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Protein

Apolipoprotein L3

Gene

APOL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipid binding Source: GO_Central
  • lipid transporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein L3
Alternative name(s):
Apolipoprotein L-III
Short name:
ApoL-III
TNF-inducible protein CG12-1
Short name:
CG12_1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000128284.19

Human Gene Nomenclature Database

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HGNCi
HGNC:14868 APOL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607253 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95236

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80833

Open Targets

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OpenTargetsi
ENSG00000128284

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24906

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APOL3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001376021 – 402Apolipoprotein L3Add BLAST402

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95236

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95236

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95236

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95236

PeptideAtlas

More...
PeptideAtlasi
O95236

PRoteomics IDEntifications database

More...
PRIDEi
O95236

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50733
50734 [O95236-2]
50735 [O95236-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95236

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95236

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In vitro, is responsive to TNF.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000128284 Expressed in 221 organ(s), highest expression level in subcutaneous adipose tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_APOL3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95236 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95236 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036228

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O95236, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344577

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95236

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95236

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWES Eukaryota
ENOG410Y0AF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000046700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294132

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG074468

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95236

KEGG Orthology (KO)

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KOi
K14480

Identification of Orthologs from Complete Genome Data

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OMAi
IGKNIRA

Database of Orthologous Groups

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OrthoDBi
1060131at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95236

TreeFam database of animal gene trees

More...
TreeFami
TF334681

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008405 ApoL

The PANTHER Classification System

More...
PANTHERi
PTHR14096 PTHR14096, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05461 ApoL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95236-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLGQGWGWE ASCFACLIRS CCQVVTFTFP FGFQGISQSL ENVSGYYADA
60 70 80 90 100
RLEVGSTQLR TAGSCSHSFK RSFLEKKRFT EEATKYFRER VSPVHLQILL
110 120 130 140 150
TNNEAWKRFV TAAELPRDEA DALYEALKKL RTYAAIEDEY VQQKDEQFRE
160 170 180 190 200
WFLKEFPQVK RKIQESIEKL RALANGIEEV HRGCTISNVV SSSTGAASGI
210 220 230 240 250
MSLAGLVLAP FTAGTSLALT AAGVGLGAAS AVTGITTSIV EHSYTSSAEA
260 270 280 290 300
EASRLTATSI DRLKVFKEVM RDITPNLLSL LNNYYEATQT IGSEIRAIRQ
310 320 330 340 350
ARARARLPVT TWRISAGSGG QAERTIAGTT RAVSRGARIL SATTSGIFLA
360 370 380 390 400
LDVVNLVYES KHLHEGAKSA SAEELRRQAQ ELEENLMELT QIYQRLNPCH

TH
Length:402
Mass (Da):44,278
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8356C8247817F66A
GO
Isoform 2 (identifier: O95236-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MGLGQGWGWE...CSHSFKRSFL → MDS

Show »
Length:331
Mass (Da):36,545
Checksum:iC7703BAE5D0302FA
GO
Isoform 3 (identifier: O95236-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Show »
Length:202
Mass (Da):21,597
Checksum:i3C560B4F74CE837E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2M3F2Z2M3_HUMAN
Apolipoprotein L3
APOL3
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYQ5H7BYQ5_HUMAN
Apolipoprotein L3
APOL3
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCT0H0YCT0_HUMAN
Apolipoprotein L3
APOL3
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD32H0YD32_HUMAN
Apolipoprotein L3
APOL3
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEQ0H0YEQ0_HUMAN
Apolipoprotein L3
APOL3
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDH5H0YDH5_HUMAN
Apolipoprotein L3
APOL3
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEJ6H0YEJ6_HUMAN
Apolipoprotein L3
APOL3
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDW3H0YDW3_HUMAN
Apolipoprotein L3
APOL3
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05300739S → R1 PublicationCorresponds to variant dbSNP:rs132653Ensembl.1
Natural variantiVAR_047488135A → V. Corresponds to variant dbSNP:rs6000152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0002941 – 200Missing in isoform 3. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_0002931 – 74MGLGQ…KRSFL → MDS in isoform 2. 5 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF070675 mRNA Translation: AAC83233.1
AF324238, AF324233, AF324237 Genomic DNA Translation: AAK26528.1
AY014904 mRNA Translation: AAG50346.1
AF324238, AF324236, AF324237 Genomic DNA Translation: AAK26529.1
AY014902 mRNA Translation: AAG50344.1
AY014903 mRNA Translation: AAG50345.1
AY014905 mRNA Translation: AAG50347.1
AF324238 Genomic DNA Translation: AAK26527.1
AY014906 mRNA Translation: AAG50348.1
AY014907 mRNA Translation: AAG50349.1
AF305227 mRNA Translation: AAK20213.1
CR456379 mRNA Translation: CAG30265.1
Z95114 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60080.1
BC042918 mRNA Translation: AAH42918.1
BC050596 mRNA Translation: AAH50596.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13922.1 [O95236-1]
CCDS13923.1 [O95236-2]
CCDS13924.1 [O95236-3]

NCBI Reference Sequences

More...
RefSeqi
NP_055164.1, NM_014349.2 [O95236-2]
NP_085147.1, NM_030644.1 [O95236-2]
NP_663614.1, NM_145639.1 [O95236-2]
NP_663615.1, NM_145640.2 [O95236-1]
NP_663616.1, NM_145641.2 [O95236-3]
NP_663617.1, NM_145642.2 [O95236-3]
XP_006724387.1, XM_006724324.1
XP_006724388.1, XM_006724325.2 [O95236-2]
XP_016884441.1, XM_017028952.1 [O95236-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.474737

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349314; ENSP00000344577; ENSG00000128284 [O95236-1]
ENST00000361710; ENSP00000355164; ENSG00000128284 [O95236-3]
ENST00000397287; ENSP00000380456; ENSG00000128284 [O95236-3]
ENST00000397293; ENSP00000380461; ENSG00000128284 [O95236-3]
ENST00000424878; ENSP00000415779; ENSG00000128284 [O95236-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80833

UCSC genome browser

More...
UCSCi
uc003aot.4 human [O95236-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070675 mRNA Translation: AAC83233.1
AF324238, AF324233, AF324237 Genomic DNA Translation: AAK26528.1
AY014904 mRNA Translation: AAG50346.1
AF324238, AF324236, AF324237 Genomic DNA Translation: AAK26529.1
AY014902 mRNA Translation: AAG50344.1
AY014903 mRNA Translation: AAG50345.1
AY014905 mRNA Translation: AAG50347.1
AF324238 Genomic DNA Translation: AAK26527.1
AY014906 mRNA Translation: AAG50348.1
AY014907 mRNA Translation: AAG50349.1
AF305227 mRNA Translation: AAK20213.1
CR456379 mRNA Translation: CAG30265.1
Z95114 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60080.1
BC042918 mRNA Translation: AAH42918.1
BC050596 mRNA Translation: AAH50596.1
CCDSiCCDS13922.1 [O95236-1]
CCDS13923.1 [O95236-2]
CCDS13924.1 [O95236-3]
RefSeqiNP_055164.1, NM_014349.2 [O95236-2]
NP_085147.1, NM_030644.1 [O95236-2]
NP_663614.1, NM_145639.1 [O95236-2]
NP_663615.1, NM_145640.2 [O95236-1]
NP_663616.1, NM_145641.2 [O95236-3]
NP_663617.1, NM_145642.2 [O95236-3]
XP_006724387.1, XM_006724324.1
XP_006724388.1, XM_006724325.2 [O95236-2]
XP_016884441.1, XM_017028952.1 [O95236-3]
UniGeneiHs.474737

3D structure databases

ProteinModelPortaliO95236
SMRiO95236
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95236, 26 interactors
STRINGi9606.ENSP00000344577

PTM databases

iPTMnetiO95236
PhosphoSitePlusiO95236

Polymorphism and mutation databases

BioMutaiAPOL3

Proteomic databases

EPDiO95236
jPOSTiO95236
MaxQBiO95236
PaxDbiO95236
PeptideAtlasiO95236
PRIDEiO95236
ProteomicsDBi50733
50734 [O95236-2]
50735 [O95236-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80833
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349314; ENSP00000344577; ENSG00000128284 [O95236-1]
ENST00000361710; ENSP00000355164; ENSG00000128284 [O95236-3]
ENST00000397287; ENSP00000380456; ENSG00000128284 [O95236-3]
ENST00000397293; ENSP00000380461; ENSG00000128284 [O95236-3]
ENST00000424878; ENSP00000415779; ENSG00000128284 [O95236-2]
GeneIDi80833
KEGGihsa:80833
UCSCiuc003aot.4 human [O95236-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80833
DisGeNETi80833
EuPathDBiHostDB:ENSG00000128284.19

GeneCards: human genes, protein and diseases

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GeneCardsi
APOL3
HGNCiHGNC:14868 APOL3
HPAiHPA036228
MIMi607253 gene
neXtProtiNX_O95236
OpenTargetsiENSG00000128284
PharmGKBiPA24906

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00510000046700
HOGENOMiHOG000294132
HOVERGENiHBG074468
InParanoidiO95236
KOiK14480
OMAiIGKNIRA
OrthoDBi1060131at2759
PhylomeDBiO95236
TreeFamiTF334681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
APOL3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
APOL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80833

Protein Ontology

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PROi
PR:O95236

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000128284 Expressed in 221 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_APOL3
ExpressionAtlasiO95236 baseline and differential
GenevisibleiO95236 HS

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95236
Secondary accession number(s): B1AHI4
, B1AHI5, Q5U5N4, Q9BQ82, Q9BQA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: January 16, 2019
This is version 144 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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