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Protein

SNARE-associated protein Snapin

Gene

SNAPIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).3 Publications

GO - Molecular functioni

  • SNARE binding Source: MGI

GO - Biological processi

Keywordsi

Biological processExocytosis, Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis
SIGNORiO95295

Protein family/group databases

TCDBi1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
SNARE-associated protein Snapin
Alternative name(s):
Biogenesis of lysosome-related organelles complex 1 subunit 7
Short name:
BLOC-1 subunit 7
Synaptosomal-associated protein 25-binding protein
Short name:
SNAP-associated protein
Gene namesi
Name:SNAPIN
Synonyms:BLOC1S7, SNAP25BP, SNAPAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143553.10
HGNCiHGNC:17145 SNAPIN
MIMi607007 gene
neXtProtiNX_O95295

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Lysosome, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi23557
OpenTargetsiENSG00000143553
PharmGKBiPA162404012

Polymorphism and mutation databases

BioMutaiSNAPIN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000975562 – 136SNARE-associated protein SnapinAdd BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei14PhosphothreonineCombined sources1
Modified residuei50Phosphoserine; by PKABy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphotyrosineCombined sources1
Modified residuei133PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CSNK1D/CK1 (By similarity). Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95295
MaxQBiO95295
PaxDbiO95295
PeptideAtlasiO95295
PRIDEiO95295
ProteomicsDBi50792

PTM databases

iPTMnetiO95295
PhosphoSitePlusiO95295

Expressioni

Tissue specificityi

Expressed in male germ cells of adult testis (at protein level).1 Publication

Developmental stagei

Expressed in germ cells of 22-week prenatal testis.1 Publication

Gene expression databases

BgeeiENSG00000143553 Expressed in 199 organ(s), highest expression level in quadriceps femoris
CleanExiHS_SNAPIN
GenevisibleiO95295 HS

Organism-specific databases

HPAiHPA046974

Interactioni

Subunit structurei

Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:15102850, PubMed:22203680). Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Associates with the SNARE complex. Interacts with CSNK1D, SNAP23 and STX4A but not with STX1A, VAMP2 and SYT1. Interacts with SNAP25; the interaction with SNAP25 is increased by its phosphorylation. Interacts with CNTRL, NANOS1, PUM2 and RGS7 (PubMed:12659861, PubMed:16213214, PubMed:19168546). Interacts with TOR1A; the interaction is direct and associates SNAPIN with the CSN complex (PubMed:18167355, PubMed:21102408).8 Publications
(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL70.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117101, 61 interactors
ComplexPortaliCPX-1910 BLOC-1 complex
CPX-1912 BLOC1S2-SNAPN-DTBP1
CORUMiO95295
IntActiO95295, 97 interactors
MINTiO95295
STRINGi9606.ENSP00000357674

Structurei

3D structure databases

ProteinModelPortaliO95295
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 136Interaction with TOR1AAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 126Sequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the SNAPIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J16C Eukaryota
ENOG4111JM9 LUCA
GeneTreeiENSGT00390000008274
HOGENOMiHOG000253926
HOVERGENiHBG056744
InParanoidiO95295
KOiK20002
OMAiCRINEHQ
OrthoDBiEOG091G0WH1
PhylomeDBiO95295
TreeFamiTF319577

Family and domain databases

InterProiView protein in InterPro
IPR017246 Snapin
IPR028119 Snapin/Pallidin/Snn1
PANTHERiPTHR31305 PTHR31305, 1 hit
PfamiView protein in Pfam
PF14712 Snapin_Pallidin, 1 hit
PIRSFiPIRSF037631 Snapin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95295-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAGSAAVS GAGTPVAGPT GRDLFAEGLL EFLRPAVQQL DSHVHAVRES
60 70 80 90 100
QVELREQIDN LATELCRINE DQKVALDLDP YVKKLLNARR RVVLVNNILQ
110 120 130
NAQERLRRLN HSVAKETARR RAMLDSGIYP PGSPGK
Length:136
Mass (Da):14,874
Last modified:May 1, 1999 - v1
Checksum:i3EA402AC53C81FFF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017423112S → C. Corresponds to variant dbSNP:rs1802461Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086837 mRNA Translation: AAD11417.1
AK024555 mRNA Translation: BAB14927.1
BT006753 mRNA Translation: AAP35399.1
AL592150 Genomic DNA Translation: CAI18797.1
CH471121 Genomic DNA Translation: EAW53288.1
CH471121 Genomic DNA Translation: EAW53289.1
BC000761 mRNA Translation: AAH00761.1
BC004494 mRNA Translation: AAH04494.1
CCDSiCCDS1049.1
RefSeqiNP_036569.1, NM_012437.5
UniGeneiHs.32018

Genome annotation databases

EnsembliENST00000368685; ENSP00000357674; ENSG00000143553
GeneIDi23557
KEGGihsa:23557
UCSCiuc001fcq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086837 mRNA Translation: AAD11417.1
AK024555 mRNA Translation: BAB14927.1
BT006753 mRNA Translation: AAP35399.1
AL592150 Genomic DNA Translation: CAI18797.1
CH471121 Genomic DNA Translation: EAW53288.1
CH471121 Genomic DNA Translation: EAW53289.1
BC000761 mRNA Translation: AAH00761.1
BC004494 mRNA Translation: AAH04494.1
CCDSiCCDS1049.1
RefSeqiNP_036569.1, NM_012437.5
UniGeneiHs.32018

3D structure databases

ProteinModelPortaliO95295
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117101, 61 interactors
ComplexPortaliCPX-1910 BLOC-1 complex
CPX-1912 BLOC1S2-SNAPN-DTBP1
CORUMiO95295
IntActiO95295, 97 interactors
MINTiO95295
STRINGi9606.ENSP00000357674

Protein family/group databases

TCDBi1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetiO95295
PhosphoSitePlusiO95295

Polymorphism and mutation databases

BioMutaiSNAPIN

Proteomic databases

EPDiO95295
MaxQBiO95295
PaxDbiO95295
PeptideAtlasiO95295
PRIDEiO95295
ProteomicsDBi50792

Protocols and materials databases

DNASUi23557
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368685; ENSP00000357674; ENSG00000143553
GeneIDi23557
KEGGihsa:23557
UCSCiuc001fcq.5 human

Organism-specific databases

CTDi23557
DisGeNETi23557
EuPathDBiHostDB:ENSG00000143553.10
GeneCardsiSNAPIN
HGNCiHGNC:17145 SNAPIN
HPAiHPA046974
MIMi607007 gene
neXtProtiNX_O95295
OpenTargetsiENSG00000143553
PharmGKBiPA162404012
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J16C Eukaryota
ENOG4111JM9 LUCA
GeneTreeiENSGT00390000008274
HOGENOMiHOG000253926
HOVERGENiHBG056744
InParanoidiO95295
KOiK20002
OMAiCRINEHQ
OrthoDBiEOG091G0WH1
PhylomeDBiO95295
TreeFamiTF319577

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis
SIGNORiO95295

Miscellaneous databases

GeneWikiiSNAPAP
GenomeRNAii23557
PROiPR:O95295
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143553 Expressed in 199 organ(s), highest expression level in quadriceps femoris
CleanExiHS_SNAPIN
GenevisibleiO95295 HS

Family and domain databases

InterProiView protein in InterPro
IPR017246 Snapin
IPR028119 Snapin/Pallidin/Snn1
PANTHERiPTHR31305 PTHR31305, 1 hit
PfamiView protein in Pfam
PF14712 Snapin_Pallidin, 1 hit
PIRSFiPIRSF037631 Snapin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNAPN_HUMAN
AccessioniPrimary (citable) accession number: O95295
Secondary accession number(s): D3DV56, Q5SXU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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