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Protein

Bile salt export pump

Gene

ABCB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30.4 µM for taurocholate1 Publication
  1. Vmax=232 pmol/min/mg enzyme for taurocholate transport1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi455 – 462ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1113 – 1120ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: ProtInc
  • bile acid-exporting ATPase activity Source: Reactome
  • canalicular bile acid transmembrane transporter activity Source: GO_Central
  • sodium-exporting ATPase activity, phosphorylative mechanism Source: ProtInc
  • transporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-159418 Recycling of bile acids and salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-5678520 Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.201.2 the atp-binding cassette (abc) superfamily

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001597

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCB11
Synonyms:BSEP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000073734.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:42 ABCB11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603201 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95342

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 62CytoplasmicSequence analysisAdd BLAST62
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 83HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini84 – 147ExtracellularSequence analysisAdd BLAST64
Transmembranei148 – 168HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini169 – 215CytoplasmicSequence analysisAdd BLAST47
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini237 – 240ExtracellularSequence analysis4
Transmembranei241 – 261HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini262 – 319CytoplasmicSequence analysisAdd BLAST58
Transmembranei320 – 340HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini341 – 353ExtracellularSequence analysisAdd BLAST13
Transmembranei354 – 374HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini375 – 755CytoplasmicSequence analysisAdd BLAST381
Transmembranei756 – 776HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini777 – 794ExtracellularSequence analysisAdd BLAST18
Transmembranei795 – 815HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini816 – 869CytoplasmicSequence analysisAdd BLAST54
Transmembranei870 – 890HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei891 – 911HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini912 – 979CytoplasmicSequence analysisAdd BLAST68
Transmembranei980 – 1000HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1001 – 1011ExtracellularSequence analysisAdd BLAST11
Transmembranei1012 – 1032HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1033 – 1321CytoplasmicSequence analysisAdd BLAST289

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cholestasis, progressive familial intrahepatic, 2 (PFIC2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood.
See also OMIM:601847
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030388238G → V in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72551306Ensembl.1
Natural variantiVAR_013332284V → L in PFIC2. 1 Publication1
Natural variantiVAR_030390336C → S in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72551305Ensembl.1
Natural variantiVAR_073967337Y → H in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_013334461K → E in PFIC2. 1 Publication1
Natural variantiVAR_073968472Y → C in PFIC2; compound heterozygous with V-1131. 1 PublicationCorresponds to variant dbSNP:rs369860506Ensembl.1
Natural variantiVAR_013335482D → G in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549402EnsemblClinVar.1
Natural variantiVAR_073969696R → W in PFIC2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs376216286Ensembl.1
Natural variantiVAR_073970931Q → P in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_013336982G → R in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549399Ensembl.1
Natural variantiVAR_0133371004G → D in PFIC2. 1 Publication1
Natural variantiVAR_0739711131D → V in PFIC2; compound heterozygous with C-472. 1 Publication1
Natural variantiVAR_0133381153R → C in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549395EnsemblClinVar.1
Natural variantiVAR_0739721198H → R in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_0133391268R → Q in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549394Ensembl.1
Cholestasis, benign recurrent intrahepatic, 2 (BRIC2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically.
See also OMIM:605479
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030386186E → G in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs72551307Ensembl.1
Natural variantiVAR_030391432R → T in BRIC2; reduced transport capacity for taurocholate. 1 PublicationCorresponds to variant dbSNP:rs121908935EnsemblClinVar.1
Natural variantiVAR_030392570A → T in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs886043807EnsemblClinVar.1
Natural variantiVAR_030394923T → P in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs777469571Ensembl.1
Natural variantiVAR_030395926A → P in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs72549400Ensembl.1
Natural variantiVAR_0303961050R → C in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs72549398EnsemblClinVar.1
Natural variantiVAR_0303971128R → H in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs756220860EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Intrahepatic cholestasis

Organism-specific databases

DisGeNET

More...
DisGeNETi
8647

MalaCards human disease database

More...
MalaCardsi
ABCB11
MIMi601847 phenotype
605479 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000073734

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99961 Benign recurrent intrahepatic cholestasis type 2
69665 Intrahepatic cholestasis of pregnancy
79304 Progressive familial intrahepatic cholestasis type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA374

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6020

Drug and drug target database

More...
DrugBanki
DB00171 Adenosine triphosphate
DB00559 Bosentan
DB00477 Chlorpromazine
DB02659 Cholic Acid
DB00501 Cimetidine
DB00845 Clofazimine
DB00091 Cyclosporine
DB00694 Daunorubicin
DB03619 Deoxycholic Acid
DB01234 Dexamethasone
DB00390 Digoxin
DB00997 Doxorubicin
DB00977 Ethinyl Estradiol
DB00693 Fluorescein
DB02703 Fusidic Acid
DB01016 Glyburide
DB02123 Glycochenodeoxycholic Acid
DB01026 Ketoconazole
DB01051 Novobiocin
DB01229 Paclitaxel
DB01174 Phenobarbital
DB08901 Ponatinib
DB00175 Pravastatin
DB00396 Progesterone
DB00908 Quinidine
DB00206 Reserpine
DB01045 Rifampicin
DB01098 Rosuvastatin
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB00197 Troglitazone
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
778

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCB11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000932961 – 1321Bile salt export pumpAdd BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi116N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi122N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi125N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei586PhosphothreonineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei690PhosphoserineBy similarity1
Modified residuei701PhosphoserineBy similarity1
Modified residuei704PhosphoserineCombined sources1
Modified residuei1214PhosphoserineCombined sources1
Modified residuei1321PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95342

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95342

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95342

PeptideAtlas

More...
PeptideAtlasi
O95342

PRoteomics IDEntifications database

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PRIDEi
O95342

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50810

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95342

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95342

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000073734 Expressed in 39 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_ABCB11

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95342 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95342 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019035

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HAX1.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114199, 5 interactors

Protein interaction database and analysis system

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IntActi
O95342, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263817

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O95342

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95342

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95342

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 385ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST324
Domaini420 – 656ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini755 – 1043ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini1078 – 1316ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni651 – 672Interaction with HAX1By similarityAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0055 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157564

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080809

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95342

KEGG Orthology (KO)

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KOi
K05664

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIQRMTT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0HVA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95342

TreeFam database of animal gene trees

More...
TreeFami
TF105193

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030278 BSEP
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter

The PANTHER Classification System

More...
PANTHERi
PTHR24221 PTHR24221, 1 hit
PTHR24221:SF165 PTHR24221:SF165, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95342-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSVILRSI KKFGEENDGF ESDKSYNNDK KSRLQDEKKG DGVRVGFFQL
60 70 80 90 100
FRFSSSTDIW LMFVGSLCAF LHGIAQPGVL LIFGTMTDVF IDYDVELQEL
110 120 130 140 150
QIPGKACVNN TIVWTNSSLN QNMTNGTRCG LLNIESEMIK FASYYAGIAV
160 170 180 190 200
AVLITGYIQI CFWVIAAARQ IQKMRKFYFR RIMRMEIGWF DCNSVGELNT
210 220 230 240 250
RFSDDINKIN DAIADQMALF IQRMTSTICG FLLGFFRGWK LTLVIISVSP
260 270 280 290 300
LIGIGAATIG LSVSKFTDYE LKAYAKAGVV ADEVISSMRT VAAFGGEKRE
310 320 330 340 350
VERYEKNLVF AQRWGIRKGI VMGFFTGFVW CLIFLCYALA FWYGSTLVLD
360 370 380 390 400
EGEYTPGTLV QIFLSVIVGA LNLGNASPCL EAFATGRAAA TSIFETIDRK
410 420 430 440 450
PIIDCMSEDG YKLDRIKGEI EFHNVTFHYP SRPEVKILND LNMVIKPGEM
460 470 480 490 500
TALVGPSGAG KSTALQLIQR FYDPCEGMVT VDGHDIRSLN IQWLRDQIGI
510 520 530 540 550
VEQEPVLFST TIAENIRYGR EDATMEDIVQ AAKEANAYNF IMDLPQQFDT
560 570 580 590 600
LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEAMVQEV
610 620 630 640 650
LSKIQHGHTI ISVAHRLSTV RAADTIIGFE HGTAVERGTH EELLERKGVY
660 670 680 690 700
FTLVTLQSQG NQALNEEDIK DATEDDMLAR TFSRGSYQDS LRASIRQRSK
710 720 730 740 750
SQLSYLVHEP PLAVVDHKST YEEDRKDKDI PVQEEVEPAP VRRILKFSAP
760 770 780 790 800
EWPYMLVGSV GAAVNGTVTP LYAFLFSQIL GTFSIPDKEE QRSQINGVCL
810 820 830 840 850
LFVAMGCVSL FTQFLQGYAF AKSGELLTKR LRKFGFRAML GQDIAWFDDL
860 870 880 890 900
RNSPGALTTR LATDASQVQG AAGSQIGMIV NSFTNVTVAM IIAFSFSWKL
910 920 930 940 950
SLVILCFFPF LALSGATQTR MLTGFASRDK QALEMVGQIT NEALSNIRTV
960 970 980 990 1000
AGIGKERRFI EALETELEKP FKTAIQKANI YGFCFAFAQC IMFIANSASY
1010 1020 1030 1040 1050
RYGGYLISNE GLHFSYVFRV ISAVVLSATA LGRAFSYTPS YAKAKISAAR
1060 1070 1080 1090 1100
FFQLLDRQPP ISVYNTAGEK WDNFQGKIDF VDCKFTYPSR PDSQVLNGLS
1110 1120 1130 1140 1150
VSISPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGKVMID GHDSKKVNVQ
1160 1170 1180 1190 1200
FLRSNIGIVS QEPVLFACSI MDNIKYGDNT KEIPMERVIA AAKQAQLHDF
1210 1220 1230 1240 1250
VMSLPEKYET NVGSQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD
1260 1270 1280 1290 1300
TESEKTVQVA LDKAREGRTC IVIAHRLSTI QNADIIAVMA QGVVIEKGTH
1310 1320
EELMAQKGAY YKLVTTGSPI S
Length:1,321
Mass (Da):146,407
Last modified:November 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61EE2173E2351D80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53S60Q53S60_HUMAN
Bile salt export pump
ABCB11
451Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C486H7C486_HUMAN
Bile salt export pump
ABCB11
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti339L → V in AAC77455 (PubMed:9806540).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05547256S → L. Corresponds to variant dbSNP:rs11568361EnsemblClinVar.1
Natural variantiVAR_030386186E → G in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs72551307Ensembl.1
Natural variantiVAR_030387206I → V1 PublicationCorresponds to variant dbSNP:rs11568357EnsemblClinVar.1
Natural variantiVAR_030388238G → V in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72551306Ensembl.1
Natural variantiVAR_035349284V → A2 PublicationsCorresponds to variant dbSNP:rs200739891EnsemblClinVar.1
Natural variantiVAR_013332284V → L in PFIC2. 1 Publication1
Natural variantiVAR_010271297E → G in PFIC2 and BRIC2; reduced transport capacity for taurocholate. 3 PublicationsCorresponds to variant dbSNP:rs11568372EnsemblClinVar.1
Natural variantiVAR_030389299R → K1 PublicationCorresponds to variant dbSNP:rs2287617Ensembl.1
Natural variantiVAR_030390336C → S in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72551305Ensembl.1
Natural variantiVAR_073967337Y → H in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_043074415R → Q1 PublicationCorresponds to variant dbSNP:rs371656014Ensembl.1
Natural variantiVAR_030391432R → T in BRIC2; reduced transport capacity for taurocholate. 1 PublicationCorresponds to variant dbSNP:rs121908935EnsemblClinVar.1
Natural variantiVAR_013333444V → A Common polymorphism; more frequent in patients with drug-induced cholestasis than healthy controls; associated with lower hepatic expression; does not affect transport capacity for taurocholate. 7 PublicationsCorresponds to variant dbSNP:rs2287622EnsemblClinVar.1
Natural variantiVAR_059106444V → D. Corresponds to variant dbSNP:rs2287622EnsemblClinVar.1
Natural variantiVAR_059107444V → G. Corresponds to variant dbSNP:rs2287622EnsemblClinVar.1
Natural variantiVAR_013334461K → E in PFIC2. 1 Publication1
Natural variantiVAR_073968472Y → C in PFIC2; compound heterozygous with V-1131. 1 PublicationCorresponds to variant dbSNP:rs369860506Ensembl.1
Natural variantiVAR_013335482D → G in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549402EnsemblClinVar.1
Natural variantiVAR_030392570A → T in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs886043807EnsemblClinVar.1
Natural variantiVAR_043075591N → S in a patient with intrahepatic cholestasis of pregnancy. 1 PublicationCorresponds to variant dbSNP:rs11568367EnsemblClinVar.1
Natural variantiVAR_035350616R → G1 Publication1
Natural variantiVAR_035351619T → A1 PublicationCorresponds to variant dbSNP:rs912519986Ensembl.1
Natural variantiVAR_043076676D → Y in fluvastatin-induced cholestasis; does not affect transport capacity for taurocholate. 1 Publication1
Natural variantiVAR_030393677M → V Does not affect transport capacity for taurocholate. 4 PublicationsCorresponds to variant dbSNP:rs11568364EnsemblClinVar.1
Natural variantiVAR_073969696R → W in PFIC2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs376216286Ensembl.1
Natural variantiVAR_035352698R → H2 PublicationsCorresponds to variant dbSNP:rs138642043EnsemblClinVar.1
Natural variantiVAR_043077855G → R in ethinylestradiol/gestodene-induced cholestasis; loss of transport capacity for taurocholate. 1 Publication1
Natural variantiVAR_035353865A → V Polymorphism. 2 PublicationsCorresponds to variant dbSNP:rs118109635EnsemblClinVar.1
Natural variantiVAR_030394923T → P in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs777469571Ensembl.1
Natural variantiVAR_030395926A → P in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs72549400Ensembl.1
Natural variantiVAR_073970931Q → P in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_035354958R → Q1 PublicationCorresponds to variant dbSNP:rs761363245Ensembl.1
Natural variantiVAR_013336982G → R in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549399Ensembl.1
Natural variantiVAR_0133371004G → D in PFIC2. 1 Publication1
Natural variantiVAR_0303961050R → C in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs72549398EnsemblClinVar.1
Natural variantiVAR_0303971128R → H in BRIC2. 1 PublicationCorresponds to variant dbSNP:rs756220860EnsemblClinVar.1
Natural variantiVAR_0739711131D → V in PFIC2; compound heterozygous with C-472. 1 Publication1
Natural variantiVAR_0133381153R → C in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549395EnsemblClinVar.1
Natural variantiVAR_0303981186E → K. Corresponds to variant dbSNP:rs1521808EnsemblClinVar.1
Natural variantiVAR_0739721198H → R in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_0133391268R → Q in PFIC2. 1 PublicationCorresponds to variant dbSNP:rs72549394Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF091582 mRNA Translation: AAC77455.1
AF136523 mRNA Translation: AAD28285.1
AC008177 Genomic DNA Translation: AAY24305.1
AC093723 Genomic DNA No translation available.
AC069137 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46444.1

NCBI Reference Sequences

More...
RefSeqi
NP_003733.2, NM_003742.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.158316
Hs.658439

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263817; ENSP00000263817; ENSG00000073734
ENST00000650372; ENSP00000497931; ENSG00000073734

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8647

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8647

UCSC genome browser

More...
UCSCi
uc002ueo.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091582 mRNA Translation: AAC77455.1
AF136523 mRNA Translation: AAD28285.1
AC008177 Genomic DNA Translation: AAY24305.1
AC093723 Genomic DNA No translation available.
AC069137 Genomic DNA No translation available.
CCDSiCCDS46444.1
RefSeqiNP_003733.2, NM_003742.2
UniGeneiHs.158316
Hs.658439

3D structure databases

ProteinModelPortaliO95342
SMRiO95342
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114199, 5 interactors
IntActiO95342, 3 interactors
STRINGi9606.ENSP00000263817

Chemistry databases

BindingDBiO95342
ChEMBLiCHEMBL6020
DrugBankiDB00171 Adenosine triphosphate
DB00559 Bosentan
DB00477 Chlorpromazine
DB02659 Cholic Acid
DB00501 Cimetidine
DB00845 Clofazimine
DB00091 Cyclosporine
DB00694 Daunorubicin
DB03619 Deoxycholic Acid
DB01234 Dexamethasone
DB00390 Digoxin
DB00997 Doxorubicin
DB00977 Ethinyl Estradiol
DB00693 Fluorescein
DB02703 Fusidic Acid
DB01016 Glyburide
DB02123 Glycochenodeoxycholic Acid
DB01026 Ketoconazole
DB01051 Novobiocin
DB01229 Paclitaxel
DB01174 Phenobarbital
DB08901 Ponatinib
DB00175 Pravastatin
DB00396 Progesterone
DB00908 Quinidine
DB00206 Reserpine
DB01045 Rifampicin
DB01098 Rosuvastatin
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB00197 Troglitazone
DB01586 Ursodeoxycholic acid
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine
GuidetoPHARMACOLOGYi778
SwissLipidsiSLP:000001597

Protein family/group databases

TCDBi3.A.1.201.2 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiO95342
PhosphoSitePlusiO95342

Polymorphism and mutation databases

BioMutaiABCB11

Proteomic databases

EPDiO95342
MaxQBiO95342
PaxDbiO95342
PeptideAtlasiO95342
PRIDEiO95342
ProteomicsDBi50810

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263817; ENSP00000263817; ENSG00000073734
ENST00000650372; ENSP00000497931; ENSG00000073734
GeneIDi8647
KEGGihsa:8647
UCSCiuc002ueo.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8647
DisGeNETi8647
EuPathDBiHostDB:ENSG00000073734.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCB11

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0029772
HGNCiHGNC:42 ABCB11
HPAiHPA019035
MalaCardsiABCB11
MIMi601847 phenotype
603201 gene
605479 phenotype
neXtProtiNX_O95342
OpenTargetsiENSG00000073734
Orphaneti99961 Benign recurrent intrahepatic cholestasis type 2
69665 Intrahepatic cholestasis of pregnancy
79304 Progressive familial intrahepatic cholestasis type 2
PharmGKBiPA374

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0055 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000157564
HOVERGENiHBG080809
InParanoidiO95342
KOiK05664
OMAiFIQRMTT
OrthoDBiEOG091G0HVA
PhylomeDBiO95342
TreeFamiTF105193

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-5678520 Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCB11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCB11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8647

Protein Ontology

More...
PROi
PR:O95342

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000073734 Expressed in 39 organ(s), highest expression level in liver
CleanExiHS_ABCB11
ExpressionAtlasiO95342 baseline and differential
GenevisibleiO95342 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030278 BSEP
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PTHR24221:SF165 PTHR24221:SF165, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCBB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95342
Secondary accession number(s): Q53TL2, Q9UNB2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 3, 2009
Last modified: December 5, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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