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Protein

Ly6/PLAUR domain-containing protein 3

Gene

LYPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.4 Publications

GO - Molecular functioni

  • laminin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 3
Alternative name(s):
GPI-anchored metastasis-associated protein C4.4A homolog
Matrigel-induced gene C4 protein
Short name:
MIG-C4
Gene namesi
Name:LYPD3
Synonyms:C4.4A
ORF Names:UNQ491/PRO1007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000124466.8
HGNCiHGNC:24880 LYPD3
MIMi609484 gene
neXtProtiNX_O95274

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27076
OpenTargetsiENSG00000124466
PharmGKBiPA142671490

Polymorphism and mutation databases

BioMutaiLYPD3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000022675131 – 326Ly6/PLAUR domain-containing protein 3Add BLAST296
PropeptideiPRO_0000226752327 – 346Removed in mature formSequence analysisAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi326GPI-anchor amidated cysteineSequence analysis1

Post-translational modificationi

N-glycosylated and O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiO95274
MaxQBiO95274
PaxDbiO95274
PeptideAtlasiO95274
PRIDEiO95274
ProteomicsDBi50778

PTM databases

GlyConnecti1471
iPTMnetiO95274
PhosphoSitePlusiO95274

Expressioni

Tissue specificityi

Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers.3 Publications

Inductioni

Up-regulated in migrating keratinocytes during epithelisation of incisional skin wounds.

Gene expression databases

BgeeiENSG00000124466 Expressed in 125 organ(s), highest expression level in esophagus mucosa
CleanExiHS_LYPD3
ExpressionAtlasiO95274 baseline and differential
GenevisibleiO95274 HS

Organism-specific databases

HPAiHPA041529
HPA041797
HPA077859

Interactioni

Subunit structurei

Binds laminin-1 and laminin-5. Interacts with LGALS3 (By similarity). Interacts with AGR2 and AGR3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117985, 117 interactors
IntActiO95274, 16 interactors
MINTiO95274
STRINGi9606.ENSP00000244333

Structurei

3D structure databases

ProteinModelPortaliO95274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 126UPAR/Ly6 1Add BLAST94
Domaini140 – 222UPAR/Ly6 2Add BLAST83

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIUT Eukaryota
ENOG41116C6 LUCA
GeneTreeiENSGT00910000144240
HOGENOMiHOG000059631
HOVERGENiHBG053008
InParanoidiO95274
OMAiCSPHKMK
OrthoDBiEOG091G0FQ6
PhylomeDBiO95274
TreeFamiTF337983

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95274-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPARKAGAQ AMIWTAGWLL LLLLRGGAQA LECYSCVQKA DDGCSPNKMK
60 70 80 90 100
TVKCAPGVDV CTEAVGAVET IHGQFSLAVR GCGSGLPGKN DRGLDLHGLL
110 120 130 140 150
AFIQLQQCAQ DRCNAKLNLT SRALDPAGNE SAYPPNGVEC YSCVGLSREA
160 170 180 190 200
CQGTSPPVVS CYNASDHVYK GCFDGNVTLT AANVTVSLPV RGCVQDEFCT
210 220 230 240 250
RDGVTGPGFT LSGSCCQGSR CNSDLRNKTY FSPRIPPLVR LPPPEPTTVA
260 270 280 290 300
STTSVTTSTS APVRPTSTTK PMPAPTSQTP RQGVEHEASR DEEPRLTGGA
310 320 330 340
AGHQDRSNSG QYPAKGGPQQ PHNKGCVAPT AGLAALLLAV AAGVLL
Length:346
Mass (Da):35,971
Last modified:March 7, 2006 - v2
Checksum:i97FF9B4A554934FF
GO

Mass spectrometryi

Molecular mass is 21442.9 Da from positions 1 - 204. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082889 mRNA Translation: AAD13751.1
AJ223603 mRNA Translation: CAA11469.2
AY359006 mRNA Translation: AAQ89365.1
AC018758 Genomic DNA Translation: AAG09062.1
BC039167 mRNA Translation: AAH39167.1
CCDSiCCDS12620.1
RefSeqiNP_055215.2, NM_014400.2
UniGeneiHs.631594

Genome annotation databases

EnsembliENST00000244333; ENSP00000244333; ENSG00000124466
GeneIDi27076
KEGGihsa:27076
UCSCiuc002owl.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082889 mRNA Translation: AAD13751.1
AJ223603 mRNA Translation: CAA11469.2
AY359006 mRNA Translation: AAQ89365.1
AC018758 Genomic DNA Translation: AAG09062.1
BC039167 mRNA Translation: AAH39167.1
CCDSiCCDS12620.1
RefSeqiNP_055215.2, NM_014400.2
UniGeneiHs.631594

3D structure databases

ProteinModelPortaliO95274
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117985, 117 interactors
IntActiO95274, 16 interactors
MINTiO95274
STRINGi9606.ENSP00000244333

PTM databases

GlyConnecti1471
iPTMnetiO95274
PhosphoSitePlusiO95274

Polymorphism and mutation databases

BioMutaiLYPD3

Proteomic databases

EPDiO95274
MaxQBiO95274
PaxDbiO95274
PeptideAtlasiO95274
PRIDEiO95274
ProteomicsDBi50778

Protocols and materials databases

DNASUi27076
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244333; ENSP00000244333; ENSG00000124466
GeneIDi27076
KEGGihsa:27076
UCSCiuc002owl.2 human

Organism-specific databases

CTDi27076
DisGeNETi27076
EuPathDBiHostDB:ENSG00000124466.8
GeneCardsiLYPD3
HGNCiHGNC:24880 LYPD3
HPAiHPA041529
HPA041797
HPA077859
MIMi609484 gene
neXtProtiNX_O95274
OpenTargetsiENSG00000124466
PharmGKBiPA142671490
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIUT Eukaryota
ENOG41116C6 LUCA
GeneTreeiENSGT00910000144240
HOGENOMiHOG000059631
HOVERGENiHBG053008
InParanoidiO95274
OMAiCSPHKMK
OrthoDBiEOG091G0FQ6
PhylomeDBiO95274
TreeFamiTF337983

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiLYPD3 human
GeneWikiiLYPD3
GenomeRNAii27076
PROiPR:O95274
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124466 Expressed in 125 organ(s), highest expression level in esophagus mucosa
CleanExiHS_LYPD3
ExpressionAtlasiO95274 baseline and differential
GenevisibleiO95274 HS

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134 LU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYPD3_HUMAN
AccessioniPrimary (citable) accession number: O95274
Secondary accession number(s): Q9UJ74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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