Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CUGBP Elav-like family member 2

Gene

CELF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233).By similarity8 Publications

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • pre-mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
CUGBP Elav-like family member 2
Short name:
CELF-2
Alternative name(s):
Bruno-like protein 3
CUG triplet repeat RNA-binding protein 2
Short name:
CUG-BP2
CUG-BP- and ETR-3-like factor 2
ELAV-type RNA-binding protein 3
Short name:
ETR-3
Neuroblastoma apoptosis-related RNA-binding protein
Short name:
hNAPOR
RNA-binding protein BRUNOL-3
Gene namesi
Name:CELF2
Synonyms:BRUNOL3, CUGBP2, ETR3, NAPOR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000048740.17
HGNCiHGNC:2550 CELF2
MIMi602538 gene
neXtProtiNX_O95319

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10659
OpenTargetsiENSG00000048740
PharmGKBiPA27046

Polymorphism and mutation databases

BioMutaiCELF2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951891 – 508CUGBP Elav-like family member 2Add BLAST508

Proteomic databases

EPDiO95319
MaxQBiO95319
PaxDbiO95319
PeptideAtlasiO95319
PRIDEiO95319
ProteomicsDBi50802
50803 [O95319-2]
50804 [O95319-3]
50805 [O95319-4]
50806 [O95319-5]

2D gel databases

UCD-2DPAGEiO95319

PTM databases

iPTMnetiO95319
PhosphoSitePlusiO95319

Expressioni

Tissue specificityi

Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.5 Publications

Developmental stagei

Isoform 1 is expressed in fetal brain. Isoform 2 is expressed in fetal heart, brain, thymus, lung, liver, skeletal muscle, kidney and spleen. Isoform 4 is expressed in fetal heart, brain, thymus, lung and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000048740 Expressed in 241 organ(s), highest expression level in forebrain
CleanExiHS_CUGBP2
ExpressionAtlasiO95319 baseline and differential
GenevisibleiO95319 HS

Organism-specific databases

HPAiCAB016395
HPA035813
HPA065098

Interactioni

Subunit structurei

Interacts with A1CF.By similarity

Protein-protein interaction databases

BioGridi115902, 25 interactors
IntActiO95319, 7 interactors
MINTiO95319
STRINGi9606.ENSP00000389951

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95319
SMRiO95319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 123RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini132 – 212RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini423 – 501RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 283Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionAdd BLAST283
Regioni357 – 508Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi284 – 397Ala-richAdd BLAST114

Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00560000076837
HOVERGENiHBG107646
InParanoidiO95319
KOiK13207
PhylomeDBiO95319

Family and domain databases

CDDicd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95319-1) [UniParc]FASTAAdd to basket
Also known as: NAPOR-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRCPKSAVTM RNEELLLSNG TANKMNGALD HSDQPDPDAI KMFVGQIPRS
60 70 80 90 100
WSEKELKELF EPYGAVYQIN VLRDRSQNPP QSKGCCFVTF YTRKAALEAQ
110 120 130 140 150
NALHNIKTLP GMHHPIQMKP ADSEKSNAVE DRKLFIGMVS KKCNENDIRV
160 170 180 190 200
MFSPFGQIEE CRILRGPDGL SRGCAFVTFS TRAMAQNAIK AMHQSQTMEG
210 220 230 240 250
CSSPIVVKFA DTQKDKEQRR LQQQLAQQMQ QLNTATWGNL TGLGGLTPQY
260 270 280 290 300
LALLQQATSS SNLGAFSGIQ QMAGMNALQL QNLATLAAAA AAAQTSATST
310 320 330 340 350
NANPLSTTSS ALGALTSPVA ASTPNSTAGA AMNSLTSLGT LQGLAGATVG
360 370 380 390 400
LNNINALAGM AALNGGLGAT GLTNGTAGTM DALTQAYSGI QQYAAAALPT
410 420 430 440 450
LYSQSLLQQQ SAAGSQKEGP EGANLFIYHL PQEFGDQDIL QMFMPFGNVI
460 470 480 490 500
SAKVFIDKQT NLSKCFGFVS YDNPVSAQAA IQAMNGFQIG MKRLKVQLKR

SKNDSKPY
Length:508
Mass (Da):54,285
Last modified:May 1, 1999 - v1
Checksum:iC65F337D462717F2
GO
Isoform 2 (identifier: O95319-2) [UniParc]FASTAAdd to basket
Also known as: NAPOR-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     358-358: A → AVAQMLS

Show »
Length:490
Mass (Da):52,268
Checksum:i3A17B1F5F31AC5BD
GO
Isoform 3 (identifier: O95319-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRCPKSAVTMRNEELLLS → MMVEGRLLVPDRI
     358-358: A → AGTINTPRSKRLLLPKDNN

Show »
Length:521
Mass (Da):55,754
Checksum:iDD6E4F77FE6B4073
GO
Isoform 4 (identifier: O95319-4) [UniParc]FASTAAdd to basket
Also known as: NAPOR-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRCPKSAVTMRNEELLLS → MMVEGRLLVPDRI
     358-358: A → AVAQMLS

Show »
Length:509
Mass (Da):54,365
Checksum:i4A0DB5E2372193ED
GO
Isoform 5 (identifier: O95319-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     359-359: G → GTINS

Show »
Length:488
Mass (Da):52,054
Checksum:iCBB835681201C245
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PC62E9PC62_HUMAN
CUGBP Elav-like family member 2
CELF2
521Annotation score:
A0A0J9YX66A0A0J9YX66_HUMAN
CUGBP Elav-like family member 2
CELF2
514Annotation score:
Q5VZZ6Q5VZZ6_HUMAN
CUGBP Elav-like family member 2
CELF2
502Annotation score:
A0A0J9YXJ0A0A0J9YXJ0_HUMAN
CUGBP Elav-like family member 2
CELF2
533Annotation score:
V9GYD9V9GYD9_HUMAN
CUGBP Elav-like family member 2
CELF2
440Annotation score:
A0A1B0GU44A0A1B0GU44_HUMAN
CUGBP Elav-like family member 2
CELF2
520Annotation score:
V9GY47V9GY47_HUMAN
CUGBP Elav-like family member 2
CELF2
70Annotation score:
A0A1B0GUN8A0A1B0GUN8_HUMAN
CUGBP Elav-like family member 2
CELF2
526Annotation score:
A0A0J9YXK1A0A0J9YXK1_HUMAN
CUGBP Elav-like family member 2
CELF2
94Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052202438D → H2 PublicationsCorresponds to variant dbSNP:rs1050942Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0267961 – 24Missing in isoform 2 and isoform 5. 4 PublicationsAdd BLAST24
Alternative sequenceiVSP_0267971 – 18MRCPK…ELLLS → MMVEGRLLVPDRI in isoform 3 and isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_026798358A → AVAQMLS in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_026799358A → AGTINTPRSKRLLLPKDNN in isoform 3. 1 Publication1
Alternative sequenceiVSP_026800359G → GTINS in isoform 5. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090694 mRNA Translation: AAD13761.1
AF090693 mRNA Translation: AAD13760.1
AF036956 mRNA Translation: AAD02074.1
U69546 mRNA Translation: AAB09040.1
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA Translation: AAK72223.1
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067, AF314199 Genomic DNA Translation: AAK72224.1
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA Translation: AAK92699.1
AF432906 mRNA Translation: AAL27627.1
AK316354 mRNA Translation: BAH14725.1
AC026887 Genomic DNA No translation available.
AL136320 Genomic DNA No translation available.
AL157704 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86346.1
BC036391 mRNA Translation: AAH36391.1
CCDSiCCDS41488.1 [O95319-2]
CCDS44354.1 [O95319-1]
CCDS44356.1 [O95319-5]
RefSeqiNP_001020247.1, NM_001025076.2 [O95319-2]
NP_001020248.1, NM_001025077.2 [O95319-1]
NP_001077060.1, NM_001083591.1 [O95319-5]
NP_001313246.1, NM_001326317.1
NP_001313247.1, NM_001326318.1 [O95319-2]
NP_001313248.1, NM_001326319.1
NP_001313249.1, NM_001326320.1 [O95319-2]
NP_001313250.1, NM_001326321.1
NP_001313253.1, NM_001326324.1 [O95319-2]
NP_001313257.1, NM_001326328.1 [O95319-2]
NP_001313258.1, NM_001326329.1
NP_001313259.1, NM_001326330.1 [O95319-2]
NP_001313261.1, NM_001326332.1 [O95319-1]
NP_001313262.1, NM_001326333.1
NP_001313263.1, NM_001326334.1 [O95319-2]
NP_001313265.1, NM_001326336.1
NP_001313268.1, NM_001326339.1
NP_001313269.1, NM_001326340.1
NP_001313271.1, NM_001326342.1
NP_001313272.1, NM_001326343.1
NP_001313273.1, NM_001326344.1
NP_001313274.1, NM_001326345.1 [O95319-2]
NP_001313277.1, NM_001326348.1
NP_001313278.1, NM_001326349.1 [O95319-2]
NP_006552.3, NM_006561.3
XP_011517596.1, XM_011519294.2
XP_011517599.1, XM_011519297.1
XP_016871042.1, XM_017015553.1
XP_016871043.1, XM_017015554.1
UniGeneiHs.309288

Genome annotation databases

EnsembliENST00000399850; ENSP00000382743; ENSG00000048740 [O95319-2]
ENST00000416382; ENSP00000406451; ENSG00000048740 [O95319-1]
ENST00000417956; ENSP00000404834; ENSG00000048740 [O95319-2]
ENST00000608830; ENSP00000476999; ENSG00000048740 [O95319-5]
ENST00000631460; ENSP00000488582; ENSG00000048740 [O95319-1]
ENST00000632728; ENSP00000487802; ENSG00000048740 [O95319-2]
ENST00000638035; ENSP00000490401; ENSG00000048740 [O95319-2]
GeneIDi10659
KEGGihsa:10659
UCSCiuc031vxc.2 human [O95319-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090694 mRNA Translation: AAD13761.1
AF090693 mRNA Translation: AAD13760.1
AF036956 mRNA Translation: AAD02074.1
U69546 mRNA Translation: AAB09040.1
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA Translation: AAK72223.1
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067, AF314199 Genomic DNA Translation: AAK72224.1
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA Translation: AAK92699.1
AF432906 mRNA Translation: AAL27627.1
AK316354 mRNA Translation: BAH14725.1
AC026887 Genomic DNA No translation available.
AL136320 Genomic DNA No translation available.
AL157704 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86346.1
BC036391 mRNA Translation: AAH36391.1
CCDSiCCDS41488.1 [O95319-2]
CCDS44354.1 [O95319-1]
CCDS44356.1 [O95319-5]
RefSeqiNP_001020247.1, NM_001025076.2 [O95319-2]
NP_001020248.1, NM_001025077.2 [O95319-1]
NP_001077060.1, NM_001083591.1 [O95319-5]
NP_001313246.1, NM_001326317.1
NP_001313247.1, NM_001326318.1 [O95319-2]
NP_001313248.1, NM_001326319.1
NP_001313249.1, NM_001326320.1 [O95319-2]
NP_001313250.1, NM_001326321.1
NP_001313253.1, NM_001326324.1 [O95319-2]
NP_001313257.1, NM_001326328.1 [O95319-2]
NP_001313258.1, NM_001326329.1
NP_001313259.1, NM_001326330.1 [O95319-2]
NP_001313261.1, NM_001326332.1 [O95319-1]
NP_001313262.1, NM_001326333.1
NP_001313263.1, NM_001326334.1 [O95319-2]
NP_001313265.1, NM_001326336.1
NP_001313268.1, NM_001326339.1
NP_001313269.1, NM_001326340.1
NP_001313271.1, NM_001326342.1
NP_001313272.1, NM_001326343.1
NP_001313273.1, NM_001326344.1
NP_001313274.1, NM_001326345.1 [O95319-2]
NP_001313277.1, NM_001326348.1
NP_001313278.1, NM_001326349.1 [O95319-2]
NP_006552.3, NM_006561.3
XP_011517596.1, XM_011519294.2
XP_011517599.1, XM_011519297.1
XP_016871042.1, XM_017015553.1
XP_016871043.1, XM_017015554.1
UniGeneiHs.309288

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MY7NMR-A416-508[»]
2MY8NMR-A416-508[»]
4LJMX-ray3.00A/B416-508[»]
4LMZX-ray2.78A36-211[»]
4TLQX-ray2.50A/B416-508[»]
5M8INMR-A416-508[»]
ProteinModelPortaliO95319
SMRiO95319
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115902, 25 interactors
IntActiO95319, 7 interactors
MINTiO95319
STRINGi9606.ENSP00000389951

PTM databases

iPTMnetiO95319
PhosphoSitePlusiO95319

Polymorphism and mutation databases

BioMutaiCELF2

2D gel databases

UCD-2DPAGEiO95319

Proteomic databases

EPDiO95319
MaxQBiO95319
PaxDbiO95319
PeptideAtlasiO95319
PRIDEiO95319
ProteomicsDBi50802
50803 [O95319-2]
50804 [O95319-3]
50805 [O95319-4]
50806 [O95319-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399850; ENSP00000382743; ENSG00000048740 [O95319-2]
ENST00000416382; ENSP00000406451; ENSG00000048740 [O95319-1]
ENST00000417956; ENSP00000404834; ENSG00000048740 [O95319-2]
ENST00000608830; ENSP00000476999; ENSG00000048740 [O95319-5]
ENST00000631460; ENSP00000488582; ENSG00000048740 [O95319-1]
ENST00000632728; ENSP00000487802; ENSG00000048740 [O95319-2]
ENST00000638035; ENSP00000490401; ENSG00000048740 [O95319-2]
GeneIDi10659
KEGGihsa:10659
UCSCiuc031vxc.2 human [O95319-1]

Organism-specific databases

CTDi10659
DisGeNETi10659
EuPathDBiHostDB:ENSG00000048740.17
GeneCardsiCELF2
HGNCiHGNC:2550 CELF2
HPAiCAB016395
HPA035813
HPA065098
MIMi602538 gene
neXtProtiNX_O95319
OpenTargetsiENSG00000048740
PharmGKBiPA27046
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00560000076837
HOVERGENiHBG107646
InParanoidiO95319
KOiK13207
PhylomeDBiO95319

Miscellaneous databases

ChiTaRSiCELF2 human
GeneWikiiCUGBP2
GenomeRNAii10659
PROiPR:O95319
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000048740 Expressed in 241 organ(s), highest expression level in forebrain
CleanExiHS_CUGBP2
ExpressionAtlasiO95319 baseline and differential
GenevisibleiO95319 HS

Family and domain databases

CDDicd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCELF2_HUMAN
AccessioniPrimary (citable) accession number: O95319
Secondary accession number(s): B7ZAN9
, Q7KYU4, Q8N499, Q92950, Q96NW9, Q96RQ5, Q96RQ6, Q9UL67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again