IL18RAP

Functionⁱ

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).1 Publication3 Publications

GO - Molecular functionⁱ

interleukin-18 receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25500532

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation Source: Ensembl
cellular response to hydrogen peroxide Source: Ensembl
immune response
Source: ProtInc
Traceable author statementⁱ
- 9792649
inflammatory response
Source: ProtInc
Traceable author statementⁱ
- 9792649
interferon-gamma production Source: Ensembl
interleukin-18-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 25500532
interleukin-6 production Source: Ensembl
neutrophil activation Source: Ensembl
positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
positive regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25500532
T-helper 1 cell cytokine production Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9012546 Interleukin-18 signaling

Reactomeⁱ

R-HSA-9012546 Interleukin-18 signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-18 receptor accessory protein Short name: IL-18 receptor accessory protein Short name: IL-18RAcP Alternative name(s): Accessory protein-like Short name: AcPL CD218 antigen-like family member B CDw218b IL-1R accessory protein-like1 Publication Short name: IL-1RAcPL Interleukin-1 receptor 7 Short name: IL-1R-7 Short name: IL-1R7 Interleukin-18 receptor accessory protein-like Interleukin-18 receptor beta3 Publications Short name: IL-18R-beta Short name: IL-18Rbeta3 Publications CD_antigen: CD218b
Gene namesⁱ	Name:IL18RAPImported Synonyms:IL1R7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115607.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5989 IL18RAP
MIMⁱ	604509 gene
neXtProtⁱ	NX_O95256

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 356	ExtracellularSequence analysisAdd BLAST	337
Transmembraneⁱ	357 – 377	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	378 – 599	CytoplasmicSequence analysisAdd BLAST	222

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	15 – 176	Missing : Impairs IL18 receptor signaling via NF-kappa-B. 1 PublicationAdd BLAST	162
Mutagenesisⁱ	167	L → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. 1 Publication	1
Mutagenesisⁱ	210	E → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-212 and A-214. 1 Publication	1
Mutagenesisⁱ	212	Y → A: Abolishes binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-210 and A-214. 1 Publication	1
Mutagenesisⁱ	214	Y → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-210 and A-212. 1 Publication	1
Mutagenesisⁱ	313	K → A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Decreases IL18 receptor signaling via NF-kappa-B. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8807
Open Targets More...OpenTargetsⁱ	ENSG00000115607
PharmGKBⁱ	PA29805

Polymorphism and mutation databases

BioMutaⁱ	IL18RAP

BioMutaⁱ

IL18RAP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000042185	20 – 599	Interleukin-18 receptor accessory proteinAdd BLAST		580

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	46 ↔ 126	Combined sources1 Publication
Glycosylationⁱ	119	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Glycosylationⁱ	152	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	155 ↔ 180	Combined sources1 Publication
Disulfide bondⁱ	175 ↔ 221	Combined sources1 Publication
Disulfide bondⁱ	180 ↔ 221	PROSITE-ProRule annotation
Disulfide bondⁱ	273 ↔ 337	PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationⁱ	345	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O95256
PeptideAtlas More...PeptideAtlasⁱ	O95256
PRIDEⁱ	O95256
ProteomicsDBⁱ	50750

PTM databases

iPTMnetⁱ	O95256
PhosphoSitePlusⁱ	O95256

Expressionⁱ

Tissue specificityⁱ

Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836). Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).5 Publications

Inductionⁱ

Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000115607 Expressed in 112 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_IL18RAP
ExpressionAtlasⁱ	O95256 baseline and differential
Genevisibleⁱ	O95256 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025270

HPAⁱ

CAB025270

Interactionⁱ

Subunit structureⁱ

Forms a ternary complex with IL18 and IL18R1 (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable).Curated2 Publications

