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Protein

Zinc finger Ran-binding domain-containing protein 2

Gene

ZRANB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Ran-binding domain-containing protein 2
Alternative name(s):
Zinc finger protein 265
Zinc finger, splicing
Gene namesi
Name:ZRANB2
Synonyms:ZIS, ZNF265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132485.12
HGNCiHGNC:13058 ZRANB2
MIMi604347 gene
neXtProtiNX_O95218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9406
OpenTargetsiENSG00000132485
PharmGKBiPA37636

Polymorphism and mutation databases

BioMutaiZRANB2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665851 – 330Zinc finger Ran-binding domain-containing protein 2Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei18N6-acetyllysineBy similarity1
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei92N6-acetyllysineBy similarity1
Modified residuei120PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Isoform 2 (identifier: O95218-2)
Modified residuei303PhosphothreonineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1

Post-translational modificationi

Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95218
MaxQBiO95218
PaxDbiO95218
PeptideAtlasiO95218
PRIDEiO95218
ProteomicsDBi50722
50723 [O95218-2]
TopDownProteomicsiO95218-1 [O95218-1]

PTM databases

iPTMnetiO95218
PhosphoSitePlusiO95218

Expressioni

Gene expression databases

BgeeiENSG00000132485 Expressed in 201 organ(s), highest expression level in endometrium
CleanExiHS_ZRANB2
GenevisibleiO95218 HS

Organism-specific databases

HPAiHPA053960
HPA061949
HPA063298

Interactioni

Subunit structurei

Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114802, 81 interactors
CORUMiO95218
IntActiO95218, 20 interactors
MINTiO95218
STRINGi9606.ENSP00000359958

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95218
SMRiO95218
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95218

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 324Required for nuclear targetingAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 262Arg/Ser-richAdd BLAST65

Domaini

The RanBP2-type zinc fingers mediate binding to RNA.

Sequence similaritiesi

Belongs to the ZRANB2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1995 Eukaryota
ENOG4111QXA LUCA
GeneTreeiENSGT00730000111078
HOVERGENiHBG066285
InParanoidiO95218
OMAiDLWGDNE
PhylomeDBiO95218
TreeFamiTF105996

Family and domain databases

InterProiView protein in InterPro
IPR017337 UCP037956_Znf_RanB2
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF00641 zf-RanBP, 2 hits
PIRSFiPIRSF037956 UCP037956_ZnF_Ran, 1 hit
SMARTiView protein in SMART
SM00547 ZnF_RBZ, 2 hits
SUPFAMiSSF90209 SSF90209, 2 hits
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 2 hits
PS50199 ZF_RANBP2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95218-1) [UniParc]FASTAAdd to basket
Also known as: ZIS-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT
60 70 80 90 100
EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT
110 120 130 140 150
GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED
160 170 180 190 200
KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR
210 220 230 240 250
RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SRSSSRERSR
260 270 280 290 300
SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK
310 320 330
RRTRSRSPER RHRSSSGSSH SGSRSSSKKK
Length:330
Mass (Da):37,404
Last modified:May 1, 2007 - v2
Checksum:i99BE2D12EBE0FF8E
GO
Isoform 2 (identifier: O95218-2) [UniParc]FASTAAdd to basket
Also known as: ZIS-2

The sequence of this isoform differs from the canonical sequence as follows:
     310-330: RRHRSSSGSSHSGSRSSSKKK → SQVIGENTKQP

Show »
Length:320
Mass (Da):36,318
Checksum:i15F1DFB7CD6CF611
GO

Sequence cautioni

The sequence AAD09746 differs from that shown. Reason: Frameshift at position 236.Curated
The sequence AAD09747 differs from that shown. Reason: Frameshift at position 236.Curated
The sequence BAD92805 differs from that shown. Intron retention.Curated
The sequence CAB66879 differs from that shown. Reason: Frameshift at position 236.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41E → G in BAD96578 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030783207R → G2 PublicationsCorresponds to variant dbSNP:rs11583800Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024945310 – 330RRHRS…SSKKK → SQVIGENTKQP in isoform 2. 5 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065391 mRNA Translation: AAD09746.1 Frameshift.
AF065392 mRNA Translation: AAD09747.1 Frameshift.
AL136945 mRNA Translation: CAB66879.1 Frameshift.
AB209568 mRNA Translation: BAD92805.1 Sequence problems.
AK222858 mRNA Translation: BAD96578.1
AL512443 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06433.1
CH471059 Genomic DNA Translation: EAX06435.1
BC039814 mRNA Translation: AAH39814.1
CCDSiCCDS659.1 [O95218-1]
CCDS660.1 [O95218-2]
RefSeqiNP_005446.2, NM_005455.4 [O95218-2]
NP_976225.1, NM_203350.2 [O95218-1]
UniGeneiHs.194718

Genome annotation databases

EnsembliENST00000254821; ENSP00000254821; ENSG00000132485 [O95218-2]
ENST00000370920; ENSP00000359958; ENSG00000132485 [O95218-1]
ENST00000611683; ENSP00000482026; ENSG00000132485 [O95218-2]
GeneIDi9406
KEGGihsa:9406
UCSCiuc001dfs.4 human [O95218-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065391 mRNA Translation: AAD09746.1 Frameshift.
AF065392 mRNA Translation: AAD09747.1 Frameshift.
AL136945 mRNA Translation: CAB66879.1 Frameshift.
AB209568 mRNA Translation: BAD92805.1 Sequence problems.
AK222858 mRNA Translation: BAD96578.1
AL512443 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06433.1
CH471059 Genomic DNA Translation: EAX06435.1
BC039814 mRNA Translation: AAH39814.1
CCDSiCCDS659.1 [O95218-1]
CCDS660.1 [O95218-2]
RefSeqiNP_005446.2, NM_005455.4 [O95218-2]
NP_976225.1, NM_203350.2 [O95218-1]
UniGeneiHs.194718

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N0ZNMR-A1-40[»]
2K1PNMR-A65-95[»]
3G9YX-ray1.40A65-95[»]
ProteinModelPortaliO95218
SMRiO95218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114802, 81 interactors
CORUMiO95218
IntActiO95218, 20 interactors
MINTiO95218
STRINGi9606.ENSP00000359958

PTM databases

iPTMnetiO95218
PhosphoSitePlusiO95218

Polymorphism and mutation databases

BioMutaiZRANB2

Proteomic databases

EPDiO95218
MaxQBiO95218
PaxDbiO95218
PeptideAtlasiO95218
PRIDEiO95218
ProteomicsDBi50722
50723 [O95218-2]
TopDownProteomicsiO95218-1 [O95218-1]

Protocols and materials databases

DNASUi9406
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254821; ENSP00000254821; ENSG00000132485 [O95218-2]
ENST00000370920; ENSP00000359958; ENSG00000132485 [O95218-1]
ENST00000611683; ENSP00000482026; ENSG00000132485 [O95218-2]
GeneIDi9406
KEGGihsa:9406
UCSCiuc001dfs.4 human [O95218-1]

Organism-specific databases

CTDi9406
DisGeNETi9406
EuPathDBiHostDB:ENSG00000132485.12
GeneCardsiZRANB2
HGNCiHGNC:13058 ZRANB2
HPAiHPA053960
HPA061949
HPA063298
MIMi604347 gene
neXtProtiNX_O95218
OpenTargetsiENSG00000132485
PharmGKBiPA37636
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1995 Eukaryota
ENOG4111QXA LUCA
GeneTreeiENSGT00730000111078
HOVERGENiHBG066285
InParanoidiO95218
OMAiDLWGDNE
PhylomeDBiO95218
TreeFamiTF105996

Miscellaneous databases

EvolutionaryTraceiO95218
GeneWikiiZRANB2
GenomeRNAii9406
PROiPR:O95218
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132485 Expressed in 201 organ(s), highest expression level in endometrium
CleanExiHS_ZRANB2
GenevisibleiO95218 HS

Family and domain databases

InterProiView protein in InterPro
IPR017337 UCP037956_Znf_RanB2
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF00641 zf-RanBP, 2 hits
PIRSFiPIRSF037956 UCP037956_ZnF_Ran, 1 hit
SMARTiView protein in SMART
SM00547 ZnF_RBZ, 2 hits
SUPFAMiSSF90209 SSF90209, 2 hits
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 2 hits
PS50199 ZF_RANBP2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZRAB2_HUMAN
AccessioniPrimary (citable) accession number: O95218
Secondary accession number(s): D3DQ75
, Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: September 12, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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