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Protein

Gap junction beta-5 protein

Gene

GJB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-5 protein
Alternative name(s):
Connexin-31.1
Short name:
Cx31.1
Gene namesi
Name:GJB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000189280.3
HGNCiHGNC:4287 GJB5
MIMi604493 gene
neXtProtiNX_O95377

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 126CytoplasmicSequence analysisAdd BLAST28
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Topological domaini150 – 187ExtracellularSequence analysisAdd BLAST38
Transmembranei188 – 210HelicalSequence analysisAdd BLAST23
Topological domaini211 – 273CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2709
OpenTargetsiENSG00000189280
PharmGKBiPA28698

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578681 – 273Gap junction beta-5 proteinAdd BLAST273

Proteomic databases

EPDiO95377
PaxDbiO95377
PeptideAtlasiO95377
PRIDEiO95377
ProteomicsDBi50830

PTM databases

iPTMnetiO95377
PhosphoSitePlusiO95377

Expressioni

Gene expression databases

BgeeiENSG00000189280 Expressed in 98 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GJB5
GenevisibleiO95377 HS

Organism-specific databases

HPAiHPA038146

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

BioGridi108974, 37 interactors
IntActiO95377, 43 interactors
MINTiO95377
STRINGi9606.ENSP00000340811

Structurei

3D structure databases

ProteinModelPortaliO95377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiO95377
KOiK07624
OMAiWSDDHKD
OrthoDBiEOG091G0FKH
PhylomeDBiO95377
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002271 Connexin303
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01141 CONNEXINB4
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95377-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWSIFEGLL SGVNKYSTAF GRIWLSLVFI FRVLVYLVTA ERVWSDDHKD
60 70 80 90 100
FDCNTRQPGC SNVCFDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREV
110 120 130 140 150
QEKRHREAHG ENSGRLYLNP GKKRGGLWWT YVCSLVFKAS VDIAFLYVFH
160 170 180 190 200
SFYPKYILPP VVKCHADPCP NIVDCFISKP SEKNIFTLFM VATAAICILL
210 220 230 240 250
NLVELIYLVS KRCHECLAAR KAQAMCTGHH PHGTTSSCKQ DDLLSGDLIF
260 270
LGSDSHPPLL PDRPRDHVKK TIL
Length:273
Mass (Da):31,088
Last modified:December 1, 2000 - v2
Checksum:iC1B9F1A4A2E070BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099731 Genomic DNA Translation: AAC95472.1
AF052693 mRNA Translation: AAD18005.1
AL121988 Genomic DNA No translation available.
BC004379 mRNA Translation: AAH04379.1
CCDSiCCDS382.1
RefSeqiNP_005259.1, NM_005268.3
XP_005270808.1, XM_005270751.3
UniGeneiHs.198249

Genome annotation databases

EnsembliENST00000338513; ENSP00000340811; ENSG00000189280
GeneIDi2709
KEGGihsa:2709
UCSCiuc001bxu.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099731 Genomic DNA Translation: AAC95472.1
AF052693 mRNA Translation: AAD18005.1
AL121988 Genomic DNA No translation available.
BC004379 mRNA Translation: AAH04379.1
CCDSiCCDS382.1
RefSeqiNP_005259.1, NM_005268.3
XP_005270808.1, XM_005270751.3
UniGeneiHs.198249

3D structure databases

ProteinModelPortaliO95377
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108974, 37 interactors
IntActiO95377, 43 interactors
MINTiO95377
STRINGi9606.ENSP00000340811

PTM databases

iPTMnetiO95377
PhosphoSitePlusiO95377

Proteomic databases

EPDiO95377
PaxDbiO95377
PeptideAtlasiO95377
PRIDEiO95377
ProteomicsDBi50830

Protocols and materials databases

DNASUi2709
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338513; ENSP00000340811; ENSG00000189280
GeneIDi2709
KEGGihsa:2709
UCSCiuc001bxu.4 human

Organism-specific databases

CTDi2709
DisGeNETi2709
EuPathDBiHostDB:ENSG00000189280.3
GeneCardsiGJB5
HGNCiHGNC:4287 GJB5
HPAiHPA038146
MIMi604493 gene
neXtProtiNX_O95377
OpenTargetsiENSG00000189280
PharmGKBiPA28698
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiO95377
KOiK07624
OMAiWSDDHKD
OrthoDBiEOG091G0FKH
PhylomeDBiO95377
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-HSA-190861 Gap junction assembly

Miscellaneous databases

GeneWikiiGJB5
GenomeRNAii2709
PROiPR:O95377
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189280 Expressed in 98 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GJB5
GenevisibleiO95377 HS

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002271 Connexin303
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01141 CONNEXINB4
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXB5_HUMAN
AccessioniPrimary (citable) accession number: O95377
Secondary accession number(s): Q9UPA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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