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Protein

Tumor necrosis factor alpha-induced protein 8

Gene

TNFAIP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.3 Publications

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB

GO - Biological processi

  • negative regulation of apoptotic process Source: ProtInc
  • positive regulation of apoptotic process Source: UniProtKB

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8
Short name:
TNF alpha-induced protein 8
Alternative name(s):
Head and neck tumor and metastasis-related protein
MDC-3.13
NF-kappa-B-inducible DED-containing protein
Short name:
NDED
SCC-S2
TNF-induced protein GG2-1
Gene namesi
Name:TNFAIP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145779.7
HGNCiHGNC:17260 TNFAIP8
MIMi612111 gene
neXtProtiNX_O95379

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi25816
OpenTargetsiENSG00000145779
PharmGKBiPA134957136

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857181 – 198Tumor necrosis factor alpha-induced protein 8Add BLAST198

Proteomic databases

EPDiO95379
MaxQBiO95379
PaxDbiO95379
PeptideAtlasiO95379
PRIDEiO95379
ProteomicsDBi50831
50832 [O95379-2]
50833 [O95379-3]

PTM databases

iPTMnetiO95379
PhosphoSitePlusiO95379

Expressioni

Tissue specificityi

Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.3 Publications

Developmental stagei

Expressed at high levels in the fetal liver, lung and kidney.1 Publication

Inductioni

By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.2 Publications

Gene expression databases

BgeeiENSG00000145779 Expressed in 202 organ(s), highest expression level in bone marrow
CleanExiHS_TNFAIP8
ExpressionAtlasiO95379 baseline and differential
GenevisibleiO95379 HS

Organism-specific databases

HPAiHPA054434
HPA057089

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi117344, 22 interactors
IntActiO95379, 11 interactors
MINTiO95379
STRINGi9606.ENSP00000421848

Structurei

3D structure databases

ProteinModelPortaliO95379
SMRiO95379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 83Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiO95379
OMAiRNNQFSE
OrthoDBiEOG091G0QQ9
PhylomeDBiO95379
TreeFamiTF323415

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV
60 70 80 90 100
LDELYRVTRE YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME
110 120 130 140 150
KFKKKVHQLA MTVVSFHQVD YTFDRNVLSR LLNECREMLH QIIQRHLTAK
160 170 180 190
SHGRVNNVFD HFSDCEFLAA LYNPFGNFKP HLQKLCDGIN KMLDEENI
Length:198
Mass (Da):23,003
Last modified:May 1, 1999 - v1
Checksum:iD9B8F6FCF9AFC2C3
GO
Isoform 2 (identifier: O95379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MA

Show »
Length:190
Mass (Da):22,048
Checksum:i0DCD250217A1209C
GO
Isoform 3 (identifier: O95379-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MHSEAEESKEV → M

Show »
Length:188
Mass (Da):21,877
Checksum:i60452EC0A684F535
GO
Isoform 4 (identifier: O95379-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MTLPRYCEVVLLIAHGEKMLKL

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):24,385
Checksum:i44DE8FBED9290476
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCM8D6RCM8_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP8
200Annotation score:
E5RIJ3E5RIJ3_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP8
68Annotation score:
J3KQT8J3KQT8_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP8
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032047151S → C. Corresponds to variant dbSNP:rs3203922Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0248981 – 11MHSEAEESKEV → M in isoform 3. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_0248991 – 10MHSEAEESKE → MA in isoform 2. 2 Publications10
Alternative sequenceiVSP_0548271 – 10MHSEAEESKE → MTLPRYCEVVLLIAHGEKML KL in isoform 4. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070671 mRNA Translation: AAC83229.1
AF099935 mRNA Translation: AAC72975.1
AF099936 mRNA Translation: AAC72976.1
CR457137 mRNA Translation: CAG33418.1
AK001850 mRNA Translation: BAG50983.1
AK001931 mRNA Translation: BAG50994.1
AK301281 mRNA Translation: BAH13449.1
AC008475 Genomic DNA No translation available.
AC027320 Genomic DNA No translation available.
AC035144 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48914.1
BC005352 mRNA Translation: AAH05352.1
BC007014 mRNA Translation: AAH07014.1
AF098933 mRNA Translation: AAF29435.1
CCDSiCCDS47257.1 [O95379-3]
CCDS47258.1 [O95379-1]
CCDS68933.1 [O95379-4]
RefSeqiNP_001071122.1, NM_001077654.2 [O95379-3]
NP_001273742.1, NM_001286813.1 [O95379-1]
NP_001273743.1, NM_001286814.1 [O95379-4]
NP_001273744.1, NM_001286815.1
NP_001273746.1, NM_001286817.1
NP_055165.2, NM_014350.3 [O95379-1]
UniGeneiHs.618488
Hs.656274

Genome annotation databases

EnsembliENST00000274456; ENSP00000274456; ENSG00000145779 [O95379-3]
ENST00000503646; ENSP00000421848; ENSG00000145779 [O95379-1]
ENST00000504771; ENSP00000422245; ENSG00000145779 [O95379-1]
ENST00000513374; ENSP00000427424; ENSG00000145779 [O95379-4]
GeneIDi25816
KEGGihsa:25816
UCSCiuc003ksg.5 human [O95379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070671 mRNA Translation: AAC83229.1
AF099935 mRNA Translation: AAC72975.1
AF099936 mRNA Translation: AAC72976.1
CR457137 mRNA Translation: CAG33418.1
AK001850 mRNA Translation: BAG50983.1
AK001931 mRNA Translation: BAG50994.1
AK301281 mRNA Translation: BAH13449.1
AC008475 Genomic DNA No translation available.
AC027320 Genomic DNA No translation available.
AC035144 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48914.1
BC005352 mRNA Translation: AAH05352.1
BC007014 mRNA Translation: AAH07014.1
AF098933 mRNA Translation: AAF29435.1
CCDSiCCDS47257.1 [O95379-3]
CCDS47258.1 [O95379-1]
CCDS68933.1 [O95379-4]
RefSeqiNP_001071122.1, NM_001077654.2 [O95379-3]
NP_001273742.1, NM_001286813.1 [O95379-1]
NP_001273743.1, NM_001286814.1 [O95379-4]
NP_001273744.1, NM_001286815.1
NP_001273746.1, NM_001286817.1
NP_055165.2, NM_014350.3 [O95379-1]
UniGeneiHs.618488
Hs.656274

3D structure databases

ProteinModelPortaliO95379
SMRiO95379
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117344, 22 interactors
IntActiO95379, 11 interactors
MINTiO95379
STRINGi9606.ENSP00000421848

PTM databases

iPTMnetiO95379
PhosphoSitePlusiO95379

Proteomic databases

EPDiO95379
MaxQBiO95379
PaxDbiO95379
PeptideAtlasiO95379
PRIDEiO95379
ProteomicsDBi50831
50832 [O95379-2]
50833 [O95379-3]

Protocols and materials databases

DNASUi25816
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274456; ENSP00000274456; ENSG00000145779 [O95379-3]
ENST00000503646; ENSP00000421848; ENSG00000145779 [O95379-1]
ENST00000504771; ENSP00000422245; ENSG00000145779 [O95379-1]
ENST00000513374; ENSP00000427424; ENSG00000145779 [O95379-4]
GeneIDi25816
KEGGihsa:25816
UCSCiuc003ksg.5 human [O95379-1]

Organism-specific databases

CTDi25816
DisGeNETi25816
EuPathDBiHostDB:ENSG00000145779.7
GeneCardsiTNFAIP8
H-InvDBiHIX0005115
HGNCiHGNC:17260 TNFAIP8
HPAiHPA054434
HPA057089
MIMi612111 gene
neXtProtiNX_O95379
OpenTargetsiENSG00000145779
PharmGKBiPA134957136
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiO95379
OMAiRNNQFSE
OrthoDBiEOG091G0QQ9
PhylomeDBiO95379
TreeFamiTF323415

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism

Miscellaneous databases

ChiTaRSiTNFAIP8 human
GeneWikiiTNFAIP8
GenomeRNAii25816
PROiPR:O95379
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145779 Expressed in 202 organ(s), highest expression level in bone marrow
CleanExiHS_TNFAIP8
ExpressionAtlasiO95379 baseline and differential
GenevisibleiO95379 HS

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTFIP8_HUMAN
AccessioniPrimary (citable) accession number: O95379
Secondary accession number(s): B3KMH1
, B3KMI2, B7Z713, Q9P1Q1, Q9UER5, Q9UP47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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