SLC25A14

Functionⁱ

Participates in the mitochondrial proton leak measured in brain mitochondria.

GO - Molecular functionⁱ

antiporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
malate transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxaloacetate transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
succinate transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sulfate transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
thiosulfate transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aerobic respiration
Source: ProtInc
Traceable author statementⁱ
- 9852133
malate transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitochondrial transport Source: InterPro
oxaloacetate transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphate ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proton transmembrane transport Source: Reactome
succinate transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sulfate transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
thiosulfate transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167826 The fatty acid cycling model R-HSA-167827 The proton buffering model

Reactomeⁱ

R-HSA-167826 The fatty acid cycling model
R-HSA-167827 The proton buffering model

Protein family/group databases

TCDBⁱ	2.A.29.24.1 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.24.1 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Brain mitochondrial carrier protein 1 Short name: BMCP-1 Alternative name(s): Mitochondrial uncoupling protein 5 Short name: UCP 5 Solute carrier family 25 member 14
Gene namesⁱ	Name:SLC25A14 Synonyms:BMCP1, UCP5 ORF Names:UNQ791/PRO1682
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102078.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10984 SLC25A14
MIMⁱ	300242 gene
neXtProtⁱ	NX_O95258

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	38 – 54	Helical; Name=1Sequence analysisAdd BLAST	17
Transmembraneⁱ	112 – 128	Helical; Name=2Sequence analysisAdd BLAST	17
Transmembraneⁱ	141 – 161	Helical; Name=3Sequence analysisAdd BLAST	21
Transmembraneⁱ	199 – 215	Helical; Name=4Sequence analysisAdd BLAST	17
Transmembraneⁱ	240 – 256	Helical; Name=5Sequence analysisAdd BLAST	17
Transmembraneⁱ	298 – 315	Helical; Name=6Sequence analysisAdd BLAST	18

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9016
Open Targets More...OpenTargetsⁱ	ENSG00000102078
PharmGKBⁱ	PA35860

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090677	1 – 325	Brain mitochondrial carrier protein 1Add BLAST		325

Proteomic databases

EPDⁱ	O95258
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95258
PaxDbⁱ	O95258
PeptideAtlas More...PeptideAtlasⁱ	O95258
PRIDEⁱ	O95258
ProteomicsDBⁱ	50752 50753 [O95258-2] 50754 [O95258-3]

PTM databases

iPTMnetⁱ	O95258
PhosphoSitePlusⁱ	O95258

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in brain. Some expression in testis and pituitary.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000102078 Expressed in 213 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_SLC25A14
ExpressionAtlasⁱ	O95258 baseline and differential
Genevisibleⁱ	O95258 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060316

HPAⁱ

HPA060316

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114485, 9 interactors
STRINGⁱ	9606.ENSP00000218197

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95258
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	42 – 131	Solcar 1Add BLAST	90
Repeatⁱ	139 – 224	Solcar 2Add BLAST	86
Repeatⁱ	233 – 323	Solcar 3Add BLAST	91

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0753 Eukaryota ENOG410XRV1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119170
HOGENOMⁱ	HOG000165140
HOVERGENⁱ	HBG009528
InParanoidⁱ	O95258
KEGG Orthology (KO) More...KOⁱ	K15106
OMAⁱ	DQVANHF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BQ7
PhylomeDBⁱ	O95258
TreeFamⁱ	TF323211

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002030 Mit_uncoupling_UCP-like IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf IPR032933 SLC25A14
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit PTHR24089:SF299 PTHR24089:SF299, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00784 MTUNCOUPLING
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95258-1) [UniParc]FASTA Add to basket

Also known as: UCP5L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA 
        60         70         80         90        100
SIVAEFGTFP VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV 
       110        120        130        140        150
LALYSGIAPA LLRQASYGTI KIGIYQSLKR LFVERLEDET LLINMICGVV 
       160        170        180        190        200
SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM IGSFIDIYQQ EGTRGLWRGV 
       210        220        230        240        250
VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV SSFTCGLAGA 
       260        270        280        290        300
LASNPVDVVR TRMMNQRAIV GHVDLYKGTV DGILKMWKHE GFFALYKGFW 
       310        320 
PNWLRLGPWN IIFFITYEQL KRLQI

Length:325

Mass (Da):36,202

Last modified:May 1, 1999 - v1

Checksum:ⁱ0447E8E3B5374982

GO

Isoform 2 (identifier: O95258-2) [UniParc]FASTA Add to basket

Also known as: UCP5S

The sequence of this isoform differs from the canonical sequence as follows:
23-25: Missing.

