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UniProtKB - O95382 (M3K6_HUMAN)

Entry version 186 (23 Feb 2022)
Sequence version 3 (03 Nov 2009)
Previous versions | rss
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Protein

Mitogen-activated protein kinase kinase kinase 6

Gene

MAP3K6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei677ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei771Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi654 – 662ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.25, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95382

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95382

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95382

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 6 (EC:2.7.11.25)
Alternative name(s):
Apoptosis signal-regulating kinase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP3K6
Synonyms:ASK2, MAPKKK6, MEKK6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6858, MAP3K6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604468, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95382

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142733

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9064

MalaCards human disease database

More...MalaCardsi		MAP3K6

Open Targets

More...OpenTargetsi		ENSG00000142733

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		26106, Hereditary diffuse gastric cancer

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30602

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95382, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1163123

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2081

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAP3K6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000862511 – 1288Mitogen-activated protein kinase kinase kinase 6Add BLAST1288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei806PhosphothreonineBy similarity1
Modified residuei964PhosphoserineCombined sources1
Modified residuei984PhosphoserineCombined sources1
Modified residuei1129PhosphoserineCombined sources1
Modified residuei1149PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-851
CPTAC-852

Encyclopedia of Proteome Dynamics

More...EPDi		O95382

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95382

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95382

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95382

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95382

PeptideAtlas

More...PeptideAtlasi		O95382

PRoteomics IDEntifications database

More...PRIDEi		O95382

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50834 [O95382-1]
50835 [O95382-2]
50836 [O95382-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95382, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95382

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95382

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142733, Expressed in left lobe of thyroid gland and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95382, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95382, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142733, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds both upstream activators and downstream substrates in multimolecular complexes.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114524, 40 interactors

Protein interaction database and analysis system

More...IntActi		O95382, 24 interactors

Molecular INTeraction database

More...MINTi		O95382

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419591

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O95382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95382, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95382

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini648 – 906Protein kinasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni899 – 997DisorderedSequence analysisAdd BLAST99
Regioni1123 – 1157DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1004 – 1029Sequence analysisAdd BLAST26
Coiled coili1166 – 1205Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi930 – 948Polar residuesSequence analysisAdd BLAST19
Compositional biasi1134 – 1151Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4279, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159398

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003687_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95382

Identification of Orthologs from Complete Genome Data

More...OMAi		VWYVASI

Database of Orthologous Groups

More...OrthoDBi		1019877at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95382

