UniProtKB - O95382 (M3K6_HUMAN)

BLAST

>sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP3K6 PE=1 SV=3
MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLE
PREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEV
SSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYV
VTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIR
RDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETL
QALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIY
KDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGM
KLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMET
FLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAK
LEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQ
LCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYG
VVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKI
FMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLIN
TFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVI
EMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTL
LGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPK
RCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLH
QEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPL
FAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGD
SQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNE
EARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYT
RIRGGMVCRIWRAILAQRAGSTPVTSGP

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History
Entry version 165 (12 Sep 2018)
Sequence version 3 (03 Nov 2009)
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Protein

Mitogen-activated protein kinase kinase kinase 6

Gene

MAP3K6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺By similarity

Activity regulationⁱ

Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	677	ATPPROSITE-ProRule annotation		1
Active siteⁱ	771	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	654 – 662	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9875215
magnesium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9875215
MAP kinase kinase kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9875215

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of JUN kinase activity
Source: ProtInc
Traceable author statementⁱ
- 9875215
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 9875215
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9875215

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.25 2681
SignaLinkⁱ	O95382

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitogen-activated protein kinase kinase kinase 6 (EC:2.7.11.25) Alternative name(s): Apoptosis signal-regulating kinase 2
Gene namesⁱ	Name:MAP3K6 Synonyms:ASK2, MAPKKK6, MEKK6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142733.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6858 MAP3K6
MIMⁱ	604468 gene
neXtProtⁱ	NX_O95382

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9064
MalaCards human disease database More...MalaCardsⁱ	MAP3K6
Open Targets More...OpenTargetsⁱ	ENSG00000142733
PharmGKBⁱ	PA30602

Chemistry databases

ChEMBLⁱ	CHEMBL1163123
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2081

Polymorphism and mutation databases

BioMutaⁱ	MAP3K6

BioMutaⁱ

MAP3K6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086251	1 – 1288	Mitogen-activated protein kinase kinase kinase 6Add BLAST		1288

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	806	PhosphothreonineBy similarity	1
Modified residueⁱ	964	PhosphoserineCombined sources	1
Modified residueⁱ	984	PhosphoserineCombined sources	1
Modified residueⁱ	1129	PhosphoserineCombined sources	1
Modified residueⁱ	1149	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95382
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95382
PaxDbⁱ	O95382
PeptideAtlas More...PeptideAtlasⁱ	O95382
PRIDEⁱ	O95382
ProteomicsDBⁱ	50834 50835 [O95382-2] 50836 [O95382-3]

PTM databases

iPTMnetⁱ	O95382
PhosphoSitePlusⁱ	O95382

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000142733 Expressed in 161 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_MAP3K6
ExpressionAtlasⁱ	O95382 baseline and differential
Genevisibleⁱ	O95382 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051192

HPAⁱ

HPA051192

Interactionⁱ

Subunit structureⁱ

Binds both upstream activators and downstream substrates in multimolecular complexes.

Protein-protein interaction databases

BioGridⁱ	114524, 21 interactors
IntActⁱ	O95382, 8 interactors
Molecular INTeraction database More...MINTⁱ	O95382
STRINGⁱ	9606.ENSP00000350195

Chemistry databases

BindingDBⁱ

O95382

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95382
SMRⁱ	O95382
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	648 – 906	Protein kinasePROSITE-ProRule annotationAdd BLAST		259

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1004 – 1029	Sequence analysisAdd BLAST		26
Coiled coilⁱ	1166 – 1205	Sequence analysisAdd BLAST		40

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4279 Eukaryota ENOG410XQGS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149049
HOVERGENⁱ	HBG006305
InParanoidⁱ	O95382
KEGG Orthology (KO) More...KOⁱ	K04425
OMAⁱ	KMQYYWD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00SJ
PhylomeDBⁱ	O95382
TreeFamⁱ	TF105115

