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UniProtKB - O95218 (ZRAB2_HUMAN)

Entry version 186 (12 Aug 2020)
Sequence version 2 (01 May 2007)
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Protein

Zinc finger Ran-binding domain-containing protein 2

Gene

ZRANB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95218

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger Ran-binding domain-containing protein 2
Alternative name(s):
Zinc finger protein 265
Zinc finger, splicing
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZRANB2
Synonyms:ZIS, ZNF265
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000132485.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:13058, ZRANB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604347, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95218

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9406

Open Targets

More...OpenTargetsi		ENSG00000132485

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37636

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95218, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZRANB2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000665851 – 330Zinc finger Ran-binding domain-containing protein 2Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Modified residuei18N6-acetyllysineBy similarity1
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei92N6-acetyllysineBy similarity1
Modified residuei120PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Isoform 2 (identifier: O95218-2)
Modified residuei303PhosphothreonineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95218

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95218

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95218

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95218

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95218

PeptideAtlas

More...PeptideAtlasi		O95218

PRoteomics IDEntifications database

More...PRIDEi		O95218

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50722 [O95218-1]
50723 [O95218-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O95218-1 [O95218-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95218

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O95218

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95218

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132485, Expressed in endometrium and 215 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95218, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132485, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114802, 104 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95218

Protein interaction database and analysis system

More...IntActi		O95218, 47 interactors

Molecular INTeraction database

More...MINTi		O95218

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359958

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95218, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95218

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O95218

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni151 – 324Required for nuclear targetingAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 262Arg/Ser-richAdd BLAST65

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RanBP2-type zinc fingers mediate binding to RNA.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZRANB2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1995, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_061048_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95218

Identification of Orthologs from Complete Genome Data

More...OMAi		DLWGDNE

Database of Orthologous Groups

More...OrthoDBi		1399319at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95218

TreeFam database of animal gene trees

More...TreeFami		TF105996

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017337, UCP037956_Znf_RanB2
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00641, zf-RanBP, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037956, UCP037956_ZnF_Ran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00547, ZnF_RBZ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90209, SSF90209, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01358, ZF_RANBP2_1, 2 hits
PS50199, ZF_RANBP2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95218-1) [UniParc]FASTAAdd to basket
Also known as: ZIS-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT 
        60         70         80         90        100
EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT 
       110        120        130        140        150
GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED 
       160        170        180        190        200
KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR 
       210        220        230        240        250
RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SRSSSRERSR 
       260        270        280        290        300
SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK 
       310        320        330
RRTRSRSPER RHRSSSGSSH SGSRSSSKKK
Length:330
Mass (Da):37,404
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99BE2D12EBE0FF8E
GO
Isoform 2 (identifier: O95218-2) [UniParc]FASTAAdd to basket
Also known as: ZIS-2

The sequence of this isoform differs from the canonical sequence as follows:
     310-330: RRHRSSSGSSHSGSRSSSKKK → SQVIGENTKQP

Show »
Length:320
Mass (Da):36,318
Checksum:i15F1DFB7CD6CF611
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD09746 differs from that shown. Reason: Frameshift.Curated
The sequence AAD09747 differs from that shown. Reason: Frameshift.Curated
The sequence BAD92805 differs from that shown. Intron retention.Curated
The sequence CAB66879 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41E → G in BAD96578 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030783207R → G2 PublicationsCorresponds to variant dbSNP:rs11583800Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024945310 – 330RRHRS…SSKKK → SQVIGENTKQP in isoform 2. 5 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF065391 mRNA Translation: AAD09746.1 Frameshift.
AF065392 mRNA Translation: AAD09747.1 Frameshift.
AL136945 mRNA Translation: CAB66879.1 Frameshift.
AB209568 mRNA Translation: BAD92805.1 Sequence problems.
AK222858 mRNA Translation: BAD96578.1
AL512443 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06433.1
CH471059 Genomic DNA Translation: EAX06435.1
BC039814 mRNA Translation: AAH39814.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS659.1 [O95218-1]
CCDS660.1 [O95218-2]

NCBI Reference Sequences

More...RefSeqi		NP_005446.2, NM_005455.4 [O95218-2]
NP_976225.1, NM_203350.2 [O95218-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000254821; ENSP00000254821; ENSG00000132485 [O95218-2]
ENST00000370920; ENSP00000359958; ENSG00000132485 [O95218-1]
ENST00000611683; ENSP00000482026; ENSG00000132485 [O95218-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9406

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9406

UCSC genome browser

More...UCSCi		uc001dfs.4, human [O95218-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065391 mRNA Translation: AAD09746.1 Frameshift.
AF065392 mRNA Translation: AAD09747.1 Frameshift.
AL136945 mRNA Translation: CAB66879.1 Frameshift.
AB209568 mRNA Translation: BAD92805.1 Sequence problems.
AK222858 mRNA Translation: BAD96578.1
AL512443 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06433.1
CH471059 Genomic DNA Translation: EAX06435.1
BC039814 mRNA Translation: AAH39814.1
CCDSiCCDS659.1 [O95218-1]
CCDS660.1 [O95218-2]
RefSeqiNP_005446.2, NM_005455.4 [O95218-2]
NP_976225.1, NM_203350.2 [O95218-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N0ZNMR-A1-40[»]
2K1PNMR-A65-95[»]
3G9YX-ray1.40A65-95[»]
SMRiO95218
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114802, 104 interactors
CORUMiO95218
IntActiO95218, 47 interactors
MINTiO95218
STRINGi9606.ENSP00000359958

PTM databases

iPTMnetiO95218
MetOSiteiO95218
PhosphoSitePlusiO95218

Polymorphism and mutation databases

BioMutaiZRANB2

Proteomic databases

EPDiO95218
jPOSTiO95218
MassIVEiO95218
MaxQBiO95218
PaxDbiO95218
PeptideAtlasiO95218
PRIDEiO95218
ProteomicsDBi50722 [O95218-1]
50723 [O95218-2]
TopDownProteomicsiO95218-1 [O95218-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19679, 274 antibodies

The DNASU plasmid repository

More...DNASUi		9406

Genome annotation databases

EnsembliENST00000254821; ENSP00000254821; ENSG00000132485 [O95218-2]
ENST00000370920; ENSP00000359958; ENSG00000132485 [O95218-1]
ENST00000611683; ENSP00000482026; ENSG00000132485 [O95218-2]
GeneIDi9406
KEGGihsa:9406
UCSCiuc001dfs.4, human [O95218-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9406
DisGeNETi9406
EuPathDBiHostDB:ENSG00000132485.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZRANB2
HGNCiHGNC:13058, ZRANB2
HPAiENSG00000132485, Low tissue specificity
MIMi604347, gene
neXtProtiNX_O95218
OpenTargetsiENSG00000132485
PharmGKBiPA37636

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1995, Eukaryota
GeneTreeiENSGT00730000111078
HOGENOMiCLU_061048_0_0_1
InParanoidiO95218
OMAiDLWGDNE
OrthoDBi1399319at2759
PhylomeDBiO95218
TreeFamiTF105996

Enzyme and pathway databases

PathwayCommonsiO95218

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9406, 214 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZRANB2, human
EvolutionaryTraceiO95218

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZRANB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9406
PharosiO95218, Tbio

Protein Ontology

More...PROi		PR:O95218
RNActiO95218, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132485, Expressed in endometrium and 215 other tissues
GenevisibleiO95218, HS

Family and domain databases

InterProiView protein in InterPro
IPR017337, UCP037956_Znf_RanB2
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PfamiView protein in Pfam
PF00641, zf-RanBP, 2 hits
PIRSFiPIRSF037956, UCP037956_ZnF_Ran, 1 hit
SMARTiView protein in SMART
SM00547, ZnF_RBZ, 2 hits
SUPFAMiSSF90209, SSF90209, 2 hits
PROSITEiView protein in PROSITE
PS01358, ZF_RANBP2_1, 2 hits
PS50199, ZF_RANBP2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZRAB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95218
Secondary accession number(s): D3DQ75
, Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: August 12, 2020
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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