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Entry version 163 (13 Feb 2019)
Sequence version 3 (02 Nov 2010)
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Protein

RasGAP-activating-like protein 1

Gene

RASAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri674 – 710Btk-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • phospholipid binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processDifferentiation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RasGAP-activating-like protein 1Curated
Alternative name(s):
RAS protein activator like 1Imported
Ras GTPase-activating-like protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASAL1Imported
Synonyms:RASAL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111344.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9873 RASAL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604118 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95294

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8437

Open Targets

More...
OpenTargetsi
ENSG00000111344

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34234

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASAL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566451 – 804RasGAP-activating-like protein 1Add BLAST804

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95294

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95294

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95294

PeptideAtlas

More...
PeptideAtlasi
O95294

PRoteomics IDEntifications database

More...
PRIDEi
O95294

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50790
50791 [O95294-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95294

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95294

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O95294

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798). Expressed in melanocytes (PubMed:23999003).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111344 Expressed in 141 organ(s), highest expression level in esophagus mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95294 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041650

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114017, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000450244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95294

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95294

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 88C2 1PROSITE-ProRule annotationAdd BLAST88
Domaini120 – 216C2 2PROSITE-ProRule annotationAdd BLAST97
Domaini301 – 511Ras-GAPPROSITE-ProRule annotationAdd BLAST211
Domaini565 – 672PHPROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi499 – 502Poly-Leu4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri674 – 710Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2059 Eukaryota
ENOG410Y128 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158715

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234324

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106587

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95294

KEGG Orthology (KO)

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KOi
K17632

Identification of Orthologs from Complete Genome Data

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OMAi
LGMVEFP

Database of Orthologous Groups

More...
OrthoDBi
145372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95294

TreeFam database of animal gene trees

More...
TreeFami
TF105302

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05135 RasGAP_RASAL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR028555 RASAL1
IPR037776 RASAL_RasGAP
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif

The PANTHER Classification System

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PANTHERi
PTHR10194 PTHR10194, 1 hit
PTHR10194:SF3 PTHR10194:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95294-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKSSSLNVR VVEGRALPAK DVSGSSDPYC LVKVDDEVVA RTATVWRSLG
60 70 80 90 100
PFWGEEYTVH LPLDFHQLAF YVLDEDTVGH DDIIGKISLS REAITADPRG
110 120 130 140 150
IDSWINLSRV DPDAEVQGEI CLSVQMLEDG QGRCLRCHVL QARDLAPRDI
160 170 180 190 200
SGTSDPFARV FWGSQSLETS TIKKTRFPHW DEVLELREMP GAPSPLRVEL
210 220 230 240 250
WDWDMVGKND FLGMVEFSPK TLQQKPPKGW FRLLPFPRAE EDSGGNLGAL
260 270 280 290 300
RVKVRLIEDR VLPSQCYQPL MELLMESVQG PAEEDTASPL ALLEELTLGD
310 320 330 340 350
CRQDLATKLV KLFLGRGLAG RFLDYLTRRE VARTMDPNTL FRSNSLASKS
360 370 380 390 400
MEQFMKLVGM PYLHEVLKPV ISRVFEEKKY MELDPCKMDL GRTRRISFKG
410 420 430 440 450
ALSEEQMRET SLGLLTGYLG PIVDAIVGSV GRCPPAMRLA FKQLHRRVEE
460 470 480 490 500
RFPQAEHQDV KYLAISGFLF LRFFAPAILT PKLFDLRDQH ADPQTSRSLL
510 520 530 540 550
LLAKAVQSIG NLGQQLGQGK ELWMAPLHPF LLQCVSRVRD FLDRLVDVDG
560 570 580 590 600
DEAGVPARAL FPPSAIVREG YLLKRKEEPA GLATRFAFKK RYVWLSGETL
610 620 630 640 650
SFSKSPEWQM CHSIPVSHIR AVERVDEGAF QLPHVMQVVT QDGTGALHTT
660 670 680 690 700
YLQCKNVNEL NQWLSALRKA SAPNPNKLAA CHPGAFRSAR WTCCLQAERS
710 720 730 740 750
AAGCSRTHSA VTLGDWSDPL DPDAEAQTVY RQLLLGRDQL RLKLLEDSNM
760 770 780 790 800
DTTLEADTGA CPEVLARQRA ATARLLEVLA DLDRAHEEFQ QQERGKAALG

PLGP
Length:804
Mass (Da):90,016
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D0065A093487FD0
GO
Isoform 2 (identifier: O95294-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-637: Missing.

Note: No experimental confirmation available.
Show »
Length:776
Mass (Da):86,847
Checksum:i3E385FF1F2F41866
GO
Isoform 3 (identifier: O95294-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-458: Q → QQ
     552-552: E → EE

Note: Gene prediction based on EST data.
Show »
Length:806
Mass (Da):90,274
Checksum:i7B82D39FBAD0E59E
GO
Isoform 4 (identifier: O95294-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-552: E → EE

