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Entry version 134 (22 Apr 2020)
Sequence version 2 (18 Mar 2008)
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Protein

Cyclin-D1-binding protein 1

Gene

CCNDBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-D1-binding protein 1
Alternative name(s):
Grap2 and cyclin-D-interacting protein
Human homolog of Maid
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNDBP1
Synonyms:DIP1, GCIP, HHM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1587 CCNDBP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607089 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95273

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23582

Open Targets

More...
OpenTargetsi
ENSG00000166946

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26154

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95273 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCNDBP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003233722 – 360Cyclin-D1-binding protein 1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95273

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95273

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O95273

MaxQB - The MaxQuant DataBase

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MaxQBi
O95273

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95273

PeptideAtlas

More...
PeptideAtlasi
O95273

PRoteomics IDEntifications database

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PRIDEi
O95273

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50774 [O95273-1]
50775 [O95273-2]
50776 [O95273-3]
50777 [O95273-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95273

MetOSite database of methionine sulfoxide sites

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MetOSitei
O95273

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95273

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression may increase during differentiation.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166946 Expressed in bone marrow and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95273 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95273 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166946 Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O95273
With#Exp.IntAct
B0FTY23EBI-748961,EBI-10175366
B2R4U63EBI-748961,EBI-10175477
F4ZW623EBI-748961,EBI-10177680
Q5XG853EBI-748961,EBI-10248413
Q8N9J23EBI-748961,EBI-10268244
Q96BA23EBI-748961,EBI-10282278
ADGRA2 - isoform 2 [Q96PE1-2]3EBI-748961,EBI-12227349
AMPD2 [Q01433]4EBI-748961,EBI-8796759
AQP1 [P29972]3EBI-748961,EBI-745213
ARHGAP22 [Q7Z5H3]3EBI-748961,EBI-3866859
ATP4B [P51164]3EBI-748961,EBI-3904463
C22orf23 [Q9BZE7]5EBI-748961,EBI-10303102
C6orf226 [Q5I0X4]4EBI-748961,EBI-10244057
CCDC146 [Q8IYE0]3EBI-748961,EBI-10749669
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-748961,EBI-10247802
CDK18 [Q07002]3EBI-748961,EBI-746238
CFAP65 - isoform 2 [Q6ZU64-3]3EBI-748961,EBI-10255250
CNNM3 [Q8NE01]3EBI-748961,EBI-741032
COPS5 [Q92905]5EBI-748961,EBI-594661
CUL5 [Q93034]4EBI-748961,EBI-1057139
DMRT3 [Q9NQL9]3EBI-748961,EBI-9679045
DOCK2 [Q92608]3EBI-748961,EBI-448771
ESR2 - isoform 3 [Q92731-3]3EBI-748961,EBI-12259414
FAM110A [Q9BQ89]3EBI-748961,EBI-1752811
FAM126A [A0A0S2Z6M9]3EBI-748961,EBI-16428876
FAM126A [Q9BYI3]3EBI-748961,EBI-11065686
FAM161A [Q3B820]5EBI-748961,EBI-719941
FAM74A6 [Q5TZK3]3EBI-748961,EBI-10247271
FH [A0A0S2Z408]3EBI-748961,EBI-16428900
FZD10 [Q9ULW2]3EBI-748961,EBI-8803802
GAS2L2 [Q8NHY3]3EBI-748961,EBI-7960826
GSTK1 [Q9Y2Q3]3EBI-748961,EBI-1053767
HBZ [P02008]3EBI-748961,EBI-719843
HDAC4 - isoform 2 [P56524-2]3EBI-748961,EBI-11953488
HMGB1 [P09429]3EBI-748961,EBI-389432
ID2 [Q02363]4EBI-748961,EBI-713450
IMP3 [Q9NV31]6EBI-748961,EBI-747481
IRGC [Q6NXR0]3EBI-748961,EBI-12021374
LIN37 [Q96GY3]3EBI-748961,EBI-748884
LNX1 [Q8TBB1]3EBI-748961,EBI-739832
MAP2K2 [P36507]3EBI-748961,EBI-1056930
MGC50722 [Q8IVT4]3EBI-748961,EBI-14086479
MOS [P00540]3EBI-748961,EBI-1757866
MRPL15 [Q9P015]7EBI-748961,EBI-2371967
NAIF1 [Q69YI7]3EBI-748961,EBI-10249231
NANOS2 [P60321]5EBI-748961,EBI-10216569
Neurod1 [Q60867] from Mus musculus.4EBI-748961,EBI-309315
NOL7 [Q9UMY1]3EBI-748961,EBI-2862609
NSMF - isoform 2 [Q6X4W1-2]3EBI-748961,EBI-12028784
PIAS2 [O75928]4EBI-748961,EBI-348555
PIMREG [Q9BSJ6]6EBI-748961,EBI-2568609
PLEKHA7 - isoform 2 [Q6IQ23-2]3EBI-748961,EBI-12069346
PMP2 [P02689]4EBI-748961,EBI-10193858
POLDIP3 [Q8WUT1]3EBI-748961,EBI-10276663
POLL - isoform 2 [Q9UGP5-2]3EBI-748961,EBI-10320765
PRPF31 [Q8WWY3]5EBI-748961,EBI-1567797
PSMB10 [P40306]5EBI-748961,EBI-603329
RARA [P10276]3EBI-748961,EBI-413374
RARB - isoform Beta-2 [P10826-2]3EBI-748961,EBI-8583223
RBP5 [P82980]3EBI-748961,EBI-3941274
RPL28 [P46779]7EBI-748961,EBI-366357
RPL39L [Q96EH5]4EBI-748961,EBI-6658607
RPL7L1 [Q6DKI1]3EBI-748961,EBI-1052408
RPLP0 [P05388]4EBI-748961,EBI-354101
RPS28 [P62857]3EBI-748961,EBI-353027
RRAD [P55042]5EBI-748961,EBI-3911502
SHFL - isoform 4 [Q9NUL5-4]3EBI-748961,EBI-11955083
SLC16A13 [Q7RTY0]3EBI-748961,EBI-12243266
SPG7 [Q9UQ90]3EBI-748961,EBI-717201
STK25 [O00506]3EBI-748961,EBI-618295
SYF2 [O95926]3EBI-748961,EBI-2557644
TCEAL1 - isoform 2 [Q15170-2]3EBI-748961,EBI-11156070
TCF3 - isoform E12 [P15923-1]3EBI-748961,EBI-769645
TEAD4 [D3DUQ6]3EBI-748961,EBI-10176734
TFPT [A0A024R4Q5]3EBI-748961,EBI-11527449
THAP10 [Q9P2Z0]5EBI-748961,EBI-745404
THAP7 [Q9BT49]4EBI-748961,EBI-741350
TMEM120B [A0PK00]3EBI-748961,EBI-10171534
TRAPPC5 [Q8IUR0]8EBI-748961,EBI-3246160
TTC23 [Q5W5X9]3EBI-748961,EBI-6447954
TYMSOS [Q8TAI1]3EBI-748961,EBI-742060
WNT11 [O96014]3EBI-748961,EBI-8058160
ZBTB24 [O43167]3EBI-748961,EBI-744471
ZGPAT [Q8N5A5]4EBI-748961,EBI-3439227
ZNF124 [Q15973]3EBI-748961,EBI-2555767
ZNF136 [P52737]5EBI-748961,EBI-749129
ZNF155 [Q12901]3EBI-748961,EBI-10747670
ZNF169 [Q14929]3EBI-748961,EBI-10234472
ZNF20 [P17024]6EBI-748961,EBI-717634
ZNF223 [Q9UK11]3EBI-748961,EBI-10322867
ZNF230 [Q9UIE0]3EBI-748961,EBI-1105361
ZNF334 [Q9HCZ1]4EBI-748961,EBI-748965
ZNF394 [Q53GI3]3EBI-748961,EBI-10211248
ZNF417 [Q8TAU3]4EBI-748961,EBI-740727
ZNF439 [Q8NDP4]3EBI-748961,EBI-747580
ZNF480 [Q8WV37]3EBI-748961,EBI-8490675
ZNF490 [Q9ULM2]3EBI-748961,EBI-1105370
ZNF552 [Q9H707]3EBI-748961,EBI-2555731
ZNF555 [Q8NEP9]4EBI-748961,EBI-10270752
ZNF557 - isoform 2 [Q8N988-2]3EBI-748961,EBI-10699005
ZNF564 [Q8TBZ8]3EBI-748961,EBI-10273713
ZNF578 [Q96N58]3EBI-748961,EBI-11955189
ZNF581 [Q9P0T4]3EBI-748961,EBI-745520
ZNF627 [Q7L945]4EBI-748961,EBI-2797561
ZNF670 [Q9BS34]6EBI-748961,EBI-745276
ZNF696 [Q9H7X3]3EBI-748961,EBI-11090299
ZNF697 [Q8N508]3EBI-748961,EBI-10265733
ZNF707 [Q96C28]7EBI-748961,EBI-748111
ZNF785 [A8K8V0]3EBI-748961,EBI-3925400
ZNF786 [Q8N393]3EBI-748961,EBI-10265203
ZNF835 [Q9Y2P0]3EBI-748961,EBI-5667516
ZNF837 [Q96EG3]3EBI-748961,EBI-11962574
ZSCAN26 [Q16670]3EBI-748961,EBI-3920053

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117117, 108 interactors

Protein interaction database and analysis system

More...
IntActi
O95273, 143 interactors

Molecular INTeraction database

More...
MINTi
O95273

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300213

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95273 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95273

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 208Required for interaction with CCND1Add BLAST207
Regioni2 – 190Interaction with RPLP01 PublicationAdd BLAST189
Regioni2 – 184Interaction with TCF31 PublicationAdd BLAST183
Regioni150 – 360Interaction with TCF31 PublicationAdd BLAST211
Regioni240 – 360Interaction with RPLP01 PublicationAdd BLAST121

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCNDBP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410II9T Eukaryota
ENOG410ZPHZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018016

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_067580_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95273

KEGG Orthology (KO)

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KOi
K21626

Identification of Orthologs from Complete Genome Data

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OMAi
YYWLPKS

Database of Orthologous Groups

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OrthoDBi
1249310at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O95273

TreeFam database of animal gene trees

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TreeFami
TF336444

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026907 CCNDBP1

The PANTHER Classification System

More...
PANTHERi
PTHR15492 PTHR15492, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASATAPAAA VPTLASPLEQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE
60 70 80 90 100
MFWRRLNEAA VTVSREATTL TIVFSQLPLP SPQETQKFCE QVHAAIKAFI
110 120 130 140 150
AVYYLLPKDQ GITLRKLVRG ATLDIVDGMA QLMEVLSVTP TQSPENNDLI
160 170 180 190 200
SYNSVWVACQ QMPQIPRDNK AAALLMLTKN VDFVKDAHEE MEQAVEECDP
210 220 230 240 250
YSGLLNDTEE NNSDNHNHED DVLGFPSNQD LYWSEDDQEL IIPCLALVRA
260 270 280 290 300
SKACLKKIRM LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC
310 320 330 340 350
HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI
360
KELTQSELEL
Length:360
Mass (Da):40,262
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40C7C3686632F6A7
GO
Isoform 2 (identifier: O95273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-309: SA → EP
     310-360: Missing.

Show »
Length:309
Mass (Da):34,553
Checksum:iAD95CB0FFA840BED
GO
Isoform 3 (identifier: O95273-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Show »
Length:232
Mass (Da):26,038
Checksum:i358E6410BEF74DB4
GO
Isoform 4 (identifier: O95273-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     308-333: SAKLVSVLKKALEITKASHVTPQPED → VSTGFEGIATEQMGRISLITSISCK
     334-360: Missing.

Show »
Length:204
Mass (Da):22,714
Checksum:iBA2C46B96005794A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR23H3BR23_HUMAN
Cyclin-D1-binding protein 1
CCNDBP1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQA6H3BQA6_HUMAN
Cyclin-D1-binding protein 1
CCNDBP1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUF4H3BUF4_HUMAN
Cyclin-D1-binding protein 1
CCNDBP1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD11777 differs from that shown. Reason: Frameshift.Curated
The sequence AAP97163 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40A → D in AAD11777 (PubMed:10854051).Curated1
Sequence conflicti41Q → R in AAP97163 (Ref. 4) Curated1
Sequence conflicti74F → S in BAC11433 (PubMed:16303743).Curated1
Sequence conflicti211N → S in BAC11433 (PubMed:16303743).Curated1
Sequence conflicti235E → G in BAF83396 (PubMed:14702039).Curated1
Sequence conflicti267K → R in BAC87645 (PubMed:14702039).Curated1
Sequence conflicti274L → M in AAD11777 (PubMed:10854051).Curated1
Sequence conflicti274L → M in AAF67182 (PubMed:10801854).Curated1
Sequence conflicti310K → R in BAC11530 (PubMed:14702039).Curated1
Sequence conflicti334S → I in BAF83354 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0320121 – 128Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST128
Alternative sequenceiVSP_032013308 – 333SAKLV…PQPED → VSTGFEGIATEQMGRISLIT SISCK in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_032014308 – 309SA → EP in isoform 2. 1 Publication2
Alternative sequenceiVSP_032015310 – 360Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_032016334 – 360Missing in isoform 4. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF082569 mRNA Translation: AAD11777.1 Frameshift.
AF132034 mRNA Translation: AAF77613.1
AF246144 mRNA Translation: AAF67182.1
AF087852 mRNA Translation: AAP97163.1 Frameshift.
AF113535 mRNA Translation: AAF14872.1
CR450331 mRNA Translation: CAG29327.1
AK075296 mRNA Translation: BAC11530.1
AK128849 mRNA Translation: BAC87645.1
AK290665 mRNA Translation: BAF83354.1
AK290707 mRNA Translation: BAF83396.1
AK075146 mRNA Translation: BAC11433.1
CH471125 Genomic DNA Translation: EAW92588.1
CH471125 Genomic DNA Translation: EAW92590.1
BC009689 mRNA Translation: AAH09689.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10092.1 [O95273-1]

