UniProtKB - O95231 (VENTX_HUMAN)
Protein
Homeobox protein VENTX
Gene
VENTX
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in ventralization.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 91 – 150 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | O95231 |
Reactomei | R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-8853884, Transcriptional Regulation by VENTX |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein VENTXAlternative name(s): VENT homeobox homolog VENT-like homeobox protein 2 |
Gene namesi | Name:VENTX Synonyms:HPX42B, VENTX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13639, VENTX |
MIMi | 607158, gene |
neXtProti | NX_O95231 |
VEuPathDBi | HostDB:ENSG00000151650.7 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27287 |
OpenTargetsi | ENSG00000151650 |
PharmGKBi | PA37803 |
Miscellaneous databases
Pharosi | O95231, Tbio |
Genetic variation databases
BioMutai | VENTX |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305938 | 1 – 258 | Homeobox protein VENTXAdd BLAST | 258 |
Proteomic databases
MassIVEi | O95231 |
PaxDbi | O95231 |
PeptideAtlasi | O95231 |
PRIDEi | O95231 |
ProteomicsDBi | 50729 |
PTM databases
iPTMneti | O95231 |
PhosphoSitePlusi | O95231 |
Expressioni
Tissue specificityi
Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.1 Publication
Gene expression databases
Bgeei | ENSG00000151650, Expressed in granulocyte and 98 other tissues |
Genevisiblei | O95231, HS |
Organism-specific databases
HPAi | ENSG00000151650, Low tissue specificity |
Interactioni
Binary interactionsi
O95231
Protein-protein interaction databases
BioGRIDi | 118111, 99 interactors |
IntActi | O95231, 84 interactors |
STRINGi | 9606.ENSP00000357556 |
Miscellaneous databases
RNActi | O95231, protein |
Family & Domainsi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000163757 |
HOGENOMi | CLU_093885_0_0_1 |
InParanoidi | O95231 |
OMAi | KHKRQMQ |
OrthoDBi | 1596695at2759 |
PhylomeDBi | O95231 |
TreeFami | TF351607 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O95231-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ
60 70 80 90 100
TSGAREPPQA VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM
110 120 130 140 150
EQVRTLEGVF QHHQYLSPLE RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM
160 170 180 190 200
QDPQLHSPFS GSLHAPPAFY STSSGLANGL QLLCPWAPLS GPQALMLPPG
210 220 230 240 250
SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA LSTGPRGLCA
MPQTGDAF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035243 | 42 | L → P1 PublicationCorresponds to variant dbSNP:rs2240892Ensembl. | 1 | |
Natural variantiVAR_035244 | 79 | M → V. Corresponds to variant dbSNP:rs2240891Ensembl. | 1 | |
Natural variantiVAR_049591 | 101 | E → K. Corresponds to variant dbSNP:rs2270192Ensembl. | 1 | |
Natural variantiVAR_049592 | 191 | G → R. Corresponds to variant dbSNP:rs9418952Ensembl. | 1 | |
Natural variantiVAR_061269 | 247 | G → D. Corresponds to variant dbSNP:rs9418953Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF068006 mRNA Translation: AAC82375.1 AF288039 Genomic DNA Translation: AAK83043.1 AL445199 Genomic DNA No translation available. BC108915 mRNA Translation: AAI08916.1 BC108916 mRNA Translation: AAI08917.1 |
CCDSi | CCDS7675.1 |
RefSeqi | NP_055283.1, NM_014468.3 |
Genome annotation databases
Ensembli | ENST00000325980; ENSP00000357556; ENSG00000151650 |
GeneIDi | 27287 |
KEGGi | hsa:27287 |
UCSCi | uc010quy.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF068006 mRNA Translation: AAC82375.1 AF288039 Genomic DNA Translation: AAK83043.1 AL445199 Genomic DNA No translation available. BC108915 mRNA Translation: AAI08916.1 BC108916 mRNA Translation: AAI08917.1 |
CCDSi | CCDS7675.1 |
RefSeqi | NP_055283.1, NM_014468.3 |
3D structure databases
SMRi | O95231 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118111, 99 interactors |
IntActi | O95231, 84 interactors |
STRINGi | 9606.ENSP00000357556 |
PTM databases
iPTMneti | O95231 |
PhosphoSitePlusi | O95231 |
Genetic variation databases
BioMutai | VENTX |
Proteomic databases
MassIVEi | O95231 |
PaxDbi | O95231 |
PeptideAtlasi | O95231 |
PRIDEi | O95231 |
ProteomicsDBi | 50729 |
Protocols and materials databases
ABCDi | O95231, 3 sequenced antibodies |
Antibodypediai | 32622, 162 antibodies |
DNASUi | 27287 |
Genome annotation databases
Ensembli | ENST00000325980; ENSP00000357556; ENSG00000151650 |
GeneIDi | 27287 |
KEGGi | hsa:27287 |
UCSCi | uc010quy.3, human |
Organism-specific databases
CTDi | 27287 |
DisGeNETi | 27287 |
GeneCardsi | VENTX |
HGNCi | HGNC:13639, VENTX |
HPAi | ENSG00000151650, Low tissue specificity |
MIMi | 607158, gene |
neXtProti | NX_O95231 |
OpenTargetsi | ENSG00000151650 |
PharmGKBi | PA37803 |
VEuPathDBi | HostDB:ENSG00000151650.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000163757 |
HOGENOMi | CLU_093885_0_0_1 |
InParanoidi | O95231 |
OMAi | KHKRQMQ |
OrthoDBi | 1596695at2759 |
PhylomeDBi | O95231 |
TreeFami | TF351607 |
Enzyme and pathway databases
PathwayCommonsi | O95231 |
Reactomei | R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-8853884, Transcriptional Regulation by VENTX |
Miscellaneous databases
BioGRID-ORCSi | 27287, 6 hits in 896 CRISPR screens |
GenomeRNAii | 27287 |
Pharosi | O95231, Tbio |
PROi | PR:O95231 |
RNActi | O95231, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151650, Expressed in granulocyte and 98 other tissues |
Genevisiblei | O95231, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VENTX_HUMAN | |
Accessioni | O95231Primary (citable) accession number: O95231 Secondary accession number(s): Q32MZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot