UniProtKB - O95239 (KIF4A_HUMAN)
Chromosome-associated kinesin KIF4A
KIF4A
Functioni
Cofactori
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 88 – 95 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- iron-sulfur cluster binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- microtubule binding Source: InterPro
- microtubule motor activity Source: ProtInc
GO - Biological processi
- anterograde axonal transport Source: ProtInc
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- microtubule-based movement Source: Reactome
- mitotic cytokinesis Source: UniProtKB
- mitotic spindle midzone assembly Source: UniProtKB
- mitotic spindle organization Source: GO_Central
- organelle organization Source: ProtInc
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: Reactome
Keywordsi
Molecular function | DNA-binding, Motor protein |
Ligand | ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O95239 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-437239, Recycling pathway of L1 R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosome-associated kinesin KIF4AAlternative name(s): Chromokinesin-A |
Gene namesi | Name:KIF4A Synonyms:KIF4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13339, KIF4A |
MIMi | 300521, gene |
neXtProti | NX_O95239 |
VEuPathDBi | HostDB:ENSG00000090889.11 |
Subcellular locationi
Cytoskeleton
- spindle 2 Publications
Nucleus
- Nucleus matrix 1 Publication
Other locations
- Cytoplasm 1 Publication
- Midbody 2 Publications
- Chromosome 3 Publications
Note: Associates with chromosomes at all stage of mitosis (PubMed:11736643, PubMed:15297875, PubMed:15625105). Chromatin localization is dependent on iron-sulfur cluster binding (PubMed:29848660). In anaphase, associates with the mitotic spindle midzone (PubMed:15297875). In telophase and cytokinesis, co-localizes with CIAO2B at the spindle midzone and midbody (PubMed:29848660, PubMed:15297875). Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). Does not localize to the nucleolus (PubMed:11736643).4 Publications
Cytoskeleton
- spindle microtubule Source: ProtInc
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear matrix Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
Other locations
- axon cytoplasm Source: GOC
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: ProtInc
- membrane Source: UniProtKB
- midbody Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Cytoplasm, Cytoskeleton, Microtubule, NucleusPathology & Biotechi
Involvement in diseasei
Mental retardation, X-linked 100 (MRX100)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1086 – 1144 | Missing : Diffuse localization and does not localize to the spindle midzone or midbody during anaphase and telophase. Does not affect the interaction with PRC1. 1 PublicationAdd BLAST | 59 | |
Mutagenesisi | 1106 | C → A: Abolishes chromatin localization; in association with A-1110 and A-1112. 1 Publication | 1 | |
Mutagenesisi | 1110 | C → A: Abolishes chromatin localization; in association with A-1106 and A-1112. 1 Publication | 1 | |
Mutagenesisi | 1112 | C → A: Abolishes chromatin localization; in association with A-1106 and A-1110. 1 Publication | 1 |
Keywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 24137 |
MalaCardsi | KIF4A |
MIMi | 300923, phenotype |
OpenTargetsi | ENSG00000090889 |
PharmGKBi | PA30105 |
Miscellaneous databases
Pharosi | O95239, Tbio |
Chemistry databases
ChEMBLi | CHEMBL6163 |
Genetic variation databases
BioMutai | KIF4A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125437 | 1 – 1232 | Chromosome-associated kinesin KIF4AAdd BLAST | 1232 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 394 | PhosphoserineBy similarity | 1 | |
Modified residuei | 799 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 801 | PhosphoserineCombined sources | 1 | |
Modified residuei | 810 | PhosphoserineBy similarity | 1 | |
Modified residuei | 815 | PhosphoserineCombined sources | 1 | |
Modified residuei | 951 | PhosphoserineCombined sources | 1 | |
Modified residuei | 995 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1001 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1013 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1017 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1028 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1126 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1181 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1186 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1194 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1225 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-971 |
EPDi | O95239 |
jPOSTi | O95239 |
MassIVEi | O95239 |
MaxQBi | O95239 |
PaxDbi | O95239 |
PeptideAtlasi | O95239 |
PRIDEi | O95239 |
ProteomicsDBi | 50738 [O95239-1] 50739 [O95239-2] |
PTM databases
iPTMneti | O95239 |
MetOSitei | O95239 |
PhosphoSitePlusi | O95239 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000090889, Expressed in oocyte and 139 other tissues |
Genevisiblei | O95239, HS |
Organism-specific databases
HPAi | ENSG00000090889, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with the cytosolic iron-sulfur protein assembly (CIA) complex components CIAO2B and MMS19; the interactions facilitate the transfer of Fe-S clusters to KIF4A to ensure proper localization of KIF4A to mitotic machinery components (PubMed:29848660).
Interacts (via C-terminus) with unphosphorylated PRC1 (via N-terminus); the interaction is required for the progression of mitosis (PubMed:15297875, PubMed:15625105, PubMed:29848660).
3 PublicationsBinary interactionsi
Hide detailsO95239
With | #Exp. | IntAct |
---|---|---|
PHF14 [O94880] | 4 | EBI-1057516,EBI-2680164 |
PHF14 - isoform 1 [O94880-1] | 3 | EBI-1057516,EBI-16716857 |
GO - Molecular functioni
- microtubule binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 117288, 44 interactors |
CORUMi | O95239 |
ELMi | O95239 |
IntActi | O95239, 17 interactors |
MINTi | O95239 |
STRINGi | 9606.ENSP00000363524 |
Miscellaneous databases
RNActi | O95239, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 336 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 328 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 663 – 1232 | Required for the interaction with PRC11 PublicationAdd BLAST | 570 | |
Regioni | 1000 – 1232 | GlobularAdd BLAST | 233 | |
Regioni | 1086 – 1144 | CRD; required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase1 PublicationAdd BLAST | 59 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 350 – 999 | Sequence analysisAdd BLAST | 650 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 793 – 798 | Nuclear localization signal1 Publication | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1086 – 1117 | Cys-richPROSITE-ProRule annotationAdd BLAST | 32 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0244, Eukaryota |
GeneTreei | ENSGT00940000158195 |
HOGENOMi | CLU_001485_4_1_1 |
InParanoidi | O95239 |
OMAi | GCLELGN |
PhylomeDBi | O95239 |
TreeFami | TF105224 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGEPQ VVVGTDKSFT
60 70 80 90 100
YDFVFDPSTE QEEVFNTAVA PLIKGVFKGY NATVLAYGQT GSGKTYSMGG
110 120 130 140 150
AYTAEQENEP TVGVIPRVIQ LLFKEIDKKS DFEFTLKVSY LEIYNEEILD
160 170 180 190 200
LLCPSREKAQ INIREDPKEG IKIVGLTEKT VLVALDTVSC LEQGNNSRTV
210 220 230 240 250
ASTAMNSQSS RSHAIFTISL EQRKKSDKNS SFRSKLHLVD LAGSERQKKT
260 270 280 290 300
KAEGDRLKEG ININRGLLCL GNVISALGDD KKGGFVPYRD SKLTRLLQDS
310 320 330 340 350
LGGNSHTLMI ACVSPADSNL EETLNTLRYA DRARKIKNKP IVNIDPQTAE
360 370 380 390 400
LNHLKQQVQQ LQVLLLQAHG GTLPGSITVE PSENLQSLME KNQSLVEENE
410 420 430 440 450
KLSRGLSEAA GQTAQMLERI ILTEQANEKM NAKLEELRQH AACKLDLQKL
460 470 480 490 500
VETLEDQELK ENVEIICNLQ QLITQLSDET VACMAAAIDT AVEQEAQVET
510 520 530 540 550
SPETSRSSDA FTTQHALRQA QMSKELVELN KALALKEALA RKMTQNDSQL
560 570 580 590 600
QPIQYQYQDN IKELELEVIN LQKEKEELVL ELQTAKKDAN QAKLSERRRK
610 620 630 640 650
RLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI RMMKNQRVQL
660 670 680 690 700
MRQMKEDAEK FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSNVL
710 720 730 740 750
RRKTEEAAAA NKRLKDALQK QREVADKRKE TQSRGMEGTA ARVKNWLGNE
760 770 780 790 800
IEVMVSTEEA KRHLNDLLED RKILAQDVAQ LKEKKESGEN PPPKLRRRTF
810 820 830 840 850
SLTEVRGQVS ESEDSITKQI ESLETEMEFR SAQIADLQQK LLDAESEDRP
860 870 880 890 900
KQRWENIATI LEAKCALKYL IGELVSSKIQ VSKLESSLKQ SKTSCADMQK
910 920 930 940 950
MLFEERNHFA EIETELQAEL VRMEQQHQEK VLYLLSQLQQ SQMAEKQLEE
960 970 980 990 1000
SVSEKEQQLL STLKCQDEEL EKMREVCEQN QQLLRENEII KQKLTLLQVA
1010 1020 1030 1040 1050
SRQKHLPKDT LLSPDSSFEY VPPKPKPSRV KEKFLEQSMD IEDLKYCSEH
1060 1070 1080 1090 1100
SVNEHEDGDG DDDEGDDEEW KPTKLVKVSR KNIQGCSCKG WCGNKQCGCR
1110 1120 1130 1140 1150
KQKSDCGVDC CCDPTKCRNR QQGKDSLGTV ERTQDSEGSF KLEDPTEVTP
1160 1170 1180 1190 1200
GLSFFNPVCA TPNSKILKEM CDVEQVLSKK TPPAPSPFDL PELKHVATEY
1210 1220 1230
QENKAPGKKK KRALASNTSF FSGCSPIEEE AH
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 223 | R → G in AAD05492 (PubMed:10978527).Curated | 1 | |
Sequence conflicti | 231 | S → T in AAF86334 (PubMed:9168136).Curated | 1 | |
Sequence conflicti | 286 | V → A in AAD05492 (PubMed:10978527).Curated | 1 | |
Sequence conflicti | 564 | L → H in AAF86334 (PubMed:9168136).Curated | 1 | |
Sequence conflicti | 564 | L → P in AAD05492 (PubMed:10978527).Curated | 1 | |
Sequence conflicti | 600 | K → E in CAB75427 (Ref. 3) Curated | 1 | |
Sequence conflicti | 668 | K → R (Ref. 1) Curated | 1 | |
Sequence conflicti | 668 | K → R (PubMed:10978527).Curated | 1 | |
Sequence conflicti | 928 | Q → P in AAD51855 (Ref. 1) Curated | 1 | |
Sequence conflicti | 958 | Q → R in CAB75427 (Ref. 3) Curated | 1 | |
Sequence conflicti | 960 | L → Q in AAD51855 (Ref. 1) Curated | 1 | |
Sequence conflicti | 996 – 997 | LL → S in AAF86334 (PubMed:9168136).Curated | 2 | |
Sequence conflicti | 1003 – 1014 | QKHLP…TLLSP → RTLPRIPFYLQ in AAF86334 (PubMed:9168136).CuratedAdd BLAST | 12 | |
Sequence conflicti | 1022 | P → Q in AAD05492 (PubMed:10978527).Curated | 1 | |
Sequence conflicti | 1077 | K → N in AAD05492 (PubMed:10978527).Curated | 1 | |
Sequence conflicti | 1138 | G → S in AAD05492 (PubMed:10978527).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021828 | 422 | L → W2 PublicationsCorresponds to variant dbSNP:rs1199457Ensembl. | 1 | |
Natural variantiVAR_049693 | 491 | A → V. Corresponds to variant dbSNP:rs2297871EnsemblClinVar. | 1 | |
Natural variantiVAR_049694 | 1193 | L → S. Corresponds to variant dbSNP:rs1046485Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013375 | 1086 – 1127 | CSCKG…GKDSL → VLLLTPVISALWEAEARGLL EARSSRPAWATWRDPVSTKP KN in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_013376 | 1128 – 1232 | Missing in isoform 2. 1 PublicationAdd BLAST | 105 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF179308 mRNA Translation: AAD51855.1 AF071592 mRNA Translation: AAD05492.2 AJ271784 mRNA Translation: CAB75427.1 AK313133 mRNA Translation: BAG35952.1 AL139398 Genomic DNA No translation available. AL357752 Genomic DNA No translation available. CH471132 Genomic DNA Translation: EAX05341.1 CH471132 Genomic DNA Translation: EAX05342.1 BC049218 mRNA Translation: AAH49218.1 Sequence problems. BC050548 mRNA Translation: AAH50548.1 AF277375 mRNA Translation: AAF86334.1 |
CCDSi | CCDS14401.1 [O95239-1] |
RefSeqi | NP_036442.3, NM_012310.4 [O95239-1] |
Genome annotation databases
Ensembli | ENST00000374403; ENSP00000363524; ENSG00000090889 [O95239-1] |
GeneIDi | 24137 |
KEGGi | hsa:24137 |
UCSCi | uc004dyg.4, human [O95239-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF179308 mRNA Translation: AAD51855.1 AF071592 mRNA Translation: AAD05492.2 AJ271784 mRNA Translation: CAB75427.1 AK313133 mRNA Translation: BAG35952.1 AL139398 Genomic DNA No translation available. AL357752 Genomic DNA No translation available. CH471132 Genomic DNA Translation: EAX05341.1 CH471132 Genomic DNA Translation: EAX05342.1 BC049218 mRNA Translation: AAH49218.1 Sequence problems. BC050548 mRNA Translation: AAH50548.1 AF277375 mRNA Translation: AAF86334.1 |
CCDSi | CCDS14401.1 [O95239-1] |
RefSeqi | NP_036442.3, NM_012310.4 [O95239-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6OYL | X-ray | 3.15 | B | 1192-1232 | [»] | |
SMRi | O95239 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117288, 44 interactors |
CORUMi | O95239 |
ELMi | O95239 |
IntActi | O95239, 17 interactors |
MINTi | O95239 |
STRINGi | 9606.ENSP00000363524 |
Chemistry databases
ChEMBLi | CHEMBL6163 |
PTM databases
iPTMneti | O95239 |
MetOSitei | O95239 |
PhosphoSitePlusi | O95239 |
Genetic variation databases
BioMutai | KIF4A |
Proteomic databases
CPTACi | CPTAC-971 |
EPDi | O95239 |
jPOSTi | O95239 |
MassIVEi | O95239 |
MaxQBi | O95239 |
PaxDbi | O95239 |
PeptideAtlasi | O95239 |
PRIDEi | O95239 |
ProteomicsDBi | 50738 [O95239-1] 50739 [O95239-2] |
Protocols and materials databases
Antibodypediai | 27394, 212 antibodies |
Genome annotation databases
Ensembli | ENST00000374403; ENSP00000363524; ENSG00000090889 [O95239-1] |
GeneIDi | 24137 |
KEGGi | hsa:24137 |
UCSCi | uc004dyg.4, human [O95239-1] |
Organism-specific databases
CTDi | 24137 |
DisGeNETi | 24137 |
GeneCardsi | KIF4A |
HGNCi | HGNC:13339, KIF4A |
HPAi | ENSG00000090889, Tissue enhanced (bone marrow, lymphoid tissue) |
MalaCardsi | KIF4A |
MIMi | 300521, gene 300923, phenotype |
neXtProti | NX_O95239 |
OpenTargetsi | ENSG00000090889 |
PharmGKBi | PA30105 |
VEuPathDBi | HostDB:ENSG00000090889.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0244, Eukaryota |
GeneTreei | ENSGT00940000158195 |
HOGENOMi | CLU_001485_4_1_1 |
InParanoidi | O95239 |
OMAi | GCLELGN |
PhylomeDBi | O95239 |
TreeFami | TF105224 |
Enzyme and pathway databases
PathwayCommonsi | O95239 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-437239, Recycling pathway of L1 R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
Miscellaneous databases
BioGRID-ORCSi | 24137, 229 hits in 508 CRISPR screens |
ChiTaRSi | KIF4A, human |
GeneWikii | KIF4A |
GenomeRNAii | 24137 |
Pharosi | O95239, Tbio |
PROi | PR:O95239 |
RNActi | O95239, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090889, Expressed in oocyte and 139 other tissues |
Genevisiblei | O95239, HS |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF4A_HUMAN | |
Accessioni | O95239Primary (citable) accession number: O95239 Secondary accession number(s): B2R7V5 Q9UMW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | April 12, 2005 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families