 586Pre-mRNA-splicing factor SLU7Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1
Cross-linki349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki408Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95391
MaxQBiO95391
PaxDbiO95391
PeptideAtlasiO95391
PRIDEiO95391
ProteomicsDBi50843

PTM databases

iPTMnetiO95391
PhosphoSitePlusiO95391

Miscellaneous databases

PMAP-CutDBiO95391

Expressioni

Gene expression databases

BgeeiENSG00000164609 Expressed in 203 organ(s), highest expression level in frontal cortex
CleanExiHS_SLU7
ExpressionAtlasiO95391 baseline and differential
GenevisibleiO95391 HS

Organism-specific databases

HPAiHPA035907
HPA058120

Interactioni

Subunit structurei

Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.

Binary interactionsi

Protein-protein interaction databases

BioGridi115820, 35 interactors
CORUMiO95391
IntActiO95391, 37 interactors
MINTiO95391
STRINGi9606.ENSP00000297151

Structurei

3D structure databases

ProteinModelPortaliO95391
SMRiO95391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 169Bipartite nuclear localization signalAdd BLAST41

Domaini

The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.1 Publication

Sequence similaritiesi

Belongs to the SLU7 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 135CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2560 Eukaryota
ENOG410XPPP LUCA
GeneTreeiENSGT00390000002292
HOGENOMiHOG000194391
HOVERGENiHBG053287
InParanoidiO95391
KOiK12819
OMAiPQTLMEM
OrthoDBiEOG091G05PK
PhylomeDBiO95391
TreeFamiTF105691

Family and domain databases

InterProiView protein in InterPro
IPR021715 Slu7_dom
IPR039974 splicing_factor_SLU7
PANTHERiPTHR12942 PTHR12942, 1 hit
PfamiView protein in Pfam
PF11708 Slu7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATVVDAVN AAPLSGSKEM SLEEPKKMTR EDWRKKKELE EQRKLGNAPA
60 70 80 90 100
EVDEEGKDIN PHIPQYISSV PWYIDPSKRP TLKHQRPQPE KQKQFSSSGE
110 120 130 140 150
WYKRGVKENS IITKYRKGAC ENCGAMTHKK KDCFERPRRV GAKFTGTNIA
160 170 180 190 200
PDEHVQPQLM FDYDGKRDRW NGYNPEEHMK IVEEYAKVDL AKRTLKAQKL
210 220 230 240 250
QEELASGKLV EQANSPKHQW GEEEPNSQME KDHNSEDEDE DKYADDIDMP
260 270 280 290 300
GQNFDSKRRI TVRNLRIRED IAKYLRNLDP NSAYYDPKTR AMRENPYANA
310 320 330 340 350
GKNPDEVSYA GDNFVRYTGD TISMAQTQLF AWEAYDKGSE VHLQADPTKL
360 370 380 390 400
ELLYKSFKVK KEDFKEQQKE SILEKYGGQE HLDAPPAELL LAQTEDYVEY
410 420 430 440 450
SRHGTVIKGQ ERAVACSKYE EDVKIHNHTH IWGSYWKEGR WGYKCCHSFF
460 470 480 490 500
KYSYCTGEAG KEIVNSEECI INEITGEESV KKPQTLMELH QEKLKEEKKK
510 520 530 540 550
KKKKKKKHRK SSSDSDDEEK KHEKLKKALN AEEARLLHVK ETMQIDERKR
560 570 580
PYNSMYETRE PTEEEMEAYR MKRQRPDDPM ASFLGQ
Length:586
Mass (Da):68,387
Last modified:November 3, 2009 - v2
Checksum:i237B8C8014EEAB6E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RK41E5RK41_HUMAN
Pre-mRNA-splicing factor SLU7
SLU7
143Annotation score:
E5RGM7E5RGM7_HUMAN
Pre-mRNA-splicing factor SLU7
SLU7
124Annotation score:
A0A0C4DGD2A0A0C4DGD2_HUMAN
Pre-mRNA-splicing factor SLU7
SLU7
101Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032598111I → V1 PublicationCorresponds to variant dbSNP:rs17856338Ensembl.1
Natural variantiVAR_032599229M → TCombined sources3 PublicationsCorresponds to variant dbSNP:rs2961944Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101074 mRNA Translation: AAD13774.1
AC091842 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61554.1
CH471062 Genomic DNA Translation: EAW61555.1
BC010634 mRNA Translation: AAH10634.1
AY486334 mRNA Translation: AAS59410.1
DQ174516 mRNA Translation: ABA08382.1
DQ174517 mRNA Translation: ABA08383.1
CCDSiCCDS4352.1
RefSeqiNP_006416.3, NM_006425.4
XP_011532720.1, XM_011534418.2
UniGeneiHs.435342

