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UniProtKB - O95319 (CELF2_HUMAN)

Entry version 162 (10 Feb 2021)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

CUGBP Elav-like family member 2

Gene

CELF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233).By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95319

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95319

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUGBP Elav-like family member 2
Short name:
CELF-2
Alternative name(s):
Bruno-like protein 3
CUG triplet repeat RNA-binding protein 2
Short name:
CUG-BP2
CUG-BP- and ETR-3-like factor 2
ELAV-type RNA-binding protein 3
Short name:
ETR-3
Neuroblastoma apoptosis-related RNA-binding protein
Short name:
hNAPOR
RNA-binding protein BRUNOL-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CELF2
Synonyms:BRUNOL3, CUGBP2, ETR3, NAPOR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2550, CELF2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602538, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95319

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000048740.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10659

Open Targets

More...OpenTargetsi		ENSG00000048740

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27046

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95319, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CELF2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002951891 – 508CUGBP Elav-like family member 2Add BLAST508

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95319

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95319

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95319

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95319

PeptideAtlas

More...PeptideAtlasi		O95319

PRoteomics IDEntifications database

More...PRIDEi		O95319

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50802 [O95319-1]
50803 [O95319-2]
50804 [O95319-3]
50805 [O95319-4]
50806 [O95319-5]

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		O95319

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95319, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95319

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O95319

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95319

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is expressed in fetal brain. Isoform 2 is expressed in fetal heart, brain, thymus, lung, liver, skeletal muscle, kidney and spleen. Isoform 4 is expressed in fetal heart, brain, thymus, lung and skeletal muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000048740, Expressed in forebrain and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95319, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95319, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000048740, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with A1CF.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115902, 27 interactors

Protein interaction database and analysis system

More...IntActi		O95319, 8 interactors

Molecular INTeraction database

More...MINTi		O95319

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000443926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95319, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O95319

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95319

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 123RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini132 – 212RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini423 – 501RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 283Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionAdd BLAST283
Regioni357 – 508Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi284 – 397Ala-richAdd BLAST114

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0144, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155461

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015367_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95319

Database of Orthologous Groups

More...OrthoDBi		1209165at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95319

Family and domain databases

Conserved Domains Database

More...CDDi		cd12631, RRM1_CELF1_2_Bruno, 1 hit
cd12634, RRM2_CELF1_2, 1 hit
cd12638, RRM3_CELF1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034196, CELF1/2_RRM1
IPR034198, CELF1/2_RRM2
IPR034199, CELF1/2_RRM3
IPR002343, Hud_Sxl_RNA
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00961, HUDSXLRNA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95319-1) [UniParc]FASTAAdd to basket
Also known as: NAPOR-3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRCPKSAVTM RNEELLLSNG TANKMNGALD HSDQPDPDAI KMFVGQIPRS 
        60         70         80         90        100
WSEKELKELF EPYGAVYQIN VLRDRSQNPP QSKGCCFVTF YTRKAALEAQ 
       110        120        130        140        150
NALHNIKTLP GMHHPIQMKP ADSEKSNAVE DRKLFIGMVS KKCNENDIRV 
       160        170        180        190        200
MFSPFGQIEE CRILRGPDGL SRGCAFVTFS TRAMAQNAIK AMHQSQTMEG 
       210        220        230        240        250
CSSPIVVKFA DTQKDKEQRR LQQQLAQQMQ QLNTATWGNL TGLGGLTPQY 
       260        270        280        290        300
LALLQQATSS SNLGAFSGIQ QMAGMNALQL QNLATLAAAA AAAQTSATST 
       310        320        330        340        350
NANPLSTTSS ALGALTSPVA ASTPNSTAGA AMNSLTSLGT LQGLAGATVG 
       360        370        380        390        400
LNNINALAGM AALNGGLGAT GLTNGTAGTM DALTQAYSGI QQYAAAALPT 
       410        420        430        440        450
LYSQSLLQQQ SAAGSQKEGP EGANLFIYHL PQEFGDQDIL QMFMPFGNVI 
       460        470        480        490        500
SAKVFIDKQT NLSKCFGFVS YDNPVSAQAA IQAMNGFQIG MKRLKVQLKR 

