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Entry version 144 (12 Aug 2020)
Sequence version 2 (13 Apr 2004)
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Protein

Leptin receptor overlapping transcript-like 1

Gene

LEPROTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O95214

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leptin receptor overlapping transcript-like 1
Alternative name(s):
Endospanin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:My047, UNQ577/PRO1139
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000104660.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6555, LEPROTL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607338, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95214

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23484

Open Targets

More...
OpenTargetsi
ENSG00000104660

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30334

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95214, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LEPROTL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002151971 – 131Leptin receptor overlapping transcript-like 1Add BLAST131

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95214

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95214

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95214

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95214

PeptideAtlas

More...
PeptideAtlasi
O95214

PRoteomics IDEntifications database

More...
PRIDEi
O95214

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20577
50721 [O95214-1]

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O95214

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104660, Expressed in forebrain and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95214, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95214, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104660, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB13.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O95214
With#Exp.IntAct
AGPAT4 [Q9NRZ5]3EBI-750776,EBI-1754287
ARL13B [Q3SXY8]3EBI-750776,EBI-11343438
C2CD2L [O14523]3EBI-750776,EBI-12822627
CD300C [Q08708]3EBI-750776,EBI-3915344
CD79A [P11912]3EBI-750776,EBI-7797864
CISD2 [Q8N5K1]3EBI-750776,EBI-1045797
CLDN7 [O95471]3EBI-750776,EBI-740744
CLEC2D - isoform 2 [Q9UHP7-3]3EBI-750776,EBI-11749983
CREB3L1 [Q96BA8]3EBI-750776,EBI-6942903
CYP4F2 [P78329]3EBI-750776,EBI-1752413
EDA [Q92838]4EBI-750776,EBI-529425
EHHADH [Q08426]5EBI-750776,EBI-2339219
ELOVL4 [Q9GZR5]3EBI-750776,EBI-18535450
EMP1 [P54849]3EBI-750776,EBI-4319440
FFAR2 [O15552]3EBI-750776,EBI-2833872
FMO1 [Q01740]3EBI-750776,EBI-12701460
GJA5 [P36382]3EBI-750776,EBI-750433
GJA8 [P48165]3EBI-750776,EBI-17458373
GPR152 [Q8TDT2]3EBI-750776,EBI-13345167
GPR42 [O15529]3EBI-750776,EBI-18076404
GPX8 [Q8TED1]3EBI-750776,EBI-11721746
JPH1 [Q9HDC5]3EBI-750776,EBI-465137
KCNJ6 [P48051]3EBI-750776,EBI-12017638
KLRG1 [Q96E93]4EBI-750776,EBI-750770
itself3EBI-750776,EBI-750776
LMBR1 [Q8WVP7]3EBI-750776,EBI-6138627
LNX1 [Q8TBB1]3EBI-750776,EBI-739832
LPAR3 [Q9UBY5]3EBI-750776,EBI-12033434
LRRC4C [Q9HCJ2]3EBI-750776,EBI-3925442
MALL [Q13021]3EBI-750776,EBI-750078
MFSD14B [Q5SR56]3EBI-750776,EBI-373355
MSR1 [P21757]4EBI-750776,EBI-1776976
NAT8 [Q9UHE5]3EBI-750776,EBI-2863634
NDUFA3 [O95167]3EBI-750776,EBI-1246131
NRM [Q8IXM6]3EBI-750776,EBI-10262547
ORMDL1 [Q9P0S3]3EBI-750776,EBI-1054848
ORMDL3 [Q8N138]3EBI-750776,EBI-721750
PAQR8 [Q8TEZ7]3EBI-750776,EBI-12847818
PDZK1IP1 [Q13113]3EBI-750776,EBI-716063
PEX16 [Q9Y5Y5]3EBI-750776,EBI-981985
PLP1 - isoform DM-20 [P60201-2]3EBI-750776,EBI-12188331
RBFA [Q8N0V3]3EBI-750776,EBI-3232108
REEP4 [Q9H6H4]3EBI-750776,EBI-7545592
REEP6 - isoform 2 [Q96HR9-2]3EBI-750776,EBI-14065960
RNF5 [Q99942]3EBI-750776,EBI-348482
RTP2 [Q5QGT7]3EBI-750776,EBI-10244780
SCN3B [Q9NY72]3EBI-750776,EBI-17247926
SDCBP [O00560]3EBI-750776,EBI-727004
SFXN3 [A0A1P0AYU5]3EBI-750776,EBI-14193895
SLC25A46 [Q96AG3]3EBI-750776,EBI-10281975
SLC30A4 [O14863]3EBI-750776,EBI-13918058
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-750776,EBI-17295964
SLC7A1 [P30825]3EBI-750776,EBI-4289564
SMCO4 [Q9NRQ5]3EBI-750776,EBI-8640191
SPG21 [Q9NZD8]3EBI-750776,EBI-742688
SSMEM1 [Q8WWF3]3EBI-750776,EBI-17280858
STING1 [Q86WV6]3EBI-750776,EBI-2800345
STX12 [Q86Y82]3EBI-750776,EBI-2691717
SYNDIG1 [Q9H7V2]3EBI-750776,EBI-726331
TGFA - isoform 2 [P01135-2]3EBI-750776,EBI-12367411
TMEM11 [P17152]3EBI-750776,EBI-723946
TMEM14B [Q9NUH8]3EBI-750776,EBI-8638294
TMEM19 [Q96HH6]3EBI-750776,EBI-741829
TMEM237 - isoform 2 [Q96Q45-2]3EBI-750776,EBI-10982110
TMEM248 [Q9NWD8]3EBI-750776,EBI-10314986
TMEM42 [Q69YG0]3EBI-750776,EBI-12038591
TMEM50A [O95807]3EBI-750776,EBI-12903814
TMEM50B [P56557]3EBI-750776,EBI-12366453
TMEM60 [Q9H2L4]3EBI-750776,EBI-2852148
TMX2 [Q9Y320]3EBI-750776,EBI-6447886
TSNARE1 [A0AVG3]3EBI-750776,EBI-12003468
TSPAN2 [O60636]3EBI-750776,EBI-3914288
TVP23A [A6NH52]3EBI-750776,EBI-13296313
VAPA [Q9P0L0]3EBI-750776,EBI-1059156
YIPF2 [Q9BWQ6]3EBI-750776,EBI-751204
ZDHHC15 [Q96MV8]3EBI-750776,EBI-12837904

