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Protein

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Gene

PDE8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.1 Publication

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Activity regulationi

Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and milrinone as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP.1 Publication

Pathwayi: 3',5'-cyclic AMP degradation

This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A)
This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei615Proton donorBy similarity1
Metal bindingi619Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi655Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi656Divalent metal cation 1By similarity1
Metal bindingi656Divalent metal cation 2By similarity1
Metal bindingi781Divalent metal cation 1By similarity1

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.4.53 2681
ReactomeiR-HSA-418555 G alpha (s) signalling events
UniPathwayi
UPA00762;UER00747

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC:3.1.4.531 Publication)
Short name:
HsPDE8B
Alternative name(s):
Cell proliferation-inducing gene 22 protein
Gene namesi
Name:PDE8B
ORF Names:PIG22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113231.13
HGNCiHGNC:8794 PDE8B
MIMi603390 gene
neXtProtiNX_O95263

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Striatal degeneration, autosomal dominant 1 (ADSD1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present.
See also OMIM:609161
Primary pigmented nodular adrenocortical disease 3 (PPNAD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
See also OMIM:614190
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066503305H → P in PPNAD3; shows significantly higher cyclic AMP levels after transfection with the mutant protein than after transfection with the wild-type, indicating an impaired ability of the mutant protein to degrade cAMP. 1 PublicationCorresponds to variant dbSNP:rs121918360EnsemblClinVar.1

Keywords - Diseasei

Cushing syndrome, Disease mutation

Organism-specific databases

DisGeNETi8622
MalaCardsiPDE8B
MIMi609161 phenotype
614190 phenotype
OpenTargetsiENSG00000113231
Orphaneti228169 Autosomal dominant striatal neurodegeneration
189439 Primary pigmented nodular adrenocortical disease
PharmGKBiPA33142

Chemistry databases

ChEMBLiCHEMBL4408
DrugBankiDB00201 Caffeine
GuidetoPHARMACOLOGYi1308

Polymorphism and mutation databases

BioMutaiPDE8B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988401 – 885High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BAdd BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei517PhosphoserineCombined sources1
Modified residuei754PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95263
MaxQBiO95263
PaxDbiO95263
PeptideAtlasiO95263
PRIDEiO95263
ProteomicsDBi50759
50760 [O95263-2]
50761 [O95263-3]
50762 [O95263-4]
50763 [O95263-5]
50764 [O95263-6]

2D gel databases

UCD-2DPAGEiO95263

PTM databases

iPTMnetiO95263
PhosphoSitePlusiO95263

Expressioni

Tissue specificityi

Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates.2 Publications

Gene expression databases

BgeeiENSG00000113231 Expressed in 201 organ(s), highest expression level in oocyte
CleanExiHS_PDE8B
ExpressionAtlasiO95263 baseline and differential
GenevisibleiO95263 HS

Organism-specific databases

HPAiHPA036911
HPA036912

Interactioni

Protein-protein interaction databases

BioGridi114177, 1 interactor
IntActiO95263, 1 interactor
STRINGi9606.ENSP00000264917

Chemistry databases

BindingDBiO95263

Structurei

3D structure databases

ProteinModelPortaliO95263
SMRiO95263
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 338PASPROSITE-ProRule annotationAdd BLAST72
Domaini539 – 875PDEasePROSITE-ProRule annotationAdd BLAST337

Domaini

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1229 Eukaryota
ENOG410XP9B LUCA
GeneTreeiENSGT00760000118889
HOVERGENiHBG053544
KOiK18437
OMAiDIMAKQP
OrthoDBiEOG091G0337
PhylomeDBiO95263
TreeFamiTF314638

Family and domain databases

CDDicd00077 HDc, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013938 PDEase_PDE8
PfamiView protein in Pfam
PF13426 PAS_9, 1 hit
PF08629 PDE8, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112 PAS, 1 hit
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95263-1) [UniParc]FASTAAdd to basket
Also known as: PDE8B1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA
60 70 80 90 100
DAIPPSRASG PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS
110 120 130 140 150
AEAETQTCYT SVKQVSSAEV RIGPMRLTQD PIQVLLIFAK EDSQSDGFWW
160 170 180 190 200
ACDRAGYRCN IARTPESALE CFLDKHHEII VIDHRQTQNF DAEAVCRSIR
210 220 230 240 250
ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME NSSIIACYNE
260 270 280 290 300
LIQIEHGEVR SQFKLRACNS VFTALDHCHE AIEITSDDHV IQYVNPAFER
310 320 330 340 350
MMGYHKGELL GKELADLPKS DKNRADLLDT INTCIKKGKE WQGVYYARRK
360 370 380 390 400
SGDSIQQHVK ITPVIGQGGK IRHFVSLKKL CCTTDNNKQI HKIHRDSGDN
410 420 430 440 450
SQTEPHSFRY KNRRKESIDV KSISSRGSDA PSLQNRRYPS MARIHSMTIE
460 470 480 490 500
APITKVINII NAAQENSPVT VAEALDRVLE ILRTTELYSP QLGTKDEDPH
510 520 530 540 550
TSDLVGGLMT DGLRRLSGNE YVFTKNVHQS HSHLAMPITI NDVPPCISQL
560 570 580 590 600
LDNEESWDFN IFELEAITHK RPLVYLGLKV FSRFGVCEFL NCSETTLRAW
610 620 630 640 650
FQVIEANYHS SNAYHNSTHA ADVLHATAFF LGKERVKGSL DQLDEVAALI
660 670 680 690 700
AATVHDVDHP GRTNSFLCNA GSELAVLYND TAVLESHHTA LAFQLTVKDT
710 720 730 740 750
KCNIFKNIDR NHYRTLRQAI IDMVLATEMT KHFEHVNKFV NSINKPMAAE
760 770 780 790 800
IEGSDCECNP AGKNFPENQI LIKRMMIKCA DVANPCRPLD LCIEWAGRIS
810 820 830 840 850
EEYFAQTDEE KRQGLPVVMP VFDRNTCSIP KSQISFIDYF ITDMFDAWDA
860 870 880
FAHLPALMQH LADNYKHWKT LDDLKCKSLR LPSDS
Note: Major isoform.
Length:885
Mass (Da):98,979
Last modified:August 22, 2003 - v2
Checksum:iDB4F763E51F745A3
GO
Isoform 2 (identifier: O95263-2) [UniParc]FASTAAdd to basket
Also known as: PDE8B2, PDE8B3

The sequence of this isoform differs from the canonical sequence as follows:
     293-389: Missing.

Show »
Length:788
Mass (Da):87,974
Checksum:i816AECACCAE45447
GO
Isoform 3 (identifier: O95263-3) [UniParc]FASTAAdd to basket
Also known as: PDE8B3

The sequence of this isoform differs from the canonical sequence as follows:
     456-510: Missing.

Show »
Length:830
Mass (Da):93,047
Checksum:i5A39ED08E2A877E4
GO
Isoform 4 (identifier: O95263-4) [UniParc]FASTAAdd to basket
Also known as: PDE8B4

The sequence of this isoform differs from the canonical sequence as follows:
     114-133: Missing.

Show »
Length:865
Mass (Da):96,771
Checksum:iDDC83E5525C7E7B7
GO
Isoform 5 (identifier: O95263-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-535: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):39,791
Checksum:iA6D4F19BE26C045F
GO
Isoform 6 (identifier: O95263-6) [UniParc]FASTAAdd to basket
Also known as: PDE8B2

The sequence of this isoform differs from the canonical sequence as follows:
     293-339: Missing.

Show »
Length:838
Mass (Da):93,674
Checksum:i013C790AC0F24F92
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9W0D6R9W0_HUMAN
High affinity cAMP-specific and IBM...
PDE8B
119Annotation score:
D6RJD7D6RJD7_HUMAN
High affinity cAMP-specific and IBM...
PDE8B
116Annotation score:
D6RH10D6RH10_HUMAN
High affinity cAMP-specific and IBM...
PDE8B
112Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147G → R in CAD38584 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066503305H → P in PPNAD3; shows significantly higher cyclic AMP levels after transfection with the mutant protein than after transfection with the wild-type, indicating an impaired ability of the mutant protein to degrade cAMP. 1 PublicationCorresponds to variant dbSNP:rs121918360EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0080811 – 535Missing in isoform 5. 2 PublicationsAdd BLAST535
Alternative sequenceiVSP_008082114 – 133Missing in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_008084293 – 389Missing in isoform 2. 2 PublicationsAdd BLAST97
Alternative sequenceiVSP_008083293 – 339Missing in isoform 6. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_008085456 – 510Missing in isoform 3. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129948 mRNA Translation: AAN71723.1
AY129949 mRNA Translation: AAN71724.1
AY129950 Genomic DNA Translation: AAN71725.1
AY129950 Genomic DNA Translation: AAN71726.1
AY129950 Genomic DNA Translation: AAN71727.1
AB085824 mRNA Translation: BAC53762.1
AB085825 mRNA Translation: BAC53763.1
AB085826 mRNA Translation: BAC53764.1
AB085827 mRNA Translation: BAC53765.1
AY423729 mRNA Translation: AAS00492.1
CH471084 Genomic DNA Translation: EAW95803.1
BC043209 mRNA No translation available.
AF079529 mRNA Translation: AAC69564.2
AL831924 mRNA Translation: CAD38584.1
CCDSiCCDS34190.1 [O95263-3]
CCDS34191.1 [O95263-6]
CCDS34192.1 [O95263-2]
CCDS34193.1 [O95263-4]
CCDS4037.1 [O95263-1]
PIRiJE0293
RefSeqiNP_001025022.1, NM_001029851.2 [O95263-2]
NP_001025023.1, NM_001029852.2 [O95263-3]
NP_001025024.1, NM_001029853.2 [O95263-4]
NP_001025025.1, NM_001029854.2 [O95263-6]
NP_003710.1, NM_003719.3 [O95263-1]
UniGeneiHs.584830