SKNDSKPY
Length:508
Mass (Da):54,285
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC65F337D462717F2
GO
Isoform 2 (identifier: O95319-2) [UniParc]FASTAAdd to basket
Also known as: NAPOR-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     358-358: A → AVAQMLS

Show »
Length:490
Mass (Da):52,268
Checksum:i3A17B1F5F31AC5BD
GO
Isoform 3 (identifier: O95319-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRCPKSAVTMRNEELLLS → MMVEGRLLVPDRI
     358-358: A → AGTINTPRSKRLLLPKDNN

Show »
Length:521
Mass (Da):55,754
Checksum:iDD6E4F77FE6B4073
GO
Isoform 4 (identifier: O95319-4) [UniParc]FASTAAdd to basket
Also known as: NAPOR-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRCPKSAVTMRNEELLLS → MMVEGRLLVPDRI
     358-358: A → AVAQMLS

Show »
Length:509
Mass (Da):54,365
Checksum:i4A0DB5E2372193ED
GO
Isoform 5 (identifier: O95319-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     359-359: G → GTINS

Show »
Length:488
Mass (Da):52,054
Checksum:iCBB835681201C245
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GU44A0A1B0GU44_HUMAN
CUGBP Elav-like family member 2
CELF2
520Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUN8A0A1B0GUN8_HUMAN
CUGBP Elav-like family member 2
CELF2
526Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PC62E9PC62_HUMAN
CUGBP Elav-like family member 2
CELF2
521Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX66A0A0J9YX66_HUMAN
CUGBP Elav-like family member 2
CELF2
514Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXJ0A0A0J9YXJ0_HUMAN
CUGBP Elav-like family member 2
CELF2
533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VZZ6Q5VZZ6_HUMAN
CUGBP Elav-like family member 2
CELF2
502Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYD9V9GYD9_HUMAN
CUGBP Elav-like family member 2
CELF2
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY47V9GY47_HUMAN
CUGBP Elav-like family member 2
CELF2
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXK1A0A0J9YXK1_HUMAN
CUGBP Elav-like family member 2
CELF2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052202438D → H2 PublicationsCorresponds to variant dbSNP:rs1050942Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0267961 – 24Missing in isoform 2 and isoform 5. 4 PublicationsAdd BLAST24
Alternative sequenceiVSP_0267971 – 18MRCPK…ELLLS → MMVEGRLLVPDRI in isoform 3 and isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_026798358A → AVAQMLS in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_026799358A → AGTINTPRSKRLLLPKDNN in isoform 3. 1 Publication1
Alternative sequenceiVSP_026800359G → GTINS in isoform 5. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF090694 mRNA Translation: AAD13761.1
AF090693 mRNA Translation: AAD13760.1
AF036956 mRNA Translation: AAD02074.1
U69546 mRNA Translation: AAB09040.1
AF295068 AF295067 Genomic DNA Translation: AAK72223.1
AF295068 AF314199 Genomic DNA Translation: AAK72224.1
AF295068 AF295067 Genomic DNA Translation: AAK92699.1
AF432906 mRNA Translation: AAL27627.1
AK316354 mRNA Translation: BAH14725.1
AC026887 Genomic DNA No translation available.
AL136320 Genomic DNA No translation available.
AL157704 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86346.1
BC036391 mRNA Translation: AAH36391.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41488.1 [O95319-2]
CCDS44354.1 [O95319-1]
CCDS44356.1 [O95319-5]

