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Entry version 177 (02 Jun 2021)
Sequence version 3 (02 Nov 2010)
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Protein

RasGAP-activating-like protein 1

Gene

RASAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798).

Plays a role in dendrite formation by melanocytes (PubMed:23999003).

2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi21Calcium 1PROSITE-ProRule annotation1
Metal bindingi21Calcium 2PROSITE-ProRule annotation1
Metal bindingi27Calcium 1PROSITE-ProRule annotation1
Metal bindingi74Calcium 1PROSITE-ProRule annotation1
Metal bindingi74Calcium 2PROSITE-ProRule annotation1
Metal bindingi76Calcium 1PROSITE-ProRule annotation1
Metal bindingi76Calcium 2PROSITE-ProRule annotation1
Metal bindingi82Calcium 2PROSITE-ProRule annotation1
Metal bindingi149Calcium 3PROSITE-ProRule annotation1
Metal bindingi149Calcium 4PROSITE-ProRule annotation1
Metal bindingi155Calcium 3PROSITE-ProRule annotation1
Metal bindingi202Calcium 3PROSITE-ProRule annotation1
Metal bindingi202Calcium 4PROSITE-ProRule annotation1
Metal bindingi204Calcium 3PROSITE-ProRule annotation1
Metal bindingi204Calcium 4PROSITE-ProRule annotation1
Metal bindingi210Calcium 4PROSITE-ProRule annotation1
Metal bindingi682ZincPROSITE-ProRule annotation1
Metal bindingi693ZincPROSITE-ProRule annotation1
Metal bindingi694ZincPROSITE-ProRule annotation1
Metal bindingi704ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri674 – 710Btk-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O95294

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5658442, Regulation of RAS by GAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RasGAP-activating-like protein 1Curated
Alternative name(s):
RAS protein activator like 1Imported
Ras GTPase-activating-like protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASAL1Imported
Synonyms:RASAL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9873, RASAL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604118, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95294

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000111344.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8437

Open Targets

More...
OpenTargetsi
ENSG00000111344

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34234

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95294, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASAL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000566451 – 804RasGAP-activating-like protein 1Add BLAST804

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95294

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95294

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95294

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95294

PeptideAtlas

More...
PeptideAtlasi
O95294

PRoteomics IDEntifications database

More...
PRIDEi
O95294

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
28360
50790 [O95294-1]
50791 [O95294-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95294

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95294

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O95294

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798). Expressed in melanocytes (PubMed:23999003).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111344, Expressed in esophagus mucosa and 166 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95294, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000111344, Tissue enhanced (parathyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114017, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000450244

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95294, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95294

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 105C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini116 – 231C2 2PROSITE-ProRule annotationAdd BLAST116
Domaini301 – 511Ras-GAPPROSITE-ProRule annotationAdd BLAST211
Domaini565 – 672PHPROSITE-ProRule annotationAdd BLAST108

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri674 – 710Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158715

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008096_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95294

Identification of Orthologs from Complete Genome Data

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OMAi
PDWQVRS

Database of Orthologous Groups

More...
OrthoDBi
145372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95294

TreeFam database of animal gene trees

More...
TreeFami
TF105302

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05135, RasGAP_RASAL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR028555, RASAL1
IPR037776, RASAL_RasGAP
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001562, Znf_Btk_motif

The PANTHER Classification System

More...
PANTHERi
PTHR10194, PTHR10194, 1 hit
PTHR10194:SF3, PTHR10194:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00779, BTK, 1 hit
PF00168, C2, 2 hits
PF00169, PH, 1 hit
PF00616, RasGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00107, BTK, 1 hit
SM00239, C2, 2 hits
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS51113, ZF_BTK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95294-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKSSSLNVR VVEGRALPAK DVSGSSDPYC LVKVDDEVVA RTATVWRSLG
60 70 80 90 100
PFWGEEYTVH LPLDFHQLAF YVLDEDTVGH DDIIGKISLS REAITADPRG
110 120 130 140 150
IDSWINLSRV DPDAEVQGEI CLSVQMLEDG QGRCLRCHVL QARDLAPRDI
160 170 180 190 200
SGTSDPFARV FWGSQSLETS TIKKTRFPHW DEVLELREMP GAPSPLRVEL
210 220 230 240 250
WDWDMVGKND FLGMVEFSPK TLQQKPPKGW FRLLPFPRAE EDSGGNLGAL
260 270 280 290 300
RVKVRLIEDR VLPSQCYQPL MELLMESVQG PAEEDTASPL ALLEELTLGD
310 320 330 340 350
CRQDLATKLV KLFLGRGLAG RFLDYLTRRE VARTMDPNTL FRSNSLASKS
360 370 380 390 400
MEQFMKLVGM PYLHEVLKPV ISRVFEEKKY MELDPCKMDL GRTRRISFKG
410 420 430 440 450
ALSEEQMRET SLGLLTGYLG PIVDAIVGSV GRCPPAMRLA FKQLHRRVEE
460 470 480 490 500
RFPQAEHQDV KYLAISGFLF LRFFAPAILT PKLFDLRDQH ADPQTSRSLL
510 520 530 540 550
LLAKAVQSIG NLGQQLGQGK ELWMAPLHPF LLQCVSRVRD FLDRLVDVDG
560 570 580 590 600
DEAGVPARAL FPPSAIVREG YLLKRKEEPA GLATRFAFKK RYVWLSGETL
610 620 630 640 650
SFSKSPEWQM CHSIPVSHIR AVERVDEGAF QLPHVMQVVT QDGTGALHTT
660 670 680 690 700
YLQCKNVNEL NQWLSALRKA SAPNPNKLAA CHPGAFRSAR WTCCLQAERS
710 720 730 740 750
AAGCSRTHSA VTLGDWSDPL DPDAEAQTVY RQLLLGRDQL RLKLLEDSNM
760 770 780 790 800
DTTLEADTGA CPEVLARQRA ATARLLEVLA DLDRAHEEFQ QQERGKAALG

PLGP
Length:804
Mass (Da):90,016
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D0065A093487FD0
GO
Isoform 2 (identifier: O95294-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-637: Missing.

Show »
Length:776
Mass (Da):86,847
Checksum:i3E385FF1F2F41866
GO
Isoform 3 (identifier: O95294-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-458: Q → QQ
     552-552: E → EE

Show »
Length:806
Mass (Da):90,274
Checksum:i7B82D39FBAD0E59E
GO
Isoform 4 (identifier: O95294-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-552: E → EE

Show »
Length:805
Mass (Da):90,145
Checksum:i0CBCCAD667337182
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92172 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141Q → H in AAD09006 (PubMed:9751798).Curated1
Sequence conflicti346L → P in CAB66607 (PubMed:11230166).Curated1
Sequence conflicti514Q → R in CAB66607 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03166511V → L1 PublicationCorresponds to variant dbSNP:rs7960087Ensembl.1
Natural variantiVAR_03166658T → M1 PublicationCorresponds to variant dbSNP:rs34598602Ensembl.1
Natural variantiVAR_031667321R → H3 PublicationsCorresponds to variant dbSNP:rs1284879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047005458Q → QQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_047006552E → EE in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_001627610 – 637Missing in isoform 2. CuratedAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF086713 mRNA Translation: AAD09006.1
AB208935 mRNA Translation: BAD92172.1 Different initiation.
AC089999 Genomic DNA No translation available.
BC014420 mRNA Translation: AAH14420.1
BC093724 mRNA Translation: AAH93724.1
BC143261 mRNA Translation: AAI43262.1
AL136672 Transcribed RNA Translation: CAB66607.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55888.1 [O95294-2]
CCDS55889.1 [O95294-3]
CCDS73529.1 [O95294-4]
CCDS9165.1 [O95294-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001180449.1, NM_001193520.1 [O95294-3]
NP_001180450.1, NM_001193521.1 [O95294-2]
NP_001288131.1, NM_001301202.1 [O95294-4]
NP_004649.2, NM_004658.2 [O95294-1]
XP_005254007.1, XM_005253950.4 [O95294-3]
XP_006719704.1, XM_006719641.3 [O95294-3]
XP_011537154.1, XM_011538852.2 [O95294-3]
XP_011537155.1, XM_011538853.2 [O95294-1]
XP_016875517.1, XM_017020028.1 [O95294-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261729; ENSP00000261729; ENSG00000111344 [O95294-1]
ENST00000446861; ENSP00000395920; ENSG00000111344 [O95294-2]
ENST00000546530; ENSP00000450244; ENSG00000111344 [O95294-3]
ENST00000548055; ENSP00000448510; ENSG00000111344 [O95294-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8437

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8437

UCSC genome browser

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UCSCi
uc001tul.4, human [O95294-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086713 mRNA Translation: AAD09006.1
AB208935 mRNA Translation: BAD92172.1 Different initiation.
AC089999 Genomic DNA No translation available.
BC014420 mRNA Translation: AAH14420.1
BC093724 mRNA Translation: AAH93724.1
BC143261 mRNA Translation: AAI43262.1
AL136672 Transcribed RNA Translation: CAB66607.2
CCDSiCCDS55888.1 [O95294-2]
CCDS55889.1 [O95294-3]
CCDS73529.1 [O95294-4]
CCDS9165.1 [O95294-1]
RefSeqiNP_001180449.1, NM_001193520.1 [O95294-3]
NP_001180450.1, NM_001193521.1 [O95294-2]
NP_001288131.1, NM_001301202.1 [O95294-4]
NP_004649.2, NM_004658.2 [O95294-1]
XP_005254007.1, XM_005253950.4 [O95294-3]
XP_006719704.1, XM_006719641.3 [O95294-3]
XP_011537154.1, XM_011538852.2 [O95294-3]
XP_011537155.1, XM_011538853.2 [O95294-1]
XP_016875517.1, XM_017020028.1 [O95294-4]

3D structure databases

SMRiO95294
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114017, 4 interactors
STRINGi9606.ENSP00000450244

PTM databases

iPTMnetiO95294
PhosphoSitePlusiO95294
SwissPalmiO95294

Genetic variation databases

BioMutaiRASAL1

Proteomic databases

jPOSTiO95294
MassIVEiO95294
MaxQBiO95294
PaxDbiO95294
PeptideAtlasiO95294
PRIDEiO95294
ProteomicsDBi28360
50790 [O95294-1]
50791 [O95294-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31222, 225 antibodies

The DNASU plasmid repository

More...
DNASUi
8437

Genome annotation databases

EnsembliENST00000261729; ENSP00000261729; ENSG00000111344 [O95294-1]
ENST00000446861; ENSP00000395920; ENSG00000111344 [O95294-2]
ENST00000546530; ENSP00000450244; ENSG00000111344 [O95294-3]
ENST00000548055; ENSP00000448510; ENSG00000111344 [O95294-4]
GeneIDi8437
KEGGihsa:8437
UCSCiuc001tul.4, human [O95294-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8437
DisGeNETi8437

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RASAL1
HGNCiHGNC:9873, RASAL1
HPAiENSG00000111344, Tissue enhanced (parathyroid)
MIMi604118, gene
neXtProtiNX_O95294
OpenTargetsiENSG00000111344
PharmGKBiPA34234
VEuPathDBiHostDB:ENSG00000111344.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2059, Eukaryota
GeneTreeiENSGT00940000158715
HOGENOMiCLU_008096_0_0_1
InParanoidiO95294
OMAiPDWQVRS
OrthoDBi145372at2759
PhylomeDBiO95294
TreeFamiTF105302

Enzyme and pathway databases

PathwayCommonsiO95294
ReactomeiR-HSA-5658442, Regulation of RAS by GAPs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8437, 5 hits in 975 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RASAL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8437
PharosiO95294, Tbio

Protein Ontology

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PROi
PR:O95294
RNActiO95294, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111344, Expressed in esophagus mucosa and 166 other tissues
GenevisibleiO95294, HS

Family and domain databases

CDDicd05135, RasGAP_RASAL, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR028555, RASAL1
IPR037776, RASAL_RasGAP
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001562, Znf_Btk_motif
PANTHERiPTHR10194, PTHR10194, 1 hit
PTHR10194:SF3, PTHR10194:SF3, 1 hit
PfamiView protein in Pfam
PF00779, BTK, 1 hit
PF00168, C2, 2 hits
PF00169, PH, 1 hit
PF00616, RasGAP, 1 hit
SMARTiView protein in SMART
SM00107, BTK, 1 hit
SM00239, C2, 2 hits
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS51113, ZF_BTK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95294
Secondary accession number(s): B7ZKM4
, C9JFK5, F8VQX1, Q52M03, Q59H24, Q96CC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 2, 2010
Last modified: June 2, 2021
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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