Note: No experimental confirmation available.
Show »
Length:805
Mass (Da):90,145
Checksum:i0CBCCAD667337182
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92172 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141Q → H in AAD09006 (PubMed:9751798).Curated1
Sequence conflicti346L → P in CAB66607 (PubMed:11230166).Curated1
Sequence conflicti514Q → R in CAB66607 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03166511V → L1 PublicationCorresponds to variant dbSNP:rs7960087Ensembl.1
Natural variantiVAR_03166658T → M1 PublicationCorresponds to variant dbSNP:rs34598602Ensembl.1
Natural variantiVAR_031667321R → H3 PublicationsCorresponds to variant dbSNP:rs1284879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047005458Q → QQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_047006552E → EE in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_001627610 – 637Missing in isoform 2. CuratedAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF086713 mRNA Translation: AAD09006.1
AB208935 mRNA Translation: BAD92172.1 Different initiation.
AC089999 Genomic DNA No translation available.
BC014420 mRNA Translation: AAH14420.1
BC093724 mRNA Translation: AAH93724.1
BC143261 mRNA Translation: AAI43262.1
AL136672 Transcribed RNA Translation: CAB66607.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55888.1 [O95294-2]
CCDS55889.1 [O95294-3]
CCDS73529.1 [O95294-4]
CCDS9165.1 [O95294-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001180449.1, NM_001193520.1 [O95294-3]
NP_001180450.1, NM_001193521.1 [O95294-2]
NP_001288131.1, NM_001301202.1 [O95294-4]
NP_004649.2, NM_004658.2 [O95294-1]
XP_005254007.1, XM_005253950.4 [O95294-3]
XP_006719704.1, XM_006719641.3 [O95294-3]
XP_011537154.1, XM_011538852.2 [O95294-3]
XP_011537155.1, XM_011538853.2 [O95294-1]
XP_016875517.1, XM_017020028.1 [O95294-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.528693

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261729; ENSP00000261729; ENSG00000111344 [O95294-1]
ENST00000446861; ENSP00000395920; ENSG00000111344 [O95294-2]
ENST00000546530; ENSP00000450244; ENSG00000111344 [O95294-3]
ENST00000548055; ENSP00000448510; ENSG00000111344 [O95294-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8437

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8437

UCSC genome browser

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UCSCi
uc001tul.4 human [O95294-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086713 mRNA Translation: AAD09006.1
AB208935 mRNA Translation: BAD92172.1 Different initiation.
AC089999 Genomic DNA No translation available.
BC014420 mRNA Translation: AAH14420.1
BC093724 mRNA Translation: AAH93724.1
BC143261 mRNA Translation: AAI43262.1
AL136672 Transcribed RNA Translation: CAB66607.2
CCDSiCCDS55888.1 [O95294-2]
CCDS55889.1 [O95294-3]
CCDS73529.1 [O95294-4]
CCDS9165.1 [O95294-1]
RefSeqiNP_001180449.1, NM_001193520.1 [O95294-3]
NP_001180450.1, NM_001193521.1 [O95294-2]
NP_001288131.1, NM_001301202.1 [O95294-4]
NP_004649.2, NM_004658.2 [O95294-1]
XP_005254007.1, XM_005253950.4 [O95294-3]
XP_006719704.1, XM_006719641.3 [O95294-3]
XP_011537154.1, XM_011538852.2 [O95294-3]
XP_011537155.1, XM_011538853.2 [O95294-1]
XP_016875517.1, XM_017020028.1 [O95294-4]
UniGeneiHs.528693

3D structure databases

ProteinModelPortaliO95294
SMRiO95294
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114017, 4 interactors
STRINGi9606.ENSP00000450244

PTM databases

iPTMnetiO95294
PhosphoSitePlusiO95294
SwissPalmiO95294

Polymorphism and mutation databases

BioMutaiRASAL1

Proteomic databases

jPOSTiO95294
MaxQBiO95294
PaxDbiO95294
PeptideAtlasiO95294
PRIDEiO95294
ProteomicsDBi50790
50791 [O95294-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8437
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261729; ENSP00000261729; ENSG00000111344 [O95294-1]
ENST00000446861; ENSP00000395920; ENSG00000111344 [O95294-2]
ENST00000546530; ENSP00000450244; ENSG00000111344 [O95294-3]
ENST00000548055; ENSP00000448510; ENSG00000111344 [O95294-4]
GeneIDi8437
KEGGihsa:8437
UCSCiuc001tul.4 human [O95294-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8437
DisGeNETi8437
EuPathDBiHostDB:ENSG00000111344.11

GeneCards: human genes, protein and diseases

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GeneCardsi
RASAL1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0011016
HGNCiHGNC:9873 RASAL1
HPAiHPA041650
MIMi604118 gene
neXtProtiNX_O95294
OpenTargetsiENSG00000111344
PharmGKBiPA34234

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2059 Eukaryota
ENOG410Y128 LUCA
GeneTreeiENSGT00940000158715
HOGENOMiHOG000234324
HOVERGENiHBG106587
InParanoidiO95294
KOiK17632
OMAiLGMVEFP
OrthoDBi145372at2759
PhylomeDBiO95294
TreeFamiTF105302

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RASAL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8437

Protein Ontology

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PROi
PR:O95294

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111344 Expressed in 141 organ(s), highest expression level in esophagus mucosa
GenevisibleiO95294 HS

Family and domain databases

CDDicd05135 RasGAP_RASAL, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR028555 RASAL1
IPR037776 RASAL_RasGAP
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif
PANTHERiPTHR10194 PTHR10194, 1 hit
PTHR10194:SF3 PTHR10194:SF3, 1 hit
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95294
Secondary accession number(s): B7ZKM4
, C9JFK5, F8VQX1, Q52M03, Q59H24, Q96CC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 2, 2010
Last modified: February 13, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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