Genome annotation databases

EnsembliENST00000264917; ENSP00000264917; ENSG00000113231 [O95263-1]
ENST00000333194; ENSP00000331336; ENSG00000113231 [O95263-3]
ENST00000340978; ENSP00000345446; ENSG00000113231 [O95263-6]
ENST00000342343; ENSP00000345646; ENSG00000113231 [O95263-4]
ENST00000346042; ENSP00000330428; ENSG00000113231 [O95263-2]
ENST00000505283; ENSP00000423461; ENSG00000113231 [O95263-5]
GeneIDi8622
KEGGihsa:8622
UCSCiuc003kfa.4 human [O95263-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129948 mRNA Translation: AAN71723.1
AY129949 mRNA Translation: AAN71724.1
AY129950 Genomic DNA Translation: AAN71725.1
AY129950 Genomic DNA Translation: AAN71726.1
AY129950 Genomic DNA Translation: AAN71727.1
AB085824 mRNA Translation: BAC53762.1
AB085825 mRNA Translation: BAC53763.1
AB085826 mRNA Translation: BAC53764.1
AB085827 mRNA Translation: BAC53765.1
AY423729 mRNA Translation: AAS00492.1
CH471084 Genomic DNA Translation: EAW95803.1
BC043209 mRNA No translation available.
AF079529 mRNA Translation: AAC69564.2
AL831924 mRNA Translation: CAD38584.1
CCDSiCCDS34190.1 [O95263-3]
CCDS34191.1 [O95263-6]
CCDS34192.1 [O95263-2]
CCDS34193.1 [O95263-4]
CCDS4037.1 [O95263-1]
PIRiJE0293
RefSeqiNP_001025022.1, NM_001029851.2 [O95263-2]
NP_001025023.1, NM_001029852.2 [O95263-3]
NP_001025024.1, NM_001029853.2 [O95263-4]
NP_001025025.1, NM_001029854.2 [O95263-6]
NP_003710.1, NM_003719.3 [O95263-1]
UniGeneiHs.584830

3D structure databases

ProteinModelPortaliO95263
SMRiO95263
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114177, 1 interactor
IntActiO95263, 1 interactor
STRINGi9606.ENSP00000264917

Chemistry databases

BindingDBiO95263
ChEMBLiCHEMBL4408
DrugBankiDB00201 Caffeine
GuidetoPHARMACOLOGYi1308

PTM databases

iPTMnetiO95263
PhosphoSitePlusiO95263

Polymorphism and mutation databases

BioMutaiPDE8B

2D gel databases

UCD-2DPAGEiO95263

Proteomic databases

EPDiO95263
MaxQBiO95263
PaxDbiO95263
PeptideAtlasiO95263
PRIDEiO95263
ProteomicsDBi50759
50760 [O95263-2]
50761 [O95263-3]
50762 [O95263-4]
50763 [O95263-5]
50764 [O95263-6]

Protocols and materials databases

DNASUi8622
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264917; ENSP00000264917; ENSG00000113231 [O95263-1]
ENST00000333194; ENSP00000331336; ENSG00000113231 [O95263-3]
ENST00000340978; ENSP00000345446; ENSG00000113231 [O95263-6]
ENST00000342343; ENSP00000345646; ENSG00000113231 [O95263-4]
ENST00000346042; ENSP00000330428; ENSG00000113231 [O95263-2]
ENST00000505283; ENSP00000423461; ENSG00000113231 [O95263-5]
GeneIDi8622
KEGGihsa:8622
UCSCiuc003kfa.4 human [O95263-1]

Organism-specific databases

CTDi8622
DisGeNETi8622
EuPathDBiHostDB:ENSG00000113231.13
GeneCardsiPDE8B
H-InvDBiHIX0004971
HGNCiHGNC:8794 PDE8B
HPAiHPA036911
HPA036912
MalaCardsiPDE8B
MIMi603390 gene
609161 phenotype
614190 phenotype
neXtProtiNX_O95263
OpenTargetsiENSG00000113231
Orphaneti228169 Autosomal dominant striatal neurodegeneration
189439 Primary pigmented nodular adrenocortical disease
PharmGKBiPA33142
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1229 Eukaryota
ENOG410XP9B LUCA
GeneTreeiENSGT00760000118889
HOVERGENiHBG053544
KOiK18437
OMAiDIMAKQP
OrthoDBiEOG091G0337
PhylomeDBiO95263
TreeFamiTF314638

Enzyme and pathway databases

UniPathwayi
UPA00762;UER00747

BRENDAi3.1.4.53 2681
ReactomeiR-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

ChiTaRSiPDE8B human
GeneWikiiPDE8B
GenomeRNAii8622
PROiPR:O95263
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113231 Expressed in 201 organ(s), highest expression level in oocyte
CleanExiHS_PDE8B
ExpressionAtlasiO95263 baseline and differential
GenevisibleiO95263 HS

Family and domain databases

CDDicd00077 HDc, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013938 PDEase_PDE8
PfamiView protein in Pfam
PF13426 PAS_9, 1 hit
PF08629 PDE8, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112 PAS, 1 hit
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDE8B_HUMAN
AccessioniPrimary (citable) accession number: O95263
Secondary accession number(s): Q5J7V7
, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 22, 2003
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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