UniProtKB - O95251 (KAT7_HUMAN)
Histone acetyltransferase KAT7
KAT7
Functioni
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 368 | ZincCombined sources2 Publications | 1 | |
Metal bindingi | 371 | ZincCombined sources2 Publications | 1 | |
Metal bindingi | 384 | ZincCombined sources2 Publications | 1 | |
Metal bindingi | 388 | ZincCombined sources2 Publications | 1 | |
Active sitei | 508 | Proton donor/acceptor1 Publication | 1 | |
Binding sitei | 512 | acetyl-CoACombined sources2 Publications | 1 | |
Binding sitei | 518 | WM-3835 inhibitorCombined sources1 Publication | 1 | |
Binding sitei | 521 | acetyl-CoACombined sources2 Publications | 1 | |
Binding sitei | 525 | WM-3835 inhibitorCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 176 – 219 | CCHHC-typePROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 365 – 390 | C2HC MYST-typePROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- DNA replication origin binding Source: CAFA
- histone acetyltransferase activity Source: UniProtKB
- histone binding Source: GO_Central
- transcription coregulator activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- DNA replication Source: UniProtKB
- histone H3 acetylation Source: UniProtKB
- histone H3-K14 acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- histone H4-K12 acetylation Source: UniProtKB
- histone H4-K5 acetylation Source: UniProtKB
- histone H4-K8 acetylation Source: UniProtKB
- internal peptidyl-lysine acetylation Source: UniProtKB
- natural killer cell differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: GO_Central
- positive regulation of DNA replication Source: UniProtKB
- positive regulation of DNA-templated transcription, elongation Source: UniProtKB
- positive regulation of erythrocyte differentiation Source: Ensembl
- positive regulation of hematopoietic stem cell proliferation Source: UniProtKB
- positive regulation of histone H4 acetylation Source: CAFA
- positive regulation of protein localization to nucleus Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: CAFA
- regulation of DNA-dependent DNA replication initiation Source: UniProtKB
- regulation of nucleotide-excision repair Source: UniProtKB
- regulation of transcription, DNA-templated Source: ProtInc
- response to actinomycin D Source: CAFA
- response to anisomycin Source: CAFA
- response to dithiothreitol Source: CAFA
- response to hydroxyurea Source: CAFA
- response to sorbitol Source: CAFA
- stress-activated protein kinase signaling cascade Source: CAFA
Keywordsi
Molecular function | Acyltransferase, Chromatin regulator, Transferase |
Biological process | DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95251 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SIGNORi | O95251 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone acetyltransferase KAT7Curated (EC:2.3.1.485 Publications)Alternative name(s): Histone acetyltransferase binding to ORC12 Publications Lysine acetyltransferase 71 Publication MOZ, YBF2/SAS3, SAS2 and TIP60 protein 21 Publication Short name: MYST-21 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000136504.11 |
HGNCi | HGNC:17016, KAT7 |
MIMi | 609880, gene |
neXtProti | NX_O95251 |
Subcellular locationi
Nucleus
- Nucleus 5 Publications
Cytosol
- cytosol By similarity
Other locations
- Chromosome 6 Publications
- centromere 1 Publication
Note: Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067, PubMed:20129055). Localizes to transcription start sites (PubMed:21753189, PubMed:24065767). Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR (PubMed:28719581). Localizes to centromeres in G1 phase (PubMed:27270040).6 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- histone acetyltransferase complex Source: UniProtKB
- histone H3-K14 acetyltransferase complex Source: UniProtKB
- nuclear chromatin Source: GO_Central
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB
- chromosome, centromeric region Source: UniProtKB-SubCell
- site of DNA damage Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 50 – 53 | SQSS → AQSA: Impaired phosphorylation by ATR, leading to decreased ubiquitination and increased stability in response to DNA damage. 1 Publication | 4 | |