NCBI Reference Sequences

More...
RefSeqi
NP_036274.3, NM_012142.4 [O95273-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300213; ENSP00000300213; ENSG00000166946 [O95273-1]
ENST00000565296; ENSP00000455419; ENSG00000166946 [O95273-2]
ENST00000566515; ENSP00000456797; ENSG00000166946 [O95273-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23582

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23582

UCSC genome browser

More...
UCSCi
uc001zqv.4 human [O95273-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082569 mRNA Translation: AAD11777.1 Frameshift.
AF132034 mRNA Translation: AAF77613.1
AF246144 mRNA Translation: AAF67182.1
AF087852 mRNA Translation: AAP97163.1 Frameshift.
AF113535 mRNA Translation: AAF14872.1
CR450331 mRNA Translation: CAG29327.1
AK075296 mRNA Translation: BAC11530.1
AK128849 mRNA Translation: BAC87645.1
AK290665 mRNA Translation: BAF83354.1
AK290707 mRNA Translation: BAF83396.1
AK075146 mRNA Translation: BAC11433.1
CH471125 Genomic DNA Translation: EAW92588.1
CH471125 Genomic DNA Translation: EAW92590.1
BC009689 mRNA Translation: AAH09689.1
CCDSiCCDS10092.1 [O95273-1]
RefSeqiNP_036274.3, NM_012142.4 [O95273-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AY5X-ray2.50A1-360[»]
SMRiO95273
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117117, 108 interactors
IntActiO95273, 143 interactors
MINTiO95273
STRINGi9606.ENSP00000300213

PTM databases

iPTMnetiO95273
MetOSiteiO95273
PhosphoSitePlusiO95273

Polymorphism and mutation databases

BioMutaiCCNDBP1

Proteomic databases

EPDiO95273
jPOSTiO95273
MassIVEiO95273
MaxQBiO95273
PaxDbiO95273
PeptideAtlasiO95273
PRIDEiO95273
ProteomicsDBi50774 [O95273-1]
50775 [O95273-2]
50776 [O95273-3]
50777 [O95273-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23815 242 antibodies

The DNASU plasmid repository

More...
DNASUi
23582

Genome annotation databases

EnsembliENST00000300213; ENSP00000300213; ENSG00000166946 [O95273-1]
ENST00000565296; ENSP00000455419; ENSG00000166946 [O95273-2]
ENST00000566515; ENSP00000456797; ENSG00000166946 [O95273-2]
GeneIDi23582
KEGGihsa:23582
UCSCiuc001zqv.4 human [O95273-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23582
DisGeNETi23582

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCNDBP1
HGNCiHGNC:1587 CCNDBP1
HPAiENSG00000166946 Tissue enhanced (bone)
MIMi607089 gene
neXtProtiNX_O95273
OpenTargetsiENSG00000166946
PharmGKBiPA26154

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II9T Eukaryota
ENOG410ZPHZ LUCA
GeneTreeiENSGT00390000018016
HOGENOMiCLU_067580_0_0_1
InParanoidiO95273
KOiK21626
OMAiYYWLPKS
OrthoDBi1249310at2759
PhylomeDBiO95273
TreeFamiTF336444

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCNDBP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CCNDBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23582
PharosiO95273 Tbio

Protein Ontology

More...
PROi
PR:O95273
RNActiO95273 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166946 Expressed in bone marrow and 199 other tissues
ExpressionAtlasiO95273 baseline and differential
GenevisibleiO95273 HS

Family and domain databases

InterProiView protein in InterPro
IPR026907 CCNDBP1
PANTHERiPTHR15492 PTHR15492, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCDB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95273
Secondary accession number(s): A8K3Q0
, A8K3U2, Q6ZQN9, Q7Z519, Q8NBS7, Q8NBY2, Q9NS19, Q9NYH3, Q9UHX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: April 22, 2020
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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