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UniProtKB - O95243 (MBD4_HUMAN)

Entry version 171 (02 Jun 2021)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Methyl-CpG-binding domain protein 4

Gene

MBD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei560By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95243

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329, Cleavage of the damaged pyrimidine
R-HSA-110357, Displacement of DNA glycosylase by APEX1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 4 (EC:3.2.2.-)
Alternative name(s):
Methyl-CpG-binding endonuclease 1
Methyl-CpG-binding protein MBD4
Mismatch-specific DNA N-glycosylase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBD4
Synonyms:MED1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6919, MBD4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603574, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95243

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000129071.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8930

Open Targets

More...OpenTargetsi		ENSG00000129071

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30663

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95243, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MBD4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000962641 – 580Methyl-CpG-binding domain protein 4Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei318PhosphoserineCombined sources1
Modified residuei428PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95243

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95243

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95243

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95243

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95243

PeptideAtlas

More...PeptideAtlasi		O95243

PRoteomics IDEntifications database

More...PRIDEi		O95243

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19871
50740 [O95243-1]
50741 [O95243-2]
50742 [O95243-3]
61389

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O95243-3 [O95243-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95243

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O95243

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95243

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000129071, Expressed in secondary oocyte and 261 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95243, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95243, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000129071, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MLH1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114444, 34 interactors

Protein interaction database and analysis system

More...IntActi		O95243, 24 interactors

Molecular INTeraction database

More...MINTi		O95243

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000249910

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95243, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O95243

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95243

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O95243

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 148MBDPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4161, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063687

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034167_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95243

Identification of Orthologs from Complete Genome Data

More...OMAi		TRSRWKK

Database of Orthologous Groups

More...OrthoDBi		1574293at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95243

TreeFam database of animal gene trees

More...TreeFami		TF329176

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016177, DNA-bd_dom_sf
IPR011257, DNA_glycosylase
IPR017352, MBD4
IPR001739, Methyl_CpG_DNA-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01429, MBD, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038005, Methyl_CpG_bd_MBD4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00391, MBD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48150, SSF48150, 1 hit
SSF54171, SSF54171, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50982, MBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95243-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE 
        60         70         80         90        100
EQMMIKRSSE CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG 
       110        120        130        140        150
KTAGRFDVYF ISPQGLKFRS KSSLANYLHK NGETSLKPED FDFTVLSKRG 
       160        170        180        190        200
IKSRYKDCSM AALTSHLQNQ SNNSNWNLRT RSKCKKDVFM PPSSSSELQE 
       210        220        230        240        250
SRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG IPIKKTKKGC 
       260        270        280        290        300
RKSCSGFVQS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL 
       310        320        330        340        350
SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED 
       360        370        380        390        400
TFLESEEIGT KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTGEKIFQ 
       410        420        430        440        450
EDTIPRTQIE RRKTSLYFSS KYNKEALSPP RRKAFKKWTP PRSPFNLVQE 
       460        470        480        490        500
TLFHDPWKLL IATIFLNRTS GKMAIPVLWK FLEKYPSAEV ARTADWRDVS 
       510        520        530        540        550
ELLKPLGLYD LRAKTIVKFS DEYLTKQWKY PIELHGIGKY GNDSYRIFCV 
       560        570        580
NEWKQVHPED HKLNKYHDWL WENHEKLSLS
Length:580
Mass (Da):66,051
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF16FB21A34B8E5F
GO
Isoform 2 (identifier: O95243-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     395-400: Missing.

Show »
Length:574
Mass (Da):65,348
Checksum:i33809A26A2E61A26
GO
Isoform 3 (identifier: O95243-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-540: KY → AP
     541-580: Missing.

Show »
Length:540
Mass (Da):60,949
Checksum:i3131CE4F9A488371
GO
Isoform 5 (identifier: O95243-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-580: HPEDHKLNKYHDWLWENHEKLSLS → RLTPIHNSAHLVSEAK

Show »
Length:572
Mass (Da):64,768
Checksum:i8550E8B5D9372097
GO
Isoform 4 (identifier: O95243-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-401: RKSVPCGWER...DFTGEKIFQE → Q

Note: Possesses uracil DNA glycosylase but not thymine DNA glycosylase activity.Curated
Show »
Length:262
Mass (Da):30,316
Checksum:i578F5642D59D353D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBI7D6RBI7_HUMAN
Methyl-CpG-binding domain protein 4
MBD4
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51E → G in BAG64144 (PubMed:14702039).Curated1
Sequence conflicti359G → R in BAG64144 (PubMed:14702039).Curated1
Sequence conflicti387S → L in BAG64144 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02930661C → R. Corresponds to variant dbSNP:rs2307296Ensembl.1
Natural variantiVAR_019357273A → S1 PublicationCorresponds to variant dbSNP:rs10342Ensembl.1
Natural variantiVAR_019514273A → T. Corresponds to variant dbSNP:rs10342Ensembl.1
Natural variantiVAR_019358342S → P1 PublicationCorresponds to variant dbSNP:rs2307289Ensembl.1
Natural variantiVAR_019359346E → K1 PublicationCorresponds to variant dbSNP:rs140693Ensembl.1
Natural variantiVAR_019515358I → T. Corresponds to variant dbSNP:rs2307298Ensembl.1
Natural variantiVAR_019360568D → H1 PublicationCorresponds to variant dbSNP:rs2307293Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05484583 – 401RKSVP…KIFQE → Q in isoform 4. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_010816395 – 400Missing in isoform 2. 2 Publications6
Alternative sequenceiVSP_010817539 – 540KY → AP in isoform 3. 1 Publication2
Alternative sequenceiVSP_010818541 – 580Missing in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_054846557 – 580HPEDH…KLSLS → RLTPIHNSAHLVSEAK in isoform 5. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF072250 mRNA Translation: AAC68879.1
AF120999, AF120997, AF120998 Genomic DNA Translation: AAD50374.1
AF114784 mRNA Translation: AAD22195.1
AM180876 mRNA Translation: CAJ55826.1
AF532602 mRNA Translation: AAP97338.1
AK303013 mRNA Translation: BAG64144.1
CR450305 mRNA Translation: CAG29301.1
AF494057 Genomic DNA Translation: AAM00008.1
AL449212 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79251.1
CH471052 Genomic DNA Translation: EAW79253.1
CH471052 Genomic DNA Translation: EAW79254.1
CH471052 Genomic DNA Translation: EAW79255.1
BC011752 mRNA Translation: AAH11752.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3058.1 [O95243-1]
CCDS63766.1 [O95243-5]
CCDS63767.1 [O95243-3]
CCDS63768.1 [O95243-2]
CCDS63769.1 [O95243-6]

NCBI Reference Sequences

More...RefSeqi		NP_001263199.1, NM_001276270.1 [O95243-2]
NP_001263200.1, NM_001276271.1 [O95243-5]
NP_001263201.1, NM_001276272.1 [O95243-3]
NP_001263202.1, NM_001276273.1 [O95243-6]
NP_003916.1, NM_003925.2 [O95243-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000249910; ENSP00000249910; ENSG00000129071 [O95243-1]
ENST00000393278; ENSP00000376959; ENSG00000129071 [O95243-6]
ENST00000429544; ENSP00000394080; ENSG00000129071 [O95243-2]
ENST00000503197; ENSP00000424873; ENSG00000129071 [O95243-3]
ENST00000507208; ENSP00000422327; ENSG00000129071 [O95243-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8930

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8930

UCSC genome browser

More...UCSCi		uc003emh.3, human [O95243-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072250 mRNA Translation: AAC68879.1
AF120999, AF120997, AF120998 Genomic DNA Translation: AAD50374.1
AF114784 mRNA Translation: AAD22195.1
AM180876 mRNA Translation: CAJ55826.1
AF532602 mRNA Translation: AAP97338.1
AK303013 mRNA Translation: BAG64144.1
CR450305 mRNA Translation: CAG29301.1
AF494057 Genomic DNA Translation: AAM00008.1
AL449212 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79251.1
CH471052 Genomic DNA Translation: EAW79253.1
CH471052 Genomic DNA Translation: EAW79254.1
CH471052 Genomic DNA Translation: EAW79255.1
BC011752 mRNA Translation: AAH11752.1
CCDSiCCDS3058.1 [O95243-1]
CCDS63766.1 [O95243-5]
CCDS63767.1 [O95243-3]
CCDS63768.1 [O95243-2]
CCDS63769.1 [O95243-6]
RefSeqiNP_001263199.1, NM_001276270.1 [O95243-2]
NP_001263200.1, NM_001276271.1 [O95243-5]
NP_001263201.1, NM_001276272.1 [O95243-3]
NP_001263202.1, NM_001276273.1 [O95243-6]
NP_003916.1, NM_003925.2 [O95243-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MOENMR-A80-148[»]
3IHOX-ray2.70A437-574[»]
4DK9X-ray2.76A426-580[»]
4E9EX-ray1.90A427-580[»]
4E9FX-ray1.79A427-580[»]
4E9GX-ray2.35A427-580[»]
4E9HX-ray3.00A427-580[»]
4EA4X-ray2.00A427-574[»]
4EA5X-ray2.14A427-580[»]
4LG7X-ray2.50A83-149[»]
4OFAX-ray1.55A426-580[»]
4OFEX-ray2.15A426-580[»]
4OFHX-ray2.22A426-580[»]
5CHZX-ray1.83A426-580[»]
6VJWX-ray2.02A438-575[»]
BMRBiO95243
SMRiO95243
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114444, 34 interactors
IntActiO95243, 24 interactors
MINTiO95243
STRINGi9606.ENSP00000249910

PTM databases

iPTMnetiO95243
MetOSiteiO95243
PhosphoSitePlusiO95243

Genetic variation databases

BioMutaiMBD4

Proteomic databases

EPDiO95243
jPOSTiO95243
MassIVEiO95243
MaxQBiO95243
PaxDbiO95243
PeptideAtlasiO95243
PRIDEiO95243
ProteomicsDBi19871
50740 [O95243-1]
50741 [O95243-2]
50742 [O95243-3]
61389
TopDownProteomicsiO95243-3 [O95243-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		O95243, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1087, 217 antibodies

The DNASU plasmid repository

More...DNASUi		8930

Genome annotation databases

EnsembliENST00000249910; ENSP00000249910; ENSG00000129071 [O95243-1]
ENST00000393278; ENSP00000376959; ENSG00000129071 [O95243-6]
ENST00000429544; ENSP00000394080; ENSG00000129071 [O95243-2]
ENST00000503197; ENSP00000424873; ENSG00000129071 [O95243-3]
ENST00000507208; ENSP00000422327; ENSG00000129071 [O95243-5]
GeneIDi8930
KEGGihsa:8930
UCSCiuc003emh.3, human [O95243-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8930
DisGeNETi8930

GeneCards: human genes, protein and diseases

More...GeneCardsi		MBD4
HGNCiHGNC:6919, MBD4
HPAiENSG00000129071, Low tissue specificity
MIMi603574, gene
neXtProtiNX_O95243
OpenTargetsiENSG00000129071
PharmGKBiPA30663
VEuPathDBiHostDB:ENSG00000129071.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4161, Eukaryota
GeneTreeiENSGT00530000063687
HOGENOMiCLU_034167_0_0_1
InParanoidiO95243
OMAiTRSRWKK
OrthoDBi1574293at2759
PhylomeDBiO95243
TreeFamiTF329176

Enzyme and pathway databases

PathwayCommonsiO95243
ReactomeiR-HSA-110328, Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329, Cleavage of the damaged pyrimidine
R-HSA-110357, Displacement of DNA glycosylase by APEX1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8930, 2 hits in 1016 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MBD4, human
EvolutionaryTraceiO95243

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MBD4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8930
PharosiO95243, Tbio

Protein Ontology

More...PROi		PR:O95243
RNActiO95243, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000129071, Expressed in secondary oocyte and 261 other tissues
ExpressionAtlasiO95243, baseline and differential
GenevisibleiO95243, HS

Family and domain databases

InterProiView protein in InterPro
IPR016177, DNA-bd_dom_sf
IPR011257, DNA_glycosylase
IPR017352, MBD4
IPR001739, Methyl_CpG_DNA-bd
PfamiView protein in Pfam
PF01429, MBD, 1 hit
PIRSFiPIRSF038005, Methyl_CpG_bd_MBD4, 1 hit
SMARTiView protein in SMART
SM00391, MBD, 1 hit
SUPFAMiSSF48150, SSF48150, 1 hit
SSF54171, SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50982, MBD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95243
Secondary accession number(s): B4DZN2
, D3DNC3, D3DNC4, E9PEE4, Q2MD36, Q7Z4T3, Q96F09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: June 2, 2021
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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