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Protein

Olfactory receptor 6A2

Gene

OR6A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6A2
Alternative name(s):
Olfactory receptor 11-55
Short name:
OR11-55
Olfactory receptor 6A1
Olfactory receptor OR11-83
hP2 olfactory receptor
Gene namesi
Name:OR6A2
Synonyms:OR6A1, OR6A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000184933.4
HGNCiHGNC:15301 OR6A2
MIMi608495 gene
neXtProtiNX_O95222

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 104ExtracellularSequence analysisAdd BLAST28
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 144CytoplasmicSequence analysisAdd BLAST19
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 201ExtracellularSequence analysisAdd BLAST36
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 242CytoplasmicSequence analysisAdd BLAST20
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 276ExtracellularSequence analysisAdd BLAST13
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 327CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32574

Polymorphism and mutation databases

BioMutaiOR6A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506191 – 327Olfactory receptor 6A2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 194PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95222
PeptideAtlasiO95222
PRIDEiO95222
ProteomicsDBi50726

Expressioni

Gene expression databases

BgeeiENSG00000184933 Expressed in 1 organ(s), highest expression level in right atrium auricular region
CleanExiHS_OR6A2
ExpressionAtlasiO95222 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi114155, 1 interactor
STRINGi9606.ENSP00000330384

Structurei

3D structure databases

ProteinModelPortaliO95222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9G Eukaryota
ENOG410YB1I LUCA
GeneTreeiENSGT00800000124041
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiO95222
KOiK04257
OMAiHYPVIVS
OrthoDBiEOG091G0DAJ
PhylomeDBiO95222
TreeFamiTF337475

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWRNHSGRV SEFVLLGFPA PAPLQVLLFA LLLLAYVLVL TENTLIIMAI
60 70 80 90 100
RNHSTLHKPM YFFLANMSFL EIWYVTVTIP KMLAGFVGSK QDHGQLISFE
110 120 130 140 150
GCMTQLYFFL GLGCTECVLL AVMAYDRYMA ICYPLHYPVI VSGRLCVQMA
160 170 180 190 200
AGSWAGGFGI SMVKVFLISG LSYCGPNIIN HFFCDVSPLL NLSCTDMSTA
210 220 230 240 250
ELTDFILAIF ILLGPLSVTG ASYVAITGAV MHIPSAAGRY KAFSTCASHL
260 270 280 290 300
TVVIIFYAAS IFIYARPKAL SAFDTNKLVS VLYAVIVPLL NPIIYCLRNQ
310 320
EVKRALCCTL HLYQHQDPDP KKASRNV
Length:327
Mass (Da):36,154
Last modified:August 16, 2004 - v2
Checksum:i9C11914D3F069FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 27APLQVL → VPIQVI in AAC70018 (PubMed:9787077).Curated6
Sequence conflicti125Y → N in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti125Y → N in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti134P → L in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti134P → L in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti137Y → N in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti137Y → N in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti173 – 174YC → NG in AAC70018 (PubMed:9787077).Curated2
Sequence conflicti173 – 174YC → NG in DAA04825 (PubMed:9787077).Curated2
Sequence conflicti250 – 251LT → FN in AAC70018 (PubMed:9787077).Curated2
Sequence conflicti250 – 251LT → FN in DAA04825 (PubMed:9787077).Curated2
Sequence conflicti309T → I in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti309T → I in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti323A → G in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti323A → G in DAA04825 (PubMed:9787077).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05321722A → V. Corresponds to variant dbSNP:rs7122644Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065870 Genomic DNA Translation: AAC70018.1
AF321237 Genomic DNA Translation: AAG45208.1
AB065822 Genomic DNA Translation: BAC06041.1
BC101489 mRNA Translation: AAI01490.1
BC101491 mRNA Translation: AAI01492.1
BK004427 Genomic DNA Translation: DAA04825.1
CCDSiCCDS7772.1
RefSeqiNP_003687.2, NM_003696.2
UniGeneiHs.652252

Genome annotation databases

EnsembliENST00000332601; ENSP00000330384; ENSG00000184933
ENST00000641196; ENSP00000492990; ENSG00000184933
GeneIDi8590
KEGGihsa:8590
UCSCiuc001mes.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065870 Genomic DNA Translation: AAC70018.1
AF321237 Genomic DNA Translation: AAG45208.1
AB065822 Genomic DNA Translation: BAC06041.1
BC101489 mRNA Translation: AAI01490.1
BC101491 mRNA Translation: AAI01492.1
BK004427 Genomic DNA Translation: DAA04825.1
CCDSiCCDS7772.1
RefSeqiNP_003687.2, NM_003696.2
UniGeneiHs.652252

3D structure databases

ProteinModelPortaliO95222
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114155, 1 interactor
STRINGi9606.ENSP00000330384

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR6A2

Proteomic databases

PaxDbiO95222
PeptideAtlasiO95222
PRIDEiO95222
ProteomicsDBi50726

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332601; ENSP00000330384; ENSG00000184933
ENST00000641196; ENSP00000492990; ENSG00000184933
GeneIDi8590
KEGGihsa:8590
UCSCiuc001mes.2 human

Organism-specific databases

CTDi8590
EuPathDBiHostDB:ENSG00000184933.4
GeneCardsiOR6A2
HGNCiHGNC:15301 OR6A2
MIMi608495 gene
neXtProtiNX_O95222
PharmGKBiPA32574
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9G Eukaryota
ENOG410YB1I LUCA
GeneTreeiENSGT00800000124041
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiO95222
KOiK04257
OMAiHYPVIVS
OrthoDBiEOG091G0DAJ
PhylomeDBiO95222
TreeFamiTF337475

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR6A2
GenomeRNAii8590
PROiPR:O95222
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184933 Expressed in 1 organ(s), highest expression level in right atrium auricular region
CleanExiHS_OR6A2
ExpressionAtlasiO95222 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR6A2_HUMAN
AccessioniPrimary (citable) accession number: O95222
Secondary accession number(s): Q3MJC7, Q6IF35, Q9H206
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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