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Protein

Potassium channel subfamily K member 5

Gene

KCNK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K+ concentrations.

Miscellaneous

Inhibited by quinine, quinidine and external acidification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-5576886 Phase 4 - resting membrane potential

Protein family/group databases

TCDBi1.A.1.8.2 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 5
Alternative name(s):
Acid-sensitive potassium channel protein TASK-2
TWIK-related acid-sensitive K(+) channel 2
Gene namesi
Name:KCNK5
Synonyms:TASK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164626.8
HGNCiHGNC:6280 KCNK5
MIMi603493 gene
neXtProtiNX_O95279

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 26HelicalSequence analysisAdd BLAST19
Intramembranei85 – 112Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST28
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 157CytoplasmicSequence analysisAdd BLAST24
Transmembranei158 – 180HelicalSequence analysisAdd BLAST23
Intramembranei190 – 215Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST26
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 325CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8645
OpenTargetsiENSG00000164626
PharmGKBiPA30062

Chemistry databases

GuidetoPHARMACOLOGYi517

Polymorphism and mutation databases

BioMutaiKCNK5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017491 – 499Potassium channel subfamily K member 5Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51Interchain
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei371PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95279
MaxQBiO95279
PaxDbiO95279
PeptideAtlasiO95279
PRIDEiO95279
ProteomicsDBi50787

PTM databases

iPTMnetiO95279
PhosphoSitePlusiO95279

Expressioni

Tissue specificityi

Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.

Gene expression databases

BgeeiENSG00000164626 Expressed in 184 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_KCNK5
ExpressionAtlasiO95279 baseline and differential
GenevisibleiO95279 HS

Organism-specific databases

HPAiHPA059148

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

BioGridi114197, 2 interactors
IntActiO95279, 26 interactors
STRINGi9606.ENSP00000352527

Structurei

3D structure databases

ProteinModelPortaliO95279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000113211
HOVERGENiHBG052236
InParanoidiO95279
KOiK04916
OMAiYFVELWI
OrthoDBiEOG091G058Z
PhylomeDBiO95279
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01095 TASKCHANNEL

Sequencei

Sequence statusi: Complete.

O95279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDRGPLLTS AIIFYLAIGA AIFEVLEEPH WKEAKKNYYT QKLHLLKEFP
60 70 80 90 100
CLGQEGLDKI LEVVSDAAGQ GVAITGNQTF NNWNWPNAMI FAATVITTIG
110 120 130 140 150
YGNVAPKTPA GRLFCVFYGL FGVPLCLTWI SALGKFFGGR AKRLGQFLTK
160 170 180 190 200
RGVSLRKAQI TCTVIFIVWG VLVHLVIPPF VFMVTEGWNY IEGLYYSFIT
210 220 230 240 250
ISTIGFGDFV AGVNPSANYH ALYRYFVELW IYLGLAWLSL FVNWKVSMFV
260 270 280 290 300
EVHKAIKKRR RRRKESFESS PHSRKALQVK GSTASKDVNI FSFLSKKEET
310 320 330 340 350
YNDLIKQIGK KAMKTSGGGE TGPGPGLGPQ GGGLPALPPS LVPLVVYSKN
360 370 380 390 400
RVPTLEEVSQ TLRSKGHVSR SPDEEAVARA PEDSSPAPEV FMNQLDRISE
410 420 430 440 450
ECEPWDAQDY HPLIFQDASI TFVNTEAGLS DEETSKSSLE DNLAGEESPQ
460 470 480 490
QGAEAKAPLN MGEFPSSSES TFTSTESELS VPYEQLMNEY NKANSPKGT
Length:499
Mass (Da):55,130
Last modified:May 1, 1999 - v1
Checksum:iE871A7A4823DDA00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti423V → A in BAG36953 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052425465P → T. Corresponds to variant dbSNP:rs9462487Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084830 mRNA Translation: AAC79458.1
EU978936 mRNA Translation: ACH86095.1
AK314298 mRNA Translation: BAG36953.1
AL451185 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03979.1
BC060793 mRNA Translation: AAH60793.1
BC069573 mRNA Translation: AAH69573.1
CCDSiCCDS4841.1
RefSeqiNP_003731.1, NM_003740.3
UniGeneiHs.444448

Genome annotation databases

EnsembliENST00000359534; ENSP00000352527; ENSG00000164626
GeneIDi8645
KEGGihsa:8645
UCSCiuc003oon.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084830 mRNA Translation: AAC79458.1
EU978936 mRNA Translation: ACH86095.1
AK314298 mRNA Translation: BAG36953.1
AL451185 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03979.1
BC060793 mRNA Translation: AAH60793.1
BC069573 mRNA Translation: AAH69573.1
CCDSiCCDS4841.1
RefSeqiNP_003731.1, NM_003740.3
UniGeneiHs.444448

3D structure databases

ProteinModelPortaliO95279
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114197, 2 interactors
IntActiO95279, 26 interactors
STRINGi9606.ENSP00000352527

Chemistry databases

GuidetoPHARMACOLOGYi517

Protein family/group databases

TCDBi1.A.1.8.2 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiO95279
PhosphoSitePlusiO95279

Polymorphism and mutation databases

BioMutaiKCNK5

Proteomic databases

EPDiO95279
MaxQBiO95279
PaxDbiO95279
PeptideAtlasiO95279
PRIDEiO95279
ProteomicsDBi50787

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359534; ENSP00000352527; ENSG00000164626
GeneIDi8645
KEGGihsa:8645
UCSCiuc003oon.4 human

Organism-specific databases

CTDi8645
DisGeNETi8645
EuPathDBiHostDB:ENSG00000164626.8
GeneCardsiKCNK5
HGNCiHGNC:6280 KCNK5
HPAiHPA059148
MIMi603493 gene
neXtProtiNX_O95279
OpenTargetsiENSG00000164626
PharmGKBiPA30062
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000113211
HOVERGENiHBG052236
InParanoidiO95279
KOiK04916
OMAiYFVELWI
OrthoDBiEOG091G058Z
PhylomeDBiO95279
TreeFamiTF313947

Enzyme and pathway databases

ReactomeiR-HSA-5576886 Phase 4 - resting membrane potential

Miscellaneous databases

ChiTaRSiKCNK5 human
GeneWikiiKCNK5
GenomeRNAii8645
PROiPR:O95279
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164626 Expressed in 184 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_KCNK5
ExpressionAtlasiO95279 baseline and differential
GenevisibleiO95279 HS

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01095 TASKCHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNK5_HUMAN
AccessioniPrimary (citable) accession number: O95279
Secondary accession number(s): B2RAQ6, B5TJL2, Q5VV76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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