UniProtKB - O95258 (UCP5_HUMAN)
Protein
Brain mitochondrial carrier protein 1
Gene
SLC25A14
Organism
Homo sapiens (Human)
Status
Functioni
Participates in the mitochondrial proton leak measured in brain mitochondria.
GO - Molecular functioni
- antiporter activity Source: GO_Central
- malate transmembrane transporter activity Source: GO_Central
- oxaloacetate transmembrane transporter activity Source: GO_Central
- succinate transmembrane transporter activity Source: GO_Central
- sulfate transmembrane transporter activity Source: GO_Central
- thiosulfate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- aerobic respiration Source: ProtInc
- malate transmembrane transport Source: GO_Central
- mitochondrial transport Source: InterPro
- oxaloacetate transport Source: GO_Central
- phosphate ion transmembrane transport Source: GO_Central
- proton transmembrane transport Source: Reactome
- succinate transmembrane transport Source: GO_Central
- sulfate transport Source: GO_Central
- thiosulfate transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | O95258 |
Reactomei | R-HSA-167826, The fatty acid cycling model R-HSA-167827, The proton buffering model |
Protein family/group databases
TCDBi | 2.A.29.24.1, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Brain mitochondrial carrier protein 1Short name: BMCP-1 Alternative name(s): Mitochondrial uncoupling protein 5 Short name: UCP 5 Solute carrier family 25 member 14 |
Gene namesi | Name:SLC25A14 Synonyms:BMCP1, UCP5 ORF Names:UNQ791/PRO1682 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102078.15 |
HGNCi | HGNC:10984, SLC25A14 |
MIMi | 300242, gene |
neXtProti | NX_O95258 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrion Source: ProtInc
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 38 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 17 | |
Transmembranei | 112 – 128 | Helical; Name=2Sequence analysisAdd BLAST | 17 | |
Transmembranei | 141 – 161 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 199 – 215 | Helical; Name=4Sequence analysisAdd BLAST | 17 | |
Transmembranei | 240 – 256 | Helical; Name=5Sequence analysisAdd BLAST | 17 | |
Transmembranei | 298 – 315 | Helical; Name=6Sequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9016 |
OpenTargetsi | ENSG00000102078 |
PharmGKBi | PA35860 |
Miscellaneous databases
Pharosi | O95258, Tbio |
Polymorphism and mutation databases
BioMutai | SLC25A14 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090677 | 1 – 325 | Brain mitochondrial carrier protein 1Add BLAST | 325 |
Proteomic databases
jPOSTi | O95258 |
MassIVEi | O95258 |
MaxQBi | O95258 |
PaxDbi | O95258 |
PeptideAtlasi | O95258 |
PRIDEi | O95258 |
ProteomicsDBi | 50752 [O95258-1] 50753 [O95258-2] 50754 [O95258-3] |
PTM databases
iPTMneti | O95258 |
PhosphoSitePlusi | O95258 |
Expressioni
Tissue specificityi
Mainly expressed in brain. Some expression in testis and pituitary.1 Publication
Gene expression databases
Bgeei | ENSG00000102078, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | O95258, baseline and differential |
Genevisiblei | O95258, HS |
Organism-specific databases
HPAi | ENSG00000102078, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114485, 10 interactors |
IntActi | O95258, 7 interactors |
STRINGi | 9606.ENSP00000477981 |
Miscellaneous databases
RNActi | O95258, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 42 – 131 | Solcar 1Add BLAST | 90 | |
Repeati | 139 – 224 | Solcar 2Add BLAST | 86 | |
Repeati | 233 – 323 | Solcar 3Add BLAST | 91 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000159471 |
InParanoidi | O95258 |
OMAi | DQVANHF |
PhylomeDBi | O95258 |
TreeFami | TF323211 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR032933, SLC25A14 |
PANTHERi | PTHR45618:SF20, PTHR45618:SF20, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O95258-1) [UniParc]FASTAAdd to basket
Also known as: UCP5L
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA
60 70 80 90 100
SIVAEFGTFP VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV
110 120 130 140 150
LALYSGIAPA LLRQASYGTI KIGIYQSLKR LFVERLEDET LLINMICGVV
160 170 180 190 200
SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM IGSFIDIYQQ EGTRGLWRGV
210 220 230 240 250
VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV SSFTCGLAGA
260 270 280 290 300
LASNPVDVVR TRMMNQRAIV GHVDLYKGTV DGILKMWKHE GFFALYKGFW
310 320
PNWLRLGPWN IIFFITYEQL KRLQI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5JY88 | Q5JY88_HUMAN | Brain mitochondrial carrier protein... | SLC25A14 | 198 | Annotation score: | ||
F6SL11 | F6SL11_HUMAN | Brain mitochondrial carrier protein... | SLC25A14 | 290 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050138 | 55 | E → A. Corresponds to variant dbSNP:rs2143598Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003272 | 23 – 25 | Missing in isoform 2 and isoform 3. Curated | 3 | |
Alternative sequenceiVSP_003273 | 198 | R → RCLCSKAVTGCVLWLMPVIP ALWEANAGGSLE in isoform 3. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF078544 mRNA Translation: AAD04346.1 AF155809 mRNA Translation: AAG29582.1 AF155810 mRNA Translation: AAG29583.1 AF155811 mRNA Translation: AAG29584.1 AY358099 mRNA Translation: AAQ88466.1 AL035423 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11804.1 BC119666 mRNA Translation: AAI19667.1 BC119667 mRNA Translation: AAI19668.1 |
CCDSi | CCDS14623.1 [O95258-1] CCDS14624.1 [O95258-2] CCDS76020.1 [O95258-3] |
RefSeqi | NP_001269124.1, NM_001282195.1 [O95258-1] NP_001269125.1, NM_001282196.1 [O95258-2] NP_001269126.1, NM_001282197.1 [O95258-3] NP_001269127.1, NM_001282198.1 |
Genome annotation databases
Ensembli | ENST00000218197; ENSP00000218197; ENSG00000102078 [O95258-1] ENST00000339231; ENSP00000342797; ENSG00000102078 [O95258-3] ENST00000361980; ENSP00000354455; ENSG00000102078 [O95258-2] ENST00000545805; ENSP00000444642; ENSG00000102078 [O95258-1] ENST00000612248; ENSP00000477981; ENSG00000102078 [O95258-3] |
GeneIDi | 9016 |
KEGGi | hsa:9016 |
UCSCi | uc004evp.3, human [O95258-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF078544 mRNA Translation: AAD04346.1 AF155809 mRNA Translation: AAG29582.1 AF155810 mRNA Translation: AAG29583.1 AF155811 mRNA Translation: AAG29584.1 AY358099 mRNA Translation: AAQ88466.1 AL035423 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11804.1 BC119666 mRNA Translation: AAI19667.1 BC119667 mRNA Translation: AAI19668.1 |
CCDSi | CCDS14623.1 [O95258-1] CCDS14624.1 [O95258-2] CCDS76020.1 [O95258-3] |
RefSeqi | NP_001269124.1, NM_001282195.1 [O95258-1] NP_001269125.1, NM_001282196.1 [O95258-2] NP_001269126.1, NM_001282197.1 [O95258-3] NP_001269127.1, NM_001282198.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114485, 10 interactors |
IntActi | O95258, 7 interactors |
STRINGi | 9606.ENSP00000477981 |
Protein family/group databases
TCDBi | 2.A.29.24.1, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | O95258 |
PhosphoSitePlusi | O95258 |
Polymorphism and mutation databases
BioMutai | SLC25A14 |
Proteomic databases
jPOSTi | O95258 |
MassIVEi | O95258 |
MaxQBi | O95258 |
PaxDbi | O95258 |
PeptideAtlasi | O95258 |
PRIDEi | O95258 |
ProteomicsDBi | 50752 [O95258-1] 50753 [O95258-2] 50754 [O95258-3] |
Protocols and materials databases
Antibodypediai | 16263, 84 antibodies |
Genome annotation databases
Ensembli | ENST00000218197; ENSP00000218197; ENSG00000102078 [O95258-1] ENST00000339231; ENSP00000342797; ENSG00000102078 [O95258-3] ENST00000361980; ENSP00000354455; ENSG00000102078 [O95258-2] ENST00000545805; ENSP00000444642; ENSG00000102078 [O95258-1] ENST00000612248; ENSP00000477981; ENSG00000102078 [O95258-3] |
GeneIDi | 9016 |
KEGGi | hsa:9016 |
UCSCi | uc004evp.3, human [O95258-1] |
Organism-specific databases
CTDi | 9016 |
DisGeNETi | 9016 |
EuPathDBi | HostDB:ENSG00000102078.15 |
GeneCardsi | SLC25A14 |
HGNCi | HGNC:10984, SLC25A14 |
HPAi | ENSG00000102078, Low tissue specificity |
MIMi | 300242, gene |
neXtProti | NX_O95258 |
OpenTargetsi | ENSG00000102078 |
PharmGKBi | PA35860 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000159471 |
InParanoidi | O95258 |
OMAi | DQVANHF |
PhylomeDBi | O95258 |
TreeFami | TF323211 |
Enzyme and pathway databases
PathwayCommonsi | O95258 |
Reactomei | R-HSA-167826, The fatty acid cycling model R-HSA-167827, The proton buffering model |
Miscellaneous databases
BioGRID-ORCSi | 9016, 4 hits in 470 CRISPR screens |
ChiTaRSi | SLC25A14, human |
GeneWikii | SLC25A14 |
GenomeRNAii | 9016 |
Pharosi | O95258, Tbio |
PROi | PR:O95258 |
RNActi | O95258, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102078, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | O95258, baseline and differential |
Genevisiblei | O95258, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf IPR032933, SLC25A14 |
PANTHERi | PTHR45618:SF20, PTHR45618:SF20, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UCP5_HUMAN | |
Accessioni | O95258Primary (citable) accession number: O95258 Secondary accession number(s): D3DTG2 Q9HC61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations