UniProtKB - O95229 (ZWINT_HUMAN)
Protein
ZW10 interactor
Gene
ZWINT
Organism
Homo sapiens (Human)
Status
Functioni
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.4 Publications
GO - Molecular functioni
- protein N-terminus binding Source: HGNC-UCL
GO - Biological processi
- cell division Source: UniProtKB-KW
- establishment of localization in cell Source: HGNC-UCL
- mitotic sister chromatid segregation Source: HGNC-UCL
- mitotic spindle assembly checkpoint Source: HGNC-UCL
- mitotic spindle organization Source: Reactome
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | O95229 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Names & Taxonomyi
Protein namesi | Recommended name: ZW10 interactorAlternative name(s): ZW10-interacting protein 1 Short name: Zwint-1 |
Gene namesi | Name:ZWINT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13195, ZWINT |
MIMi | 609177, gene |
neXtProti | NX_O95229 |
VEuPathDBi | HostDB:ENSG00000122952.16 |
Subcellular locationi
Nucleus
Other locations
Note: Localizes to kinetochores from late prophase to anaphase.
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- cytoplasm Source: BHF-UCL
- dendrite Source: GO_Central
- kinetochore Source: BHF-UCL
Keywords - Cellular componenti
Centromere, Chromosome, Kinetochore, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 11130 |
OpenTargetsi | ENSG00000122952 |
PharmGKBi | PA37761 |
Miscellaneous databases
Pharosi | O95229, Tbio |
Genetic variation databases
BioMutai | ZWINT |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066594 | 1 – 277 | ZW10 interactorAdd BLAST | 277 |
Proteomic databases
EPDi | O95229 |
jPOSTi | O95229 |
MassIVEi | O95229 |
MaxQBi | O95229 |
PaxDbi | O95229 |
PeptideAtlasi | O95229 |
PRIDEi | O95229 |
ProteomicsDBi | 1641 50728 [O95229-1] |
PTM databases
iPTMneti | O95229 |
PhosphoSitePlusi | O95229 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122952, Expressed in oocyte and 205 other tissues |
ExpressionAtlasi | O95229, baseline and differential |
Genevisiblei | O95229, HS |
Organism-specific databases
HPAi | ENSG00000122952, Tissue enhanced (lymphoid tissue, testis) |
Interactioni
Subunit structurei
Interacts with ZW10 and MIS12.
Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis.
Also interacts with KNL1, CETN3, DSN1 and PMF1.
4 PublicationsBinary interactionsi
Hide detailsO95229
GO - Molecular functioni
- protein N-terminus binding Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 116303, 132 interactors |
ComplexPortali | CPX-5644, Kinetochore KNL1 complex |
CORUMi | O95229 |
IntActi | O95229, 109 interactors |
MINTi | O95229 |
STRINGi | 9606.ENSP00000363055 |
Miscellaneous databases
RNActi | O95229, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 80 – 155 | Interaction with NDC80 and ZW10Add BLAST | 76 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 104 – 217 | Sequence analysisAdd BLAST | 114 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S6PG, Eukaryota |
GeneTreei | ENSGT00390000017639 |
HOGENOMi | CLU_089675_0_0_1 |
InParanoidi | O95229 |
OMAi | LPEGQQH |
OrthoDBi | 1313012at2759 |
PhylomeDBi | O95229 |
TreeFami | TF338101 |
Family and domain databases
InterProi | View protein in InterPro IPR029092, Zwint-1 |
PANTHERi | PTHR31504, PTHR31504, 1 hit |
Pfami | View protein in Pfam PF15556, Zwint, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O95229-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAAETEAEA AALEVLAEVA GILEPVGLQE EAELPAKILV EFVVDSQKKD
60 70 80 90 100
KLLCSQLQVA DFLQNILAQE DTAKGLDPLA SEDTSRQKAI AAKEQWKELK
110 120 130 140 150
ATYREHVEAI KIGLTKALTQ MEEAQRKRTQ LREAFEQLQA KKQMAMEKRR
160 170 180 190 200
AVQNQWQLQQ EKHLQHLAEV SAEVRERKTG TQQELDRVFQ KLGNLKQQAE
210 220 230 240 250
QERDKLQRYQ TFLQLLYTLQ GKLLFPEAEA EAENLPDDKP QQPTRPQEQS
260 270
TGDTMGRDPG VSFKAVGLQP AGDVNLP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6NH27 | A6NH27_HUMAN | ZW10 interactor | ZWINT | 157 | Annotation score: | ||
R4GMS7 | R4GMS7_HUMAN | ZW10 interactor | ZWINT | 48 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028783 | 4 | A → S. Corresponds to variant dbSNP:rs11005328Ensembl. | 1 | |
Natural variantiVAR_051505 | 187 | R → G2 PublicationsCorresponds to variant dbSNP:rs2241666Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047660 | 174 – 220 | Missing in isoform 2. CuratedAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF067656 mRNA Translation: AAC78629.1 AC010996 Genomic DNA No translation available. BC000411 mRNA Translation: AAH00411.1 BC020979 mRNA Translation: AAH20979.1 BC110399 mRNA Translation: AAI10400.1 |
CCDSi | CCDS31205.1 [O95229-2] CCDS7249.1 [O95229-1] |
RefSeqi | NP_001005413.1, NM_001005413.1 [O95229-2] NP_008988.2, NM_007057.3 [O95229-1] NP_127490.1, NM_032997.2 [O95229-1] |
Genome annotation databases
Ensembli | ENST00000361148; ENSP00000354921; ENSG00000122952 [O95229-2] ENST00000373944; ENSP00000363055; ENSG00000122952 [O95229-1] ENST00000395405; ENSP00000378801; ENSG00000122952 [O95229-1] |
GeneIDi | 11130 |
KEGGi | hsa:11130 |
UCSCi | uc001jjx.2, human [O95229-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF067656 mRNA Translation: AAC78629.1 AC010996 Genomic DNA No translation available. BC000411 mRNA Translation: AAH00411.1 BC020979 mRNA Translation: AAH20979.1 BC110399 mRNA Translation: AAI10400.1 |
CCDSi | CCDS31205.1 [O95229-2] CCDS7249.1 [O95229-1] |
RefSeqi | NP_001005413.1, NM_001005413.1 [O95229-2] NP_008988.2, NM_007057.3 [O95229-1] NP_127490.1, NM_032997.2 [O95229-1] |
3D structure databases
SMRi | O95229 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116303, 132 interactors |
ComplexPortali | CPX-5644, Kinetochore KNL1 complex |
CORUMi | O95229 |
IntActi | O95229, 109 interactors |
MINTi | O95229 |
STRINGi | 9606.ENSP00000363055 |
PTM databases
iPTMneti | O95229 |
PhosphoSitePlusi | O95229 |
Genetic variation databases
BioMutai | ZWINT |
Proteomic databases
EPDi | O95229 |
jPOSTi | O95229 |
MassIVEi | O95229 |
MaxQBi | O95229 |
PaxDbi | O95229 |
PeptideAtlasi | O95229 |
PRIDEi | O95229 |
ProteomicsDBi | 1641 50728 [O95229-1] |
Protocols and materials databases
Antibodypediai | 28018, 253 antibodies |
DNASUi | 11130 |
Genome annotation databases
Ensembli | ENST00000361148; ENSP00000354921; ENSG00000122952 [O95229-2] ENST00000373944; ENSP00000363055; ENSG00000122952 [O95229-1] ENST00000395405; ENSP00000378801; ENSG00000122952 [O95229-1] |
GeneIDi | 11130 |
KEGGi | hsa:11130 |
UCSCi | uc001jjx.2, human [O95229-1] |
Organism-specific databases
CTDi | 11130 |
DisGeNETi | 11130 |
GeneCardsi | ZWINT |
HGNCi | HGNC:13195, ZWINT |
HPAi | ENSG00000122952, Tissue enhanced (lymphoid tissue, testis) |
MIMi | 609177, gene |
neXtProti | NX_O95229 |
OpenTargetsi | ENSG00000122952 |
PharmGKBi | PA37761 |
VEuPathDBi | HostDB:ENSG00000122952.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6PG, Eukaryota |
GeneTreei | ENSGT00390000017639 |
HOGENOMi | CLU_089675_0_0_1 |
InParanoidi | O95229 |
OMAi | LPEGQQH |
OrthoDBi | 1313012at2759 |
PhylomeDBi | O95229 |
TreeFami | TF338101 |
Enzyme and pathway databases
PathwayCommonsi | O95229 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
Miscellaneous databases
BioGRID-ORCSi | 11130, 403 hits in 1004 CRISPR screens |
ChiTaRSi | ZWINT, human |
GeneWikii | ZWINT |
GenomeRNAii | 11130 |
Pharosi | O95229, Tbio |
PROi | PR:O95229 |
RNActi | O95229, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122952, Expressed in oocyte and 205 other tissues |
ExpressionAtlasi | O95229, baseline and differential |
Genevisiblei | O95229, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029092, Zwint-1 |
PANTHERi | PTHR31504, PTHR31504, 1 hit |
Pfami | View protein in Pfam PF15556, Zwint, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZWINT_HUMAN | |
Accessioni | O95229Primary (citable) accession number: O95229 Secondary accession number(s): A6NNV6, Q0D2I3, Q9BWD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2002 |
Last sequence update: | October 31, 2006 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot