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Protein

Luc7-like protein 3

Gene

LUC7L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA splice site selection Source: GO_Central
  • RNA splicing Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Luc7-like protein 3
Alternative name(s):
Cisplatin resistance-associated-overexpressed protein
Luc7A
Okadaic acid-inducible phosphoprotein OA48-18
cAMP regulatory element-associated protein 1
Short name:
CRE-associated protein 1
Short name:
CREAP-1
Gene namesi
Name:LUC7L3
Synonyms:CREAP1, CROP, O48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108848.15
HGNCiHGNC:24309 LUC7L3
MIMi609434 gene
neXtProtiNX_O95232

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51747
OpenTargetsiENSG00000108848
PharmGKBiPA165432062

Polymorphism and mutation databases

BioMutaiLUC7L3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580131 – 432Luc7-like protein 3Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei231N6-acetyllysineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei425PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in vitro by SRPK1, SRPK2 and CLK1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95232
MaxQBiO95232
PaxDbiO95232
PeptideAtlasiO95232
PRIDEiO95232
ProteomicsDBi50730
50731 [O95232-2]

PTM databases

CarbonylDBiO95232
iPTMnetiO95232
PhosphoSitePlusiO95232
SwissPalmiO95232

Expressioni

Tissue specificityi

Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung.2 Publications

Gene expression databases

BgeeiENSG00000108848 Expressed in 242 organ(s), highest expression level in testis
ExpressionAtlasiO95232 baseline and differential
GenevisibleiO95232 HS

Organism-specific databases

HPAiHPA018475
HPA018484
HPA020017

Interactioni

Subunit structurei

May interact with SFRS1 and form homodimers (PubMed:12565863). Interacts with JMJD6 (PubMed:19574390). Interacts with RBM25 (PubMed:18663000). Interacts with RSRC1 (via Arg/Ser-rich domain) (PubMed:15798186). Interacts with RRP1B (PubMed:23604122).5 Publications

Protein-protein interaction databases

BioGridi119710, 68 interactors
CORUMiO95232
IntActiO95232, 20 interactors
MINTiO95232
STRINGi9606.ENSP00000240304

Structurei

3D structure databases

ProteinModelPortaliO95232
SMRiO95232
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili124 – 181Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi228 – 282Glu-richAdd BLAST55
Compositional biasi235 – 395Arg/Ser-richAdd BLAST161

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiO95232
PhylomeDBiO95232
TreeFamiTF354312

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95232-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISAAQLLDE LMGRDRNLAP DEKRSNVRWD HESVCKYYLC GFCPAELFTN
60 70 80 90 100
TRSDLGPCEK IHDENLRKQY EKSSRFMKVG YERDFLRYLQ SLLAEVERRI
110 120 130 140 150
RRGHARLALS QNQQSSGAAG PTGKNEEKIQ VLTDKIDVLL QQIEELGSEG
160 170 180 190 200
KVEEAQGMMK LVEQLKEERE LLRSTTSTIE SFAAQEKQME VCEVCGAFLI
210 220 230 240 250
VGDAQSRVDD HLMGKQHMGY AKIKATVEEL KEKLRKRTEE PDRDERLKKE
260 270 280 290 300
KQEREEREKE REREREERER KRRREEEERE KERARDRERR KRSRSRSRHS
310 320 330 340 350
SRTSDRRCSR SRDHKRSRSR ERRRSRSRDR RRSRSHDRSE RKHRSRSRDR
360 370 380 390 400
RRSKSRDRKS YKHRSKSRDR EQDRKSKEKE KRGSDDKKSS VKSGSREKQS
410 420 430
EDTNTESKES DTKNEVNGTS EDIKSEGDTQ SN
Length:432
Mass (Da):51,466
Last modified:May 2, 2006 - v2
Checksum:iE75F55EC0137310C
GO
Isoform 2 (identifier: O95232-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-79: GPCEKIHDENLRKQYEKSSRFMKV → DVFGRGDNISDVSKFLEDDKWMEE
     80-432: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:79
Mass (Da):9,194
Checksum:iD204FE4F76DF2FD2
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPP4J3KPP4_HUMAN
Cisplatin resistance-associated ove...
LUC7L3 CROP, hCG_27416
489Annotation score:
H0YAR4H0YAR4_HUMAN
Luc7-like protein 3
LUC7L3
123Annotation score:
H0YBV7H0YBV7_HUMAN
Luc7-like protein 3
LUC7L3
118Annotation score:
H0YA81H0YA81_HUMAN
Luc7-like protein 3
LUC7L3
207Annotation score:
D6RDI2D6RDI2_HUMAN
Luc7-like protein 3
LUC7L3
184Annotation score:
H7C5U7H7C5U7_HUMAN
Luc7-like protein 3
LUC7L3
39Annotation score:
C9JL41C9JL41_HUMAN
Luc7-like protein 3
LUC7L3
79Annotation score:
U3KQT3U3KQT3_HUMAN
Luc7-like protein 3
LUC7L3
46Annotation score:
H0YAX1H0YAX1_HUMAN
Luc7-like protein 3
LUC7L3
86Annotation score:
E7EN55E7EN55_HUMAN
Luc7-like protein 3
LUC7L3
54Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAC79807 differs from that shown. Reason: Erroneous translation. Erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217H → Y in BAA91981 (PubMed:14702039).Curated1
Sequence conflicti378 – 379EK → HE in AAC79807 (PubMed:10754390).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01813656 – 79GPCEK…RFMKV → DVFGRGDNISDVSKFLEDDK WMEE in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_01813780 – 432Missing in isoform 2. 1 PublicationAdd BLAST353