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117042, 6 interactors

Protein interaction database and analysis system

More...
IntActi
O95214, 75 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428281

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95214, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2174, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006503

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1577984_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95214

Database of Orthologous Groups

More...
OrthoDBi
1642378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95214

TreeFam database of animal gene trees

More...
TreeFami
TF313689

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007262, Vps55/LEPROT

The PANTHER Classification System

More...
PANTHERi
PTHR12050, PTHR12050, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04133, Vps55, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95214-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC
60 70 80 90 100
IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA
110 120 130
LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W
Length:131
Mass (Da):14,428
Last modified:April 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5E75B7C77A99DD7
GO
Isoform 2 (identifier: O95214-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ

Show »
Length:169
Mass (Da):18,366
Checksum:i4B9D1D720138E4D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHU8E5RHU8_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVM4C9JVM4_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJS9E5RJS9_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBC1H0YBC1_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIL0E5RIL0_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIQ0E5RIQ0_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS19A0A3B3IS19_HUMAN
Leptin receptor overlapping transcr...
LEPROTL1 hCG_15463
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123N → K in AAC98697 (PubMed:11342119).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04630794 – 131IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF063605 mRNA Translation: AAC98697.1
AY358674 mRNA Translation: AAQ89037.1
AC026979 Genomic DNA No translation available.
AC044849 Genomic DNA No translation available.
AL546441 mRNA No translation available.
BC000642 mRNA Translation: AAH00642.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47834.1 [O95214-2]
CCDS6075.1 [O95214-1]

NCBI Reference Sequences

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RefSeqi
NP_001121680.1, NM_001128208.1 [O95214-2]
NP_056159.2, NM_015344.2 [O95214-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000321250; ENSP00000314625; ENSG00000104660 [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660 [O95214-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23484

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23484

UCSC genome browser

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UCSCi
uc003xhx.3, human [O95214-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063605 mRNA Translation: AAC98697.1
AY358674 mRNA Translation: AAQ89037.1
AC026979 Genomic DNA No translation available.
AC044849 Genomic DNA No translation available.
AL546441 mRNA No translation available.
BC000642 mRNA Translation: AAH00642.1
CCDSiCCDS47834.1 [O95214-2]
CCDS6075.1 [O95214-1]
RefSeqiNP_001121680.1, NM_001128208.1 [O95214-2]
NP_056159.2, NM_015344.2 [O95214-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117042, 6 interactors
IntActiO95214, 75 interactors
STRINGi9606.ENSP00000428281

PTM databases

SwissPalmiO95214

Polymorphism and mutation databases

BioMutaiLEPROTL1

Proteomic databases

EPDiO95214
jPOSTiO95214
MassIVEiO95214
PaxDbiO95214
PeptideAtlasiO95214
PRIDEiO95214
ProteomicsDBi20577
50721 [O95214-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
63110, 26 antibodies

The DNASU plasmid repository

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DNASUi
23484

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660 [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660 [O95214-2]
GeneIDi23484
KEGGihsa:23484
UCSCiuc003xhx.3, human [O95214-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23484
DisGeNETi23484
EuPathDBiHostDB:ENSG00000104660.17

GeneCards: human genes, protein and diseases

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GeneCardsi
LEPROTL1
HGNCiHGNC:6555, LEPROTL1
HPAiENSG00000104660, Low tissue specificity
MIMi607338, gene
neXtProtiNX_O95214
OpenTargetsiENSG00000104660
PharmGKBiPA30334

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2174, Eukaryota
GeneTreeiENSGT00390000006503
HOGENOMiCLU_1577984_0_0_1
InParanoidiO95214
OrthoDBi1642378at2759
PhylomeDBiO95214
TreeFamiTF313689

Enzyme and pathway databases

PathwayCommonsiO95214

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23484, 4 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LEPROTL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23484
PharosiO95214, Tdark

Protein Ontology

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PROi
PR:O95214
RNActiO95214, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000104660, Expressed in forebrain and 237 other tissues
ExpressionAtlasiO95214, baseline and differential
GenevisibleiO95214, HS

Family and domain databases

InterProiView protein in InterPro
IPR007262, Vps55/LEPROT
PANTHERiPTHR12050, PTHR12050, 1 hit
PfamiView protein in Pfam
PF04133, Vps55, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLERL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95214
Secondary accession number(s): E9PHP8, Q9BW48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: August 12, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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