Mutagenesisi | 57 | S → A: Leads to cell cycle arrest in the G1/S phase. 1 Publication | 1 | |
Mutagenesisi | 338 | K → R: Decreases ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 371 | C → A: No interaction with MCM2 and ORC1. 1 Publication | 1 | |
Mutagenesisi | 485 | G → A: Abolishes histone acetyltransferase activity. 2 Publications | 1 | |
Mutagenesisi | 508 | E → A: Abolished histone acetyltransferase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11143 |
OpenTargetsi | ENSG00000136504 |
PharmGKBi | PA134886407 |
Miscellaneous databases
Pharosi | O95251, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3774299 |
Polymorphism and mutation databases
BioMutai | KAT7 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051569 | 1 – 611 | Histone acetyltransferase KAT7Add BLAST | 611 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 50 | Phosphoserine; by ATRCombined sources2 Publications | 1 | |
Modified residuei | 53 | Phosphoserine; by ATR2 Publications | 1 | |
Modified residuei | 57 | Phosphoserine; by PLK1Combined sources1 Publication | 1 | |
Modified residuei | 64 | PhosphoserineCombined sources | 1 | |
Modified residuei | 85 | Phosphothreonine; by CDK1Combined sources1 Publication | 1 | |
Modified residuei | 88 | Phosphothreonine; by CDK1Combined sources1 Publication | 1 | |
Modified residuei | 102 | PhosphoserineCombined sources | 1 | |
Modified residuei | 104 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 111 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphoserineCombined sources | 1 | |
Modified residuei | 128 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 158 | PhosphoserineCombined sources | 1 | |
Modified residuei | 162 | PhosphoserineCombined sources | 1 | |
Modified residuei | 164 | PhosphoserineCombined sources | 1 | |
Modified residuei | 178 | PhosphoserineCombined sources | 1 | |
Modified residuei | 199 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 277 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 323 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 338 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 432 | N6-acetyllysine; by autocatalysisBy similarity | 1 | |
Modified residuei | 506 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O95251 |
jPOSTi | O95251 |
MassIVEi | O95251 |
MaxQBi | O95251 |
PaxDbi | O95251 |
PeptideAtlasi | O95251 |
PRIDEi | O95251 |
ProteomicsDBi | 17693 33968 50746 [O95251-1] 50747 [O95251-2] 50748 [O95251-3] |
PTM databases
iPTMneti | O95251 |
MetOSitei | O95251 |
PhosphoSitePlusi | O95251 |
SwissPalmi | O95251 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000136504, Expressed in testis and 234 other tissues |
ExpressionAtlasi | O95251, baseline and differential |
Genevisiblei | O95251, HS |
Organism-specific databases
HPAi | ENSG00000136504, Low tissue specificity |
Interactioni
Subunit structurei
Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:29382722).
Interacts with MCM2 and ORC1 (PubMed:10438470, PubMed:11278932, PubMed:16387653).
Interacts with the androgen receptor (AR); in the presence of dihydrotestosterone (PubMed:10930412).
Interacts with CDT1 (PubMed:18832067).
Interacts with MAP2K1 and CUL1 (By similarity).
Interacts with p53/TP53; leading to inhibit histone acetyltransferase activity (PubMed:17954561).
Interacts with MIS18BP1 (PubMed:27270040).
By similarity13 PublicationsBinary interactionsi
Hide detailsO95251
GO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116315, 87 interactors |
ComplexPortali | CPX-718, HBO1-4.1 histone acetyltransferase complex CPX-719, HBO1-4.2 histone acetyltransferase complex CPX-720, HBO1-4.3 histone acetyltransferase complex CPX-721, HBO1-5.1 histone acetyltransferase complex CPX-722, HBO1-5.2 histone acetyltransferase complex CPX-723, HBO1-5.3 histone acetyltransferase complex |
CORUMi | O95251 |
DIPi | DIP-29697N |
IntActi | O95251, 62 interactors |
MINTi | O95251 |
STRINGi | 9606.ENSP00000259021 |
Miscellaneous databases
RNActi | O95251, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O95251 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 332 – 607 | MYST-type HATPROSITE-ProRule annotationAdd BLAST | 276 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 475 – 477 | acetyl-CoA bindingCombined sources2 Publications | 3 | |
Regioni | 483 – 488 | acetyl-CoA bindingCombined sources2 Publications | 6 | |
Regioni | 483 – 488 | WM-3835 inhibitor bindingCombined sources1 Publication | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 57 | Ser-richAdd BLAST | 48 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 176 – 219 | CCHHC-typePROSITE-ProRule annotationAdd BLAST | 44 | |
Zinc fingeri | 365 – 390 | C2HC MYST-typePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2747, Eukaryota |
GeneTreei | ENSGT00940000157744 |
HOGENOMi | CLU_011815_6_1_1 |
InParanoidi | O95251 |
OMAi | XVRAQSR |
OrthoDBi | 629545at2759 |
PhylomeDBi | O95251 |
TreeFami | TF317619 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR002717, HAT_MYST-type IPR036388, WH-like_DNA-bd_sf IPR040706, Zf-MYST IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF01853, MOZ_SAS, 1 hit PF01530, zf-C2HC, 1 hit PF17772, zf-MYST, 1 hit |
SUPFAMi | SSF103637, SSF103637, 1 hit SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51726, MYST_HAT, 1 hit PS51802, ZF_CCHHC, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRRKRNAGS SSDGTEDSDF STDLEHTDSS ESDGTSRRSA RVTRSSARLS
60 70 80 90 100
QSSQDSSPVR NLQSFGTEEP AYSTRRVTRS QQQPTPVTPK KYPLRQTRSS
110 120 130 140 150
GSETEQVVDF SDRETKNTAD HDESPPRTPT GNAPSSESDI DISSPNVSHD
160 170 180 190 200
ESIAKDMSLK DSGSDLSHRP KRRRFHESYN FNMKCPTPGC NSLGHLTGKH
210 220 230 240 250
ERHFSISGCP LYHNLSADEC KVRAQSRDKQ IEERMLSHRQ DDNNRHATRH
260 270 280 290 300
QAPTERQLRY KEKVAELRKK RNSGLSKEQK EKYMEHRQTY GNTREPLLEN
310 320 330 340 350
LTSEYDLDLF RRAQARASED LEKLRLQGQI TEGSNMIKTI AFGRYELDTW
360 370 380 390 400
YHSPYPEEYA RLGRLYMCEF CLKYMKSQTI LRRHMAKCVW KHPPGDEIYR
410 420 430 440 450
KGSISVFEVD GKKNKIYCQN LCLLAKLFLD HKTLYYDVEP FLFYVMTEAD
460 470 480 490 500
NTGCHLIGYF SKEKNSFLNY NVSCILTMPQ YMRQGYGKML IDFSYLLSKV
510 520 530 540 550
EEKVGSPERP LSDLGLISYR SYWKEVLLRY LHNFQGKEIS IKEISQETAV
560 570 580 590 600
NPVDIVSTLQ ALQMLKYWKG KHLVLKRQDL IDEWIAKEAK RSNSNKTMDP
610
SCLKWTPPKG T
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EUP3 | E7EUP3_HUMAN | Histone acetyltransferase | KAT7 | 425 | Annotation score: | ||
D6RFZ5 | D6RFZ5_HUMAN | Histone acetyltransferase KAT7 | KAT7 | 16 | Annotation score: | ||
A0A6Q8PHH2 | A0A6Q8PHH2_HUMAN | Histone acetyltransferase KAT7 | KAT7 | 524 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 – 44 | Missing in BAG57945 (PubMed:14702039).Curated | 7 | |
Sequence conflicti | 41 | R → Q in BAG57346 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042552 | 55 – 113 | Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST | 59 | |
Alternative sequenceiVSP_042553 | 114 – 193 | Missing in isoform 2, isoform 3 and isoform 5. 1 PublicationAdd BLAST | 80 | |
Alternative sequenceiVSP_042554 | 222 – 251 | Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074606 mRNA Translation: AAC99368.1 AF140360 mRNA Translation: AAD42348.1 AF217502 mRNA Translation: AAL56649.1 AK023890 mRNA Translation: BAG51236.1 AK293976 mRNA Translation: BAG57346.1 AK294014 mRNA Translation: BAG57375.1 AK294052 mRNA Translation: BAG57401.1 AK294836 mRNA Translation: BAG57945.1 AC015795 Genomic DNA No translation available. AC027801 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94658.1 CH471109 Genomic DNA Translation: EAW94659.1 BC032640 mRNA Translation: AAH32640.1 |
CCDSi | CCDS11554.1 [O95251-1] CCDS56035.1 [O95251-4] CCDS56036.1 [O95251-2] CCDS56037.1 [O95251-5] CCDS56038.1 [O95251-3] |
RefSeqi | NP_001186084.1, NM_001199155.1 [O95251-4] NP_001186085.1, NM_001199156.1 [O95251-5] NP_001186086.1, NM_001199157.1 [O95251-2] NP_001186087.1, NM_001199158.1 [O95251-3] NP_008998.1, NM_007067.4 [O95251-1] |
Genome annotation databases
Ensembli | ENST00000259021; ENSP00000259021; ENSG00000136504 [O95251-1] ENST00000424009; ENSP00000398961; ENSG00000136504 [O95251-4] ENST00000454930; ENSP00000413415; ENSG00000136504 [O95251-5] ENST00000509773; ENSP00000424577; ENSG00000136504 [O95251-2] ENST00000510819; ENSP00000423385; ENSG00000136504 [O95251-3] |
GeneIDi | 11143 |
KEGGi | hsa:11143 |
UCSCi | uc002ipl.3, human [O95251-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074606 mRNA Translation: AAC99368.1 AF140360 mRNA Translation: AAD42348.1 AF217502 mRNA Translation: AAL56649.1 AK023890 mRNA Translation: BAG51236.1 AK293976 mRNA Translation: BAG57346.1 AK294014 mRNA Translation: BAG57375.1 AK294052 mRNA Translation: BAG57401.1 AK294836 mRNA Translation: BAG57945.1 AC015795 Genomic DNA No translation available. AC027801 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94658.1 CH471109 Genomic DNA Translation: EAW94659.1 BC032640 mRNA Translation: AAH32640.1 |
CCDSi | CCDS11554.1 [O95251-1] CCDS56035.1 [O95251-4] CCDS56036.1 [O95251-2] CCDS56037.1 [O95251-5] CCDS56038.1 [O95251-3] |
RefSeqi | NP_001186084.1, NM_001199155.1 [O95251-4] NP_001186085.1, NM_001199156.1 [O95251-5] NP_001186086.1, NM_001199157.1 [O95251-2] NP_001186087.1, NM_001199158.1 [O95251-3] NP_008998.1, NM_007067.4 [O95251-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GK9 | X-ray | 2.40 | A | 336-611 | [»] | |
6MAJ | X-ray | 2.14 | A | 336-609 | [»] | |
6MAK | X-ray | 2.13 | A | 336-609 | [»] | |
SMRi | O95251 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116315, 87 interactors |
ComplexPortali | CPX-718, HBO1-4.1 histone acetyltransferase complex CPX-719, HBO1-4.2 histone acetyltransferase complex CPX-720, HBO1-4.3 histone acetyltransferase complex CPX-721, HBO1-5.1 histone acetyltransferase complex CPX-722, HBO1-5.2 histone acetyltransferase complex CPX-723, HBO1-5.3 histone acetyltransferase complex |
CORUMi | O95251 |
DIPi | DIP-29697N |
IntActi | O95251, 62 interactors |
MINTi | O95251 |
STRINGi | 9606.ENSP00000259021 |
Chemistry databases
ChEMBLi | CHEMBL3774299 |
PTM databases
iPTMneti | O95251 |
MetOSitei | O95251 |
PhosphoSitePlusi | O95251 |
SwissPalmi | O95251 |
Polymorphism and mutation databases
BioMutai | KAT7 |
Proteomic databases
EPDi | O95251 |
jPOSTi | O95251 |
MassIVEi | O95251 |
MaxQBi | O95251 |
PaxDbi | O95251 |
PeptideAtlasi | O95251 |
PRIDEi | O95251 |
ProteomicsDBi | 17693 33968 50746 [O95251-1] 50747 [O95251-2] 50748 [O95251-3] |
Protocols and materials databases
Antibodypediai | 17983, 354 antibodies |
DNASUi | 11143 |
Genome annotation databases
Ensembli | ENST00000259021; ENSP00000259021; ENSG00000136504 [O95251-1] ENST00000424009; ENSP00000398961; ENSG00000136504 [O95251-4] ENST00000454930; ENSP00000413415; ENSG00000136504 [O95251-5] ENST00000509773; ENSP00000424577; ENSG00000136504 [O95251-2] ENST00000510819; ENSP00000423385; ENSG00000136504 [O95251-3] |
GeneIDi | 11143 |
KEGGi | hsa:11143 |
UCSCi | uc002ipl.3, human [O95251-1] |
Organism-specific databases
CTDi | 11143 |
DisGeNETi | 11143 |
EuPathDBi | HostDB:ENSG00000136504.11 |
GeneCardsi | KAT7 |
HGNCi | HGNC:17016, KAT7 |
HPAi | ENSG00000136504, Low tissue specificity |
MIMi | 609880, gene |
neXtProti | NX_O95251 |
OpenTargetsi | ENSG00000136504 |
PharmGKBi | PA134886407 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2747, Eukaryota |
GeneTreei | ENSGT00940000157744 |
HOGENOMi | CLU_011815_6_1_1 |
InParanoidi | O95251 |
OMAi | XVRAQSR |
OrthoDBi | 629545at2759 |
PhylomeDBi | O95251 |
TreeFami | TF317619 |
Enzyme and pathway databases
PathwayCommonsi | O95251 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SIGNORi | O95251 |
Miscellaneous databases
BioGRID-ORCSi | 11143, 135 hits in 868 CRISPR screens |
ChiTaRSi | KAT7, human |
GeneWikii | MYST2 |
GenomeRNAii | 11143 |
Pharosi | O95251, Tbio |
PROi | PR:O95251 |
RNActi | O95251, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136504, Expressed in testis and 234 other tissues |
ExpressionAtlasi | O95251, baseline and differential |
Genevisiblei | O95251, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR002717, HAT_MYST-type IPR036388, WH-like_DNA-bd_sf IPR040706, Zf-MYST IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF01853, MOZ_SAS, 1 hit PF01530, zf-C2HC, 1 hit PF17772, zf-MYST, 1 hit |
SUPFAMi | SSF103637, SSF103637, 1 hit SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51726, MYST_HAT, 1 hit PS51802, ZF_CCHHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KAT7_HUMAN | |
Accessioni | O95251Primary (citable) accession number: O95251 Secondary accession number(s): B3KN74 G5E9K7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM