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Protein

Zinc finger and BTB domain-containing protein 7A

Gene

ZBTB7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149).By similarity8 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri382 – 404C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO95365
SIGNORiO95365

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7ACurated
Alternative name(s):
Factor binding IST protein 11 Publication
Short name:
FBI-11 Publication
Factor that binds to inducer of short transcripts protein 1
HIV-1 1st-binding protein 1
Leukemia/lymphoma-related factor1 Publication
POZ and Krueppel erythroid myeloid ontogenic factor1 Publication
Short name:
POK erythroid myeloid ontogenic factor1 Publication
Short name:
Pokemon1 Publication
Short name:
Pokemon 11 Publication
TTF-I-interacting peptide 21Imported
Short name:
TIP21Imported
Zinc finger protein 857A
Gene namesi
Name:ZBTB7AImported
Synonyms:FBI1, LRF1 Publication, ZBTB7Imported, ZNF857A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178951.8
HGNCiHGNC:18078 ZBTB7A
MIMi605878 gene
neXtProtiNX_O95365

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14P → S: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi22S → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi49R → H: Increased proteasomal degradation. No effect on nuclear localization. 1 Publication1
Mutagenesisi60K → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi61K → R: Loss of sumoylation with SUMO1. May decrease interaction with transcriptional corepressors. 1 Publication1
Mutagenesisi78D → E: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi112R → C: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi184P → S: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi322Q → L: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi326S → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi354K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. 1 Publication1
Mutagenesisi357S → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi371K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. 1 Publication1
Mutagenesisi377R → L: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi379K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi383K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. 1 Publication1
Mutagenesisi387C → F: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi391I → L: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi396K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi399R → L: Decreased transcription repressor activity, dominant negative effect. Increased glycolysis and cell proliferation, dominant negative effect. No effect on nuclear localization. 1 Publication1
Mutagenesisi402R → H: Decreased transcription repressor activity. Acts as a dominant negative. No effect on nuclear localization. 1 Publication1
Mutagenesisi403T → N: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi404H → R: Decreased transcription repressor activity. Acts as a dominant negative. No effect on nuclear localization. 1 Publication1
Mutagenesisi406G → V: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi409P → S: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi412C → Y: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi424K → N: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi424K → T: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi430R → W: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi461T → M: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi463L → M: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi466Y → D: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi486K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. No effect on nuclear localization. 1 Publication1
Mutagenesisi487K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. No effect on nuclear localization. 1 Publication1
Mutagenesisi522A → T: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi536K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi539K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi541E → K: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi562G → D: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi576D → V: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1

Organism-specific databases

DisGeNETi51341
OpenTargetsiENSG00000178951
PharmGKBiPA134885165

Polymorphism and mutation databases

BioMutaiZBTB7A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477151 – 584Zinc finger and BTB domain-containing protein 7AAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Cross-linki436Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei511PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Cross-linki539Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei549PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated. Undergoes sumoylation with SUMO1 that may regulate its transcriptional activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95365
MaxQBiO95365
PaxDbiO95365
PeptideAtlasiO95365
PRIDEiO95365
ProteomicsDBi50825

PTM databases

iPTMnetiO95365
PhosphoSitePlusiO95365

Expressioni

Tissue specificityi

Widely expressed (PubMed:9927193). In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) (PubMed:15662416). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level) (PubMed:15662416). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) (PubMed:15662416). Expressed in adipose tissues (PubMed:14701838).3 Publications

Developmental stagei

Expression is increased in differentiating erythroid cells (at protein level) (PubMed:26816381). Up-regulated during adipocyte differentiation (PubMed:14701838).2 Publications

Gene expression databases

BgeeiENSG00000178951 Expressed in 229 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZBTB7A
GenevisibleiO95365 HS

Organism-specific databases

HPAiCAB037214
CAB037285
HPA046387

Interactioni

Subunit structurei

Homodimer (PubMed:9973611). Interacts with BCL6 (By similarity). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Interacts with AR (via NR LBD domain); the interaction is direct and androgen-dependent (PubMed:20812024). Interacts with NCOR1 (PubMed:20812024). Interacts with NCOR2 (PubMed:20812024). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (PubMed:25514493). Interacts with HDAC1 (PubMed:25514493). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (PubMed:12004059). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (PubMed:26446488). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (PubMed:24514149).By similarity7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119488, 35 interactors
DIPiDIP-56307N
IntActiO95365, 14 interactors
MINTiO95365
STRINGi9606.ENSP00000323670

Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95365
SMRiO95365
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95365

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 101BTBPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 584Mediates interaction with KHDRBS11 PublicationAdd BLAST308
Regioni349 – 584Mediates interaction with RELABy similarityAdd BLAST236
Regioni377 – 584Mediates interaction with SMAD41 PublicationAdd BLAST208

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi175 – 211Ala-richAdd BLAST37
Compositional biasi175 – 181Poly-Ala7
Compositional biasi560 – 565Poly-Gly6

Domaini

The BTB domain mediates the interaction with the androgen receptor/AR and HDAC1 (PubMed:20812024, PubMed:25514493). Also mediates the interaction with SP1 (PubMed:12004059).3 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri382 – 404C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000082521
HOVERGENiHBG106747
InParanoidiO95365
KOiK10494
OMAiIDQRNHL
OrthoDBiEOG091G057O
PhylomeDBiO95365
TreeFamiTF331824

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

O95365-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS
60 70 80 90 100
VLAACSQYFK KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS
110 120 130 140 150
TANVGDILSA ARLLEIPAVS HVCADLLDRQ ILAADAGADA GQLDLVDQID
160 170 180 190 200
QRNLLRAKEY LEFFQSNPMN SLPPAAAAAA ASFPWSAFGA SDDDLDATKE
210 220 230 240 250
AVAAAVAAVA AGDCNGLDFY GPGPPAERPP TGDGDEGDSN PGLWPERDED
260 270 280 290 300
APTGGLFPPP VAPPAATQNG HYGRGGEEEA ASLSEAAPEP GDSPGFLSGA
310 320 330 340 350
AEGEDGDGPD VDGLAASTLL QQMMSSVGRA GAAAGDSDEE SRADDKGVMD
360 370 380 390 400
YYLKYFSGAH DGDVYPAWSQ KVEKKIRAKA FQKCPICEKV IQGAGKLPRH
410 420 430 440 450
IRTHTGEKPY ECNICKVRFT RQDKLKVHMR KHTGEKPYLC QQCGAAFAHN
460 470 480 490 500
YDLKNHMRVH TGLRPYQCDS CCKTFVRSDH LHRHLKKDGC NGVPSRRGRK
510 520 530 540 550
PRVRGGAPDP SPGATATPGA PAQPSSPDAR RNGQEKHFKD EDEDEDVASP
560 570 580
DGLGRLNVAG AGGGGDSGGG PGAATDGNFT AGLA
Length:584
Mass (Da):61,439
Last modified:May 1, 1999 - v1
Checksum:i50073663F3D393A0
GO

Sequence cautioni

The sequence AAB58414 differs from that shown. Reason: Frameshift at positions 8 and 324.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti554G → C in AAH84568 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097916 mRNA Translation: AAC72973.1
AF000561 mRNA Translation: AAB58414.1 Frameshift.
CH471139 Genomic DNA Translation: EAW69267.1
CH471139 Genomic DNA Translation: EAW69268.1
CH471139 Genomic DNA Translation: EAW69270.1
CH471139 Genomic DNA Translation: EAW69271.1
CH471139 Genomic DNA Translation: EAW69272.1
BC084568 mRNA Translation: AAH84568.1
BC113511 mRNA Translation: AAI13512.1
CCDSiCCDS12119.1
RefSeqiNP_001304919.1, NM_001317990.1
NP_056982.1, NM_015898.3
XP_005259628.1, XM_005259571.4
UniGeneiHs.591384

Genome annotation databases

EnsembliENST00000322357; ENSP00000323670; ENSG00000178951
ENST00000601588; ENSP00000471865; ENSG00000178951
GeneIDi51341
KEGGihsa:51341
UCSCiuc002lzh.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097916 mRNA Translation: AAC72973.1
AF000561 mRNA Translation: AAB58414.1 Frameshift.
CH471139 Genomic DNA Translation: EAW69267.1
CH471139 Genomic DNA Translation: EAW69268.1
CH471139 Genomic DNA Translation: EAW69270.1
CH471139 Genomic DNA Translation: EAW69271.1
CH471139 Genomic DNA Translation: EAW69272.1
BC084568 mRNA Translation: AAH84568.1
BC113511 mRNA Translation: AAI13512.1
CCDSiCCDS12119.1
RefSeqiNP_001304919.1, NM_001317990.1
NP_056982.1, NM_015898.3
XP_005259628.1, XM_005259571.4
UniGeneiHs.591384

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF5X-ray2.00A9-128[»]
2NN2X-ray2.10A/B1-131[»]
ProteinModelPortaliO95365
SMRiO95365
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119488, 35 interactors
DIPiDIP-56307N
IntActiO95365, 14 interactors
MINTiO95365
STRINGi9606.ENSP00000323670

PTM databases

iPTMnetiO95365
PhosphoSitePlusiO95365

Polymorphism and mutation databases

BioMutaiZBTB7A

Proteomic databases

EPDiO95365
MaxQBiO95365
PaxDbiO95365
PeptideAtlasiO95365
PRIDEiO95365
ProteomicsDBi50825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322357; ENSP00000323670; ENSG00000178951
ENST00000601588; ENSP00000471865; ENSG00000178951
GeneIDi51341
KEGGihsa:51341
UCSCiuc002lzh.4 human

Organism-specific databases

CTDi51341
DisGeNETi51341
EuPathDBiHostDB:ENSG00000178951.8
GeneCardsiZBTB7A
HGNCiHGNC:18078 ZBTB7A
HPAiCAB037214
CAB037285
HPA046387
MIMi605878 gene
neXtProtiNX_O95365
OpenTargetsiENSG00000178951
PharmGKBiPA134885165
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000082521
HOVERGENiHBG106747
InParanoidiO95365
KOiK10494
OMAiIDQRNHL
OrthoDBiEOG091G057O
PhylomeDBiO95365
TreeFamiTF331824

Enzyme and pathway databases

SignaLinkiO95365
SIGNORiO95365

Miscellaneous databases

ChiTaRSiZBTB7A human
EvolutionaryTraceiO95365
GeneWikiiZBTB7A
GenomeRNAii51341
PROiPR:O95365
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178951 Expressed in 229 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZBTB7A
GenevisibleiO95365 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT7A_HUMAN
AccessioniPrimary (citable) accession number: O95365
Secondary accession number(s): D6W619
, O00456, Q14D41, Q5XG86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: October 10, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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