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Entry version 189 (17 Jun 2020)
Sequence version 2 (22 Aug 2003)
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Protein

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Gene

PDE8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and milrinone as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 3',5'-cyclic AMP degradation

This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B)
This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei615Proton donorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi619Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi655Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi656Divalent metal cation 1By similarity1
Metal bindingi656Divalent metal cation 2By similarity1
Metal bindingi781Divalent metal cation 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.53 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418555 G alpha (s) signalling events

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00762;UER00747

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC:3.1.4.531 Publication)
Short name:
HsPDE8B
Alternative name(s):
Cell proliferation-inducing gene 22 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDE8B
ORF Names:PIG22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000113231.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8794 PDE8B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603390 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95263

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Striatal degeneration, autosomal dominant 1 (ADSD1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present.
Related information in OMIM
Primary pigmented nodular adrenocortical disease 3 (PPNAD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066503305H → P in PPNAD3; shows significantly higher cyclic AMP levels after transfection with the mutant protein than after transfection with the wild-type, indicating an impaired ability of the mutant protein to degrade cAMP. 1 PublicationCorresponds to variant dbSNP:rs121918360Ensembl.1

Keywords - Diseasei

Cushing syndrome, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8622

MalaCards human disease database

More...
MalaCardsi
PDE8B
MIMi609161 phenotype
614190 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113231

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
228169 Autosomal dominant striatal neurodegeneration
189439 Primary pigmented nodular adrenocortical disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33142

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95263 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4408

Drug and drug target database

More...
DrugBanki
DB00201 Caffeine
DB09283 Trapidil

DrugCentral

More...
DrugCentrali
O95263

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1308

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PDE8B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988401 – 885High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BAdd BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei517PhosphoserineCombined sources1
Modified residuei754PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95263

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O95263

MaxQB - The MaxQuant DataBase

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MaxQBi
O95263

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95263

PeptideAtlas

More...
PeptideAtlasi
O95263

PRoteomics IDEntifications database

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PRIDEi
O95263

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50759 [O95263-1]
50760 [O95263-2]
50761 [O95263-3]
50762 [O95263-4]
50763 [O95263-5]
50764 [O95263-6]

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
O95263

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95263

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95263

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113231 Expressed in oocyte and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95263 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95263 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000113231 Tissue enriched (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114177, 1 interactor

Protein interaction database and analysis system

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IntActi
O95263, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264917

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O95263

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95263 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95263

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini267 – 338PASPROSITE-ProRule annotationAdd BLAST72
Domaini539 – 875PDEasePROSITE-ProRule annotationAdd BLAST337

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1229 Eukaryota
ENOG410XP9B LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157817

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005940_4_2_1

KEGG Orthology (KO)

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KOi
K18437

Identification of Orthologs from Complete Genome Data

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OMAi
DIMAKQP

Database of Orthologous Groups

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OrthoDBi
904682at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95263

TreeFam database of animal gene trees

More...
TreeFami
TF314638

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00077 HDc, 1 hit
cd00130 PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003607 HD/PDEase_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013938 PDEase_PDE8

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13426 PAS_9, 1 hit
PF08629 PDE8, 1 hit
PF00233 PDEase_I, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00387 PDIESTERASE1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00471 HDc, 1 hit
SM00091 PAS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55785 SSF55785, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00229 sensory_box, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50112 PAS, 1 hit
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95263-1) [UniParc]FASTAAdd to basket
Also known as: PDE8B1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA
60 70 80 90 100
DAIPPSRASG PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS
110 120 130 140 150
AEAETQTCYT SVKQVSSAEV RIGPMRLTQD PIQVLLIFAK EDSQSDGFWW
160 170 180 190 200
ACDRAGYRCN IARTPESALE CFLDKHHEII VIDHRQTQNF DAEAVCRSIR
210 220 230 240 250
ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME NSSIIACYNE
260 270 280 290 300
LIQIEHGEVR SQFKLRACNS VFTALDHCHE AIEITSDDHV IQYVNPAFER
310 320 330 340 350
MMGYHKGELL GKELADLPKS DKNRADLLDT INTCIKKGKE WQGVYYARRK
360 370 380 390 400
SGDSIQQHVK ITPVIGQGGK IRHFVSLKKL CCTTDNNKQI HKIHRDSGDN
410 420 430 440 450
SQTEPHSFRY KNRRKESIDV KSISSRGSDA PSLQNRRYPS MARIHSMTIE
460 470 480 490 500
APITKVINII NAAQENSPVT VAEALDRVLE ILRTTELYSP QLGTKDEDPH
510 520 530 540 550
TSDLVGGLMT DGLRRLSGNE YVFTKNVHQS HSHLAMPITI NDVPPCISQL
560 570 580 590 600
LDNEESWDFN IFELEAITHK RPLVYLGLKV FSRFGVCEFL NCSETTLRAW
610 620 630 640 650
FQVIEANYHS SNAYHNSTHA ADVLHATAFF LGKERVKGSL DQLDEVAALI
660 670 680 690 700
AATVHDVDHP GRTNSFLCNA GSELAVLYND TAVLESHHTA LAFQLTVKDT
710 720 730 740 750
KCNIFKNIDR NHYRTLRQAI IDMVLATEMT KHFEHVNKFV NSINKPMAAE
760 770 780 790 800
IEGSDCECNP AGKNFPENQI LIKRMMIKCA DVANPCRPLD LCIEWAGRIS
810 820 830 840 850
EEYFAQTDEE KRQGLPVVMP VFDRNTCSIP KSQISFIDYF ITDMFDAWDA
860 870 880
FAHLPALMQH LADNYKHWKT LDDLKCKSLR LPSDS
Note: Major isoform.
Length:885
Mass (Da):98,979
Last modified:August 22, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB4F763E51F745A3
GO
Isoform 2 (identifier: O95263-2) [UniParc]FASTAAdd to basket
Also known as: PDE8B2, PDE8B3

The sequence of this isoform differs from the canonical sequence as follows:
     293-389: Missing.

Show »
Length:788
Mass (Da):87,974
Checksum:i816AECACCAE45447
GO
Isoform 3 (identifier: O95263-3) [UniParc]FASTAAdd to basket
Also known as: PDE8B3

The sequence of this isoform differs from the canonical sequence as follows:
     456-510: Missing.

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Length:830
Mass (Da):93,047
Checksum:i5A39ED08E2A877E4
GO
Isoform 4 (identifier: O95263-4) [UniParc]FASTAAdd to basket
Also known as: PDE8B4

The sequence of this isoform differs from the canonical sequence as follows:
     114-133: Missing.

Show »
Length:865
Mass (Da):96,771
Checksum:iDDC83E5525C7E7B7
GO
Isoform 5 (identifier: O95263-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-535: Missing.

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Length:350
Mass (Da):39,791
Checksum:iA6D4F19BE26C045F
GO
Isoform 6 (identifier: O95263-6) [UniParc]FASTAAdd to basket
Also known as: PDE8B2

The sequence of this isoform differs from the canonical sequence as follows:
     293-339: Missing.

Show »
Length:838
Mass (Da):93,674
Checksum:i013C790AC0F24F92
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9W0D6R9W0_HUMAN
High affinity cAMP-specific and IBM...
PDE8B
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJD7D6RJD7_HUMAN
High affinity cAMP-specific and IBM...
PDE8B
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH10D6RH10_HUMAN
High affinity cAMP-specific and IBM...
PDE8B
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti147G → R in CAD38584 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066503305H → P in PPNAD3; shows significantly higher cyclic AMP levels after transfection with the mutant protein than after transfection with the wild-type, indicating an impaired ability of the mutant protein to degrade cAMP. 1 PublicationCorresponds to variant dbSNP:rs121918360Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0080811 – 535Missing in isoform 5. 2 PublicationsAdd BLAST535
Alternative sequenceiVSP_008082114 – 133Missing in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_008084293 – 389Missing in isoform 2. 2 PublicationsAdd BLAST97
Alternative sequenceiVSP_008083293 – 339Missing in isoform 6. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_008085456 – 510Missing in isoform 3. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY129948 mRNA Translation: AAN71723.1
AY129949 mRNA Translation: AAN71724.1
AY129950 Genomic DNA Translation: AAN71725.1
AY129950 Genomic DNA Translation: AAN71726.1
AY129950 Genomic DNA Translation: AAN71727.1
AB085824 mRNA Translation: BAC53762.1
AB085825 mRNA Translation: BAC53763.1
AB085826 mRNA Translation: BAC53764.1
AB085827 mRNA Translation: BAC53765.1
AY423729 mRNA Translation: AAS00492.1
CH471084 Genomic DNA Translation: EAW95803.1
BC043209 mRNA No translation available.
AF079529 mRNA Translation: AAC69564.2
AL831924 mRNA Translation: CAD38584.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34190.1 [O95263-3]
CCDS34191.1 [O95263-6]
CCDS34192.1 [O95263-2]
CCDS34193.1 [O95263-4]
CCDS4037.1 [O95263-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0293

NCBI Reference Sequences

More...
RefSeqi
NP_001025022.1, NM_001029851.2 [O95263-2]
NP_001025023.1, NM_001029852.2 [O95263-3]
NP_001025024.1, NM_001029853.2 [O95263-4]
NP_001025025.1, NM_001029854.2 [O95263-6]
NP_003710.1, NM_003719.3 [O95263-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264917; ENSP00000264917; ENSG00000113231 [O95263-1]
ENST00000333194; ENSP00000331336; ENSG00000113231 [O95263-3]
ENST00000340978; ENSP00000345446; ENSG00000113231 [O95263-6]
ENST00000342343; ENSP00000345646; ENSG00000113231 [O95263-4]
ENST00000346042; ENSP00000330428; ENSG00000113231 [O95263-2]
ENST00000505283; ENSP00000423461; ENSG00000113231 [O95263-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8622

UCSC genome browser

More...
UCSCi
uc003kfa.4 human [O95263-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129948 mRNA Translation: AAN71723.1
AY129949 mRNA Translation: AAN71724.1
AY129950 Genomic DNA Translation: AAN71725.1
AY129950 Genomic DNA Translation: AAN71726.1
AY129950 Genomic DNA Translation: AAN71727.1
AB085824 mRNA Translation: BAC53762.1
AB085825 mRNA Translation: BAC53763.1
AB085826 mRNA Translation: BAC53764.1
AB085827 mRNA Translation: BAC53765.1
AY423729 mRNA Translation: AAS00492.1
CH471084 Genomic DNA Translation: EAW95803.1
BC043209 mRNA No translation available.
AF079529 mRNA Translation: AAC69564.2
AL831924 mRNA Translation: CAD38584.1
CCDSiCCDS34190.1 [O95263-3]
CCDS34191.1 [O95263-6]
CCDS34192.1 [O95263-2]
CCDS34193.1 [O95263-4]
CCDS4037.1 [O95263-1]
PIRiJE0293
RefSeqiNP_001025022.1, NM_001029851.2 [O95263-2]
NP_001025023.1, NM_001029852.2 [O95263-3]
NP_001025024.1, NM_001029853.2 [O95263-4]
NP_001025025.1, NM_001029854.2 [O95263-6]
NP_003710.1, NM_003719.3 [O95263-1]

3D structure databases

SMRiO95263
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114177, 1 interactor
IntActiO95263, 1 interactor
STRINGi9606.ENSP00000264917

Chemistry databases

BindingDBiO95263
ChEMBLiCHEMBL4408
DrugBankiDB00201 Caffeine
DB09283 Trapidil
DrugCentraliO95263
GuidetoPHARMACOLOGYi1308

PTM databases

iPTMnetiO95263
PhosphoSitePlusiO95263

Polymorphism and mutation databases

BioMutaiPDE8B

2D gel databases

UCD-2DPAGEiO95263

Proteomic databases

jPOSTiO95263
MassIVEiO95263
MaxQBiO95263
PaxDbiO95263
PeptideAtlasiO95263
PRIDEiO95263
ProteomicsDBi50759 [O95263-1]
50760 [O95263-2]
50761 [O95263-3]
50762 [O95263-4]
50763 [O95263-5]
50764 [O95263-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12495 147 antibodies

The DNASU plasmid repository

More...
DNASUi
8622

Genome annotation databases

EnsembliENST00000264917; ENSP00000264917; ENSG00000113231 [O95263-1]
ENST00000333194; ENSP00000331336; ENSG00000113231 [O95263-3]
ENST00000340978; ENSP00000345446; ENSG00000113231 [O95263-6]
ENST00000342343; ENSP00000345646; ENSG00000113231 [O95263-4]
ENST00000346042; ENSP00000330428; ENSG00000113231 [O95263-2]
ENST00000505283; ENSP00000423461; ENSG00000113231 [O95263-5]
GeneIDi8622
KEGGihsa:8622
UCSCiuc003kfa.4 human [O95263-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8622
DisGeNETi8622
EuPathDBiHostDB:ENSG00000113231.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDE8B
HGNCiHGNC:8794 PDE8B
HPAiENSG00000113231 Tissue enriched (thyroid)
MalaCardsiPDE8B
MIMi603390 gene
609161 phenotype
614190 phenotype
neXtProtiNX_O95263
OpenTargetsiENSG00000113231
Orphaneti228169 Autosomal dominant striatal neurodegeneration
189439 Primary pigmented nodular adrenocortical disease
PharmGKBiPA33142

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1229 Eukaryota
ENOG410XP9B LUCA
GeneTreeiENSGT00940000157817
HOGENOMiCLU_005940_4_2_1
KOiK18437
OMAiDIMAKQP
OrthoDBi904682at2759
PhylomeDBiO95263
TreeFamiTF314638

Enzyme and pathway databases

UniPathwayiUPA00762;UER00747
BRENDAi3.1.4.53 2681
ReactomeiR-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8622 4 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PDE8B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PDE8B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8622
PharosiO95263 Tclin

Protein Ontology

More...
PROi
PR:O95263
RNActiO95263 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113231 Expressed in oocyte and 200 other tissues
ExpressionAtlasiO95263 baseline and differential
GenevisibleiO95263 HS

Family and domain databases

CDDicd00077 HDc, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013938 PDEase_PDE8
PfamiView protein in Pfam
PF13426 PAS_9, 1 hit
PF08629 PDE8, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112 PAS, 1 hit
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE8B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95263
Secondary accession number(s): Q5J7V7
, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 22, 2003
Last modified: June 17, 2020
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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