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Protein

Tankyrase-1

Gene

TNKS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.7 Publications

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation1 Publication

Activity regulationi

Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1234ZincCombined sources1 Publication1
Metal bindingi1237ZincCombined sources1 Publication1
Metal bindingi1242ZincCombined sources1 Publication1
Metal bindingi1245ZincCombined sources1 Publication1

GO - Molecular functioni

  • histone binding Source: BHF-UCL
  • NAD+ ADP-ribosyltransferase activity Source: UniProtKB
  • zinc ion binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport, Wnt signaling pathway
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi2.4.2.30 2681
ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8948751 Regulation of PTEN stability and activity
SIGNORiO95271

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tankyrase-1 (EC:2.4.2.30)
Short name:
TANK1
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 5
Short name:
ARTD5
Poly [ADP-ribose] polymerase 5A
TNKS-1
TRF1-interacting ankyrin-related ADP-ribose polymerase
Tankyrase I
Gene namesi
Name:TNKS
Synonyms:PARP5A, PARPL, TIN1, TINF1, TNKS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000173273.15
HGNCiHGNC:11941 TNKS
MIMi603303 gene
neXtProtiNX_O95271

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nuclear pore complex, Nucleus, Telomere

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1184H → A: Loss of activity; when associated with A-1291. 1 Publication1
Mutagenesisi1291E → A: Loss of activity; when associated with A-1184. 1 Publication1

Organism-specific databases

DisGeNETi8658
OpenTargetsiENSG00000173273
PharmGKBiPA36631

Chemistry databases

ChEMBLiCHEMBL6164

Polymorphism and mutation databases

BioMutaiTNKS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113331 – 1327Tankyrase-1Add BLAST1327

Post-translational modificationi

Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis.1 Publication
Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation.1 Publication
ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.1 Publication

Keywords - PTMi

ADP-ribosylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95271
MaxQBiO95271
PaxDbiO95271
PeptideAtlasiO95271
PRIDEiO95271
ProteomicsDBi50772
50773 [O95271-2]

PTM databases

iPTMnetiO95271
PhosphoSitePlusiO95271

Expressioni

Tissue specificityi

Ubiquitous; highest levels in testis.

Gene expression databases

BgeeiENSG00000173273 Expressed in 230 organ(s), highest expression level in forebrain
CleanExiHS_TNKS
ExpressionAtlasiO95271 baseline and differential
GenevisibleiO95271 HS

Organism-specific databases

HPAiHPA025690

Interactioni

Subunit structurei

Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2 (PubMed:12768206). Interacts with AXIN1 (PubMed:19759537, PubMed:21478859, PubMed:21799911). Interacts with AXIN2 (PubMed:19759537, PubMed:21478859). Interacts with BLZF1 and CASC3 (PubMed:21478859). Interacts with NUMA1 (PubMed:12080061).5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114207, 52 interactors
CORUMiO95271
DIPiDIP-36652N
ELMiO95271
IntActiO95271, 27 interactors
MINTiO95271
STRINGi9606.ENSP00000311579

Chemistry databases

BindingDBiO95271

Structurei

Secondary structure

11327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95271
SMRiO95271
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95271

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati181 – 209ANK 1Sequence analysisAdd BLAST29
Repeati215 – 244ANK 2Sequence analysisAdd BLAST30
Repeati248 – 277ANK 3Sequence analysisAdd BLAST30
Repeati281 – 310ANK 4Sequence analysisAdd BLAST30
Repeati335 – 364ANK 5Sequence analysisAdd BLAST30
Repeati368 – 397ANK 6Sequence analysisAdd BLAST30
Repeati401 – 430ANK 7Sequence analysisAdd BLAST30
Repeati434 – 463ANK 8Sequence analysisAdd BLAST30
Repeati521 – 553ANK 9Sequence analysisAdd BLAST33
Repeati557 – 586ANK 10Sequence analysisAdd BLAST30
Repeati590 – 619ANK 11Sequence analysisAdd BLAST30
Repeati621 – 647ANK 12Sequence analysisAdd BLAST27
Repeati649 – 679ANK 13Sequence analysisAdd BLAST31
Repeati683 – 712ANK 14Sequence analysisAdd BLAST30
Repeati716 – 745ANK 15Sequence analysisAdd BLAST30
Repeati749 – 778ANK 16Sequence analysisAdd BLAST30
Repeati782 – 810ANK 17Sequence analysisAdd BLAST29
Repeati836 – 865ANK 18Sequence analysisAdd BLAST30
Repeati869 – 898ANK 19Sequence analysisAdd BLAST30
Repeati902 – 931ANK 20Sequence analysisAdd BLAST30
Repeati935 – 964ANK 21Sequence analysisAdd BLAST30
Domaini1030 – 1089SAMPROSITE-ProRule annotationAdd BLAST60
Domaini1112 – 1317PARP catalyticPROSITE-ProRule annotationAdd BLAST206

