UniProtKB - O95256 (I18RA_HUMAN)
Interleukin-18 receptor accessory protein
IL18RAP
Functioni
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532).
May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
1 Publication3 PublicationsCatalytic activityi
- EC:3.2.2.6PROSITE-ProRule annotationThis reaction proceeds in the forwardPROSITE-ProRule annotation direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 493 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- interleukin-18 receptor activity Source: UniProtKB
- NAD(P)+ nucleosidase activity Source: UniProtKB-EC
- NAD+ nucleotidase, cyclic ADP-ribose generating Source: UniProtKB-EC
GO - Biological processi
- immune response Source: ProtInc
- inflammatory response Source: ProtInc
- interleukin-18-mediated signaling pathway Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Receptor |
Biological process | Inflammatory response |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | O95256 |
Reactomei | R-HSA-9012546, Interleukin-18 signaling |
SignaLinki | O95256 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-18 receptor accessory protein (EC:3.2.2.6PROSITE-ProRule annotation)Short name: IL-18 receptor accessory protein Short name: IL-18RAcP Alternative name(s): Accessory protein-like Short name: AcPL CD218 antigen-like family member B CDw218b IL-1R accessory protein-like1 Publication Short name: IL-1RAcPL Interleukin-1 receptor 7 Short name: IL-1R-7 Short name: IL-1R7 Interleukin-18 receptor accessory protein-like Interleukin-18 receptor beta3 Publications Short name: IL-18R-beta Short name: IL-18Rbeta3 Publications CD_antigen: CD218b |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5989, IL18RAP |
MIMi | 604509, gene |
neXtProti | NX_O95256 |
VEuPathDBi | HostDB:ENSG00000115607 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Plasma Membrane
- interleukin-18 receptor complex Source: UniProtKB
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 356 | ExtracellularSequence analysisAdd BLAST | 337 | |
Transmembranei | 357 – 377 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 378 – 599 | CytoplasmicSequence analysisAdd BLAST | 222 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 15 – 176 | Missing : Impairs IL18 receptor signaling via NF-kappa-B. 1 PublicationAdd BLAST | 162 | |
Mutagenesisi | 167 | L → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. 1 Publication | 1 | |
Mutagenesisi | 210 | E → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-212 and A-214. 1 Publication | 1 | |
Mutagenesisi | 212 | Y → A: Abolishes binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-210 and A-214. 1 Publication | 1 | |
Mutagenesisi | 214 | Y → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-210 and A-212. 1 Publication | 1 | |
Mutagenesisi | 313 | K → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Decreases IL18 receptor signaling via NF-kappa-B. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8807 |
OpenTargetsi | ENSG00000115607 |
PharmGKBi | PA29805 |
Miscellaneous databases
Pharosi | O95256, Tbio |
Genetic variation databases
BioMutai | IL18RAP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000042185 | 20 – 599 | Interleukin-18 receptor accessory proteinAdd BLAST | 580 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 46 ↔ 126 | Combined sources1 Publication | ||
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Glycosylationi | 152 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 155 ↔ 180 | Combined sources1 Publication | ||
Disulfide bondi | 175 ↔ 221 | Combined sources1 Publication | ||
Disulfide bondi | 180 ↔ 221 | PROSITE-ProRule annotation | ||
Disulfide bondi | 273 ↔ 337 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 345 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O95256 |
PeptideAtlasi | O95256 |
PRIDEi | O95256 |
ProteomicsDBi | 50750 [O95256-1] 61717 |
PTM databases
GlyGeni | O95256, 4 sites |
iPTMneti | O95256 |
PhosphoSitePlusi | O95256 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000115607, Expressed in bone marrow and 130 other tissues |
ExpressionAtlasi | O95256, baseline and differential |
Genevisiblei | O95256, HS |
Organism-specific databases
HPAi | ENSG00000115607, Group enriched (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
O95256
With | #Exp. | IntAct |
---|---|---|
WFS1 [O76024] | 4 | EBI-21018056,EBI-720609 |
Protein-protein interaction databases
BioGRIDi | 114335, 20 interactors |
IntActi | O95256, 5 interactors |
STRINGi | 9606.ENSP00000264260 |
Miscellaneous databases
RNActi | O95256, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O95256 |
SASBDBi | O95256 |
SMRi | O95256 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 235 | Ig-like C2-type 1Add BLAST | 87 | |
Domaini | 251 – 353 | Ig-like C2-type 2Add BLAST | 103 | |
Domaini | 406 – 559 | TIRPROSITE-ProRule annotationAdd BLAST | 154 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUSU, Eukaryota |
GeneTreei | ENSGT01030000234568 |
HOGENOMi | CLU_025552_2_0_1 |
InParanoidi | O95256 |
OMAi | EPQKSHF |
OrthoDBi | 985064at2759 |
PhylomeDBi | O95256 |
TreeFami | TF325519 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR041416, IL-1RAcP-like_ig IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF18452, Ig_6, 1 hit PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits PS50104, TIR, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE
60 70 80 90 100
PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS
110 120 130 140 150
YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ
160 170 180 190 200
TNASCEYSAS HKQDLLLGST GSISCPSLSC QSDAQSPAVT WYKNGKLLSV
210 220 230 240 250
ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK
260 270 280 290 300
PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV
310 320 330 340 350
SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV
360 370 380 390 400
QLKEKRGVVL LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ
410 420 430 440 450
TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYSL
460 470 480 490 500
CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL
510 520 530 540 550
ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR
560 570 580 590
FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JLE2 | C9JLE2_HUMAN | Interleukin-18 receptor accessory p... | IL18RAP | 44 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034005 | 350 | V → I. Corresponds to variant dbSNP:rs11465716EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056295 | 1 – 142 | Missing in isoform 2. 1 PublicationAdd BLAST | 142 | |
Alternative sequenceiVSP_059114 | 118 – 126 | VNNSGSYIC → LGHIFVDPR in isoform 4. 1 Publication | 9 | |
Alternative sequenceiVSP_059115 | 127 – 599 | Missing in isoform 4. 1 PublicationAdd BLAST | 473 | |
Alternative sequenceiVSP_059116 | 133 – 149 | SPYDV…LEVKP → YDPNTFLSENISKSSII in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_059117 | 150 – 599 | Missing in isoform 3. 1 PublicationAdd BLAST | 450 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF077346 mRNA Translation: AAC72196.1 DQ116957 mRNA Translation: AAZ52551.1 AC007278 Genomic DNA Translation: AAY15080.1 AC007248 Genomic DNA Translation: AAY15049.1 CH471127 Genomic DNA Translation: EAX01791.1 AK300026 mRNA Translation: BAG61837.1 BC069630 mRNA Translation: AAH69630.1 BC106764 mRNA Translation: AAI06765.1 BC106765 mRNA Translation: AAI06766.1 BC137474 mRNA Translation: AAI37475.1 BC137475 mRNA Translation: AAI37476.1 |
CCDSi | CCDS2061.1 [O95256-1] |
RefSeqi | NP_003844.1, NM_003853.3 [O95256-1] XP_011510389.1, XM_011512087.2 [O95256-2] XP_011510390.1, XM_011512088.2 [O95256-2] |