NCBI Reference Sequences

More...RefSeqi		NP_001020247.1, NM_001025076.2 [O95319-2]
NP_001020248.1, NM_001025077.2 [O95319-1]
NP_001077060.1, NM_001083591.1 [O95319-5]
NP_001313246.1, NM_001326317.1
NP_001313247.1, NM_001326318.1 [O95319-2]
NP_001313248.1, NM_001326319.1
NP_001313249.1, NM_001326320.1 [O95319-2]
NP_001313250.1, NM_001326321.1
NP_001313253.1, NM_001326324.1 [O95319-2]
NP_001313257.1, NM_001326328.1 [O95319-2]
NP_001313258.1, NM_001326329.1
NP_001313259.1, NM_001326330.1 [O95319-2]
NP_001313261.1, NM_001326332.1 [O95319-1]
NP_001313262.1, NM_001326333.1
NP_001313263.1, NM_001326334.1 [O95319-2]
NP_001313265.1, NM_001326336.1
NP_001313268.1, NM_001326339.1
NP_001313269.1, NM_001326340.1
NP_001313271.1, NM_001326342.1
NP_001313272.1, NM_001326343.1
NP_001313273.1, NM_001326344.1
NP_001313274.1, NM_001326345.1 [O95319-2]
NP_001313277.1, NM_001326348.1
NP_001313278.1, NM_001326349.1 [O95319-2]
NP_006552.3, NM_006561.3
XP_011517596.1, XM_011519294.2
XP_011517599.1, XM_011519297.1
XP_016871042.1, XM_017015553.1
XP_016871043.1, XM_017015554.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000399850; ENSP00000382743; ENSG00000048740 [O95319-2]
ENST00000416382; ENSP00000406451; ENSG00000048740 [O95319-1]
ENST00000417956; ENSP00000404834; ENSG00000048740 [O95319-2]
ENST00000608830; ENSP00000476999; ENSG00000048740 [O95319-5]
ENST00000631460; ENSP00000488582; ENSG00000048740 [O95319-1]
ENST00000632728; ENSP00000487802; ENSG00000048740 [O95319-2]
ENST00000638035; ENSP00000490401; ENSG00000048740 [O95319-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10659

UCSC genome browser

More...UCSCi		uc031vxc.2, human [O95319-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090694 mRNA Translation: AAD13761.1
AF090693 mRNA Translation: AAD13760.1
AF036956 mRNA Translation: AAD02074.1
U69546 mRNA Translation: AAB09040.1
AF295068 AF295067 Genomic DNA Translation: AAK72223.1
AF295068 AF314199 Genomic DNA Translation: AAK72224.1
AF295068 AF295067 Genomic DNA Translation: AAK92699.1
AF432906 mRNA Translation: AAL27627.1
AK316354 mRNA Translation: BAH14725.1
AC026887 Genomic DNA No translation available.
AL136320 Genomic DNA No translation available.
AL157704 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86346.1
BC036391 mRNA Translation: AAH36391.1
CCDSiCCDS41488.1 [O95319-2]
CCDS44354.1 [O95319-1]
CCDS44356.1 [O95319-5]
RefSeqiNP_001020247.1, NM_001025076.2 [O95319-2]
NP_001020248.1, NM_001025077.2 [O95319-1]
NP_001077060.1, NM_001083591.1 [O95319-5]
NP_001313246.1, NM_001326317.1
NP_001313247.1, NM_001326318.1 [O95319-2]
NP_001313248.1, NM_001326319.1
NP_001313249.1, NM_001326320.1 [O95319-2]
NP_001313250.1, NM_001326321.1
NP_001313253.1, NM_001326324.1 [O95319-2]
NP_001313257.1, NM_001326328.1 [O95319-2]
NP_001313258.1, NM_001326329.1
NP_001313259.1, NM_001326330.1 [O95319-2]
NP_001313261.1, NM_001326332.1 [O95319-1]
NP_001313262.1, NM_001326333.1
NP_001313263.1, NM_001326334.1 [O95319-2]
NP_001313265.1, NM_001326336.1
NP_001313268.1, NM_001326339.1
NP_001313269.1, NM_001326340.1
NP_001313271.1, NM_001326342.1
NP_001313272.1, NM_001326343.1
NP_001313273.1, NM_001326344.1
NP_001313274.1, NM_001326345.1 [O95319-2]
NP_001313277.1, NM_001326348.1
NP_001313278.1, NM_001326349.1 [O95319-2]
NP_006552.3, NM_006561.3
XP_011517596.1, XM_011519294.2
XP_011517599.1, XM_011519297.1
XP_016871042.1, XM_017015553.1
XP_016871043.1, XM_017015554.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MY7NMR-A416-508[»]
2MY8NMR-A416-508[»]
4LJMX-ray3.00A/B416-508[»]
4LMZX-ray2.78A36-211[»]
4TLQX-ray2.50A/B416-508[»]
5M8INMR-A416-508[»]
BMRBiO95319
SMRiO95319
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115902, 27 interactors
IntActiO95319, 8 interactors
MINTiO95319
STRINGi9606.ENSP00000443926

PTM databases

GlyGeniO95319, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO95319
MetOSiteiO95319
PhosphoSitePlusiO95319

Genetic variation databases

BioMutaiCELF2

2D gel databases

UCD-2DPAGEiO95319

Proteomic databases

jPOSTiO95319
MassIVEiO95319
MaxQBiO95319
PaxDbiO95319
PeptideAtlasiO95319
PRIDEiO95319
ProteomicsDBi50802 [O95319-1]
50803 [O95319-2]
50804 [O95319-3]
50805 [O95319-4]
50806 [O95319-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5602, 222 antibodies

Genome annotation databases

EnsembliENST00000399850; ENSP00000382743; ENSG00000048740 [O95319-2]
ENST00000416382; ENSP00000406451; ENSG00000048740 [O95319-1]
ENST00000417956; ENSP00000404834; ENSG00000048740 [O95319-2]
ENST00000608830; ENSP00000476999; ENSG00000048740 [O95319-5]
ENST00000631460; ENSP00000488582; ENSG00000048740 [O95319-1]
ENST00000632728; ENSP00000487802; ENSG00000048740 [O95319-2]
ENST00000638035; ENSP00000490401; ENSG00000048740 [O95319-2]
GeneIDi10659
KEGGihsa:10659
UCSCiuc031vxc.2, human [O95319-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10659
DisGeNETi10659

GeneCards: human genes, protein and diseases

More...GeneCardsi		CELF2
HGNCiHGNC:2550, CELF2
HPAiENSG00000048740, Low tissue specificity
MIMi602538, gene
neXtProtiNX_O95319
OpenTargetsiENSG00000048740
PharmGKBiPA27046
VEuPathDBiHostDB:ENSG00000048740.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0144, Eukaryota
GeneTreeiENSGT00940000155461
HOGENOMiCLU_015367_0_2_1
InParanoidiO95319
OrthoDBi1209165at2759
PhylomeDBiO95319

Enzyme and pathway databases

PathwayCommonsiO95319
SIGNORiO95319

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10659, 6 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CELF2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CUGBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10659
PharosiO95319, Tbio

Protein Ontology

More...PROi		PR:O95319
RNActiO95319, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000048740, Expressed in forebrain and 253 other tissues
ExpressionAtlasiO95319, baseline and differential
GenevisibleiO95319, HS

Family and domain databases

CDDicd12631, RRM1_CELF1_2_Bruno, 1 hit
cd12634, RRM2_CELF1_2, 1 hit
cd12638, RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196, CELF1/2_RRM1
IPR034198, CELF1/2_RRM2
IPR034199, CELF1/2_RRM3
IPR002343, Hud_Sxl_RNA
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 3 hits
PRINTSiPR00961, HUDSXLRNA
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95319
Secondary accession number(s): B7ZAN9
, Q7KYU4, Q8N499, Q92950, Q96NW9, Q96RQ5, Q96RQ6, Q9UL67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 1999
Last modified: February 10, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with genetic variants
    List of human entries with genetic variants
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