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Protein

Zinc finger and BTB domain-containing protein 7A

Gene

ZBTB7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149).By similarity8 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri382 – 404C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O95365

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O95365

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7ACurated
Alternative name(s):
Factor binding IST protein 11 Publication
Short name:
FBI-11 Publication
Factor that binds to inducer of short transcripts protein 1
HIV-1 1st-binding protein 1
Leukemia/lymphoma-related factor1 Publication
POZ and Krueppel erythroid myeloid ontogenic factor1 Publication
Short name:
POK erythroid myeloid ontogenic factor1 Publication
Short name:
Pokemon1 Publication
Short name:
Pokemon 11 Publication
TTF-I-interacting peptide 21Imported
Short name:
TIP21Imported
Zinc finger protein 857A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB7AImported
Synonyms:FBI1, LRF1 Publication, ZBTB7Imported, ZNF857A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000178951.8

Human Gene Nomenclature Database

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HGNCi
HGNC:18078 ZBTB7A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605878 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O95365

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14P → S: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi22S → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi49R → H: Increased proteasomal degradation. No effect on nuclear localization. 1 Publication1
Mutagenesisi60K → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi61K → R: Loss of sumoylation with SUMO1. May decrease interaction with transcriptional corepressors. 1 Publication1
Mutagenesisi78D → E: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi112R → C: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi184P → S: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi322Q → L: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi326S → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi354K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. 1 Publication1
Mutagenesisi357S → R: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi371K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. 1 Publication1
Mutagenesisi377R → L: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi379K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi383K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. 1 Publication1
Mutagenesisi387C → F: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi391I → L: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi396K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi399R → L: Decreased transcription repressor activity, dominant negative effect. Increased glycolysis and cell proliferation, dominant negative effect. No effect on nuclear localization. 1 Publication1
Mutagenesisi402R → H: Decreased transcription repressor activity. Acts as a dominant negative. No effect on nuclear localization. 1 Publication1
Mutagenesisi403T → N: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi404H → R: Decreased transcription repressor activity. Acts as a dominant negative. No effect on nuclear localization. 1 Publication1
Mutagenesisi406G → V: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi409P → S: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi412C → Y: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi424K → N: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi424K → T: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi430R → W: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi461T → M: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi463L → M: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi466Y → D: Decreased transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi486K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. No effect on nuclear localization. 1 Publication1
Mutagenesisi487K → R: No effect on sumoylation with SUMO1. No effect on promoter binding. No effect on nuclear localization. 1 Publication1
Mutagenesisi522A → T: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi536K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi539K → R: No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. 1 Publication1
Mutagenesisi541E → K: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi562G → D: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1
Mutagenesisi576D → V: No effect on transcription repressor activity. No effect on nuclear localization. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
51341

Open Targets

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OpenTargetsi
ENSG00000178951

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134885165

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZBTB7A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477151 – 584Zinc finger and BTB domain-containing protein 7AAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei337PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki436Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei511PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Cross-linki539Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei549PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated. Undergoes sumoylation with SUMO1 that may regulate its transcriptional activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95365

MaxQB - The MaxQuant DataBase

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MaxQBi
O95365

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95365

PeptideAtlas

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PeptideAtlasi
O95365

PRoteomics IDEntifications database

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PRIDEi
O95365

ProteomicsDB human proteome resource

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ProteomicsDBi
50825

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95365

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95365

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:9927193). In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) (PubMed:15662416). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level) (PubMed:15662416). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) (PubMed:15662416). Expressed in adipose tissues (PubMed:14701838).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is increased in differentiating erythroid cells (at protein level) (PubMed:26816381). Up-regulated during adipocyte differentiation (PubMed:14701838).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178951 Expressed in 229 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

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CleanExi
HS_ZBTB7A

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95365 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037214
CAB037285
HPA046387

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:9973611). Interacts with BCL6 (By similarity). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Interacts with AR (via NR LBD domain); the interaction is direct and androgen-dependent (PubMed:20812024). Interacts with NCOR1 (PubMed:20812024). Interacts with NCOR2 (PubMed:20812024). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (PubMed:25514493). Interacts with HDAC1 (PubMed:25514493). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (PubMed:12004059). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (PubMed:26446488). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (PubMed:24514149).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119488, 35 interactors

Database of interacting proteins

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DIPi
DIP-56307N

Protein interaction database and analysis system

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IntActi
O95365, 15 interactors

Molecular INTeraction database

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MINTi
O95365

STRING: functional protein association networks

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STRINGi
9606.ENSP00000323670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95365

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95365

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O95365

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 101BTBPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni277 – 584Mediates interaction with KHDRBS11 PublicationAdd BLAST308
Regioni349 – 584Mediates interaction with RELABy similarityAdd BLAST236
Regioni377 – 584Mediates interaction with SMAD41 PublicationAdd BLAST208

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi175 – 211Ala-richAdd BLAST37
Compositional biasi175 – 181Poly-Ala7
Compositional biasi560 – 565Poly-Gly6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BTB domain mediates the interaction with the androgen receptor/AR and HDAC1 (PubMed:20812024, PubMed:25514493). Also mediates the interaction with SP1 (PubMed:12004059).3 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri382 – 404C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162053

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000082521

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106747

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95365

KEGG Orthology (KO)

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KOi
K10494

Identification of Orthologs from Complete Genome Data

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OMAi
IDQRNHL

Database of Orthologous Groups

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OrthoDBi
EOG091G057O

Database for complete collections of gene phylogenies

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PhylomeDBi
O95365

TreeFam database of animal gene trees

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TreeFami
TF331824

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

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Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O95365-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS
60 70 80 90 100
VLAACSQYFK KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS
110 120 130 140 150
TANVGDILSA ARLLEIPAVS HVCADLLDRQ ILAADAGADA GQLDLVDQID
160 170 180 190 200
QRNLLRAKEY LEFFQSNPMN SLPPAAAAAA ASFPWSAFGA SDDDLDATKE
210 220 230 240 250
AVAAAVAAVA AGDCNGLDFY GPGPPAERPP TGDGDEGDSN PGLWPERDED
260 270 280 290 300
APTGGLFPPP VAPPAATQNG HYGRGGEEEA ASLSEAAPEP GDSPGFLSGA
310 320 330 340 350
AEGEDGDGPD VDGLAASTLL QQMMSSVGRA GAAAGDSDEE SRADDKGVMD
360 370 380 390 400
YYLKYFSGAH DGDVYPAWSQ KVEKKIRAKA FQKCPICEKV IQGAGKLPRH
410 420 430 440 450
IRTHTGEKPY ECNICKVRFT RQDKLKVHMR KHTGEKPYLC QQCGAAFAHN
460 470 480 490 500
YDLKNHMRVH TGLRPYQCDS CCKTFVRSDH LHRHLKKDGC NGVPSRRGRK
510 520 530 540 550
PRVRGGAPDP SPGATATPGA PAQPSSPDAR RNGQEKHFKD EDEDEDVASP
560 570 580
DGLGRLNVAG AGGGGDSGGG PGAATDGNFT AGLA
Length:584
Mass (Da):61,439
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50073663F3D393A0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB58414 differs from that shown. Reason: Frameshift at positions 8 and 324.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti554G → C in AAH84568 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF097916 mRNA Translation: AAC72973.1
AF000561 mRNA Translation: AAB58414.1 Frameshift.
CH471139 Genomic DNA Translation: EAW69267.1
CH471139 Genomic DNA Translation: EAW69268.1
CH471139 Genomic DNA Translation: EAW69270.1
CH471139 Genomic DNA Translation: EAW69271.1
CH471139 Genomic DNA Translation: EAW69272.1
BC084568 mRNA Translation: AAH84568.1
BC113511 mRNA Translation: AAI13512.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12119.1

NCBI Reference Sequences

More...
RefSeqi
NP_001304919.1, NM_001317990.1
NP_056982.1, NM_015898.3
XP_005259628.1, XM_005259571.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591384

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322357; ENSP00000323670; ENSG00000178951
ENST00000601588; ENSP00000471865; ENSG00000178951

Database of genes from NCBI RefSeq genomes

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GeneIDi
51341

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51341

UCSC genome browser

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UCSCi
uc002lzh.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097916 mRNA Translation: AAC72973.1
AF000561 mRNA Translation: AAB58414.1 Frameshift.
CH471139 Genomic DNA Translation: EAW69267.1
CH471139 Genomic DNA Translation: EAW69268.1
CH471139 Genomic DNA Translation: EAW69270.1
CH471139 Genomic DNA Translation: EAW69271.1
CH471139 Genomic DNA Translation: EAW69272.1
BC084568 mRNA Translation: AAH84568.1
BC113511 mRNA Translation: AAI13512.1
CCDSiCCDS12119.1
RefSeqiNP_001304919.1, NM_001317990.1
NP_056982.1, NM_015898.3
XP_005259628.1, XM_005259571.4
UniGeneiHs.591384

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF5X-ray2.00A9-128[»]
2NN2X-ray2.10A/B1-131[»]
ProteinModelPortaliO95365
SMRiO95365
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119488, 35 interactors
DIPiDIP-56307N
IntActiO95365, 15 interactors
MINTiO95365
STRINGi9606.ENSP00000323670

PTM databases

iPTMnetiO95365
PhosphoSitePlusiO95365

Polymorphism and mutation databases

BioMutaiZBTB7A

Proteomic databases

EPDiO95365
MaxQBiO95365
PaxDbiO95365
PeptideAtlasiO95365
PRIDEiO95365
ProteomicsDBi50825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322357; ENSP00000323670; ENSG00000178951
ENST00000601588; ENSP00000471865; ENSG00000178951
GeneIDi51341
KEGGihsa:51341
UCSCiuc002lzh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51341
DisGeNETi51341
EuPathDBiHostDB:ENSG00000178951.8

GeneCards: human genes, protein and diseases

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GeneCardsi
ZBTB7A
HGNCiHGNC:18078 ZBTB7A
HPAiCAB037214
CAB037285
HPA046387
MIMi605878 gene
neXtProtiNX_O95365
OpenTargetsiENSG00000178951
PharmGKBiPA134885165

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162053
HOGENOMiHOG000082521
HOVERGENiHBG106747
InParanoidiO95365
KOiK10494
OMAiIDQRNHL
OrthoDBiEOG091G057O
PhylomeDBiO95365
TreeFamiTF331824

Enzyme and pathway databases

SignaLinkiO95365
SIGNORiO95365

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZBTB7A human
EvolutionaryTraceiO95365

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZBTB7A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51341

Protein Ontology

More...
PROi
PR:O95365

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178951 Expressed in 229 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ZBTB7A
GenevisibleiO95365 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT7A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95365
Secondary accession number(s): D6W619
, O00456, Q14D41, Q5XG86
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: December 5, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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