Genome annotation databases

EnsembliENST00000297151; ENSP00000297151; ENSG00000164609
GeneIDi10569
KEGGihsa:10569
UCSCiuc003lyg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101074 mRNA Translation: AAD13774.1
AC091842 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61554.1
CH471062 Genomic DNA Translation: EAW61555.1
BC010634 mRNA Translation: AAH10634.1
AY486334 mRNA Translation: AAS59410.1
DQ174516 mRNA Translation: ABA08382.1
DQ174517 mRNA Translation: ABA08383.1
CCDSiCCDS4352.1
RefSeqiNP_006416.3, NM_006425.4
XP_011532720.1, XM_011534418.2
UniGeneiHs.435342

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XJCelectron microscopy3.60Z1-586[»]
ProteinModelPortaliO95391
SMRiO95391
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115820, 35 interactors
CORUMiO95391
IntActiO95391, 37 interactors
MINTiO95391
STRINGi9606.ENSP00000297151

PTM databases

iPTMnetiO95391
PhosphoSitePlusiO95391

Polymorphism and mutation databases

BioMutaiSLU7

Proteomic databases

EPDiO95391
MaxQBiO95391
PaxDbiO95391
PeptideAtlasiO95391
PRIDEiO95391
ProteomicsDBi50843

Protocols and materials databases

DNASUi10569
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297151; ENSP00000297151; ENSG00000164609
GeneIDi10569
KEGGihsa:10569
UCSCiuc003lyg.4 human

Organism-specific databases

CTDi10569
DisGeNETi10569
EuPathDBiHostDB:ENSG00000164609.9
GeneCardsiSLU7
HGNCiHGNC:16939 SLU7
HPAiHPA035907
HPA058120
MIMi605974 gene
neXtProtiNX_O95391
OpenTargetsiENSG00000164609
PharmGKBiPA128394574
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2560 Eukaryota
ENOG410XPPP LUCA
GeneTreeiENSGT00390000002292
HOGENOMiHOG000194391
HOVERGENiHBG053287
InParanoidiO95391
KOiK12819
OMAiPQTLMEM
OrthoDBiEOG091G05PK
PhylomeDBiO95391
TreeFamiTF105691

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSiSLU7 human
GeneWikiiSLU7
GenomeRNAii10569
PMAP-CutDBiO95391
PROiPR:O95391
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164609 Expressed in 203 organ(s), highest expression level in frontal cortex
CleanExiHS_SLU7
ExpressionAtlasiO95391 baseline and differential
GenevisibleiO95391 HS

Family and domain databases

InterProiView protein in InterPro
IPR021715 Slu7_dom
IPR039974 splicing_factor_SLU7
PANTHERiPTHR12942 PTHR12942, 1 hit
PfamiView protein in Pfam
PF11708 Slu7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLU7_HUMAN
AccessioniPrimary (citable) accession number: O95391
Secondary accession number(s): D3DQK2
, Q3LUJ0, Q3LUJ1, Q6RXQ5, Q96FM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 3, 2009
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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