« Hide

        10         20         30         40         50
MGIFPGIILI FLRVKFATAA VIHQKSTTVS HEMSGLNWKP FVYGGLASIV 
        60         70         80         90        100
AEFGTFPVDL TKTRLQVQGQ SIDARFKEIK YRGMFHALFR ICKEEGVLAL 
       110        120        130        140        150
YSGIAPALLR QASYGTIKIG IYQSLKRLFV ERLEDETLLI NMICGVVSGV 
       160        170        180        190        200
ISSTIANPTD VLKIRMQAQG SLFQGSMIGS FIDIYQQEGT RGLWRGVVPT 
       210        220        230        240        250
AQRAAIVVGV ELPVYDITKK HLILSGMMGD TILTHFVSSF TCGLAGALAS 
       260        270        280        290        300
NPVDVVRTRM MNQRAIVGHV DLYKGTVDGI LKMWKHEGFF ALYKGFWPNW 
       310        320 
LRLGPWNIIF FITYEQLKRL QI

Show »

Length:322

Mass (Da):35,958

Checksum:ⁱF3C186B06ADC0F6A

GO

Isoform 3 (identifier: O95258-3) [UniParc]FASTA Add to basket

Also known as: UCP5SI

The sequence of this isoform differs from the canonical sequence as follows:
23-25: Missing.
198-198: R → RCLCSKAVTGCVLWLMPVIPALWEANAGGSLE

« Hide

        10         20         30         40         50
MGIFPGIILI FLRVKFATAA VIHQKSTTVS HEMSGLNWKP FVYGGLASIV 
        60         70         80         90        100
AEFGTFPVDL TKTRLQVQGQ SIDARFKEIK YRGMFHALFR ICKEEGVLAL 
       110        120        130        140        150
YSGIAPALLR QASYGTIKIG IYQSLKRLFV ERLEDETLLI NMICGVVSGV 
       160        170        180        190        200
ISSTIANPTD VLKIRMQAQG SLFQGSMIGS FIDIYQQEGT RGLWRCLCSK 
       210        220        230        240        250
AVTGCVLWLM PVIPALWEAN AGGSLEGVVP TAQRAAIVVG VELPVYDITK 
       260        270        280        290        300
KHLILSGMMG DTILTHFVSS FTCGLAGALA SNPVDVVRTR MMNQRAIVGH 
       310        320        330        340        350
VDLYKGTVDG ILKMWKHEGF FALYKGFWPN WLRLGPWNII FFITYEQLKR 

LQI

Show »

Length:353

Mass (Da):39,173

Checksum:ⁱ8A66113E6FAE9C7B

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JY88	Q5JY88_HUMAN	Brain mitochondrial carrier protein... Brain mitochondrial carrier protein 1	SLC25A14	198	Annotation score:
F6SL11	F6SL11_HUMAN	Brain mitochondrial carrier protein... Brain mitochondrial carrier protein 1	SLC25A14	290	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050138	55	E → A. Corresponds to variant dbSNP:rs2143598Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003272	23 – 25	Missing in isoform 2 and isoform 3. Curated		3
Alternative sequenceⁱVSP_003273	198	R → RCLCSKAVTGCVLWLMPVIP ALWEANAGGSLE in isoform 3. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF078544 mRNA Translation: AAD04346.1 AF155809 mRNA Translation: AAG29582.1 AF155810 mRNA Translation: AAG29583.1 AF155811 mRNA Translation: AAG29584.1 AY358099 mRNA Translation: AAQ88466.1 AL035423 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11804.1 BC119666 mRNA Translation: AAI19667.1 BC119667 mRNA Translation: AAI19668.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14623.1 [O95258-1] CCDS14624.1 [O95258-2] CCDS76020.1 [O95258-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001269124.1, NM_001282195.1 [O95258-1] NP_001269125.1, NM_001282196.1 [O95258-2] NP_001269126.1, NM_001282197.1 [O95258-3] NP_001269127.1, NM_001282198.1
UniGeneⁱ	Hs.194686

Genome annotation databases

Ensemblⁱ	ENST00000218197; ENSP00000218197; ENSG00000102078 [O95258-1] ENST00000339231; ENSP00000342797; ENSG00000102078 [O95258-3] ENST00000361980; ENSP00000354455; ENSG00000102078 [O95258-2] ENST00000545805; ENSP00000444642; ENSG00000102078 [O95258-1] ENST00000612248; ENSP00000477981; ENSG00000102078 [O95258-3]
GeneIDⁱ	9016
KEGGⁱ	hsa:9016
UCSC genome browser More...UCSCⁱ	uc004evp.3 human [O95258-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95258	Brain mitochondrial carrier protein 1 isoform UCP5L		CALJA		325	UniRef100_O95258
Brain mitochondrial carrier protein 1 isoform UCP5L		MACMU		325
SLC25A14 isoform 1		PANTR		325
Uncharacterized protein		CERAT		325
Uncharacterized protein		RHIRO		325
+5
O95258-2	Brain mitochondrial carrier protein 1 isoform UCP5S		CALJA		322	UniRef100_U3CVS5
Uncharacterized protein		MACMU		322
SLC25A14 isoform 10		PANTR		322