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 14Poly-HisPROSITE-ProRule annotation6
Compositional biasi20 – 83Pro-richPROSITE-ProRule annotationAdd BLAST64
Compositional biasi109 – 161Ser-richPROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00840000129677
HOGENOMiHOG000246964
HOVERGENiHBG059472
InParanoidiO95271
KOiK10799
OMAiDSTSCCS
OrthoDBiEOG091G00W8
PhylomeDBiO95271
TreeFamiTF326036

Family and domain databases

CDDicd00204 ANK, 5 hits
Gene3Di1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR028731 TNKS
PANTHERiPTHR24180:SF3 PTHR24180:SF3, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 4 hits
PF13606 Ank_3, 1 hit
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 17 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95271-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRRSQHH HHHHQQQLQP APGASAPPPP PPPPLSPGLA PGTTPASPTA
60 70 80 90 100
SGLAPFASPR HGLALPEGDG SRDPPDRPRS PDPVDGTSCC STTSTICTVA
110 120 130 140 150
AAPVVPAVST SSAAGVAPNP AGSGSNNSPS SSSSPTSSSS SSPSSPGSSL
160 170 180 190 200
AESPEAAGVS STAPLGPGAA GPGTGVPAVS GALRELLEAC RNGDVSRVKR
210 220 230 240 250
LVDAANVNAK DMAGRKSSPL HFAAGFGRKD VVEHLLQMGA NVHARDDGGL
260 270 280 290 300
IPLHNACSFG HAEVVSLLLC QGADPNARDN WNYTPLHEAA IKGKIDVCIV
310 320 330 340 350
LLQHGADPNI RNTDGKSALD LADPSAKAVL TGEYKKDELL EAARSGNEEK
360 370 380 390 400
LMALLTPLNV NCHASDGRKS TPLHLAAGYN RVRIVQLLLQ HGADVHAKDK
410 420 430 440 450
GGLVPLHNAC SYGHYEVTEL LLKHGACVNA MDLWQFTPLH EAASKNRVEV
460 470 480 490 500
CSLLLSHGAD PTLVNCHGKS AVDMAPTPEL RERLTYEFKG HSLLQAAREA
510 520 530 540 550
DLAKVKKTLA LEIINFKQPQ SHETALHCAV ASLHPKRKQV TELLLRKGAN
560 570 580 590 600
VNEKNKDFMT PLHVAAERAH NDVMEVLHKH GAKMNALDTL GQTALHRAAL
610 620 630 640 650
AGHLQTCRLL LSYGSDPSII SLQGFTAAQM GNEAVQQILS ESTPIRTSDV
660 670 680 690 700
DYRLLEASKA GDLETVKQLC SSQNVNCRDL EGRHSTPLHF AAGYNRVSVV
710 720 730 740 750
EYLLHHGADV HAKDKGGLVP LHNACSYGHY EVAELLVRHG ASVNVADLWK
760 770 780 790 800
FTPLHEAAAK GKYEICKLLL KHGADPTKKN RDGNTPLDLV KEGDTDIQDL
810 820 830 840 850
LRGDAALLDA AKKGCLARVQ KLCTPENINC RDTQGRNSTP LHLAAGYNNL
860 870 880 890 900
EVAEYLLEHG ADVNAQDKGG LIPLHNAASY GHVDIAALLI KYNTCVNATD
910 920 930 940 950
KWAFTPLHEA AQKGRTQLCA LLLAHGADPT MKNQEGQTPL DLATADDIRA
960 970 980 990 1000
LLIDAMPPEA LPTCFKPQAT VVSASLISPA STPSCLSAAS SIDNLTGPLA
1010 1020 1030 1040 1050
ELAVGGASNA GDGAAGTERK EGEVAGLDMN ISQFLKSLGL EHLRDIFETE
1060 1070 1080 1090 1100
QITLDVLADM GHEELKEIGI NAYGHRHKLI KGVERLLGGQ QGTNPYLTFH
1110 1120 1130 1140 1150
CVNQGTILLD LAPEDKEYQS VEEEMQSTIR EHRDGGNAGG IFNRYNVIRI
1160 1170 1180 1190 1200
QKVVNKKLRE RFCHRQKEVS EENHNHHNER MLFHGSPFIN AIIHKGFDER
1210 1220 1230 1240 1250
HAYIGGMFGA GIYFAENSSK SNQYVYGIGG GTGCPTHKDR SCYICHRQML
1260 1270 1280 1290 1300
FCRVTLGKSF LQFSTMKMAH APPGHHSVIG RPSVNGLAYA EYVIYRGEQA
1310 1320
YPEYLITYQI MKPEAPSQTA TAAEQKT
Length:1,327
Mass (Da):142,039
Last modified:April 14, 2009 - v2
Checksum:i44BDE985C715BEFF
GO
Isoform 2 (identifier: O95271-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     641-643: EST → GHS
     644-1327: Missing.