TreeFam database of animal gene trees

More...TreeFami		TF105115

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR043969, MAP3K_PH
IPR025136, MAP3K_TRAF-bd
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR013761, SAM/pointed_sf
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19039, ASK_PH, 1 hit
PF13281, MAP3K_TRAF_bd, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95382-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV 
        60         70         80         90        100
LTREPQPGLE PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE 
       110        120        130        140        150
LGDTAALDAF YNADVVVLEV SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ 
       160        170        180        190        200
ADLPDLQALR EDVFQKNSDC VGSYTLIPYV VTATGRVLCG DAGLLRGLAD 
       210        220        230        240        250
GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR RDIRQARERF 
       260        270        280        290        300
SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL 
       310        320        330        340        350
QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALSVLLP LVQLEGSVAP 
       360        370        380        390        400
DLYCMCGRIY KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV 
       410        420        430        440        450
LLIAAGQHFE DSKELRLIGM KLGCLLARKG CVEKMQYYWD VGFYLGAQIL 
       460        470        480        490        500
ANDPTQVVLA AEQLYKLNAP IWYLVSVMET FLLYQHFRPT PEPPGGPPRR 
       510        520        530        540        550
AHFWLHFLLQ SCQPFKTACA QGDQCLVLVL EMNKVLLPAK LEVRGTDPVS 
       560        570        580        590        600
TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ 
       610        620        630        640        650
LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGAGEMLE FDYEYTETGE 
       660        670        680        690        700
RLVLGKGTYG VVYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHRRL 
       710        720        730        740        750
RHKNIVRYLG SASQGGYLKI FMEEVPGGSL SSLLRSVWGP LKDNESTISF 
       760        770        780        790        800
YTRQILQGLG YLHDNHIVHR DIKGDNVLIN TFSGLLKISD FGTSKRLAGI 
       810        820        830        840        850
TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI EMATGRPPFH 
       860        870        880        890        900
ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL 
       910        920        930        940        950
LGDPFLQPGK RSRSPSSPRH APRPSDAPSA SPTPSANSTT QSQTFPCPQA 
       960        970        980        990       1000
PSQHPPSPPK RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR 
      1010       1020       1030       1040       1050
RAMLAAVLEQ ELPALAENLH QEQKQEQGAR LGRNHVEELL RCLGAHIHTP 
      1060       1070       1080       1090       1100
NRRQLAQELR ALQGRLRAQG LGPALLHRPL FAFPDAVKQI LRKRQIRPHW 
      1110       1120       1130       1140       1150
MFVLDSLLSR AVRAALGVLG PEVEKEAVSP RSEELSNEGD SQQSPGQQSP 
      1160       1170       1180       1190       1200
LPVEPEQGPA PLMVQLSLLR AETDRLREIL AGKEREYQAL VQRALQRLNE 
      1210       1220       1230       1240       1250
EARTYVLAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT 
      1260       1270       1280 
YATRDDLIYT RIRGGMVCRI WRAILAQRAG STPVTSGP
Length:1,288
Mass (Da):142,596
Last modified:November 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i013AF3729698080F
GO
Isoform 2 (identifier: O95382-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.
     1065-1074: RLRAQGLGPA → WMNGEDKGSF
     1075-1288: Missing.

Show »
Length:797
Mass (Da):88,674
Checksum:i8EA06171D8396464
GO
Isoform 3 (identifier: O95382-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-168: Missing.

Show »
Length:1,280
Mass (Da):141,648
Checksum:iC9763EC2F44C5790
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8A3H0Y8A3_HUMAN
Mitogen-activated protein kinase ki...
MAP3K6
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJN3A0A590UJN3_HUMAN
Mitogen-activated protein kinase ki...
MAP3K6
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD05304 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti435 – 440MQYYWD → ALWVPV in AAI29952 (PubMed:15489334).Curated6
Sequence conflicti435 – 440MQYYWD → HTWVPV in AAI29951 (PubMed:15489334).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032832455T → I2 PublicationsCorresponds to variant dbSNP:rs1138294Ensembl.1
Natural variantiVAR_046050499R → C. Corresponds to variant dbSNP:rs11247641EnsemblClinVar.1
Natural variantiVAR_046051544R → W1 PublicationCorresponds to variant dbSNP:rs55671988Ensembl.1
Natural variantiVAR_032833622N → K2 PublicationsCorresponds to variant dbSNP:rs35659744EnsemblClinVar.1
Natural variantiVAR_046052668R → G1 PublicationCorresponds to variant dbSNP:rs55869163Ensembl.1
Natural variantiVAR_046053673R → L1 PublicationCorresponds to variant dbSNP:rs56359841Ensembl.1
Natural variantiVAR_035629869P → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_046054925S → L in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046055968T → I in an ovarian endometrioid cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_032834969S → N1 PublicationCorresponds to variant dbSNP:rs17856498Ensembl.1
Natural variantiVAR_0460561061A → T1 PublicationCorresponds to variant dbSNP:rs55990440Ensembl.1
Natural variantiVAR_0460571233G → A. Corresponds to variant dbSNP:rs17162549Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0262011 – 277Missing in isoform 2. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_026202161 – 168Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_0262031065 – 1074RLRAQGLGPA → WMNGEDKGSF in isoform 2. 1 Publication10
Alternative sequenceiVSP_0262041075 – 1288Missing in isoform 2. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB167411 mRNA Translation: BAD12485.1
FO393419 Genomic DNA No translation available.
BC015914 mRNA Translation: AAH15914.1
BC129950 mRNA Translation: AAI29951.1
BC129951 mRNA Translation: AAI29952.1
AB208805 mRNA Translation: BAD92042.1
AF100318 mRNA Translation: AAD05304.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS299.1 [O95382-1]
CCDS72738.1 [O95382-3]

