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Protein

Leptin receptor overlapping transcript-like 1

Gene

LEPROTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor overlapping transcript-like 1
Alternative name(s):
Endospanin-2
Gene namesi
ORF Names:My047, UNQ577/PRO1139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104660.17
HGNCiHGNC:6555 LEPROTL1
MIMi607338 gene
neXtProtiNX_O95214

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23484
OpenTargetsiENSG00000104660
PharmGKBiPA30334

Polymorphism and mutation databases

BioMutaiLEPROTL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151971 – 131Leptin receptor overlapping transcript-like 1Add BLAST131

Proteomic databases

EPDiO95214
PaxDbiO95214
PeptideAtlasiO95214
PRIDEiO95214
ProteomicsDBi50721

PTM databases

SwissPalmiO95214

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Gene expression databases

BgeeiENSG00000104660 Expressed in 227 organ(s), highest expression level in forebrain
CleanExiHS_LEPROTL1
ExpressionAtlasiO95214 baseline and differential
GenevisibleiO95214 HS

Organism-specific databases

HPAiHPA047911

Interactioni

Subunit structurei

Interacts with RAB13.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRG1Q96E933EBI-750776,EBI-750770

Protein-protein interaction databases

BioGridi117042, 6 interactors
IntActiO95214, 59 interactors
STRINGi9606.ENSP00000428281

Structurei

3D structure databases

ProteinModelPortaliO95214
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2174 Eukaryota
ENOG4111UCZ LUCA
GeneTreeiENSGT00390000006503
HOGENOMiHOG000038515
HOVERGENiHBG001034
InParanoidiO95214
OrthoDBiEOG091G0V32
PhylomeDBiO95214
TreeFamiTF313689

Family and domain databases

InterProiView protein in InterPro
IPR007262 VPS55
PANTHERiPTHR12050 PTHR12050, 1 hit
PfamiView protein in Pfam
PF04133 Vps55, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95214-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC
60 70 80 90 100
IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA
110 120 130
LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W
Length:131
Mass (Da):14,428
Last modified:April 13, 2004 - v2
Checksum:iE5E75B7C77A99DD7
GO
Isoform 2 (identifier: O95214-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):18,366
Checksum:i4B9D1D720138E4D6
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJS9E5RJS9_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
154Annotation score:
C9JVM4C9JVM4_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
144Annotation score:
E5RHU8E5RHU8_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
162Annotation score:
H0YBC1H0YBC1_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
136Annotation score:
E5RIL0E5RIL0_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
106Annotation score:
E5RIQ0E5RIQ0_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123N → K in AAC98697 (PubMed:11342119).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04630794 – 131IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063605 mRNA Translation: AAC98697.1
AY358674 mRNA Translation: AAQ89037.1
AC026979 Genomic DNA No translation available.
AC044849 Genomic DNA No translation available.
AL546441 mRNA No translation available.
BC000642 mRNA Translation: AAH00642.1
CCDSiCCDS47834.1 [O95214-2]
CCDS6075.1 [O95214-1]
RefSeqiNP_001121680.1, NM_001128208.1 [O95214-2]
NP_056159.2, NM_015344.2 [O95214-1]
UniGeneiHs.146585

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660 [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660 [O95214-2]
GeneIDi23484
KEGGihsa:23484
UCSCiuc003xhx.3 human [O95214-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063605 mRNA Translation: AAC98697.1
AY358674 mRNA Translation: AAQ89037.1
AC026979 Genomic DNA No translation available.
AC044849 Genomic DNA No translation available.
AL546441 mRNA No translation available.
BC000642 mRNA Translation: AAH00642.1
CCDSiCCDS47834.1 [O95214-2]
CCDS6075.1 [O95214-1]
RefSeqiNP_001121680.1, NM_001128208.1 [O95214-2]
NP_056159.2, NM_015344.2 [O95214-1]
UniGeneiHs.146585

3D structure databases

ProteinModelPortaliO95214
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117042, 6 interactors
IntActiO95214, 59 interactors
STRINGi9606.ENSP00000428281

PTM databases

SwissPalmiO95214

Polymorphism and mutation databases

BioMutaiLEPROTL1

Proteomic databases

EPDiO95214
PaxDbiO95214
PeptideAtlasiO95214
PRIDEiO95214
ProteomicsDBi50721

Protocols and materials databases

DNASUi23484
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660 [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660 [O95214-2]
GeneIDi23484
KEGGihsa:23484
UCSCiuc003xhx.3 human [O95214-1]

Organism-specific databases

CTDi23484
DisGeNETi23484
EuPathDBiHostDB:ENSG00000104660.17
GeneCardsiLEPROTL1
HGNCiHGNC:6555 LEPROTL1
HPAiHPA047911
MIMi607338 gene
neXtProtiNX_O95214
OpenTargetsiENSG00000104660
PharmGKBiPA30334
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2174 Eukaryota
ENOG4111UCZ LUCA
GeneTreeiENSGT00390000006503
HOGENOMiHOG000038515
HOVERGENiHBG001034
InParanoidiO95214
OrthoDBiEOG091G0V32
PhylomeDBiO95214
TreeFamiTF313689

Miscellaneous databases

ChiTaRSiLEPROTL1 human
GenomeRNAii23484
PROiPR:O95214
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104660 Expressed in 227 organ(s), highest expression level in forebrain
CleanExiHS_LEPROTL1
ExpressionAtlasiO95214 baseline and differential
GenevisibleiO95214 HS

Family and domain databases

InterProiView protein in InterPro
IPR007262 VPS55
PANTHERiPTHR12050 PTHR12050, 1 hit
PfamiView protein in Pfam
PF04133 Vps55, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLERL1_HUMAN
AccessioniPrimary (citable) accession number: O95214
Secondary accession number(s): E9PHP8, Q9BW48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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