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Protein

Olfactory receptor 2C1

Gene

OR2C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2C1
Alternative name(s):
OLFmf3
Olfactory receptor 2C2
Olfactory receptor OR16-1
Olfactory receptor OR16-2
Gene namesi
Name:OR2C1
Synonyms:OR2C2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168158.3
HGNCiHGNC:8242 OR2C1
neXtProtiNX_O95371

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32147

Polymorphism and mutation databases

BioMutaiOR2C1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504651 – 312Olfactory receptor 2C1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95371
PRIDEiO95371
ProteomicsDBi50826

Expressioni

Gene expression databases

BgeeiENSG00000168158
CleanExiHS_OR2C1
GenevisibleiO95371 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307726

Structurei

3D structure databases

ProteinModelPortaliO95371
SMRiO95371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIM Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118914
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO95371
KOiK04257
OMAiGHRRVDN
OrthoDBiEOG091G0CU6
PhylomeDBiO95371
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR
60 70 80 90 100
LEARLHTPMY FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ
110 120 130 140 150
LYVFLWLGAT ECILLVVMAF DRYVAVCRPL RYTAIMNPQL CWLLAVIACL
160 170 180 190 200
GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE VPAMIKLACG DTSLNQAVLN
210 220 230 240 250
GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT CLSHLLVVFL
260 270 280 290 300
FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA
310
LRRLLGKGRE VG
Length:312
Mass (Da):34,412
Last modified:November 2, 2010 - v3
Checksum:i33A2697D06ED8E9E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04749016G → S2 PublicationsCorresponds to variant dbSNP:rs1218762Ensembl.1
Natural variantiVAR_047491149C → W4 PublicationsCorresponds to variant dbSNP:rs1218763Ensembl.1
Natural variantiVAR_047492229R → H2 PublicationsCorresponds to variant dbSNP:rs11648783Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098664 Genomic DNA Translation: AAC83557.1
AC025283 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85373.1
BC069456 mRNA Translation: AAH69456.1
BC126269 mRNA Translation: AAI26270.1
BC130328 mRNA Translation: AAI30329.1
BK004407 Genomic DNA Translation: DAA04805.1
BK004428 Genomic DNA Translation: DAA04826.1
CCDSiCCDS10502.1
RefSeqiNP_036500.2, NM_012368.2
UniGeneiHs.258574

Genome annotation databases

EnsembliENST00000304936; ENSP00000307726; ENSG00000168158
GeneIDi4993
KEGGihsa:4993
UCSCiuc002cuw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2C1_HUMAN
AccessioniPrimary (citable) accession number: O95371
Secondary accession number(s): A0AVA4, Q6IF34, Q6IF55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: June 20, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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