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Protein

Histone acetyltransferase KAT7

Gene

KAT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.By similarity5 Publications

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei508Proton donor/acceptorBy similarity1
Binding sitei512Acetyl-CoABy similarity1
Binding sitei521Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 219CCHHC-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri365 – 390C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processDNA replication, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiO95251

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT7 (EC:2.3.1.481 Publication)
Alternative name(s):
Histone acetyltransferase binding to ORC1
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name:
MYST-2
Gene namesi
Name:KAT7
Synonyms:HBO1, HBOa, MYST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136504.11
HGNCiHGNC:17016 KAT7
MIMi609880 gene
neXtProtiNX_O95251

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi338K → R: Decreases ubiquitination. 1 Publication1
Mutagenesisi371C → A: No interaction with MCM2 and ORC1. 1 Publication1

Organism-specific databases

DisGeNETi11143
OpenTargetsiENSG00000136504
PharmGKBiPA134886407

Chemistry databases

ChEMBLiCHEMBL3774299

Polymorphism and mutation databases

BioMutaiKAT7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515691 – 611Histone acetyltransferase KAT7Add BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei57Phosphoserine; by PLK1Combined sources1 Publication1
Modified residuei64PhosphoserineCombined sources1
Modified residuei85Phosphothreonine; by CDK1Combined sources1 Publication1
Modified residuei88Phosphothreonine; by CDK1Combined sources1 Publication1
Modified residuei102PhosphoserineCombined sources1
Modified residuei104PhosphothreonineBy similarity1
Modified residuei111PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei128PhosphothreonineBy similarity1
Modified residuei158PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei277N6-acetyllysineBy similarity1
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki338Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei432N6-acetyllysine; by autocatalysisBy similarity1
Modified residuei506PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1 (PubMed:18250300). Phosphorylated by MAP2K1, which accelerates its degradation (By similarity).By similarity1 Publication
Autoacetylation at Lys-432 is required for proper function.By similarity
Ubiquitinated at Lys-338, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95251
MaxQBiO95251
PaxDbiO95251
PeptideAtlasiO95251
PRIDEiO95251
ProteomicsDBi50746
50747 [O95251-2]
50748 [O95251-3]

PTM databases

iPTMnetiO95251
PhosphoSitePlusiO95251

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in testis.2 Publications

Gene expression databases

BgeeiENSG00000136504 Expressed in 224 organ(s), highest expression level in testis
CleanExiHS_MYST2
ExpressionAtlasiO95251 baseline and differential
GenevisibleiO95251 HS

Organism-specific databases

HPAiHPA044470

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone (PubMed:10930412). Interacts with CDT1 (PubMed:18832067). Interacts with MAP2K1 and CUL1 (By similarity).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116315, 69 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CPX-722 HBO1-5.2 histone acetyltransferase complex
CPX-723 HBO1-5.3 histone acetyltransferase complex
CORUMiO95251
DIPiDIP-29697N
IntActiO95251, 55 interactors
MINTiO95251
STRINGi9606.ENSP00000259021

Structurei

Secondary structure

1611
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95251
SMRiO95251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 607MYST-type HATPROSITE-ProRule annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni475 – 477Acetyl-CoA bindingBy similarity3
Regioni482 – 488Acetyl-CoA bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 57Ser-richAdd BLAST48

Domaini

The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1.1 Publication
The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 219CCHHC-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri365 – 390C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00930000150839
HOGENOMiHOG000182457
HOVERGENiHBG053268
InParanoidiO95251
KOiK11307
OMAiVYSTRRV
OrthoDBiEOG091G00D2
PhylomeDBiO95251
TreeFamiTF317619

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR036388 WH-like_DNA-bd_sf
IPR002515 Znf_C2HC
IPR036060 Znf_C2HC_sf
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF01530 zf-C2HC, 1 hit
SUPFAMiSSF103637 SSF103637, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit
PS51802 ZF_CCHHC, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95251-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRKRNAGS SSDGTEDSDF STDLEHTDSS ESDGTSRRSA RVTRSSARLS
60 70 80 90 100
QSSQDSSPVR NLQSFGTEEP AYSTRRVTRS QQQPTPVTPK KYPLRQTRSS
110 120 130 140 150
GSETEQVVDF SDRETKNTAD HDESPPRTPT GNAPSSESDI DISSPNVSHD
160 170 180 190 200
ESIAKDMSLK DSGSDLSHRP KRRRFHESYN FNMKCPTPGC NSLGHLTGKH
210 220 230 240 250
ERHFSISGCP LYHNLSADEC KVRAQSRDKQ IEERMLSHRQ DDNNRHATRH
260 270 280 290 300
QAPTERQLRY KEKVAELRKK RNSGLSKEQK EKYMEHRQTY GNTREPLLEN
310 320 330 340 350
LTSEYDLDLF RRAQARASED LEKLRLQGQI TEGSNMIKTI AFGRYELDTW
360 370 380 390 400
YHSPYPEEYA RLGRLYMCEF CLKYMKSQTI LRRHMAKCVW KHPPGDEIYR
410 420 430 440 450
KGSISVFEVD GKKNKIYCQN LCLLAKLFLD HKTLYYDVEP FLFYVMTEAD
460 470 480 490 500
NTGCHLIGYF SKEKNSFLNY NVSCILTMPQ YMRQGYGKML IDFSYLLSKV
510 520 530 540 550
EEKVGSPERP LSDLGLISYR SYWKEVLLRY LHNFQGKEIS IKEISQETAV
560 570 580 590 600
NPVDIVSTLQ ALQMLKYWKG KHLVLKRQDL IDEWIAKEAK RSNSNKTMDP
610
SCLKWTPPKG T
Length:611
Mass (Da):70,642
Last modified:May 1, 1999 - v1
Checksum:i8368E7C4F07D8D7C
GO
Isoform 2 (identifier: O95251-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-193: Missing.
     222-251: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):58,136
Checksum:i005414956B922380
GO
Isoform 3 (identifier: O95251-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-113: Missing.
     114-193: Missing.
     222-251: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):51,440
Checksum:iEF5AA3D8E63B35D0
GO
Isoform 4 (identifier: O95251-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-251: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):66,947
Checksum:i30A3E4C3E47EFBED
GO
Isoform 5 (identifier: O95251-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-113: Missing.
     114-193: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):55,135
Checksum:i906F630E44BAFD2B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUP3E7EUP3_HUMAN
Histone acetyltransferase
KAT7
425Annotation score:
D6RFZ5D6RFZ5_HUMAN
Histone acetyltransferase KAT7
KAT7
16Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38 – 44Missing in BAG57945 (PubMed:14702039).Curated7
Sequence conflicti41R → Q in BAG57346 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04255255 – 113Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_042553114 – 193Missing in isoform 2, isoform 3 and isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_042554222 – 251Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074606 mRNA Translation: AAC99368.1
AF140360 mRNA Translation: AAD42348.1
AF217502 mRNA Translation: AAL56649.1
AK023890 mRNA Translation: BAG51236.1
AK293976 mRNA Translation: BAG57346.1
AK294014 mRNA Translation: BAG57375.1
AK294052 mRNA Translation: BAG57401.1
AK294836 mRNA Translation: BAG57945.1
AC015795 Genomic DNA No translation available.
AC027801 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94658.1
CH471109 Genomic DNA Translation: EAW94659.1
BC032640 mRNA Translation: AAH32640.1
CCDSiCCDS11554.1 [O95251-1]
CCDS56035.1 [O95251-4]
CCDS56036.1 [O95251-2]
CCDS56037.1 [O95251-5]
CCDS56038.1 [O95251-3]
RefSeqiNP_001186084.1, NM_001199155.1 [O95251-4]
NP_001186085.1, NM_001199156.1 [O95251-5]
NP_001186086.1, NM_001199157.1 [O95251-2]
NP_001186087.1, NM_001199158.1 [O95251-3]
NP_008998.1, NM_007067.4 [O95251-1]
UniGeneiHs.21907

Genome annotation databases

EnsembliENST00000259021; ENSP00000259021; ENSG00000136504 [O95251-1]
ENST00000424009; ENSP00000398961; ENSG00000136504 [O95251-4]
ENST00000454930; ENSP00000413415; ENSG00000136504 [O95251-5]
ENST00000509773; ENSP00000424577; ENSG00000136504 [O95251-2]
ENST00000510819; ENSP00000423385; ENSG00000136504 [O95251-3]
GeneIDi11143
KEGGihsa:11143
UCSCiuc002ipl.3 human [O95251-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074606 mRNA Translation: AAC99368.1
AF140360 mRNA Translation: AAD42348.1
AF217502 mRNA Translation: AAL56649.1
AK023890 mRNA Translation: BAG51236.1
AK293976 mRNA Translation: BAG57346.1
AK294014 mRNA Translation: BAG57375.1
AK294052 mRNA Translation: BAG57401.1
AK294836 mRNA Translation: BAG57945.1
AC015795 Genomic DNA No translation available.
AC027801 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94658.1
CH471109 Genomic DNA Translation: EAW94659.1
BC032640 mRNA Translation: AAH32640.1
CCDSiCCDS11554.1 [O95251-1]
CCDS56035.1 [O95251-4]
CCDS56036.1 [O95251-2]
CCDS56037.1 [O95251-5]
CCDS56038.1 [O95251-3]
RefSeqiNP_001186084.1, NM_001199155.1 [O95251-4]
NP_001186085.1, NM_001199156.1 [O95251-5]
NP_001186086.1, NM_001199157.1 [O95251-2]
NP_001186087.1, NM_001199158.1 [O95251-3]
NP_008998.1, NM_007067.4 [O95251-1]
UniGeneiHs.21907

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GK9X-ray2.40A336-611[»]
ProteinModelPortaliO95251
SMRiO95251
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116315, 69 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CPX-722 HBO1-5.2 histone acetyltransferase complex
CPX-723 HBO1-5.3 histone acetyltransferase complex
CORUMiO95251
DIPiDIP-29697N
IntActiO95251, 55 interactors
MINTiO95251
STRINGi9606.ENSP00000259021

Chemistry databases

ChEMBLiCHEMBL3774299

PTM databases

iPTMnetiO95251
PhosphoSitePlusiO95251

Polymorphism and mutation databases

BioMutaiKAT7

Proteomic databases

EPDiO95251
MaxQBiO95251
PaxDbiO95251
PeptideAtlasiO95251
PRIDEiO95251
ProteomicsDBi50746
50747 [O95251-2]
50748 [O95251-3]

Protocols and materials databases

DNASUi11143
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259021; ENSP00000259021; ENSG00000136504 [O95251-1]
ENST00000424009; ENSP00000398961; ENSG00000136504 [O95251-4]
ENST00000454930; ENSP00000413415; ENSG00000136504 [O95251-5]
ENST00000509773; ENSP00000424577; ENSG00000136504 [O95251-2]
ENST00000510819; ENSP00000423385; ENSG00000136504 [O95251-3]
GeneIDi11143
KEGGihsa:11143
UCSCiuc002ipl.3 human [O95251-1]

Organism-specific databases

CTDi11143
DisGeNETi11143
EuPathDBiHostDB:ENSG00000136504.11
GeneCardsiKAT7
HGNCiHGNC:17016 KAT7
HPAiHPA044470
MIMi609880 gene
neXtProtiNX_O95251
OpenTargetsiENSG00000136504
PharmGKBiPA134886407
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00930000150839
HOGENOMiHOG000182457
HOVERGENiHBG053268
InParanoidiO95251
KOiK11307
OMAiVYSTRRV
OrthoDBiEOG091G00D2
PhylomeDBiO95251
TreeFamiTF317619

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiO95251

Miscellaneous databases

ChiTaRSiKAT7 human
GeneWikiiMYST2
GenomeRNAii11143
PROiPR:O95251
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136504 Expressed in 224 organ(s), highest expression level in testis
CleanExiHS_MYST2
ExpressionAtlasiO95251 baseline and differential
GenevisibleiO95251 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR036388 WH-like_DNA-bd_sf
IPR002515 Znf_C2HC
IPR036060 Znf_C2HC_sf
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF01530 zf-C2HC, 1 hit
SUPFAMiSSF103637 SSF103637, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit
PS51802 ZF_CCHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAT7_HUMAN
AccessioniPrimary (citable) accession number: O95251
Secondary accession number(s): B3KN74
, B4DF85, B4DFB4, B4DFE0, B4DGY4, E7ER15, G5E9K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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