Protein-protein interaction databases

BioGridⁱ	114335, 3 interactors
STRINGⁱ	9606.ENSP00000264260

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	32 – 36	Combined sources	5
Beta strandⁱ	41 – 44	Combined sources	4
Beta strandⁱ	110 – 115	Combined sources	6
Beta strandⁱ	117 – 120	Combined sources	4
Beta strandⁱ	122 – 126	Combined sources	5
Beta strandⁱ	141 – 149	Combined sources	9
Beta strandⁱ	154 – 157	Combined sources	4
Beta strandⁱ	161 – 166	Combined sources	6
Beta strandⁱ	171 – 174	Combined sources	4
Helixⁱ	176 – 178	Combined sources	3
Turnⁱ	180 – 183	Combined sources	4
Beta strandⁱ	189 – 193	Combined sources	5
Beta strandⁱ	203 – 210	Combined sources	8
Helixⁱ	213 – 215	Combined sources	3
Beta strandⁱ	217 – 224	Combined sources	8
Beta strandⁱ	233 – 243	Combined sources	11
Beta strandⁱ	252 – 255	Combined sources	4
Beta strandⁱ	258 – 263	Combined sources	6
Beta strandⁱ	269 – 278	Combined sources	10
Beta strandⁱ	286 – 293	Combined sources	8
Beta strandⁱ	296 – 299	Combined sources	4
Beta strandⁱ	306 – 310	Combined sources	5
Beta strandⁱ	312 – 325	Combined sources	14
Helixⁱ	328 – 331	Combined sources	4
Beta strandⁱ	333 – 341	Combined sources	9
Beta strandⁱ	344 – 354	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	O95256
SMRⁱ	O95256
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	149 – 235	Ig-like C2-type 1Add BLAST	87
Domainⁱ	251 – 353	Ig-like C2-type 2Add BLAST	103
Domainⁱ	406 – 562	TIRPROSITE-ProRule annotationAdd BLAST	157

Sequence similaritiesⁱ

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IGUG Eukaryota ENOG410Y9SN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119071
HOGENOMⁱ	HOG000060101
HOVERGENⁱ	HBG081778
InParanoidⁱ	O95256
KEGG Orthology (KO) More...KOⁱ	K05174
OMAⁱ	YVCDYTQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GXW
PhylomeDBⁱ	O95256
TreeFamⁱ	TF325519

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits 3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR015621 IL-1_rcpt_fam IPR000157 TIR_dom IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR11890 PTHR11890, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13895 Ig_2, 1 hit PF01582 TIR, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00255 TIR, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits PS50104 TIR, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O95256-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE 
        60         70         80         90        100
PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS 
       110        120        130        140        150
YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ 
       160        170        180        190        200
TNASCEYSAS HKQDLLLGST GSISCPSLSC QSDAQSPAVT WYKNGKLLSV 
       210        220        230        240        250
ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK 
       260        270        280        290        300
PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV 
       310        320        330        340        350
SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV 
       360        370        380        390        400
QLKEKRGVVL LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ 
       410        420        430        440        450
TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYSL 
       460        470        480        490        500
CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL 
       510        520        530        540        550
ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR 
       560        570        580        590 
FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW

Length:599

Mass (Da):68,310

Last modified:May 1, 1999 - v1

Checksum:ⁱ54807DA3E05462F1

GO

Isoform 2 (identifier: O95256-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-142: Missing.

« Hide

        10         20         30         40         50
MILEVKPQTN ASCEYSASHK QDLLLGSTGS ISCPSLSCQS DAQSPAVTWY 
        60         70         80         90        100
KNGKLLSVER SNRIVVDEVY DYHQGTYVCD YTQSDTVSSW TVRAVVQVRT 
       110        120        130        140        150
IVGDTKLKPD ILDPVEDTLE VELGKPLTIS CKARFGFERV FNPVIKWYIK 
       160        170        180        190        200
DSDLEWEVSV PEAKSIKSTL KDEIIERNII LEKVTQRDLR RKFVCFVQNS 
       210        220        230        240        250
IGNTTQSVQL KEKRGVVLLY ILLGTIGTLV AVLAASALLY RHWIEIVLLY 
       260        270        280        290        300
RTYQSKDQTL GDKKDFDAFV SYAKWSSFPS EATSSLSEEH LALSLFPDVL 
       310        320        330        340        350
ENKYGYSLCL LERDVAPGGV YAEDIVSIIK RSRRGIFILS PNYVNGPSIF 
       360        370        380        390        400
ELQAAVNLAL DDQTLKLILI KFCYFQEPES LPHLVKKALR VLPTVTWRGL 
       410        420        430        440        450
KSVPPNSRFW AKMRYHMPVK NSQGFTWNQL RITSRIFQWK GLSRTETTGR 

SSQPKEW

Note: No experimental confirmation available.

Show »

Length:457

Mass (Da):51,945

Checksum:ⁱD18892A9D90312DA

GO

Isoform 3 (identifier: O95256-3) [UniParc]FASTA Add to basket

Also known as: IL-18RAPshort1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
133-149: SPYDVACCVKMILEVKP → YDPNTFLSENISKSSII
150-599: Missing.

« Hide

        10         20         30         40         50
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE 
        60         70         80         90        100
PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS 
       110        120        130        140 
YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKYDPNTFLS ENISKSSII

Show »

Length:149

Mass (Da):17,227

Checksum:ⁱ26676206402988BE

GO

Isoform 4 (identifier: O95256-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
118-126: VNNSGSYIC → LGHIFVDPR
127-599: Missing.

« Hide

        10         20         30         40         50
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE 
        60         70         80         90        100
PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS 
       110        120 
YPHIIQDKCT LHFLTPGLGH IFVDPR

Show »

Length:126

Mass (Da):14,660

Checksum:ⁱ5288B8BC906E5ED5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JLE2	C9JLE2_HUMAN		Interleukin-18 receptor accessory p... Interleukin-18 receptor accessory protein	IL18RAP	44	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034005	350	V → I. Corresponds to variant dbSNP:rs11465716Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056295	1 – 142	Missing in isoform 2. 1 PublicationAdd BLAST	142
Alternative sequenceⁱVSP_059114	118 – 126	VNNSGSYIC → LGHIFVDPR in isoform 4. 1 Publication	9
Alternative sequenceⁱVSP_059115	127 – 599	Missing in isoform 4. 1 PublicationAdd BLAST	473
Alternative sequenceⁱVSP_059116	133 – 149	SPYDV…LEVKP → YDPNTFLSENISKSSII in isoform 3. 1 PublicationAdd BLAST	17
Alternative sequenceⁱVSP_059117	150 – 599	Missing in isoform 3. 1 PublicationAdd BLAST	450

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF077346 mRNA Translation: AAC72196.1 DQ116957 mRNA Translation: AAZ52551.1 AC007278 Genomic DNA Translation: AAY15080.1 AC007248 Genomic DNA Translation: AAY15049.1 CH471127 Genomic DNA Translation: EAX01791.1 AK300026 mRNA Translation: BAG61837.1 BC069630 mRNA Translation: AAH69630.1 BC106764 mRNA Translation: AAI06765.1 BC106765 mRNA Translation: AAI06766.1 BC137474 mRNA Translation: AAI37475.1 BC137475 mRNA Translation: AAI37476.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2061.1 [O95256-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003844.1, NM_003853.3 [O95256-1] XP_011510389.1, XM_011512087.2 [O95256-2] XP_011510390.1, XM_011512088.2 [O95256-2]
UniGeneⁱ	Hs.158315

Genome annotation databases

Ensemblⁱ	ENST00000264260; ENSP00000264260; ENSG00000115607 [O95256-1] ENST00000409369; ENSP00000387201; ENSG00000115607 [O95256-2]
GeneIDⁱ	8807
KEGGⁱ	hsa:8807
UCSC genome browser More...UCSCⁱ	uc002tbx.4 human [O95256-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O95256	Interleukin-18 receptor accessory protein (Fragment)		HUMAN		44	UniRef100_O95256
IL18RAP isoform 4 (Fragment)		PANTR		44
Isoform 2 of Interleukin-18 receptor accessory protein		HUMAN		457

Protein	Similar proteins		Species	Score	Length	Source
O95256	Interleukin-18 receptor accessory protein (Fragment)		HUMAN		44	UniRef90_O95256
IL18RAP isoform 4 (Fragment)		PANTR		44
Uncharacterized protein		PANPA		599
Uncharacterized protein		COLAP		599
IL18RAP isoform 1		PONAB		599
+25

Protein	Similar proteins		Species	Score	Length	Source
O95256	Interleukin-18 receptor accessory protein (Fragment)		HUMAN		44	UniRef50_O95256
IL18RAP isoform 4 (Fragment)		PANTR		44
Uncharacterized protein		COLAP		599
IL18RAP isoform 1		PONAB		599
Interleukin 18 receptor accessory protein		GORGO		599
+71
O95256-3	Isoform 4 of Interleukin-18 receptor accessory protein		HUMAN		126	UniRef50_O95256-3
Interleukin-18 receptor accessory protein (Small)		RAT		139
O95256-4	Isoform 3 of Interleukin-18 receptor accessory protein		HUMAN		149	UniRef50_O95256-3
Interleukin-18 receptor accessory protein (Small)		RAT		139

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF077346 mRNA Translation: AAC72196.1 DQ116957 mRNA Translation: AAZ52551.1 AC007278 Genomic DNA Translation: AAY15080.1 AC007248 Genomic DNA Translation: AAY15049.1 CH471127 Genomic DNA Translation: EAX01791.1 AK300026 mRNA Translation: BAG61837.1 BC069630 mRNA Translation: AAH69630.1 BC106764 mRNA Translation: AAI06765.1 BC106765 mRNA Translation: AAI06766.1 BC137474 mRNA Translation: AAI37475.1 BC137475 mRNA Translation: AAI37476.1
CCDSⁱ	CCDS2061.1 [O95256-1]
RefSeqⁱ	NP_003844.1, NM_003853.3 [O95256-1] XP_011510389.1, XM_011512087.2 [O95256-2] XP_011510390.1, XM_011512088.2 [O95256-2]
UniGeneⁱ	Hs.158315

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3WO4	X-ray	3.10	C	15-356	[»]
ProteinModelPortalⁱ	O95256
SMRⁱ	O95256
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114335, 3 interactors
STRINGⁱ	9606.ENSP00000264260

PTM databases

iPTMnetⁱ	O95256
PhosphoSitePlusⁱ	O95256

Polymorphism and mutation databases

BioMutaⁱ	IL18RAP

BioMutaⁱ

IL18RAP

Proteomic databases

PaxDbⁱ	O95256
PeptideAtlasⁱ	O95256
PRIDEⁱ	O95256
ProteomicsDBⁱ	50750

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000264260; ENSP00000264260; ENSG00000115607 [O95256-1] ENST00000409369; ENSP00000387201; ENSG00000115607 [O95256-2]
GeneIDⁱ	8807
KEGGⁱ	hsa:8807
UCSCⁱ	uc002tbx.4 human [O95256-1]

Organism-specific databases

CTDⁱ	8807
DisGeNETⁱ	8807
EuPathDBⁱ	HostDB:ENSG00000115607.9
GeneCardsⁱ	IL18RAP
HGNCⁱ	HGNC:5989 IL18RAP
HPAⁱ	CAB025270
MIMⁱ	604509 gene
neXtProtⁱ	NX_O95256
OpenTargetsⁱ	ENSG00000115607
PharmGKBⁱ	PA29805
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGUG Eukaryota ENOG410Y9SN LUCA
GeneTreeⁱ	ENSGT00760000119071
HOGENOMⁱ	HOG000060101
HOVERGENⁱ	HBG081778
InParanoidⁱ	O95256
KOⁱ	K05174
OMAⁱ	YVCDYTQ
OrthoDBⁱ	EOG091G0GXW
PhylomeDBⁱ	O95256
TreeFamⁱ	TF325519

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9012546 Interleukin-18 signaling

Reactomeⁱ

R-HSA-9012546 Interleukin-18 signaling

Miscellaneous databases

GeneWikiⁱ	IL18RAP
GenomeRNAiⁱ	8807
Protein Ontology More...PROⁱ	PR:O95256
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115607 Expressed in 112 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_IL18RAP
ExpressionAtlasⁱ	O95256 baseline and differential
Genevisibleⁱ	O95256 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits 3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR015621 IL-1_rcpt_fam IPR000157 TIR_dom IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR11890 PTHR11890, 1 hit
Pfamⁱ	View protein in Pfam PF13895 Ig_2, 1 hit PF01582 TIR, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00255 TIR, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits PS50104 TIR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I18RA_HUMAN
Accessionⁱ	O95256Primary (citable) accession number: O95256 Secondary accession number(s): B2RPJ3 , Q2QDE5, Q3KPE7, Q3KPE8, Q53TT4, Q53TU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	May 1, 1999
	Last modified:	September 12, 2018
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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Annotation systems

Supporting data

UniProtKB - O95256 (I18RA_HUMAN)

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Interleukin-18 receptor accessory protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