UniProtKB - O95249 (GOSR1_HUMAN)
Golgi SNAP receptor complex member 1
GOSR1
Functioni
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
2 PublicationsGO - Molecular functioni
- SNAP receptor activity Source: HGNC-UCL
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: ProtInc
- protein transport Source: UniProtKB-KW
- retrograde transport, endosome to Golgi Source: HGNC-UCL
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O95249 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811438, Intra-Golgi traffic |
SignaLinki | O95249 |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi SNAP receptor complex member 1Alternative name(s): 28 kDa Golgi SNARE protein 28 kDa cis-Golgi SNARE p28 Short name: GOS-28 |
Gene namesi | Name:GOSR1 Synonyms:GS28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4430, GOSR1 |
MIMi | 604026, gene |
neXtProti | NX_O95249 |
VEuPathDBi | HostDB:ENSG00000108587 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 5 Publications; Single-pass type IV membrane protein 5 Publications
Note: Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius).By similarity
Cytosol
- cytosol Source: GOC
Golgi apparatus
- cis-Golgi network Source: GO_Central
- Golgi apparatus Source: UniProtKB
- Golgi medial cisterna Source: GO_Central
- Golgi membrane Source: BHF-UCL
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
- SNARE complex Source: GO_Central
- transport vesicle Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 229 | CytoplasmicSequence analysisAdd BLAST | 228 | |
Transmembranei | 230 – 250 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9527 |
OpenTargetsi | ENSG00000108587 |
PharmGKBi | PA28815 |
Miscellaneous databases
Pharosi | O95249, Tbio |
Genetic variation databases
BioMutai | GOSR1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000212542 | 2 – 250 | Golgi SNAP receptor complex member 1Add BLAST | 249 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 141 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95249 |
jPOSTi | O95249 |
MassIVEi | O95249 |
MaxQBi | O95249 |
PaxDbi | O95249 |
PeptideAtlasi | O95249 |
PRIDEi | O95249 |
ProteomicsDBi | 50745 [O95249-1] |
PTM databases
iPTMneti | O95249 |
MetOSitei | O95249 |
PhosphoSitePlusi | O95249 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000108587, Expressed in prostate gland and 251 other tissues |
ExpressionAtlasi | O95249, baseline and differential |
Genevisiblei | O95249, HS |
Organism-specific databases
HPAi | ENSG00000108587, Low tissue specificity |
Interactioni
Subunit structurei
Component of several multiprotein Golgi SNARE complexes.
Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3.
Interacts with GABARAPL2 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 114903, 316 interactors |
IntActi | O95249, 21 interactors |
MINTi | O95249 |
STRINGi | 9606.ENSP00000225724 |
Miscellaneous databases
RNActi | O95249, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 38 – 59 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 9 – 30 | Sequence analysisAdd BLAST | 22 | |
Coiled coili | 68 – 95 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3208, Eukaryota |
GeneTreei | ENSGT00390000008688 |
HOGENOMi | CLU_078034_0_0_1 |
InParanoidi | O95249 |
OMAi | QAYAVND |
OrthoDBi | 1319902at2759 |
PhylomeDBi | O95249 |
TreeFami | TF105782 |
Family and domain databases
InterProi | View protein in InterPro IPR023601, Golgi_SNAP_su1 |
PANTHERi | PTHR21094, PTHR21094, 1 hit |
PIRSFi | PIRSF027109, Golgi_SNARE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGTSSYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS STRDGRRDRY
60 70 80 90 100
SSDTTPLLNG SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTNSAGVPSL
110 120 130 140 150
NAALMHTLQR HRDILQDYTH EFHKTKANFM AIRERENLMG SVRKDIESYK
160 170 180 190 200
SGSGVNNRRT ELFLKEHDHL RNSDRLIEET ISIAMATKEN MTSQRGMLKS
210 220 230 240 250
IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC TILLLLYAFH
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PCW1 | E9PCW1_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 | 248 | Annotation score: | ||
G5E9T8 | G5E9T8_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 | 255 | Annotation score: | ||
K7EJC8 | K7EJC8_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 | 236 | Annotation score: | ||
B4DQA8 | B4DQA8_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 | 174 | Annotation score: | ||
F6RU00 | F6RU00_HUMAN | Golgi SNAP receptor complex member ... | GOSR1 | 81 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | D → GEARRPPD in AAC39889 (PubMed:9653160).Curated | 1 | |
Sequence conflicti | 49 – 50 | Missing in AAC39889 (PubMed:9653160).Curated | 2 | |
Sequence conflicti | 156 – 157 | NN → TT in AAC39889 (PubMed:9653160).Curated | 2 | |
Sequence conflicti | 159 | R → G in AAC39889 (PubMed:9653160).Curated | 1 | |
Sequence conflicti | 170 | L → F in AAC39889 (PubMed:9653160).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047326 | 1 – 65 | Missing in isoform 2. CuratedAdd BLAST | 65 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047438 mRNA Translation: AAC39889.1 AF073926 mRNA Translation: AAD12945.1 AC006050 Genomic DNA No translation available. AC011840 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51229.1 BC040471 mRNA Translation: AAH40471.1 |
CCDSi | CCDS11258.1 [O95249-1] CCDS45644.1 [O95249-2] |
RefSeqi | NP_001007025.1, NM_001007024.1 [O95249-2] NP_001007026.1, NM_001007025.1 NP_004862.1, NM_004871.2 [O95249-1] XP_005258129.1, XM_005258072.2 [O95249-2] |
Genome annotation databases
Ensembli | ENST00000225724.9; ENSP00000225724.5; ENSG00000108587.16 ENST00000467337.6; ENSP00000462638.1; ENSG00000108587.16 [O95249-2] |
GeneIDi | 9527 |
KEGGi | hsa:9527 |
UCSCi | uc002hfe.4, human [O95249-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047438 mRNA Translation: AAC39889.1 AF073926 mRNA Translation: AAD12945.1 AC006050 Genomic DNA No translation available. AC011840 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51229.1 BC040471 mRNA Translation: AAH40471.1 |
CCDSi | CCDS11258.1 [O95249-1] CCDS45644.1 [O95249-2] |
RefSeqi | NP_001007025.1, NM_001007024.1 [O95249-2] NP_001007026.1, NM_001007025.1 NP_004862.1, NM_004871.2 [O95249-1] XP_005258129.1, XM_005258072.2 [O95249-2] |
3D structure databases
AlphaFoldDBi | O95249 |
SMRi | O95249 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114903, 316 interactors |
IntActi | O95249, 21 interactors |
MINTi | O95249 |
STRINGi | 9606.ENSP00000225724 |
PTM databases
iPTMneti | O95249 |
MetOSitei | O95249 |
PhosphoSitePlusi | O95249 |
Genetic variation databases
BioMutai | GOSR1 |
Proteomic databases
EPDi | O95249 |
jPOSTi | O95249 |
MassIVEi | O95249 |
MaxQBi | O95249 |
PaxDbi | O95249 |
PeptideAtlasi | O95249 |
PRIDEi | O95249 |
ProteomicsDBi | 50745 [O95249-1] |
Protocols and materials databases
Antibodypediai | 15149, 189 antibodies from 29 providers |
DNASUi | 9527 |
Genome annotation databases
Ensembli | ENST00000225724.9; ENSP00000225724.5; ENSG00000108587.16 ENST00000467337.6; ENSP00000462638.1; ENSG00000108587.16 [O95249-2] |
GeneIDi | 9527 |
KEGGi | hsa:9527 |
UCSCi | uc002hfe.4, human [O95249-1] |
Organism-specific databases
CTDi | 9527 |
DisGeNETi | 9527 |
GeneCardsi | GOSR1 |
HGNCi | HGNC:4430, GOSR1 |
HPAi | ENSG00000108587, Low tissue specificity |
MIMi | 604026, gene |
neXtProti | NX_O95249 |
OpenTargetsi | ENSG00000108587 |
PharmGKBi | PA28815 |
VEuPathDBi | HostDB:ENSG00000108587 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3208, Eukaryota |
GeneTreei | ENSGT00390000008688 |
HOGENOMi | CLU_078034_0_0_1 |
InParanoidi | O95249 |
OMAi | QAYAVND |
OrthoDBi | 1319902at2759 |
PhylomeDBi | O95249 |
TreeFami | TF105782 |
Enzyme and pathway databases
PathwayCommonsi | O95249 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811438, Intra-Golgi traffic |
SignaLinki | O95249 |
Miscellaneous databases
BioGRID-ORCSi | 9527, 35 hits in 1085 CRISPR screens |
ChiTaRSi | GOSR1, human |
GeneWikii | GOSR1 |
GenomeRNAii | 9527 |
Pharosi | O95249, Tbio |
PROi | PR:O95249 |
RNActi | O95249, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108587, Expressed in prostate gland and 251 other tissues |
ExpressionAtlasi | O95249, baseline and differential |
Genevisiblei | O95249, HS |
Family and domain databases
InterProi | View protein in InterPro IPR023601, Golgi_SNAP_su1 |
PANTHERi | PTHR21094, PTHR21094, 1 hit |
PIRSFi | PIRSF027109, Golgi_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GOSR1_HUMAN | |
Accessioni | O95249Primary (citable) accession number: O95249 Secondary accession number(s): J3KST5, O75392 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families