Protein	Similar proteins		Species	Score	Length	Source
O95258	Brain mitochondrial carrier protein 1		MOUSE		325	UniRef90_O95258
Brain mitochondrial carrier protein 1 isoform UCP5L		CALJA		325
Brain mitochondrial carrier protein 1 isoform UCP5L		MACMU		325
SLC25A14 isoform 1		PANTR		325
Uncharacterized protein		CERAT		325
+129
O95258-3	Uncharacterized protein		PROCO		368	UniRef90_O95258-3
SLC25A14 isoform 11		PANTR		353
SLC25A14 isoform 12		PONAB		353
Uncharacterized protein		MACMU		353
Uncharacterized protein		MACFA		353
+9

Protein	Similar proteins		Species	Score	Length	Source
O95258	Brain mitochondrial carrier protein 1		MOUSE		325	UniRef50_O95258
Kidney mitochondrial carrier protein 1		RAT		291
Kidney mitochondrial carrier protein 1		MACFA		291
Kidney mitochondrial carrier protein 1		HUMAN		291
Brain mitochondrial carrier protein 1 isoform UCP5L		CALJA		325
+302
O95258-3	Uncharacterized protein		PROCO		368	UniRef50_O95258-3
Uncharacterized protein		MACMU		353
Uncharacterized protein		MACFA		353
Uncharacterized protein		CERAT		353
Uncharacterized protein		MANLE		353
+26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF078544 mRNA Translation: AAD04346.1 AF155809 mRNA Translation: AAG29582.1 AF155810 mRNA Translation: AAG29583.1 AF155811 mRNA Translation: AAG29584.1 AY358099 mRNA Translation: AAQ88466.1 AL035423 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11804.1 BC119666 mRNA Translation: AAI19667.1 BC119667 mRNA Translation: AAI19668.1
CCDSⁱ	CCDS14623.1 [O95258-1] CCDS14624.1 [O95258-2] CCDS76020.1 [O95258-3]
RefSeqⁱ	NP_001269124.1, NM_001282195.1 [O95258-1] NP_001269125.1, NM_001282196.1 [O95258-2] NP_001269126.1, NM_001282197.1 [O95258-3] NP_001269127.1, NM_001282198.1
UniGeneⁱ	Hs.194686

3D structure databases

ProteinModelPortalⁱ	O95258
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114485, 9 interactors
STRINGⁱ	9606.ENSP00000218197

Protein family/group databases

TCDBⁱ	2.A.29.24.1 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.24.1 the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	O95258
PhosphoSitePlusⁱ	O95258

Proteomic databases

EPDⁱ	O95258
MaxQBⁱ	O95258
PaxDbⁱ	O95258
PeptideAtlasⁱ	O95258
PRIDEⁱ	O95258
ProteomicsDBⁱ	50752 50753 [O95258-2] 50754 [O95258-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000218197; ENSP00000218197; ENSG00000102078 [O95258-1] ENST00000339231; ENSP00000342797; ENSG00000102078 [O95258-3] ENST00000361980; ENSP00000354455; ENSG00000102078 [O95258-2] ENST00000545805; ENSP00000444642; ENSG00000102078 [O95258-1] ENST00000612248; ENSP00000477981; ENSG00000102078 [O95258-3]
GeneIDⁱ	9016
KEGGⁱ	hsa:9016
UCSCⁱ	uc004evp.3 human [O95258-1]

Organism-specific databases

CTDⁱ	9016
DisGeNETⁱ	9016
EuPathDBⁱ	HostDB:ENSG00000102078.15
GeneCardsⁱ	SLC25A14
HGNCⁱ	HGNC:10984 SLC25A14
HPAⁱ	HPA060316
MIMⁱ	300242 gene
neXtProtⁱ	NX_O95258
OpenTargetsⁱ	ENSG00000102078
PharmGKBⁱ	PA35860
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0753 Eukaryota ENOG410XRV1 LUCA
GeneTreeⁱ	ENSGT00760000119170
HOGENOMⁱ	HOG000165140
HOVERGENⁱ	HBG009528
InParanoidⁱ	O95258
KOⁱ	K15106
OMAⁱ	DQVANHF
OrthoDBⁱ	EOG091G0BQ7
PhylomeDBⁱ	O95258
TreeFamⁱ	TF323211

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167826 The fatty acid cycling model R-HSA-167827 The proton buffering model

Reactomeⁱ

R-HSA-167826 The fatty acid cycling model
R-HSA-167827 The proton buffering model

Miscellaneous databases

ChiTaRSⁱ	SLC25A14 human
GeneWikiⁱ	SLC25A14
GenomeRNAiⁱ	9016
Protein Ontology More...PROⁱ	PR:O95258
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102078 Expressed in 213 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_SLC25A14
ExpressionAtlasⁱ	O95258 baseline and differential
Genevisibleⁱ	O95258 HS

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002030 Mit_uncoupling_UCP-like IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf IPR032933 SLC25A14
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit PTHR24089:SF299 PTHR24089:SF299, 1 hit
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00784 MTUNCOUPLING
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UCP5_HUMAN
Accessionⁱ	O95258Primary (citable) accession number: O95258 Secondary accession number(s): D3DTG2 , Q0VDH7, Q9HC60, Q9HC61
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

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UniProtKB - O95258 (UCP5_HUMAN)

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Brain mitochondrial carrier protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