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Protein

Olfactory receptor 5F1

Gene

OR5F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5F1
Alternative name(s):
Olfactory receptor 11-10
Short name:
OR11-10
Olfactory receptor OR11-167
Gene namesi
Name:OR5F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149133.1
HGNCiHGNC:8343 OR5F1
MIMi608492 gene
neXtProtiNX_O95221

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32526

Polymorphism and mutation databases

BioMutaiOR5F1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505951 – 314Olfactory receptor 5F1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95221
PeptideAtlasiO95221
PRIDEiO95221
ProteomicsDBi50725

PTM databases

iPTMnetiO95221
PhosphoSitePlusiO95221

Expressioni

Gene expression databases

CleanExiHS_OR5F1

Organism-specific databases

HPAiHPA059360

Interactioni

Protein-protein interaction databases

BioGridi130779, 11 interactors
STRINGi9606.ENSP00000278409

Structurei

3D structure databases

ProteinModelPortaliO95221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU6 Eukaryota
ENOG4111BJM LUCA
GeneTreeiENSGT00910000144101
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO95221
KOiK04257
OMAiSCSDTIL
OrthoDBiEOG091G0AZH
PhylomeDBiO95221
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR
60 70 80 90 100
IDSQLHTPMY FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ
110 120 130 140 150
MYFFISLATT ECILFGLMAY DRYAAICRPL LYSLIMSRTV YLKMAAGAFA
160 170 180 190 200
AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD SPPLFKLSCS DTILKESISS
210 220 230 240 250
ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST CASHLTAIIL
260 270 280 290 300
FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA
310
LANVISRKRT SSFL
Length:314
Mass (Da):35,132
Last modified:June 20, 2001 - v2
Checksum:iC14A9A35CD76E3A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062043192T → A. Corresponds to variant dbSNP:rs35607186Ensembl.1
Natural variantiVAR_053194278Y → H. Corresponds to variant dbSNP:rs11825964Ensembl.1
Natural variantiVAR_034225294S → N2 PublicationsCorresponds to variant dbSNP:rs2449134Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW73694.1
BC101239 mRNA Translation: AAI01240.1
BC101241 mRNA Translation: AAI01242.1
AF065863 Genomic DNA Translation: AAC70017.1
AF399527 Genomic DNA Translation: AAK95012.1
BK004343 Genomic DNA Translation: DAA04741.1
CCDSiCCDS31515.1
RefSeqiNP_003688.1, NM_003697.1
UniGeneiHs.553702

Genome annotation databases

EnsembliENST00000278409; ENSP00000278409; ENSG00000149133
GeneIDi338674
KEGGihsa:338674
UCSCiuc010riv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW73694.1
BC101239 mRNA Translation: AAI01240.1
BC101241 mRNA Translation: AAI01242.1
AF065863 Genomic DNA Translation: AAC70017.1
AF399527 Genomic DNA Translation: AAK95012.1
BK004343 Genomic DNA Translation: DAA04741.1
CCDSiCCDS31515.1
RefSeqiNP_003688.1, NM_003697.1
UniGeneiHs.553702

3D structure databases

ProteinModelPortaliO95221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130779, 11 interactors
STRINGi9606.ENSP00000278409

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95221
PhosphoSitePlusiO95221

Polymorphism and mutation databases

BioMutaiOR5F1

Proteomic databases

PaxDbiO95221
PeptideAtlasiO95221
PRIDEiO95221
ProteomicsDBi50725

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278409; ENSP00000278409; ENSG00000149133
GeneIDi338674
KEGGihsa:338674
UCSCiuc010riv.2 human

Organism-specific databases

CTDi338674
EuPathDBiHostDB:ENSG00000149133.1
GeneCardsiOR5F1
HGNCiHGNC:8343 OR5F1
HPAiHPA059360
MIMi608492 gene
neXtProtiNX_O95221
PharmGKBiPA32526
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIU6 Eukaryota
ENOG4111BJM LUCA
GeneTreeiENSGT00910000144101
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO95221
KOiK04257
OMAiSCSDTIL
OrthoDBiEOG091G0AZH
PhylomeDBiO95221
TreeFamiTF352753

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR5F1
GenomeRNAii338674
PROiPR:O95221
SOURCEiSearch...

Gene expression databases

CleanExiHS_OR5F1

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR5F1_HUMAN
AccessioniPrimary (citable) accession number: O95221
Secondary accession number(s): Q495D1, Q6IFB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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