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UniProtKB - O95295 (SNAPN_HUMAN)

Entry version 176 (25 May 2022)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

SNARE-associated protein Snapin

Gene

SNAPIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355).

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNARE binding Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Host-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95295

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-432722, Golgi Associated Vesicle Biogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95295

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95295

Protein family/group databases

Transport Classification Database

More...TCDBi		1.F.1.1.1, the synaptosomal vesicle fusion pore (svf-pore) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SNARE-associated protein Snapin
Alternative name(s):
Biogenesis of lysosome-related organelles complex 1 subunit 7
Short name:
BLOC-1 subunit 7
Synaptosomal-associated protein 25-binding protein
Short name:
SNAP-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNAPIN
Synonyms:BLOC1S7, SNAP25BP, SNAPAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17145, SNAPIN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607007, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95295

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143553

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Lysosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23557

Open Targets

More...OpenTargetsi		ENSG00000143553

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162404012

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95295, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SNAPIN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975562 – 136SNARE-associated protein SnapinAdd BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei14PhosphothreonineCombined sources1
Modified residuei50Phosphoserine; by PKABy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphotyrosineCombined sources1
Modified residuei133PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CSNK1D/CK1 (By similarity). Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95295

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95295

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95295

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95295

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95295

PeptideAtlas

More...PeptideAtlasi		O95295

PRoteomics IDEntifications database

More...PRIDEi		O95295

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50792

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95295, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95295

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95295

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in male germ cells of adult testis (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in germ cells of 22-week prenatal testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143553, Expressed in quadriceps femoris and 215 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95295, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143553, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:15102850, PubMed:22203680).

Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Associates with the SNARE complex.

Interacts with CSNK1D, SNAP23 and STX4A but not with STX1A, VAMP2 and SYT1.

Interacts with SNAP25; the interaction with SNAP25 is increased by its phosphorylation.

Interacts with CNTRL, NANOS1, PUM2 and RGS7 (PubMed:12659861, PubMed:16213214, PubMed:19168546).

Interacts with TOR1A; the interaction is direct and associates SNAPIN with the CSN complex (PubMed:18167355, PubMed:21102408).

8 Publications

(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL70.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O95295
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]5EBI-296723,EBI-11096309
BANP - isoform 2 [Q8N9N5-2]3EBI-296723,EBI-11524452
BFSP1 - isoform 2 [Q12934-2]3EBI-296723,EBI-12123320
BFSP2 [Q13515]3EBI-296723,EBI-10229433
BLOC1S1 [P78537]6EBI-296723,EBI-348630
BLOC1S2 [Q6QNY1]10EBI-296723,EBI-465872
C20orf202 [A1L168]3EBI-296723,EBI-18396958
CCDC102B [Q68D86]3EBI-296723,EBI-10171570
CCNH [P51946]3EBI-296723,EBI-741406
DENND1C [Q8IV53]3EBI-296723,EBI-2871584
DTNBP1 [Q96EV8]7EBI-296723,EBI-465804
ENTHD1 [Q8IYW4]3EBI-296723,EBI-20842218
EXOC7 - isoform 1 [Q9UPT5-1]3EBI-296723,EBI-6251402
FSD2 [A1L4K1]3EBI-296723,EBI-5661036
IKBIP - isoform 4 [Q70UQ0-4]4EBI-296723,EBI-12190633
INSYN1 [Q2T9L4]3EBI-296723,EBI-4311436
KANK2 [Q63ZY3]3EBI-296723,EBI-2556193
KRT15 [P19012]3EBI-296723,EBI-739566
KRT16 [P08779]3EBI-296723,EBI-356410
KRT19 [P08727]3EBI-296723,EBI-742756
KRT20 [P35900]3EBI-296723,EBI-742094
KRT24 [Q2M2I5]6EBI-296723,EBI-2952736
KRT26 [Q7Z3Y9]3EBI-296723,EBI-12084444
KRT27 [Q7Z3Y8]3EBI-296723,EBI-3044087
LMNB1 [P20700]3EBI-296723,EBI-968218
LRRK2 [Q5S007]5EBI-296723,EBI-5323863
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-296723,EBI-10172876
NME7 [Q9Y5B8]3EBI-296723,EBI-744782
NUP62CL [Q9H1M0]3EBI-296723,EBI-751933
PCYT1A [P49585]3EBI-296723,EBI-2563309
PLAC9 [Q5JTB6]3EBI-296723,EBI-3923605
RABGEF1 - isoform 3 [Q9UJ41-4]3EBI-296723,EBI-14093916
SKA1 [Q96BD8]5EBI-296723,EBI-741854
SLC14A2 - isoform 1 [Q15849-1]5EBI-296723,EBI-1633392
SPTB [P11277]3EBI-296723,EBI-514908
TFIP11 [Q9UBB9]3EBI-296723,EBI-1105213
TPM2 - isoform 2 [P07951-2]3EBI-296723,EBI-10977815
TPM3 [P06753]3EBI-296723,EBI-355607
TPM4 [P67936]3EBI-296723,EBI-1642100
TSG101 [Q99816]3EBI-296723,EBI-346882
WASHC3 [Q9Y3C0]3EBI-296723,EBI-712969
Slc14a2 - isoform 1 [Q62668-1] from Rattus norvegicus.6EBI-296723,EBI-1635608

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117101, 150 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1910, BLOC-1 complex
CPX-5029, BORC complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95295

Protein interaction database and analysis system

More...IntActi		O95295, 121 interactors

Molecular INTeraction database

More...MINTi		O95295

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357674

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95295, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O95295

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95295

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni83 – 136Interaction with TOR1AAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili37 – 126Sequence analysisAdd BLAST90

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNAPIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S07W, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008274

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_124640_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95295

Identification of Orthologs from Complete Genome Data

More...OMAi		QLDTHVH

Database of Orthologous Groups

More...OrthoDBi		1532513at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95295

TreeFam database of animal gene trees

More...TreeFami		TF319577

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017246, Snapin
IPR028119, Snapin/Pallidin/Snn1

The PANTHER Classification System

More...PANTHERi		PTHR31305, PTHR31305, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14712, Snapin_Pallidin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037631, Snapin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O95295-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAGSAAVS GAGTPVAGPT GRDLFAEGLL EFLRPAVQQL DSHVHAVRES 
        60         70         80         90        100
QVELREQIDN LATELCRINE DQKVALDLDP YVKKLLNARR RVVLVNNILQ 
       110        120        130 
NAQERLRRLN HSVAKETARR RAMLDSGIYP PGSPGK
Length:136
Mass (Da):14,874
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EA402AC53C81FFF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017423112S → C. Corresponds to variant dbSNP:rs1802461Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF086837 mRNA Translation: AAD11417.1
AK024555 mRNA Translation: BAB14927.1
BT006753 mRNA Translation: AAP35399.1
AL592150 Genomic DNA Translation: CAI18797.1
CH471121 Genomic DNA Translation: EAW53288.1
CH471121 Genomic DNA Translation: EAW53289.1
BC000761 mRNA Translation: AAH00761.1
BC004494 mRNA Translation: AAH04494.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1049.1

NCBI Reference Sequences

More...RefSeqi		NP_036569.1, NM_012437.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368685.6; ENSP00000357674.5; ENSG00000143553.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23557

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23557

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000368685.6; ENSP00000357674.5; NM_012437.6; NP_036569.1

UCSC genome browser

More...UCSCi		uc001fcq.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086837 mRNA Translation: AAD11417.1
AK024555 mRNA Translation: BAB14927.1
BT006753 mRNA Translation: AAP35399.1
AL592150 Genomic DNA Translation: CAI18797.1
CH471121 Genomic DNA Translation: EAW53288.1
CH471121 Genomic DNA Translation: EAW53289.1
BC000761 mRNA Translation: AAH00761.1
BC004494 mRNA Translation: AAH04494.1
CCDSiCCDS1049.1
RefSeqiNP_036569.1, NM_012437.5

3D structure databases

AlphaFoldDBiO95295
SMRiO95295
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117101, 150 interactors
ComplexPortaliCPX-1910, BLOC-1 complex
CPX-5029, BORC complex
CORUMiO95295
IntActiO95295, 121 interactors
MINTiO95295
STRINGi9606.ENSP00000357674

Protein family/group databases

TCDBi1.F.1.1.1, the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

GlyGeniO95295, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO95295
PhosphoSitePlusiO95295

Genetic variation databases

BioMutaiSNAPIN

Proteomic databases

EPDiO95295
jPOSTiO95295
MassIVEiO95295
MaxQBiO95295
PaxDbiO95295
PeptideAtlasiO95295
PRIDEiO95295
ProteomicsDBi50792

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		O95295, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34134, 135 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		23557

Genome annotation databases

EnsembliENST00000368685.6; ENSP00000357674.5; ENSG00000143553.11
GeneIDi23557
KEGGihsa:23557
MANE-SelectiENST00000368685.6; ENSP00000357674.5; NM_012437.6; NP_036569.1
UCSCiuc001fcq.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23557
DisGeNETi23557

GeneCards: human genes, protein and diseases

More...GeneCardsi		SNAPIN
HGNCiHGNC:17145, SNAPIN
HPAiENSG00000143553, Low tissue specificity
MIMi607007, gene
neXtProtiNX_O95295
OpenTargetsiENSG00000143553
PharmGKBiPA162404012
VEuPathDBiHostDB:ENSG00000143553

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S07W, Eukaryota
GeneTreeiENSGT00390000008274
HOGENOMiCLU_124640_1_0_1
InParanoidiO95295
OMAiQLDTHVH
OrthoDBi1532513at2759
PhylomeDBiO95295
TreeFamiTF319577

Enzyme and pathway databases

PathwayCommonsiO95295
ReactomeiR-HSA-432722, Golgi Associated Vesicle Biogenesis
SignaLinkiO95295
SIGNORiO95295

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23557, 107 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SNAPIN, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SNAPAP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23557
PharosiO95295, Tbio

Protein Ontology

More...PROi		PR:O95295
RNActiO95295, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143553, Expressed in quadriceps femoris and 215 other tissues
GenevisibleiO95295, HS

Family and domain databases

InterProiView protein in InterPro
IPR017246, Snapin
IPR028119, Snapin/Pallidin/Snn1
PANTHERiPTHR31305, PTHR31305, 1 hit
PfamiView protein in Pfam
PF14712, Snapin_Pallidin, 1 hit
PIRSFiPIRSF037631, Snapin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNAPN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95295
Secondary accession number(s): D3DV56, Q5SXU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: May 25, 2022
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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