Family and domain databases

InterProⁱ	View protein in InterPro IPR025136 DUF4071 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR013761 SAM/pointed_sf IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13281 DUF4071, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95382-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV 
        60         70         80         90        100
LTREPQPGLE PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE 
       110        120        130        140        150
LGDTAALDAF YNADVVVLEV SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ 
       160        170        180        190        200
ADLPDLQALR EDVFQKNSDC VGSYTLIPYV VTATGRVLCG DAGLLRGLAD 
       210        220        230        240        250
GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR RDIRQARERF 
       260        270        280        290        300
SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL 
       310        320        330        340        350
QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALSVLLP LVQLEGSVAP 
       360        370        380        390        400
DLYCMCGRIY KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV 
       410        420        430        440        450
LLIAAGQHFE DSKELRLIGM KLGCLLARKG CVEKMQYYWD VGFYLGAQIL 
       460        470        480        490        500
ANDPTQVVLA AEQLYKLNAP IWYLVSVMET FLLYQHFRPT PEPPGGPPRR 
       510        520        530        540        550
AHFWLHFLLQ SCQPFKTACA QGDQCLVLVL EMNKVLLPAK LEVRGTDPVS 
       560        570        580        590        600
TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ 
       610        620        630        640        650
LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGAGEMLE FDYEYTETGE 
       660        670        680        690        700
RLVLGKGTYG VVYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHRRL 
       710        720        730        740        750
RHKNIVRYLG SASQGGYLKI FMEEVPGGSL SSLLRSVWGP LKDNESTISF 
       760        770        780        790        800
YTRQILQGLG YLHDNHIVHR DIKGDNVLIN TFSGLLKISD FGTSKRLAGI 
       810        820        830        840        850
TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI EMATGRPPFH 
       860        870        880        890        900
ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL 
       910        920        930        940        950
LGDPFLQPGK RSRSPSSPRH APRPSDAPSA SPTPSANSTT QSQTFPCPQA 
       960        970        980        990       1000
PSQHPPSPPK RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR 
      1010       1020       1030       1040       1050
RAMLAAVLEQ ELPALAENLH QEQKQEQGAR LGRNHVEELL RCLGAHIHTP 
      1060       1070       1080       1090       1100
NRRQLAQELR ALQGRLRAQG LGPALLHRPL FAFPDAVKQI LRKRQIRPHW 
      1110       1120       1130       1140       1150
MFVLDSLLSR AVRAALGVLG PEVEKEAVSP RSEELSNEGD SQQSPGQQSP 
      1160       1170       1180       1190       1200
LPVEPEQGPA PLMVQLSLLR AETDRLREIL AGKEREYQAL VQRALQRLNE 
      1210       1220       1230       1240       1250
EARTYVLAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT 
      1260       1270       1280 
YATRDDLIYT RIRGGMVCRI WRAILAQRAG STPVTSGP

Length:1,288

Mass (Da):142,596

Last modified:November 3, 2009 - v3

Checksum:ⁱ013AF3729698080F

Isoform 2 (identifier: O95382-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.
     1065-1074: RLRAQGLGPA → WMNGEDKGSF
     1075-1288: Missing.

« Hide

        10         20         30         40         50
MNLLLSYRDV QDYSAIIELV ETLQALPTCD VAEQHNVCFH YTFALNRRNR 
        60         70         80         90        100
PGDRAKALSV LLPLVQLEGS VAPDLYCMCG RIYKDMFFSS GFQDAGHREQ 
       110        120        130        140        150
AYHWYRKAFD VEPSLHSGIN AAVLLIAAGQ HFEDSKELRL IGMKLGCLLA 
       160        170        180        190        200
RKGCVEKMQY YWDVGFYLGA QILANDPTQV VLAAEQLYKL NAPIWYLVSV 
       210        220        230        240        250
METFLLYQHF RPTPEPPGGP PRRAHFWLHF LLQSCQPFKT ACAQGDQCLV 
       260        270        280        290        300
LVLEMNKVLL PAKLEVRGTD PVSTVTLSLL EPETQDIPSS WTFPVASICG 
       310        320        330        340        350
VSASKRDERC CFLYALPPAQ DVQLCFPSVG HCQWFCGLIQ AWVTNPDSTA 
       360        370        380        390        400
PAEEAEGAGE MLEFDYEYTE TGERLVLGKG TYGVVYAGRD RHTRVRIAIK 
       410        420        430        440        450
EIPERDSRFS QPLHEEIALH RRLRHKNIVR YLGSASQGGY LKIFMEEVPG 
       460        470        480        490        500
GSLSSLLRSV WGPLKDNEST ISFYTRQILQ GLGYLHDNHI VHRDIKGDNV 
       510        520        530        540        550
LINTFSGLLK ISDFGTSKRL AGITPCTETF TGTLQYMAPE IIDQGPRGYG 
       560        570        580        590        600
KAADIWSLGC TVIEMATGRP PFHELGSPQA AMFQVGMYKV HPPMPSSLSA 
       610        620        630        640        650
EAQAFLLRTF EPDPRLRASA QTLLGDPFLQ PGKRSRSPSS PRHAPRPSDA 
       660        670        680        690        700
PSASPTPSAN STTQSQTFPC PQAPSQHPPS PPKRCLSYGG TSQLRVPEEP 
       710        720        730        740        750
AAEEPASPEE SSGLSLLHQE SKRRAMLAAV LEQELPALAE NLHQEQKQEQ 
       760        770        780        790 
GARLGRNHVE ELLRCLGAHI HTPNRRQLAQ ELRALQGWMN GEDKGSF

Note: No experimental confirmation available.

Show »

Length:797

Mass (Da):88,674

Checksum:ⁱ8EA06171D8396464

Isoform 3 (identifier: O95382-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
161-168: Missing.

« Hide

        10         20         30         40         50
MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV 
        60         70         80         90        100
LTREPQPGLE PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE 
       110        120        130        140        150
LGDTAALDAF YNADVVVLEV SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ 
       160        170        180        190        200
ADLPDLQALR DCVGSYTLIP YVVTATGRVL CGDAGLLRGL ADGLVQAGVG 
       210        220        230        240        250
TEALLTPLVG RLARLLEATP TDSCGYFRET IRRDIRQARE RFSGPQLRQE 
       260        270        280        290        300
LARLQRRLDS VELLSPDIIM NLLLSYRDVQ DYSAIIELVE TLQALPTCDV 
       310        320        330        340        350
AEQHNVCFHY TFALNRRNRP GDRAKALSVL LPLVQLEGSV APDLYCMCGR 
       360        370        380        390        400
IYKDMFFSSG FQDAGHREQA YHWYRKAFDV EPSLHSGINA AVLLIAAGQH 
       410        420        430        440        450
FEDSKELRLI GMKLGCLLAR KGCVEKMQYY WDVGFYLGAQ ILANDPTQVV 
       460        470        480        490        500
LAAEQLYKLN APIWYLVSVM ETFLLYQHFR PTPEPPGGPP RRAHFWLHFL 
       510        520        530        540        550
LQSCQPFKTA CAQGDQCLVL VLEMNKVLLP AKLEVRGTDP VSTVTLSLLE 
       560        570        580        590        600
PETQDIPSSW TFPVASICGV SASKRDERCC FLYALPPAQD VQLCFPSVGH 
       610        620        630        640        650
CQWFCGLIQA WVTNPDSTAP AEEAEGAGEM LEFDYEYTET GERLVLGKGT 
       660        670        680        690        700
YGVVYAGRDR HTRVRIAIKE IPERDSRFSQ PLHEEIALHR RLRHKNIVRY 
       710        720        730        740        750
LGSASQGGYL KIFMEEVPGG SLSSLLRSVW GPLKDNESTI SFYTRQILQG 
       760        770        780        790        800
LGYLHDNHIV HRDIKGDNVL INTFSGLLKI SDFGTSKRLA GITPCTETFT 
       810        820        830        840        850
GTLQYMAPEI IDQGPRGYGK AADIWSLGCT VIEMATGRPP FHELGSPQAA 
       860        870        880        890        900
MFQVGMYKVH PPMPSSLSAE AQAFLLRTFE PDPRLRASAQ TLLGDPFLQP 
       910        920        930        940        950
GKRSRSPSSP RHAPRPSDAP SASPTPSANS TTQSQTFPCP QAPSQHPPSP 
       960        970        980        990       1000
PKRCLSYGGT SQLRVPEEPA AEEPASPEES SGLSLLHQES KRRAMLAAVL 
      1010       1020       1030       1040       1050
EQELPALAEN LHQEQKQEQG ARLGRNHVEE LLRCLGAHIH TPNRRQLAQE 
      1060       1070       1080       1090       1100
LRALQGRLRA QGLGPALLHR PLFAFPDAVK QILRKRQIRP HWMFVLDSLL 
      1110       1120       1130       1140       1150
SRAVRAALGV LGPEVEKEAV SPRSEELSNE GDSQQSPGQQ SPLPVEPEQG 
      1160       1170       1180       1190       1200
PAPLMVQLSL LRAETDRLRE ILAGKEREYQ ALVQRALQRL NEEARTYVLA 
      1210       1220       1230       1240       1250
PEPPTALSTD QGLVQWLQEL NVDSGTIQML LNHSFTLHTL LTYATRDDLI 
      1260       1270       1280
YTRIRGGMVC RIWRAILAQR AGSTPVTSGP

Note: No experimental confirmation available.

Show »

Length:1,280

Mass (Da):141,648

Checksum:ⁱC9763EC2F44C5790

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y894	H0Y894_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase 6	MAP3K6	798	Annotation score:
H0Y8A3	H0Y8A3_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase 6	MAP3K6	82	Annotation score:

Sequence cautionⁱ

The sequence AAD05304 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	435 – 440	MQYYWD → ALWVPV in AAI29952 (PubMed:15489334).Curated		6
Sequence conflictⁱ	435 – 440	MQYYWD → HTWVPV in AAI29951 (PubMed:15489334).Curated		6

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032832	455	T → I2 PublicationsCorresponds to variant dbSNP:rs1138294Ensembl.	1
Natural variantⁱVAR_046050	499	R → C. Corresponds to variant dbSNP:rs11247641Ensembl.	1
Natural variantⁱVAR_046051	544	R → W1 PublicationCorresponds to variant dbSNP:rs55671988Ensembl.	1
Natural variantⁱVAR_032833	622	N → K2 PublicationsCorresponds to variant dbSNP:rs35659744EnsemblClinVar.	1
Natural variantⁱVAR_046052	668	R → G1 PublicationCorresponds to variant dbSNP:rs55869163Ensembl.	1
Natural variantⁱVAR_046053	673	R → L1 PublicationCorresponds to variant dbSNP:rs56359841Ensembl.	1
Natural variantⁱVAR_035629	869	P → T in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_046054	925	S → L in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_046055	968	T → I in an ovarian endometrioid cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_032834	969	S → N1 PublicationCorresponds to variant dbSNP:rs17856498Ensembl.	1
Natural variantⁱVAR_046056	1061	A → T1 PublicationCorresponds to variant dbSNP:rs55990440Ensembl.	1
Natural variantⁱVAR_046057	1233	G → A. Corresponds to variant dbSNP:rs17162549Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_026201	1 – 277	Missing in isoform 2. 1 PublicationAdd BLAST	277
Alternative sequenceⁱVSP_026202	161 – 168	Missing in isoform 3. 1 Publication	8
Alternative sequenceⁱVSP_026203	1065 – 1074	RLRAQGLGPA → WMNGEDKGSF in isoform 2. 1 Publication	10
Alternative sequenceⁱVSP_026204	1075 – 1288	Missing in isoform 2. 1 PublicationAdd BLAST	214

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB167411 mRNA Translation: BAD12485.1 FO393419 Genomic DNA No translation available. BC015914 mRNA Translation: AAH15914.1 BC129950 mRNA Translation: AAI29951.1 BC129951 mRNA Translation: AAI29952.1 AB208805 mRNA Translation: BAD92042.1 AF100318 mRNA Translation: AAD05304.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS299.1 [O95382-1] CCDS72738.1 [O95382-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001284538.1, NM_001297609.1 [O95382-3] NP_004663.3, NM_004672.4 [O95382-1]
UniGeneⁱ	Hs.194694

Genome annotation databases

Ensemblⁱ	ENST00000357582; ENSP00000350195; ENSG00000142733 [O95382-1] ENST00000374040; ENSP00000363152; ENSG00000142733 [O95382-3] ENST00000493901; ENSP00000419591; ENSG00000142733 [O95382-1]
GeneIDⁱ	9064
KEGGⁱ	hsa:9064
UCSC genome browser More...UCSCⁱ	uc001bny.2 human [O95382-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O95382	Mitogen-activated protein kinase kinase kinase 6 (Fragment)		synthetic construct		490	UniRef100_O95382
MAP3K6 protein		HUMAN		441
UPI0007DC6313		HUMAN		869
O95382-2	Mitogen-activated protein kinase kinase kinase 6 (Fragment)		HUMAN		798	UniRef100_O95382-2

Protein	Similar proteins		Species	Score	Length	Source
O95382	Mitogen-activated protein kinase kinase kinase 6 (Fragment)		synthetic construct		490	UniRef90_O95382
MAP3K6 protein		HUMAN		441
Uncharacterized protein		CHLSB		1300
Uncharacterized protein		PROCO		1295
MAP3K6 isoform 4		PANTR		1288
+45
O95382-2	Mitogen-activated protein kinase kinase kinase 6 (Fragment)		HUMAN		798	UniRef90_O95382-2
MAP3K6 isoform 5 (Fragment)		PONAB		797
MAP3K6 isoform 2 (Fragment)		PANTR		797

Protein	Similar proteins		Species	Score	Length	Source
O95382	Mitogen-activated protein kinase kinase kinase 6 (Fragment)		synthetic construct		490	UniRef50_O95382
MAP3K6 protein		HUMAN		441
Uncharacterized protein		CHLSB		1300
Uncharacterized protein		PROCO		1295
Uncharacterized protein		PONAB		1288
+187
O95382-2	Mitogen-activated protein kinase kinase kinase 6 (Fragment)		HUMAN		798	UniRef50_O95382-2
MAP3K6 isoform 5 (Fragment)		PONAB		797
MAP3K6 isoform 2 (Fragment)		PANTR		797
Mitogen-activated protein kinase kinase kinase 6 (Fragment)		MUSPF		673
UPI000737EADE		VICPA		841
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB167411 mRNA Translation: BAD12485.1 FO393419 Genomic DNA No translation available. BC015914 mRNA Translation: AAH15914.1 BC129950 mRNA Translation: AAI29951.1 BC129951 mRNA Translation: AAI29952.1 AB208805 mRNA Translation: BAD92042.1 AF100318 mRNA Translation: AAD05304.1 Different initiation.
CCDSⁱ	CCDS299.1 [O95382-1] CCDS72738.1 [O95382-3]
RefSeqⁱ	NP_001284538.1, NM_001297609.1 [O95382-3] NP_004663.3, NM_004672.4 [O95382-1]
UniGeneⁱ	Hs.194694

3D structure databases

ProteinModelPortalⁱ	O95382
SMRⁱ	O95382
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114524, 21 interactors
IntActⁱ	O95382, 8 interactors
MINTⁱ	O95382
STRINGⁱ	9606.ENSP00000350195

Chemistry databases

BindingDBⁱ	O95382
ChEMBLⁱ	CHEMBL1163123
GuidetoPHARMACOLOGYⁱ	2081

PTM databases

iPTMnetⁱ	O95382
PhosphoSitePlusⁱ	O95382

Polymorphism and mutation databases

BioMutaⁱ	MAP3K6

BioMutaⁱ

MAP3K6

Proteomic databases

EPDⁱ	O95382
MaxQBⁱ	O95382
PaxDbⁱ	O95382
PeptideAtlasⁱ	O95382
PRIDEⁱ	O95382
ProteomicsDBⁱ	50834 50835 [O95382-2] 50836 [O95382-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000357582; ENSP00000350195; ENSG00000142733 [O95382-1] ENST00000374040; ENSP00000363152; ENSG00000142733 [O95382-3] ENST00000493901; ENSP00000419591; ENSG00000142733 [O95382-1]
GeneIDⁱ	9064
KEGGⁱ	hsa:9064
UCSCⁱ	uc001bny.2 human [O95382-1]

Organism-specific databases

CTDⁱ	9064
DisGeNETⁱ	9064
EuPathDBⁱ	HostDB:ENSG00000142733.14
GeneCardsⁱ	MAP3K6
H-InvDBⁱ	HIX0000314
HGNCⁱ	HGNC:6858 MAP3K6
HPAⁱ	HPA051192
MalaCardsⁱ	MAP3K6
MIMⁱ	604468 gene
neXtProtⁱ	NX_O95382
OpenTargetsⁱ	ENSG00000142733
PharmGKBⁱ	PA30602
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4279 Eukaryota ENOG410XQGS LUCA
GeneTreeⁱ	ENSGT00920000149049
HOVERGENⁱ	HBG006305
InParanoidⁱ	O95382
KOⁱ	K04425
OMAⁱ	KMQYYWD
OrthoDBⁱ	EOG091G00SJ
PhylomeDBⁱ	O95382
TreeFamⁱ	TF105115

Enzyme and pathway databases

BRENDAⁱ	2.7.11.25 2681
SignaLinkⁱ	O95382

Miscellaneous databases

ChiTaRSⁱ	MAP3K6 human
GenomeRNAiⁱ	9064
Protein Ontology More...PROⁱ	PR:O95382
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142733 Expressed in 161 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_MAP3K6
ExpressionAtlasⁱ	O95382 baseline and differential
Genevisibleⁱ	O95382 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025136 DUF4071 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR013761 SAM/pointed_sf IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF13281 DUF4071, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M3K6_HUMAN
Accessionⁱ	O95382Primary (citable) accession number: O95382 Secondary accession number(s): A2ACE8 Q96B75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 3, 2009
	Last modified:	September 12, 2018
	This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O95382 (M3K6_HUMAN)

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Mitogen-activated protein kinase kinase kinase 6

MAP3K6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

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Keywords - Technical termⁱ