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Protein

RAS guanyl-releasing protein 1

Gene

RASGRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).By similarity9 Publications

Activity regulationi

Autoinhibited. Activated by diacylglycerol and calcium binding, which induces a conformational change releasing the autoinhibitory state (PubMed:23908768). Regulated by DGKA (PubMed:11919165). Regulated by DGKZ (PubMed:11257115). Regulated by PLC gamma and F-actin polymerization (PubMed:12839994).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi483 – 494PROSITE-ProRule annotationAdd BLAST12
Zinc fingeri541 – 591Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-1169092 Activation of RAS in B cells
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-392517 Rap1 signalling
R-HSA-5673001 RAF/MAP kinase cascade
SIGNORiO95267

Names & Taxonomyi

Protein namesi
Recommended name:
RAS guanyl-releasing protein 1
Alternative name(s):
Calcium and DAG-regulated guanine nucleotide exchange factor II
Short name:
CalDAG-GEFII
Ras guanyl-releasing protein
Gene namesi
Name:RASGRP1
Synonyms:RASGRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000172575.11
HGNCiHGNC:9878 RASGRP1
MIMi603962 gene
neXtProtiNX_O95267

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus (SLE)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:152700

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi271R → E: Loss of function; prevents Ras activation. 2 Publications1
Mutagenesisi483 – 487DHDQD → AHAQA: Decrease of Ras activation indicated by decrease of ERK phosphorylation. 1 Publication5
Mutagenesisi494E → A: Decrease of Ras activation indicated by decrease of ERK phosphorylation. 1 Publication1
Mutagenesisi506F → D: Increase of Ras activation indicated by increase of ERK phosphorylation. 1 Publication1
Mutagenesisi508V → D: Increase of Ras activation indicated by increase of ERK phosphorylation. 1 Publication1
Mutagenesisi549Y → F: Loss of localization to the endoplasmic reticulum and the Golgi apparatus. 1 Publication1

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNETi10125
MIMi152700 phenotype
OpenTargetsiENSG00000172575
PharmGKBiPA34240

Chemistry databases

ChEMBLiCHEMBL5953

Polymorphism and mutation databases

BioMutaiRASGRP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169781 – 797RAS guanyl-releasing protein 1Add BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184Phosphothreonine; by PKC2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95267
PaxDbiO95267
PeptideAtlasiO95267
PRIDEiO95267
ProteomicsDBi50767
50768 [O95267-2]
50769 [O95267-3]
50770 [O95267-4]
50771 [O95267-5]

PTM databases

iPTMnetiO95267
PhosphoSitePlusiO95267

Expressioni

Tissue specificityi

Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).4 Publications

Developmental stagei

Expressed in fetal brain and kidney.1 Publication

Gene expression databases

BgeeiENSG00000172575 Expressed in 198 organ(s), highest expression level in cerebellum
ExpressionAtlasiO95267 baseline and differential
GenevisibleiO95267 HS

Organism-specific databases

HPAiHPA039389

Interactioni

Subunit structurei

Homodimer (PubMed:23908768). Forms a signaling complex with DGKZ and HRAS (PubMed:11257115). Interacts with F-actin (PubMed:12839994). Interacts with SKAP1 (PubMed:17658605).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115429, 4 interactors
CORUMiO95267
IntActiO95267, 1 interactor
MINTiO95267
STRINGi9606.ENSP00000310244

Chemistry databases

BindingDBiO95267

Structurei

Secondary structure

1797
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95267
SMRiO95267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 176N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST124
Domaini205 – 436Ras-GEFPROSITE-ProRule annotationAdd BLAST232
Domaini470 – 505EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini497 – 532EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 110Ras exchanger motif region; required for transforming activityBy similarityAdd BLAST54
Regioni686 – 694Suppress the PT region-mediated translocation to plasma membraneBy similarity9
Regioni718 – 797PT region; mediates the BCR-dependent translocation to plasma membraneBy similarityAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili746 – 786Sequence analysisAdd BLAST41

Domaini

The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding.
Two EF-hand domains are present. However, only EF-hand 1 (and not EF-hand 2) binds calcium.1 Publication

Sequence similaritiesi

Belongs to the RASGRP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri541 – 591Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ6J Eukaryota
ENOG410ZKZ2 LUCA
GeneTreeiENSGT00880000137870
HOVERGENiHBG007513
InParanoidiO95267
KOiK04350
PhylomeDBiO95267
TreeFamiTF312918

Family and domain databases

CDDicd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Several splicing events may be used independently in a modular way.

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95267-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTLGKAREA PRKPSHGCRA ASKARLEAKP ANSPFPSHPS LAHITQFRMM
60 70 80 90 100
VSLGHLAKGA SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIVISSA
110 120 130 140 150
ELLQKVITLY KDALAKNSPG LCLKICYFVR YWITEFWVMF KMDASLTDTM
160 170 180 190 200
EEFQELVKAK GEELHCRLID TTQINARDWS RKLTQRIKSN TSKKRKVSLL
210 220 230 240 250
FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE NPTMERSIAL
260 270 280 290 300
CNGISQWVQL MVLSRPTPQL RAEVFIKFIQ VAQKLHQLQN FNTLMAVIGG
310 320 330 340 350
LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSSRNYDNY RRAYGECTDF
360 370 380 390 400
KIPILGVHLK DLISLYEAMP DYLEDGKVNV HKLLALYNHI SELVQLQEVA
410 420 430 440 450
PPLEANKDLV HLLTLSLDLY YTEDEIYELS YAREPRNHRA PPLTPSKPPV
460 470 480 490 500
VVDWASGVSP KPDPKTISKH VQRMVDSVFK NYDHDQDGYI SQEEFEKIAA
510 520 530 540 550
SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF PHNFQETTYL
560 570 580 590 600
KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRAKNPVA
610 620 630 640 650
PTENNTSVGP VSNLCSLGAK DLLHAPEEGP FTFPNGEAVE HGEESKDRTI
660 670 680 690 700
MLMGVSSQKI SLRLKRAVAH KATQTESQPW IGSEGPSGPF VLSSPRKTAQ
710 720 730 740 750
DTLYVLPSPT SPCPSPVLVR KRAFVKWENK DSLIKSKEEL RHLRLPTYQE
760 770 780 790
LEQEINTLKA DNDALKIQLK YAQKKIESLQ LEKSNHVLAQ MEQGDCS
Length:797
Mass (Da):90,402
Last modified:February 5, 2008 - v2
Checksum:i8ACDCF0F715ABAA9
GO
Isoform 2 (identifier: O95267-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.

Show »
Length:762
Mass (Da):86,625
Checksum:iC3ACFFF5888E3236
GO
Isoform 3 (identifier: O95267-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.
     625-632: APEEGPFT → GNKYSESR
     633-797: Missing.

Show »
Length:597
Mass (Da):68,170
Checksum:i979AEA31D0FBE5DC
GO
Isoform 4 (identifier: O95267-4) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.
     513-516: REGL → SSGE
     517-797: Missing.

Show »
Length:481
Mass (Da):55,100
Checksum:i11408850F4E84118
GO
Isoform 5 (identifier: O95267-5) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.
     574-581: DCGMNCHK → GNKYSESR
     582-797: Missing.

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):62,674
Checksum:i54018A113532AF92
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKM0H0YKM0_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
848Annotation score:
H0YMF3H0YMF3_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
811Annotation score:
F5H514F5H514_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
797Annotation score:
H0YNK9H0YNK9_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
217Annotation score:
H0YN83H0YN83_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
96Annotation score:
H0YNG8H0YNG8_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
57Annotation score:
H0YMT0H0YMT0_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
123Annotation score:
H0YKP8H0YKP8_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
32Annotation score:

Sequence cautioni

The sequence AAH67298 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374E → G in AAC79699 (PubMed:9789079).Curated1
Sequence conflicti374E → G in AAF21898 (PubMed:9789079).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030836442 – 476Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_030837513 – 516REGL → SSGE in isoform 4. 1 Publication4
Alternative sequenceiVSP_030838517 – 797Missing in isoform 4. 1 PublicationAdd BLAST281
Alternative sequenceiVSP_030839574 – 581DCGMNCHK → GNKYSESR in isoform 5. 1 Publication8
Alternative sequenceiVSP_030840582 – 797Missing in isoform 5. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_030841625 – 632APEEGPFT → GNKYSESR in isoform 3. 1 Publication8
Alternative sequenceiVSP_030842633 – 797Missing in isoform 3. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081195 mRNA Translation: AAC79699.1
AF081197 mRNA Translation: AAF21898.1
AF106071 mRNA Translation: AAC97349.1
AY634315 mRNA Translation: AAT47482.2
AY858556 mRNA Translation: AAW32406.2
AY954625 mRNA Translation: AAX54699.4
AY966005 mRNA Translation: AAX76907.1
BC067298 mRNA Translation: AAH67298.1 Sequence problems.
BC109296 mRNA Translation: AAI09297.1
BC109297 mRNA Translation: AAI09298.1
AB208848 mRNA Translation: BAD92085.1
CCDSiCCDS45221.1 [O95267-2]
CCDS45222.1 [O95267-1]
CCDS76733.1 [O95267-3]
RefSeqiNP_001122074.1, NM_001128602.1 [O95267-2]
NP_001293015.1, NM_001306086.1 [O95267-3]
NP_005730.2, NM_005739.3 [O95267-1]
UniGeneiHs.591127

Genome annotation databases

EnsembliENST00000310803; ENSP00000310244; ENSG00000172575 [O95267-1]
ENST00000414708; ENSP00000413105; ENSG00000172575 [O95267-4]
ENST00000450598; ENSP00000388540; ENSG00000172575 [O95267-2]
ENST00000558164; ENSP00000454164; ENSG00000172575 [O95267-5]
ENST00000559830; ENSP00000452721; ENSG00000172575 [O95267-3]
GeneIDi10125
KEGGihsa:10125
UCSCiuc001zkd.5 human [O95267-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081195 mRNA Translation: AAC79699.1
AF081197 mRNA Translation: AAF21898.1
AF106071 mRNA Translation: AAC97349.1
AY634315 mRNA Translation: AAT47482.2
AY858556 mRNA Translation: AAW32406.2
AY954625 mRNA Translation: AAX54699.4
AY966005 mRNA Translation: AAX76907.1
BC067298 mRNA Translation: AAH67298.1 Sequence problems.
BC109296 mRNA Translation: AAI09297.1
BC109297 mRNA Translation: AAI09298.1
AB208848 mRNA Translation: BAD92085.1
CCDSiCCDS45221.1 [O95267-2]
CCDS45222.1 [O95267-1]
CCDS76733.1 [O95267-3]
RefSeqiNP_001122074.1, NM_001128602.1 [O95267-2]
NP_001293015.1, NM_001306086.1 [O95267-3]
NP_005730.2, NM_005739.3 [O95267-1]
UniGeneiHs.591127

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L9MX-ray3.00A50-607[»]
4L9UX-ray1.60A/B739-793[»]
ProteinModelPortaliO95267
SMRiO95267
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115429, 4 interactors
CORUMiO95267
IntActiO95267, 1 interactor
MINTiO95267
STRINGi9606.ENSP00000310244

Chemistry databases

BindingDBiO95267
ChEMBLiCHEMBL5953

PTM databases

iPTMnetiO95267
PhosphoSitePlusiO95267

Polymorphism and mutation databases

BioMutaiRASGRP1

Proteomic databases

MaxQBiO95267
PaxDbiO95267
PeptideAtlasiO95267
PRIDEiO95267
ProteomicsDBi50767
50768 [O95267-2]
50769 [O95267-3]
50770 [O95267-4]
50771 [O95267-5]

Protocols and materials databases

DNASUi10125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310803; ENSP00000310244; ENSG00000172575 [O95267-1]
ENST00000414708; ENSP00000413105; ENSG00000172575 [O95267-4]
ENST00000450598; ENSP00000388540; ENSG00000172575 [O95267-2]
ENST00000558164; ENSP00000454164; ENSG00000172575 [O95267-5]
ENST00000559830; ENSP00000452721; ENSG00000172575 [O95267-3]
GeneIDi10125
KEGGihsa:10125
UCSCiuc001zkd.5 human [O95267-1]

Organism-specific databases

CTDi10125
DisGeNETi10125
EuPathDBiHostDB:ENSG00000172575.11
GeneCardsiRASGRP1
H-InvDBiHIX0038076
HGNCiHGNC:9878 RASGRP1
HPAiHPA039389
MIMi152700 phenotype
603962 gene
neXtProtiNX_O95267
OpenTargetsiENSG00000172575
PharmGKBiPA34240
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ6J Eukaryota
ENOG410ZKZ2 LUCA
GeneTreeiENSGT00880000137870
HOVERGENiHBG007513
InParanoidiO95267
KOiK04350
PhylomeDBiO95267
TreeFamiTF312918

Enzyme and pathway databases

ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-1169092 Activation of RAS in B cells
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-392517 Rap1 signalling
R-HSA-5673001 RAF/MAP kinase cascade
SIGNORiO95267

Miscellaneous databases

GeneWikiiRASGRP1
GenomeRNAii10125
PROiPR:O95267
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172575 Expressed in 198 organ(s), highest expression level in cerebellum
ExpressionAtlasiO95267 baseline and differential
GenevisibleiO95267 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRP1_HUMAN
AccessioniPrimary (citable) accession number: O95267
Secondary accession number(s): Q56CZ0
, Q58G75, Q59HB1, Q5I3A8, Q6GV31, Q6NX39, Q7LDG6, Q9UI94, Q9UNN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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