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Protein

Acyl-protein thioesterase 2

Gene

LYPLA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity).By similarity2 Publications

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122Charge relay system1 Publication1
Active sitei176Charge relay systemBy similarity1
Active sitei210Charge relay systemBy similarity1

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • carboxylic ester hydrolase activity Source: GO_Central
  • palmitoyl-(protein) hydrolase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-373760 L1CAM interactions

Protein family/group databases

ESTHERihuman-LYPLA2 LYsophospholipase_carboxylesterase
MEROPSiS09.025

Chemistry databases

SwissLipidsiSLP:000001479

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-protein thioesterase 2 (EC:3.1.2.-1 Publication)
Short name:
APT-2
Alternative name(s):
Lysophospholipase II
Short name:
LPL-II
Short name:
LysoPLA II
Gene namesi
Name:LYPLA2
Synonyms:APT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000011009.10
HGNCiHGNC:6738 LYPLA2
neXtProtiNX_O95372

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2C → A: Abolishes palmitoylation. 1 Publication1
Mutagenesisi122S → A: Abolishes ability to mediate depalmitoylation of ZDHHC6. 1 Publication1

Organism-specific databases

DisGeNETi11313
OpenTargetsiENSG00000011009
PharmGKBiPA30500

Chemistry databases

ChEMBLiCHEMBL1932891

Polymorphism and mutation databases

BioMutaiLYPLA2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001022711 – 231Acyl-protein thioesterase 2Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2S-palmitoyl cysteine1 Publication1
Modified residuei82PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiO95372
MaxQBiO95372
PaxDbiO95372
PeptideAtlasiO95372
PRIDEiO95372
ProteomicsDBi50827

2D gel databases

OGPiO95372

PTM databases

iPTMnetiO95372
PhosphoSitePlusiO95372
SwissPalmiO95372

Expressioni

Gene expression databases

BgeeiENSG00000011009 Expressed in 209 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_LYPLA2
ExpressionAtlasiO95372 baseline and differential
GenevisibleiO95372 HS

Organism-specific databases

HPAiHPA063151

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116444, 23 interactors
IntActiO95372, 5 interactors
STRINGi9606.ENSP00000363638

Chemistry databases

BindingDBiO95372

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95372
SMRiO95372
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112 Eukaryota
COG0400 LUCA
GeneTreeiENSGT00390000009648
HOGENOMiHOG000260139
HOVERGENiHBG052378
InParanoidiO95372
KOiK06130
OMAiGYVMPAW
OrthoDBiEOG091G080L
PhylomeDBiO95372
TreeFamiTF314619

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR003140 PLipase/COase/thioEstase
PfamiView protein in Pfam
PF02230 Abhydrolase_2, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O95372-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP
60 70 80 90 100
HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK
110 120 130 140 150
ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP
160 170 180 190 200
LHRAFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRSVVTPARV
210 220 230
QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V
Length:231
Mass (Da):24,737
Last modified:May 1, 1999 - v1
Checksum:i813C9C71757C5135
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QPQ3Q5QPQ3_HUMAN
Acyl-protein thioesterase 2
LYPLA2
180Annotation score:
Q5QPQ1Q5QPQ1_HUMAN
Acyl-protein thioesterase 2
LYPLA2
162Annotation score:
Q5QPQ0Q5QPQ0_HUMAN
Acyl-protein thioesterase 2
LYPLA2
164Annotation score:
Q5QPQ2Q5QPQ2_HUMAN
Acyl-protein thioesterase 2
LYPLA2
182Annotation score:
Q5QPN9Q5QPN9_HUMAN
Acyl-protein thioesterase 2
LYPLA2
137Annotation score:
Q5QPN5Q5QPN5_HUMAN
Acyl-protein thioesterase 2
LYPLA2
90Annotation score:

Sequence cautioni

The sequence AAP97210 differs from that shown. Reason: Frameshift at positions 5, 164 and 179.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098668 mRNA Translation: AAC72844.1
AF090423 mRNA Translation: AAP97210.1 Frameshift.
AL031295 Genomic DNA No translation available.
BC017034 mRNA Translation: AAH17034.1
BC017193 mRNA Translation: AAH17193.1
CCDSiCCDS241.1
RefSeqiNP_009191.1, NM_007260.2
UniGeneiHs.533479

Genome annotation databases

EnsembliENST00000374514; ENSP00000363638; ENSG00000011009
GeneIDi11313
KEGGihsa:11313
UCSCiuc001bht.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098668 mRNA Translation: AAC72844.1
AF090423 mRNA Translation: AAP97210.1 Frameshift.
AL031295 Genomic DNA No translation available.
BC017034 mRNA Translation: AAH17034.1
BC017193 mRNA Translation: AAH17193.1
CCDSiCCDS241.1
RefSeqiNP_009191.1, NM_007260.2
UniGeneiHs.533479

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SYNX-ray1.64A/B/C/D1-231[»]
ProteinModelPortaliO95372
SMRiO95372
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116444, 23 interactors
IntActiO95372, 5 interactors
STRINGi9606.ENSP00000363638

Chemistry databases

BindingDBiO95372
ChEMBLiCHEMBL1932891
SwissLipidsiSLP:000001479

Protein family/group databases

ESTHERihuman-LYPLA2 LYsophospholipase_carboxylesterase
MEROPSiS09.025

PTM databases

iPTMnetiO95372
PhosphoSitePlusiO95372
SwissPalmiO95372

Polymorphism and mutation databases

BioMutaiLYPLA2

2D gel databases

OGPiO95372

Proteomic databases

EPDiO95372
MaxQBiO95372
PaxDbiO95372
PeptideAtlasiO95372
PRIDEiO95372
ProteomicsDBi50827

Protocols and materials databases

DNASUi11313
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374514; ENSP00000363638; ENSG00000011009
GeneIDi11313
KEGGihsa:11313
UCSCiuc001bht.4 human

Organism-specific databases

CTDi11313
DisGeNETi11313
EuPathDBiHostDB:ENSG00000011009.10
GeneCardsiLYPLA2
HGNCiHGNC:6738 LYPLA2
HPAiHPA063151
neXtProtiNX_O95372
OpenTargetsiENSG00000011009
PharmGKBiPA30500
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2112 Eukaryota
COG0400 LUCA
GeneTreeiENSGT00390000009648
HOGENOMiHOG000260139
HOVERGENiHBG052378
InParanoidiO95372
KOiK06130
OMAiGYVMPAW
OrthoDBiEOG091G080L
PhylomeDBiO95372
TreeFamiTF314619

Enzyme and pathway databases

ReactomeiR-HSA-373760 L1CAM interactions

Miscellaneous databases

GenomeRNAii11313
PROiPR:O95372

Gene expression databases

BgeeiENSG00000011009 Expressed in 209 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_LYPLA2
ExpressionAtlasiO95372 baseline and differential
GenevisibleiO95372 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR003140 PLipase/COase/thioEstase
PfamiView protein in Pfam
PF02230 Abhydrolase_2, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYPA2_HUMAN
AccessioniPrimary (citable) accession number: O95372
Secondary accession number(s): Q7Z4Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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