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034205 mRNA Translation: BAA90542.1
DQ013876 mRNA Translation: AAY26238.1
AK001925 mRNA Translation: BAA91981.1
AK023672 mRNA Translation: BAG51216.1
CH471109 Genomic DNA Translation: EAW94583.1
CH471109 Genomic DNA Translation: EAW94585.1
CH471109 Genomic DNA Translation: EAW94587.1
BC056409 mRNA Translation: AAH56409.1
AF069250 mRNA Translation: AAC79807.1 Sequence problems.
CCDSiCCDS11573.1 [O95232-1]
RefSeqiNP_006098.2, NM_006107.3 [O95232-1]
NP_057508.2, NM_016424.4 [O95232-1]
UniGeneiHs.130293
Hs.655691

Genome annotation databases

EnsembliENST00000240304; ENSP00000240304; ENSG00000108848 [O95232-1]
ENST00000505658; ENSP00000425092; ENSG00000108848 [O95232-1]
GeneIDi51747
KEGGihsa:51747
UCSCiuc002isr.4 human [O95232-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034205 mRNA Translation: BAA90542.1
DQ013876 mRNA Translation: AAY26238.1
AK001925 mRNA Translation: BAA91981.1
AK023672 mRNA Translation: BAG51216.1
CH471109 Genomic DNA Translation: EAW94583.1
CH471109 Genomic DNA Translation: EAW94585.1
CH471109 Genomic DNA Translation: EAW94587.1
BC056409 mRNA Translation: AAH56409.1
AF069250 mRNA Translation: AAC79807.1 Sequence problems.
CCDSiCCDS11573.1 [O95232-1]
RefSeqiNP_006098.2, NM_006107.3 [O95232-1]
NP_057508.2, NM_016424.4 [O95232-1]
UniGeneiHs.130293
Hs.655691

3D structure databases

ProteinModelPortaliO95232
SMRiO95232
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119710, 68 interactors
CORUMiO95232
IntActiO95232, 20 interactors
MINTiO95232
STRINGi9606.ENSP00000240304

PTM databases

CarbonylDBiO95232
iPTMnetiO95232
PhosphoSitePlusiO95232
SwissPalmiO95232

Polymorphism and mutation databases

BioMutaiLUC7L3

Proteomic databases

EPDiO95232
MaxQBiO95232
PaxDbiO95232
PeptideAtlasiO95232
PRIDEiO95232
ProteomicsDBi50730
50731 [O95232-2]

Protocols and materials databases

DNASUi51747
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240304; ENSP00000240304; ENSG00000108848 [O95232-1]
ENST00000505658; ENSP00000425092; ENSG00000108848 [O95232-1]
GeneIDi51747
KEGGihsa:51747
UCSCiuc002isr.4 human [O95232-1]

Organism-specific databases

CTDi51747
DisGeNETi51747
EuPathDBiHostDB:ENSG00000108848.15
GeneCardsiLUC7L3
HGNCiHGNC:24309 LUC7L3
HPAiHPA018475
HPA018484
HPA020017
MIMi609434 gene
neXtProtiNX_O95232
OpenTargetsiENSG00000108848
PharmGKBiPA165432062
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0796 Eukaryota
COG5200 LUCA
GeneTreeiENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG062167
InParanoidiO95232
PhylomeDBiO95232
TreeFamiTF354312

Miscellaneous databases

ChiTaRSiLUC7L3 human
GeneWikiiCROP_(gene)
GenomeRNAii51747
PROiPR:O95232
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108848 Expressed in 242 organ(s), highest expression level in testis
ExpressionAtlasiO95232 baseline and differential
GenevisibleiO95232 HS

Family and domain databases

InterProiView protein in InterPro
IPR004882 Luc7-rel
PANTHERiPTHR12375 PTHR12375, 1 hit
PfamiView protein in Pfam
PF03194 LUC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLC7L3_HUMAN
AccessioniPrimary (citable) accession number: O95232
Secondary accession number(s): B3KN54
, D3DTY1, Q6PHR9, Q9NUY0, Q9P2S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 2, 2006
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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