NCBI Reference Sequences

More...RefSeqi		NP_001284538.1, NM_001297609.1 [O95382-3]
NP_004663.3, NM_004672.4 [O95382-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357582; ENSP00000350195; ENSG00000142733
ENST00000374040; ENSP00000363152; ENSG00000142733 [O95382-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9064

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000357582.3; ENSP00000350195.2; NM_004672.5; NP_004663.3

UCSC genome browser

More...UCSCi		uc001bny.2, human [O95382-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167411 mRNA Translation: BAD12485.1
FO393419 Genomic DNA No translation available.
BC015914 mRNA Translation: AAH15914.1
BC129950 mRNA Translation: AAI29951.1
BC129951 mRNA Translation: AAI29952.1
AB208805 mRNA Translation: BAD92042.1
AF100318 mRNA Translation: AAD05304.1 Different initiation.
CCDSiCCDS299.1 [O95382-1]
CCDS72738.1 [O95382-3]
RefSeqiNP_001284538.1, NM_001297609.1 [O95382-3]
NP_004663.3, NM_004672.4 [O95382-1]

3D structure databases

SMRiO95382
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114524, 40 interactors
IntActiO95382, 24 interactors
MINTiO95382
STRINGi9606.ENSP00000419591

Chemistry databases

BindingDBiO95382
ChEMBLiCHEMBL1163123
DrugBankiDB12010, Fostamatinib
GuidetoPHARMACOLOGYi2081

PTM databases

GlyGeniO95382, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO95382
PhosphoSitePlusiO95382

Genetic variation databases

BioMutaiMAP3K6

Proteomic databases

CPTACiCPTAC-851
CPTAC-852
EPDiO95382
jPOSTiO95382
MassIVEiO95382
MaxQBiO95382
PaxDbiO95382
PeptideAtlasiO95382
PRIDEiO95382
ProteomicsDBi50834 [O95382-1]
50835 [O95382-2]
50836 [O95382-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30762, 221 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		9064

Genome annotation databases

EnsembliENST00000357582; ENSP00000350195; ENSG00000142733
ENST00000374040; ENSP00000363152; ENSG00000142733 [O95382-3]
GeneIDi9064
KEGGihsa:9064
MANE-SelectiENST00000357582.3; ENSP00000350195.2; NM_004672.5; NP_004663.3
UCSCiuc001bny.2, human [O95382-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9064
DisGeNETi9064

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAP3K6
HGNCiHGNC:6858, MAP3K6
HPAiENSG00000142733, Low tissue specificity
MalaCardsiMAP3K6
MIMi604468, gene
neXtProtiNX_O95382
OpenTargetsiENSG00000142733
Orphaneti26106, Hereditary diffuse gastric cancer
PharmGKBiPA30602
VEuPathDBiHostDB:ENSG00000142733

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4279, Eukaryota
GeneTreeiENSGT00940000159398
HOGENOMiCLU_003687_3_0_1
InParanoidiO95382
OMAiVWYVASI
OrthoDBi1019877at2759
PhylomeDBiO95382
TreeFamiTF105115

Enzyme and pathway databases

BRENDAi2.7.11.25, 2681
PathwayCommonsiO95382
SignaLinkiO95382
SIGNORiO95382

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9064, 8 hits in 1075 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAP3K6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9064
PharosiO95382, Tchem

Protein Ontology

More...PROi		PR:O95382
RNActiO95382, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142733, Expressed in left lobe of thyroid gland and 180 other tissues
ExpressionAtlasiO95382, baseline and differential
GenevisibleiO95382, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR043969, MAP3K_PH
IPR025136, MAP3K_TRAF-bd
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR013761, SAM/pointed_sf
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF19039, ASK_PH, 1 hit
PF13281, MAP3K_TRAF_bd, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3K6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95382
Secondary accession number(s): A2ACE8
, A2VDG4, A2VDG5, Q59HF4, Q5SSD4, Q75PK3, Q96B75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 3, 2009
Last modified: February 23, 2022
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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