Note: No experimental confirmation available.
Show »
Length:643
Mass (Da):67,203
Checksum:iFA67DE30C2A2F3B8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWY6E7EWY6_HUMAN
Tankyrase-1
TNKS
617Annotation score:
E5RHD2E5RHD2_HUMAN
Tankyrase-1
TNKS
243Annotation score:
E7EQ52E7EQ52_HUMAN
Poly [ADP-ribose] polymerase
TNKS
1,090Annotation score:
A0A0C4DGE3A0A0C4DGE3_HUMAN
Tankyrase-1
TNKS
68Annotation score:
H0YAW5H0YAW5_HUMAN
Tankyrase-1
TNKS
61Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83P → Q in AAH98394 (PubMed:15489334).Curated1
Sequence conflicti802R → K in AAC79841 (PubMed:9822378).Curated1
Sequence conflicti802R → K in AAC79842 (PubMed:9822378).Curated1
Sequence conflicti1001E → G in AAH98394 (PubMed:15489334).Curated1
Sequence conflicti1266M → I in AAH98394 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004538641 – 643EST → GHS in isoform 2. 1 Publication3
Alternative sequenceiVSP_004539644 – 1327Missing in isoform 2. 1 PublicationAdd BLAST684

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082556 mRNA Translation: AAC79841.1
AF082557 mRNA Translation: AAC79842.1
AF082558 mRNA Translation: AAC79843.1
AF082559 mRNA Translation: AAC79844.1
AC103834 Genomic DNA No translation available.
AC103877 Genomic DNA No translation available.
AC104052 Genomic DNA No translation available.
AC021242 Genomic DNA No translation available.
BC098394 mRNA Translation: AAH98394.1
CCDSiCCDS5974.1 [O95271-1]
RefSeqiNP_003738.2, NM_003747.2 [O95271-1]
UniGeneiHs.370267

Genome annotation databases

EnsembliENST00000310430; ENSP00000311579; ENSG00000173273 [O95271-1]
GeneIDi8658
KEGGihsa:8658
UCSCiuc003wss.4 human [O95271-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082556 mRNA Translation: AAC79841.1
AF082557 mRNA Translation: AAC79842.1
AF082558 mRNA Translation: AAC79843.1
AF082559 mRNA Translation: AAC79844.1
AC103834 Genomic DNA No translation available.
AC103877 Genomic DNA No translation available.
AC104052 Genomic DNA No translation available.
AC021242 Genomic DNA No translation available.
BC098394 mRNA Translation: AAH98394.1
CCDSiCCDS5974.1 [O95271-1]
RefSeqiNP_003738.2, NM_003747.2 [O95271-1]
UniGeneiHs.370267

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RF5X-ray2.30A1091-1325[»]
3UDDX-ray1.95A/B1105-1327[»]
3UH2X-ray2.00A/B1105-1327[»]
3UH4X-ray2.00A/B1105-1327[»]
4DVIX-ray1.90A/B1104-1314[»]
4I9IX-ray2.40A/B/C/D1104-1314[»]
4K4EX-ray2.30A/B1104-1314[»]
4K4FX-ray2.90A/B1104-1314[»]
4KRSX-ray2.29A/B1105-1327[»]
4LI6X-ray2.05A/B1105-1327[»]
4LI7X-ray2.20A/B1105-1327[»]
4LI8X-ray2.52A/B1105-1327[»]
4MSGX-ray1.80A/B1104-1314[»]
4MSKX-ray2.30A/B/C/D1104-1314[»]
4MT9X-ray2.00A/B1104-1314[»]
4N3RX-ray1.90A/B1104-1314[»]
4N4VX-ray2.00A/B1104-1314[»]
4OA7X-ray2.30A/B/C/D1105-1313[»]
4TORX-ray1.50A/B/C/D1105-1315[»]
4TOSX-ray1.80A/B1105-1315[»]
4U6AX-ray2.37A1091-1325[»]
4UUHX-ray2.52A1091-1325[»]
4UW1X-ray3.37A/B/C/D/E/F/G/H1091-1325[»]
4W5SX-ray2.80A1105-1314[»]
4W6EX-ray1.95A1106-1314[»]
5EBTX-ray2.24A/B/C/D1106-1314[»]
5ECEX-ray2.20A/B/C/D1105-1316[»]
5ETYX-ray2.90A/B/C/D1091-1324[»]
5GP7X-ray1.50A799-957[»]
5JHQX-ray3.20A/B/C/D174-649[»]
5JTIX-ray2.90A/B/C/D/E/F1018-1093[»]
5JU5X-ray2.50A/B/C/D/E/F1018-1093[»]
5KNIX-ray2.50A/B/C/D/E/F/G1026-1091[»]
ProteinModelPortaliO95271
SMRiO95271
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114207, 52 interactors
CORUMiO95271
DIPiDIP-36652N
ELMiO95271
IntActiO95271, 27 interactors
MINTiO95271
STRINGi9606.ENSP00000311579

Chemistry databases

BindingDBiO95271
ChEMBLiCHEMBL6164

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO95271
PhosphoSitePlusiO95271

Polymorphism and mutation databases

BioMutaiTNKS

Proteomic databases

EPDiO95271
MaxQBiO95271
PaxDbiO95271
PeptideAtlasiO95271
PRIDEiO95271
ProteomicsDBi50772
50773 [O95271-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310430; ENSP00000311579; ENSG00000173273 [O95271-1]
GeneIDi8658
KEGGihsa:8658
UCSCiuc003wss.4 human [O95271-1]

Organism-specific databases

CTDi8658
DisGeNETi8658
EuPathDBiHostDB:ENSG00000173273.15
GeneCardsiTNKS
H-InvDBiHIX0034248
HGNCiHGNC:11941 TNKS
HPAiHPA025690
MIMi603303 gene
neXtProtiNX_O95271
OpenTargetsiENSG00000173273
PharmGKBiPA36631
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00840000129677
HOGENOMiHOG000246964
HOVERGENiHBG059472
InParanoidiO95271
KOiK10799
OMAiDSTSCCS
OrthoDBiEOG091G00W8
PhylomeDBiO95271
TreeFamiTF326036

Enzyme and pathway databases

BRENDAi2.4.2.30 2681
ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8948751 Regulation of PTEN stability and activity
SIGNORiO95271

Miscellaneous databases

ChiTaRSiTNKS human
EvolutionaryTraceiO95271
GeneWikiiTNKS
GenomeRNAii8658
PROiPR:O95271
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173273 Expressed in 230 organ(s), highest expression level in forebrain
CleanExiHS_TNKS
ExpressionAtlasiO95271 baseline and differential
GenevisibleiO95271 HS

Family and domain databases

CDDicd00204 ANK, 5 hits
Gene3Di1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR028731 TNKS
PANTHERiPTHR24180:SF3 PTHR24180:SF3, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 4 hits
PF13606 Ank_3, 1 hit
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 17 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNKS1_HUMAN
AccessioniPrimary (citable) accession number: O95271
Secondary accession number(s): O95272, Q4G0F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: April 14, 2009
Last modified: October 10, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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