Genome annotation databases
Ensembli | ENST00000264260.6; ENSP00000264260.2; ENSG00000115607.10 ENST00000409369.1; ENSP00000387201.1; ENSG00000115607.10 [O95256-2] ENST00000687160.1; ENSP00000510345.1; ENSG00000115607.10 |
GeneIDi | 8807 |
KEGGi | hsa:8807 |
MANE-Selecti | ENST00000687160.1; ENSP00000510345.1; NM_001393487.1; NP_001380416.1 |
UCSCi | uc002tbx.4, human [O95256-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF077346 mRNA Translation: AAC72196.1 DQ116957 mRNA Translation: AAZ52551.1 AC007278 Genomic DNA Translation: AAY15080.1 AC007248 Genomic DNA Translation: AAY15049.1 CH471127 Genomic DNA Translation: EAX01791.1 AK300026 mRNA Translation: BAG61837.1 BC069630 mRNA Translation: AAH69630.1 BC106764 mRNA Translation: AAI06765.1 BC106765 mRNA Translation: AAI06766.1 BC137474 mRNA Translation: AAI37475.1 BC137475 mRNA Translation: AAI37476.1 |
CCDSi | CCDS2061.1 [O95256-1] |
RefSeqi | NP_003844.1, NM_003853.3 [O95256-1] XP_011510389.1, XM_011512087.2 [O95256-2] XP_011510390.1, XM_011512088.2 [O95256-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3WO4 | X-ray | 3.10 | C | 15-356 | [»] | |
6KN9 | X-ray | 3.30 | A/B/C | 20-356 | [»] | |
AlphaFoldDBi | O95256 | |||||
SASBDBi | O95256 | |||||
SMRi | O95256 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114335, 20 interactors |
IntActi | O95256, 5 interactors |
STRINGi | 9606.ENSP00000264260 |
PTM databases
GlyGeni | O95256, 4 sites |
iPTMneti | O95256 |
PhosphoSitePlusi | O95256 |
Genetic variation databases
BioMutai | IL18RAP |
Proteomic databases
PaxDbi | O95256 |
PeptideAtlasi | O95256 |
PRIDEi | O95256 |
ProteomicsDBi | 50750 [O95256-1] 61717 |
Protocols and materials databases
ABCDi | O95256, 3 sequenced antibodies |
Antibodypediai | 17791, 389 antibodies from 30 providers |
DNASUi | 8807 |
Genome annotation databases
Ensembli | ENST00000264260.6; ENSP00000264260.2; ENSG00000115607.10 ENST00000409369.1; ENSP00000387201.1; ENSG00000115607.10 [O95256-2] ENST00000687160.1; ENSP00000510345.1; ENSG00000115607.10 |
GeneIDi | 8807 |
KEGGi | hsa:8807 |
MANE-Selecti | ENST00000687160.1; ENSP00000510345.1; NM_001393487.1; NP_001380416.1 |
UCSCi | uc002tbx.4, human [O95256-1] |
Organism-specific databases
CTDi | 8807 |
DisGeNETi | 8807 |
GeneCardsi | IL18RAP |
HGNCi | HGNC:5989, IL18RAP |
HPAi | ENSG00000115607, Group enriched (bone marrow, lymphoid tissue) |
MIMi | 604509, gene |
neXtProti | NX_O95256 |
OpenTargetsi | ENSG00000115607 |
PharmGKBi | PA29805 |
VEuPathDBi | HostDB:ENSG00000115607 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUSU, Eukaryota |
GeneTreei | ENSGT01030000234568 |
HOGENOMi | CLU_025552_2_0_1 |
InParanoidi | O95256 |
OMAi | EPQKSHF |
OrthoDBi | 985064at2759 |
PhylomeDBi | O95256 |
TreeFami | TF325519 |
Enzyme and pathway databases
PathwayCommonsi | O95256 |
Reactomei | R-HSA-9012546, Interleukin-18 signaling |
SignaLinki | O95256 |
Miscellaneous databases
BioGRID-ORCSi | 8807, 5 hits in 1076 CRISPR screens |
GeneWikii | IL18RAP |
GenomeRNAii | 8807 |
Pharosi | O95256, Tbio |
PROi | PR:O95256 |
RNActi | O95256, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115607, Expressed in bone marrow and 130 other tissues |
ExpressionAtlasi | O95256, baseline and differential |
Genevisiblei | O95256, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR041416, IL-1RAcP-like_ig IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF18452, Ig_6, 1 hit PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits PS50104, TIR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | I18RA_HUMAN | |
Accessioni | O95256Primary (citable) accession number: O95256 Secondary accession number(s): B2RPJ3 Q53TU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families