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Protein

Sorting nexin-4

Gene

SNX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei106Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei108Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei132Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei154Phosphatidylinositol 3-phosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: UniProtKB
  • leptin receptor binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • transferrin receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000114520.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11175 SNX4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605931 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95219

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi132K → A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8723

Open Targets

More...
OpenTargetsi
ENSG00000114520

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36014

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138421 – 450Sorting nexin-4Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei22PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95219

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95219

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95219

PeptideAtlas

More...
PeptideAtlasi
O95219

PRoteomics IDEntifications database

More...
PRIDEi
O95219

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50724

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
O95219

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95219

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95219

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114520 Expressed in 234 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_SNX4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95219 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95219 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005709

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (PubMed:17994011). Interacts with BIN1 (PubMed:12668730).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114262, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O95219

Database of interacting proteins

More...
DIPi
DIP-36719N

Protein interaction database and analysis system

More...
IntActi
O95219, 27 interactors

Molecular INTeraction database

More...
MINTi
O95219

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251775

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95219

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95219

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 187PXPROSITE-ProRule annotationAdd BLAST127

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2273 Eukaryota
COG5391 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007933

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG017826

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95219

KEGG Orthology (KO)

More...
KOi
K17919

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYTEFEL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CLA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95219

TreeFam database of animal gene trees

More...
TreeFami
TF328543

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07622 BAR_SNX4, 1 hit
cd06864 PX_SNX4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR034902 PX_SNX4
IPR034783 SNX4
IPR037430 SNX4_BAR
IPR039358 Sorting_nexin-like

The PANTHER Classification System

More...
PANTHERi
PTHR10555 PTHR10555, 1 hit
PTHR10555:SF139 PTHR10555:SF139, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787 PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312 PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195 PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQAPPDPER QLQPAPLEPL GSPDAGLGAA VGKEAEGAGE ESSGVDTMTH
60 70 80 90 100
NNFWLKKIEI SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHTDGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRSYLLVY YPHIVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRIGLEN FLLRIASHPI LCRDKIFYLF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELVTGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV
410 420 430 440 450
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):51,909
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D5B52AC52A07686
GO
Isoform 2 (identifier: O95219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):35,611
Checksum:i2A82E353F65B99BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W9T3F8W9T3_HUMAN
Sorting nexin-4
SNX4
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDD4F8WDD4_HUMAN
Sorting nexin-4
SNX4
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0566651 – 145Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF065485 mRNA Translation: AAC83149.1
AK001835 mRNA Translation: BAG50982.1
AK298972 mRNA Translation: BAG61066.1
AC080096 Genomic DNA No translation available.
AC117487 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79390.1
CH471052 Genomic DNA Translation: EAW79391.1
CH471052 Genomic DNA Translation: EAW79393.1
BC018762 mRNA Translation: AAH18762.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3032.1 [O95219-1]

NCBI Reference Sequences

More...
RefSeqi
NP_003785.1, NM_003794.3 [O95219-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.507243

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251775; ENSP00000251775; ENSG00000114520 [O95219-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8723

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8723

UCSC genome browser

More...
UCSCi
uc003eib.5 human [O95219-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065485 mRNA Translation: AAC83149.1
AK001835 mRNA Translation: BAG50982.1
AK298972 mRNA Translation: BAG61066.1
AC080096 Genomic DNA No translation available.
AC117487 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79390.1
CH471052 Genomic DNA Translation: EAW79391.1
CH471052 Genomic DNA Translation: EAW79393.1
BC018762 mRNA Translation: AAH18762.1
CCDSiCCDS3032.1 [O95219-1]
RefSeqiNP_003785.1, NM_003794.3 [O95219-1]
UniGeneiHs.507243

3D structure databases

ProteinModelPortaliO95219
SMRiO95219
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114262, 26 interactors
CORUMiO95219
DIPiDIP-36719N
IntActiO95219, 27 interactors
MINTiO95219
STRINGi9606.ENSP00000251775

PTM databases

iPTMnetiO95219
PhosphoSitePlusiO95219

2D gel databases

DOSAC-COBS-2DPAGEiO95219

Proteomic databases

EPDiO95219
MaxQBiO95219
PaxDbiO95219
PeptideAtlasiO95219
PRIDEiO95219
ProteomicsDBi50724

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8723
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251775; ENSP00000251775; ENSG00000114520 [O95219-1]
GeneIDi8723
KEGGihsa:8723
UCSCiuc003eib.5 human [O95219-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8723
DisGeNETi8723
EuPathDBiHostDB:ENSG00000114520.10

GeneCards: human genes, protein and diseases

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GeneCardsi
SNX4
HGNCiHGNC:11175 SNX4
HPAiHPA005709
MIMi605931 gene
neXtProtiNX_O95219
OpenTargetsiENSG00000114520
PharmGKBiPA36014

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2273 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00930000151029
HOGENOMiHOG000007933
HOVERGENiHBG017826
InParanoidiO95219
KOiK17919
OMAiRYTEFEL
OrthoDBiEOG091G0CLA
PhylomeDBiO95219
TreeFamiTF328543

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SNX4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SNX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8723

Protein Ontology

More...
PROi
PR:O95219

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114520 Expressed in 234 organ(s), highest expression level in secondary oocyte
CleanExiHS_SNX4
ExpressionAtlasiO95219 baseline and differential
GenevisibleiO95219 HS

Family and domain databases

CDDicd07622 BAR_SNX4, 1 hit
cd06864 PX_SNX4, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR034902 PX_SNX4
IPR034783 SNX4
IPR037430 SNX4_BAR
IPR039358 Sorting_nexin-like
PANTHERiPTHR10555 PTHR10555, 1 hit
PTHR10555:SF139 PTHR10555:SF139, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNX4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95219
Secondary accession number(s): B3KMH0, B4DQV4, D3DNA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: December 5, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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