Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apolipoprotein L3

Gene

APOL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  • lipid binding Source: GO_Central
  • lipid transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L3
Alternative name(s):
Apolipoprotein L-III
Short name:
ApoL-III
TNF-inducible protein CG12-1
Short name:
CG12_1
Gene namesi
Name:APOL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128284.19
HGNCiHGNC:14868 APOL3
MIMi607253 gene
neXtProtiNX_O95236

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80833
OpenTargetsiENSG00000128284
PharmGKBiPA24906

Polymorphism and mutation databases

BioMutaiAPOL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001376021 – 402Apolipoprotein L3Add BLAST402

Proteomic databases

EPDiO95236
MaxQBiO95236
PaxDbiO95236
PeptideAtlasiO95236
PRIDEiO95236
ProteomicsDBi50733
50734 [O95236-2]
50735 [O95236-3]

PTM databases

iPTMnetiO95236
PhosphoSitePlusiO95236

Expressioni

Tissue specificityi

Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.

Inductioni

In vitro, is responsive to TNF.

Gene expression databases

BgeeiENSG00000128284 Expressed in 221 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_APOL3
ExpressionAtlasiO95236 baseline and differential
GenevisibleiO95236 HS

Organism-specific databases

HPAiHPA036228

Interactioni

Protein-protein interaction databases

IntActiO95236, 26 interactors
STRINGi9606.ENSP00000344577

Structurei

3D structure databases

ProteinModelPortaliO95236
SMRiO95236
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00510000046700
HOGENOMiHOG000294132
HOVERGENiHBG074468
InParanoidiO95236
KOiK14480
OMAiIGKNIRA
OrthoDBiEOG091G0IH5
PhylomeDBiO95236
TreeFamiTF334681

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95236-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLGQGWGWE ASCFACLIRS CCQVVTFTFP FGFQGISQSL ENVSGYYADA
60 70 80 90 100
RLEVGSTQLR TAGSCSHSFK RSFLEKKRFT EEATKYFRER VSPVHLQILL
110 120 130 140 150
TNNEAWKRFV TAAELPRDEA DALYEALKKL RTYAAIEDEY VQQKDEQFRE
160 170 180 190 200
WFLKEFPQVK RKIQESIEKL RALANGIEEV HRGCTISNVV SSSTGAASGI
210 220 230 240 250
MSLAGLVLAP FTAGTSLALT AAGVGLGAAS AVTGITTSIV EHSYTSSAEA
260 270 280 290 300
EASRLTATSI DRLKVFKEVM RDITPNLLSL LNNYYEATQT IGSEIRAIRQ
310 320 330 340 350
ARARARLPVT TWRISAGSGG QAERTIAGTT RAVSRGARIL SATTSGIFLA
360 370 380 390 400
LDVVNLVYES KHLHEGAKSA SAEELRRQAQ ELEENLMELT QIYQRLNPCH

TH
Length:402
Mass (Da):44,278
Last modified:November 25, 2008 - v3
Checksum:i8356C8247817F66A
GO
Isoform 2 (identifier: O95236-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MGLGQGWGWE...CSHSFKRSFL → MDS

Show »
Length:331
Mass (Da):36,545
Checksum:iC7703BAE5D0302FA
GO
Isoform 3 (identifier: O95236-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Show »
Length:202
Mass (Da):21,597
Checksum:i3C560B4F74CE837E
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2M3F2Z2M3_HUMAN
Apolipoprotein L3
APOL3
82Annotation score:
H7BYQ5H7BYQ5_HUMAN
Apolipoprotein L3
APOL3
97Annotation score:
H0YCT0H0YCT0_HUMAN
Apolipoprotein L3
APOL3
40Annotation score:
H0YDH5H0YDH5_HUMAN
Apolipoprotein L3
APOL3
33Annotation score:
H0YD32H0YD32_HUMAN
Apolipoprotein L3
APOL3
86Annotation score:
H0YEQ0H0YEQ0_HUMAN
Apolipoprotein L3
APOL3
39Annotation score:
H0YEJ6H0YEJ6_HUMAN
Apolipoprotein L3
APOL3
37Annotation score:
H0YDW3H0YDW3_HUMAN
Apolipoprotein L3
APOL3
52Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05300739S → R1 PublicationCorresponds to variant dbSNP:rs132653Ensembl.1
Natural variantiVAR_047488135A → V. Corresponds to variant dbSNP:rs6000152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0002941 – 200Missing in isoform 3. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_0002931 – 74MGLGQ…KRSFL → MDS in isoform 2. 5 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070675 mRNA Translation: AAC83233.1
AF324238, AF324233, AF324237 Genomic DNA Translation: AAK26528.1
AY014904 mRNA Translation: AAG50346.1
AF324238, AF324236, AF324237 Genomic DNA Translation: AAK26529.1
AY014902 mRNA Translation: AAG50344.1
AY014903 mRNA Translation: AAG50345.1
AY014905 mRNA Translation: AAG50347.1
AF324238 Genomic DNA Translation: AAK26527.1
AY014906 mRNA Translation: AAG50348.1
AY014907 mRNA Translation: AAG50349.1
AF305227 mRNA Translation: AAK20213.1
CR456379 mRNA Translation: CAG30265.1
Z95114 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60080.1
BC042918 mRNA Translation: AAH42918.1
BC050596 mRNA Translation: AAH50596.1
CCDSiCCDS13922.1 [O95236-1]
CCDS13923.1 [O95236-2]
CCDS13924.1 [O95236-3]
RefSeqiNP_055164.1, NM_014349.2 [O95236-2]
NP_085147.1, NM_030644.1 [O95236-2]
NP_663614.1, NM_145639.1 [O95236-2]
NP_663615.1, NM_145640.2 [O95236-1]
NP_663616.1, NM_145641.2 [O95236-3]
NP_663617.1, NM_145642.2 [O95236-3]
XP_006724387.1, XM_006724324.1
XP_006724388.1, XM_006724325.2 [O95236-2]
XP_016884441.1, XM_017028952.1 [O95236-3]
UniGeneiHs.474737

Genome annotation databases

EnsembliENST00000349314; ENSP00000344577; ENSG00000128284 [O95236-1]
ENST00000361710; ENSP00000355164; ENSG00000128284 [O95236-3]
ENST00000397287; ENSP00000380456; ENSG00000128284 [O95236-3]
ENST00000397293; ENSP00000380461; ENSG00000128284 [O95236-3]
ENST00000424878; ENSP00000415779; ENSG00000128284 [O95236-2]
GeneIDi80833
KEGGihsa:80833
UCSCiuc003aot.4 human [O95236-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070675 mRNA Translation: AAC83233.1
AF324238, AF324233, AF324237 Genomic DNA Translation: AAK26528.1
AY014904 mRNA Translation: AAG50346.1
AF324238, AF324236, AF324237 Genomic DNA Translation: AAK26529.1
AY014902 mRNA Translation: AAG50344.1
AY014903 mRNA Translation: AAG50345.1
AY014905 mRNA Translation: AAG50347.1
AF324238 Genomic DNA Translation: AAK26527.1
AY014906 mRNA Translation: AAG50348.1
AY014907 mRNA Translation: AAG50349.1
AF305227 mRNA Translation: AAK20213.1
CR456379 mRNA Translation: CAG30265.1
Z95114 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60080.1
BC042918 mRNA Translation: AAH42918.1
BC050596 mRNA Translation: AAH50596.1
CCDSiCCDS13922.1 [O95236-1]
CCDS13923.1 [O95236-2]
CCDS13924.1 [O95236-3]
RefSeqiNP_055164.1, NM_014349.2 [O95236-2]
NP_085147.1, NM_030644.1 [O95236-2]
NP_663614.1, NM_145639.1 [O95236-2]
NP_663615.1, NM_145640.2 [O95236-1]
NP_663616.1, NM_145641.2 [O95236-3]
NP_663617.1, NM_145642.2 [O95236-3]
XP_006724387.1, XM_006724324.1
XP_006724388.1, XM_006724325.2 [O95236-2]
XP_016884441.1, XM_017028952.1 [O95236-3]
UniGeneiHs.474737

3D structure databases

ProteinModelPortaliO95236
SMRiO95236
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95236, 26 interactors
STRINGi9606.ENSP00000344577

PTM databases

iPTMnetiO95236
PhosphoSitePlusiO95236

Polymorphism and mutation databases

BioMutaiAPOL3

Proteomic databases

EPDiO95236
MaxQBiO95236
PaxDbiO95236
PeptideAtlasiO95236
PRIDEiO95236
ProteomicsDBi50733
50734 [O95236-2]
50735 [O95236-3]

Protocols and materials databases

DNASUi80833
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349314; ENSP00000344577; ENSG00000128284 [O95236-1]
ENST00000361710; ENSP00000355164; ENSG00000128284 [O95236-3]
ENST00000397287; ENSP00000380456; ENSG00000128284 [O95236-3]
ENST00000397293; ENSP00000380461; ENSG00000128284 [O95236-3]
ENST00000424878; ENSP00000415779; ENSG00000128284 [O95236-2]
GeneIDi80833
KEGGihsa:80833
UCSCiuc003aot.4 human [O95236-1]

Organism-specific databases

CTDi80833
DisGeNETi80833
EuPathDBiHostDB:ENSG00000128284.19
GeneCardsiAPOL3
HGNCiHGNC:14868 APOL3
HPAiHPA036228
MIMi607253 gene
neXtProtiNX_O95236
OpenTargetsiENSG00000128284
PharmGKBiPA24906
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00510000046700
HOGENOMiHOG000294132
HOVERGENiHBG074468
InParanoidiO95236
KOiK14480
OMAiIGKNIRA
OrthoDBiEOG091G0IH5
PhylomeDBiO95236
TreeFamiTF334681

Miscellaneous databases

ChiTaRSiAPOL3 human
GeneWikiiAPOL3
GenomeRNAii80833
PROiPR:O95236
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128284 Expressed in 221 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_APOL3
ExpressionAtlasiO95236 baseline and differential
GenevisibleiO95236 HS

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPOL3_HUMAN
AccessioniPrimary (citable) accession number: O95236
Secondary accession number(s): B1AHI4
, B1AHI5, Q5U5N4, Q9BQ82, Q9BQA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again