UniProtKB - O95218 (ZRAB2_HUMAN)
Protein
Zinc finger Ran-binding domain-containing protein 2
Gene
ZRANB2
Organism
Homo sapiens (Human)
Status
Functioni
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 9 – 40 | RanBP2-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 65 – 94 | RanBP2-type 2PROSITE-ProRule annotationAdd BLAST | 30 |
GO - Molecular functioni
- lipopolysaccharide binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95218 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger Ran-binding domain-containing protein 2Alternative name(s): Zinc finger protein 265 Zinc finger, splicing |
Gene namesi | Name:ZRANB2 Synonyms:ZIS, ZNF265 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000132485.12 |
HGNCi | HGNC:13058, ZRANB2 |
MIMi | 604347, gene |
neXtProti | NX_O95218 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9406 |
OpenTargetsi | ENSG00000132485 |
PharmGKBi | PA37636 |
Miscellaneous databases
Pharosi | O95218, Tbio |
Polymorphism and mutation databases
BioMutai | ZRANB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066585 | 1 – 330 | Zinc finger Ran-binding domain-containing protein 2Add BLAST | 330 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 9 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 18 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 54 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 92 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 120 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 153 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 181 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 188 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 193 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: O95218-2) | |||||
Modified residuei | 303 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 305 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 307 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 310 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95218 |
jPOSTi | O95218 |
MassIVEi | O95218 |
MaxQBi | O95218 |
PaxDbi | O95218 |
PeptideAtlasi | O95218 |
PRIDEi | O95218 |
ProteomicsDBi | 50722 [O95218-1] 50723 [O95218-2] |
TopDownProteomicsi | O95218-1 [O95218-1] |
PTM databases
iPTMneti | O95218 |
MetOSitei | O95218 |
PhosphoSitePlusi | O95218 |
Expressioni
Gene expression databases
Bgeei | ENSG00000132485, Expressed in endometrium and 215 other tissues |
Genevisiblei | O95218, HS |
Organism-specific databases
HPAi | ENSG00000132485, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
2 PublicationsBinary interactionsi
Hide detailsO95218
With | #Exp. | IntAct |
---|---|---|
AKAP17A [Q02040] | 4 | EBI-1051583,EBI-1042725 |
ARRB1 [P49407] | 4 | EBI-1051583,EBI-743313 |
ARRB2 [P32121] | 4 | EBI-1051583,EBI-714559 |
LRRK2 [Q5S007] | 2 | EBI-1051583,EBI-5323863 |
Protein-protein interaction databases
BioGRIDi | 114802, 108 interactors |
CORUMi | O95218 |
IntActi | O95218, 47 interactors |
MINTi | O95218 |
STRINGi | 9606.ENSP00000359958 |
Miscellaneous databases
RNActi | O95218, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O95218 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95218 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 151 – 324 | Required for nuclear targetingAdd BLAST | 174 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 198 – 262 | Arg/Ser-richAdd BLAST | 65 |
Domaini
The RanBP2-type zinc fingers mediate binding to RNA.
Sequence similaritiesi
Belongs to the ZRANB2 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 9 – 40 | RanBP2-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 65 – 94 | RanBP2-type 2PROSITE-ProRule annotationAdd BLAST | 30 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1995, Eukaryota |
GeneTreei | ENSGT00730000111078 |
HOGENOMi | CLU_061048_0_0_1 |
InParanoidi | O95218 |
OMAi | DLWGDNE |
OrthoDBi | 1399319at2759 |
PhylomeDBi | O95218 |
TreeFami | TF105996 |
Family and domain databases
InterProi | View protein in InterPro IPR017337, UCP037956_Znf_RanB2 IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
Pfami | View protein in Pfam PF00641, zf-RanBP, 2 hits |
PIRSFi | PIRSF037956, UCP037956_ZnF_Ran, 1 hit |
SMARTi | View protein in SMART SM00547, ZnF_RBZ, 2 hits |
SUPFAMi | SSF90209, SSF90209, 2 hits |
PROSITEi | View protein in PROSITE PS01358, ZF_RANBP2_1, 2 hits PS50199, ZF_RANBP2_2, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O95218-1) [UniParc]FASTAAdd to basket
Also known as: ZIS-1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT
60 70 80 90 100
EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT
110 120 130 140 150
GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED
160 170 180 190 200
KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR
210 220 230 240 250
RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SRSSSRERSR
260 270 280 290 300
SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK
310 320 330
RRTRSRSPER RHRSSSGSSH SGSRSSSKKK
Sequence cautioni
The sequence AAD09746 differs from that shown. Reason: Frameshift.Curated
The sequence AAD09747 differs from that shown. Reason: Frameshift.Curated
The sequence CAB66879 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | E → G in BAD96578 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030783 | 207 | R → G2 PublicationsCorresponds to variant dbSNP:rs11583800Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024945 | 310 – 330 | RRHRS…SSKKK → SQVIGENTKQP in isoform 2. 5 PublicationsAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF065391 mRNA Translation: AAD09746.1 Frameshift. AF065392 mRNA Translation: AAD09747.1 Frameshift. AL136945 mRNA Translation: CAB66879.1 Frameshift. AB209568 mRNA Translation: BAD92805.1 Sequence problems. AK222858 mRNA Translation: BAD96578.1 AL512443 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06433.1 CH471059 Genomic DNA Translation: EAX06435.1 BC039814 mRNA Translation: AAH39814.1 |
CCDSi | CCDS659.1 [O95218-1] CCDS660.1 [O95218-2] |
RefSeqi | NP_005446.2, NM_005455.4 [O95218-2] NP_976225.1, NM_203350.2 [O95218-1] |
Genome annotation databases
Ensembli | ENST00000254821; ENSP00000254821; ENSG00000132485 [O95218-2] ENST00000370920; ENSP00000359958; ENSG00000132485 [O95218-1] ENST00000611683; ENSP00000482026; ENSG00000132485 [O95218-2] |
GeneIDi | 9406 |
KEGGi | hsa:9406 |
UCSCi | uc001dfs.4, human [O95218-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF065391 mRNA Translation: AAD09746.1 Frameshift. AF065392 mRNA Translation: AAD09747.1 Frameshift. AL136945 mRNA Translation: CAB66879.1 Frameshift. AB209568 mRNA Translation: BAD92805.1 Sequence problems. AK222858 mRNA Translation: BAD96578.1 AL512443 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06433.1 CH471059 Genomic DNA Translation: EAX06435.1 BC039814 mRNA Translation: AAH39814.1 |
CCDSi | CCDS659.1 [O95218-1] CCDS660.1 [O95218-2] |
RefSeqi | NP_005446.2, NM_005455.4 [O95218-2] NP_976225.1, NM_203350.2 [O95218-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N0Z | NMR | - | A | 1-40 | [»] | |
2K1P | NMR | - | A | 65-95 | [»] | |
3G9Y | X-ray | 1.40 | A | 65-95 | [»] | |
SMRi | O95218 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114802, 108 interactors |
CORUMi | O95218 |
IntActi | O95218, 47 interactors |
MINTi | O95218 |
STRINGi | 9606.ENSP00000359958 |
PTM databases
iPTMneti | O95218 |
MetOSitei | O95218 |
PhosphoSitePlusi | O95218 |
Polymorphism and mutation databases
BioMutai | ZRANB2 |
Proteomic databases
EPDi | O95218 |
jPOSTi | O95218 |
MassIVEi | O95218 |
MaxQBi | O95218 |
PaxDbi | O95218 |
PeptideAtlasi | O95218 |
PRIDEi | O95218 |
ProteomicsDBi | 50722 [O95218-1] 50723 [O95218-2] |
TopDownProteomicsi | O95218-1 [O95218-1] |
Protocols and materials databases
Antibodypediai | 19679, 274 antibodies |
DNASUi | 9406 |
Genome annotation databases
Ensembli | ENST00000254821; ENSP00000254821; ENSG00000132485 [O95218-2] ENST00000370920; ENSP00000359958; ENSG00000132485 [O95218-1] ENST00000611683; ENSP00000482026; ENSG00000132485 [O95218-2] |
GeneIDi | 9406 |
KEGGi | hsa:9406 |
UCSCi | uc001dfs.4, human [O95218-1] |
Organism-specific databases
CTDi | 9406 |
DisGeNETi | 9406 |
EuPathDBi | HostDB:ENSG00000132485.12 |
GeneCardsi | ZRANB2 |
HGNCi | HGNC:13058, ZRANB2 |
HPAi | ENSG00000132485, Low tissue specificity |
MIMi | 604347, gene |
neXtProti | NX_O95218 |
OpenTargetsi | ENSG00000132485 |
PharmGKBi | PA37636 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1995, Eukaryota |
GeneTreei | ENSGT00730000111078 |
HOGENOMi | CLU_061048_0_0_1 |
InParanoidi | O95218 |
OMAi | DLWGDNE |
OrthoDBi | 1399319at2759 |
PhylomeDBi | O95218 |
TreeFami | TF105996 |
Enzyme and pathway databases
PathwayCommonsi | O95218 |
Miscellaneous databases
BioGRID-ORCSi | 9406, 215 hits in 848 CRISPR screens |
ChiTaRSi | ZRANB2, human |
EvolutionaryTracei | O95218 |
GeneWikii | ZRANB2 |
GenomeRNAii | 9406 |
Pharosi | O95218, Tbio |
PROi | PR:O95218 |
RNActi | O95218, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132485, Expressed in endometrium and 215 other tissues |
Genevisiblei | O95218, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017337, UCP037956_Znf_RanB2 IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
Pfami | View protein in Pfam PF00641, zf-RanBP, 2 hits |
PIRSFi | PIRSF037956, UCP037956_ZnF_Ran, 1 hit |
SMARTi | View protein in SMART SM00547, ZnF_RBZ, 2 hits |
SUPFAMi | SSF90209, SSF90209, 2 hits |
PROSITEi | View protein in PROSITE PS01358, ZF_RANBP2_1, 2 hits PS50199, ZF_RANBP2_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZRAB2_HUMAN | |
Accessioni | O95218Primary (citable) accession number: O95218 Secondary accession number(s): D3DQ75 Q9UP63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations