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Protein

6-phosphogluconolactonase

Gene

PGLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (PGLS)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (PGD), 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating (gntZ)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: UniProtKB

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • pentose-phosphate shunt Source: UniProtKB
  • pentose-phosphate shunt, oxidative branch Source: GO_Central

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS05370-MONOMER
BRENDAi3.1.1.31 2681
ReactomeiR-HSA-71336 Pentose phosphate pathway
UniPathwayi
UPA00115;UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:PGLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130313.6
HGNCiHGNC:8903 PGLS
MIMi604951 gene
neXtProtiNX_O95336

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi25796
OpenTargetsiENSG00000130313
PharmGKBiPA33240

Polymorphism and mutation databases

BioMutaiPGLS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000900782 – 2586-phosphogluconolactonaseAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei180N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95336
MaxQBiO95336
PaxDbiO95336
PeptideAtlasiO95336
PRIDEiO95336
ProteomicsDBi50807
TopDownProteomicsiO95336

2D gel databases

OGPiO95336
REPRODUCTION-2DPAGEiIPI00029997

PTM databases

iPTMnetiO95336
PhosphoSitePlusiO95336
SwissPalmiO95336

Expressioni

Gene expression databases

BgeeiENSG00000130313 Expressed in 218 organ(s), highest expression level in esophagus mucosa
CleanExiHS_PGLS
ExpressionAtlasiO95336 baseline and differential
GenevisibleiO95336 HS

Organism-specific databases

HPAiHPA040744
HPA042032

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-11307753,EBI-750109

Protein-protein interaction databases

BioGridi117328, 22 interactors
IntActiO95336, 7 interactors
STRINGi9606.ENSP00000252603

Structurei

3D structure databases

ProteinModelPortaliO95336
SMRiO95336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00550000075110
HOGENOMiHOG000256285
HOVERGENiHBG000030
InParanoidiO95336
KOiK01057
OMAiKQPHLAI
OrthoDBiEOG091G0NKD
PhylomeDBiO95336
TreeFamiTF318609

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
IPR039104 PGLS
PANTHERiPTHR11054 PTHR11054, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95336-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL
60 70 80 90 100
VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI
210 220 230 240 250
FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV

PFEKHSTL
Length:258
Mass (Da):27,547
Last modified:May 30, 2000 - v2
Checksum:iA753FB7E662116DD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R261M0R261_HUMAN
6-phosphogluconolactonase
PGLS
216Annotation score:
M0R1L2M0R1L2_HUMAN
6-phosphogluconolactonase
PGLS
147Annotation score:
M0R0U3M0R0U3_HUMAN
6-phosphogluconolactonase
PGLS
179Annotation score:

Sequence cautioni

The sequence AAC72960 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243972 mRNA Translation: CAB57866.1
BC014006 mRNA Translation: AAH14006.1
AF091091 mRNA Translation: AAC72960.1 Different initiation.
CCDSiCCDS12361.1
RefSeqiNP_036220.1, NM_012088.2
UniGeneiHs.466165

Genome annotation databases

EnsembliENST00000252603; ENSP00000252603; ENSG00000130313
GeneIDi25796
KEGGihsa:25796
UCSCiuc002ngw.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243972 mRNA Translation: CAB57866.1
BC014006 mRNA Translation: AAH14006.1
AF091091 mRNA Translation: AAC72960.1 Different initiation.
CCDSiCCDS12361.1
RefSeqiNP_036220.1, NM_012088.2
UniGeneiHs.466165

3D structure databases

ProteinModelPortaliO95336
SMRiO95336
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117328, 22 interactors
IntActiO95336, 7 interactors
STRINGi9606.ENSP00000252603

PTM databases

iPTMnetiO95336
PhosphoSitePlusiO95336
SwissPalmiO95336

Polymorphism and mutation databases

BioMutaiPGLS

2D gel databases

OGPiO95336
REPRODUCTION-2DPAGEiIPI00029997

Proteomic databases

EPDiO95336
MaxQBiO95336
PaxDbiO95336
PeptideAtlasiO95336
PRIDEiO95336
ProteomicsDBi50807
TopDownProteomicsiO95336

Protocols and materials databases

DNASUi25796
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252603; ENSP00000252603; ENSG00000130313
GeneIDi25796
KEGGihsa:25796
UCSCiuc002ngw.4 human

Organism-specific databases

CTDi25796
DisGeNETi25796
EuPathDBiHostDB:ENSG00000130313.6
GeneCardsiPGLS
HGNCiHGNC:8903 PGLS
HPAiHPA040744
HPA042032
MIMi604951 gene
neXtProtiNX_O95336
OpenTargetsiENSG00000130313
PharmGKBiPA33240
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00550000075110
HOGENOMiHOG000256285
HOVERGENiHBG000030
InParanoidiO95336
KOiK01057
OMAiKQPHLAI
OrthoDBiEOG091G0NKD
PhylomeDBiO95336
TreeFamiTF318609

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00409

BioCyciMetaCyc:HS05370-MONOMER
BRENDAi3.1.1.31 2681
ReactomeiR-HSA-71336 Pentose phosphate pathway

Miscellaneous databases

GenomeRNAii25796
PROiPR:O95336
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130313 Expressed in 218 organ(s), highest expression level in esophagus mucosa
CleanExiHS_PGLS
ExpressionAtlasiO95336 baseline and differential
GenevisibleiO95336 HS

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
IPR039104 PGLS
PANTHERiPTHR11054 PTHR11054, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_HUMAN
AccessioniPrimary (citable) accession number: O95336
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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