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UniProtKB - O95214 (LERL1_HUMAN)
Protein
Leptin receptor overlapping transcript-like 1
Gene
LEPROTL1
Organism
Homo sapiens (Human)
Status
Functioni
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
1 PublicationGO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- late endosome to vacuole transport via multivesicular body sorting pathway Source: GO_Central
- negative regulation of growth hormone receptor signaling pathway Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O95214 |
SignaLinki | O95214 |
Names & Taxonomyi
Protein namesi | Recommended name: Leptin receptor overlapping transcript-like 1Alternative name(s): Endospanin-2 |
Gene namesi | Name:LEPROTL1 ORF Names:My047, UNQ577/PRO1139 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6555, LEPROTL1 |
MIMi | 607338, gene |
neXtProti | NX_O95214 |
VEuPathDBi | HostDB:ENSG00000104660 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endosome
- endosome Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 32 – 52 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23484 |
OpenTargetsi | ENSG00000104660 |
PharmGKBi | PA30334 |
Miscellaneous databases
Pharosi | O95214, Tdark |
Genetic variation databases
BioMutai | LEPROTL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215197 | 1 – 131 | Leptin receptor overlapping transcript-like 1Add BLAST | 131 |
Proteomic databases
EPDi | O95214 |
jPOSTi | O95214 |
MassIVEi | O95214 |
MaxQBi | O95214 |
PaxDbi | O95214 |
PeptideAtlasi | O95214 |
PRIDEi | O95214 |
ProteomicsDBi | 20577 50721 [O95214-1] |
PTM databases
SwissPalmi | O95214 |
Expressioni
Tissue specificityi
Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.
Gene expression databases
Bgeei | ENSG00000104660, Expressed in forebrain and 238 other tissues |
ExpressionAtlasi | O95214, baseline and differential |
Genevisiblei | O95214, HS |
Organism-specific databases
HPAi | ENSG00000104660, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RAB13.
By similarityBinary interactionsi
O95214
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 117042, 77 interactors |
IntActi | O95214, 75 interactors |
STRINGi | 9606.ENSP00000428281 |
Miscellaneous databases
RNActi | O95214, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the OB-RGRP/VPS55 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2174, Eukaryota |
GeneTreei | ENSGT00390000006503 |
HOGENOMi | CLU_1577984_0_0_1 |
InParanoidi | O95214 |
OMAi | HSAVITW |
OrthoDBi | 1642378at2759 |
PhylomeDBi | O95214 |
TreeFami | TF313689 |
Family and domain databases
InterProi | View protein in InterPro IPR007262, Vps55/LEPROT |
PANTHERi | PTHR12050, PTHR12050, 1 hit |
Pfami | View protein in Pfam PF04133, Vps55, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O95214-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC
60 70 80 90 100
IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA
110 120 130
LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RHU8 | E5RHU8_HUMAN | Leptin receptor overlapping transcr... | LEPROTL1 | 162 | Annotation score: | ||
C9JVM4 | C9JVM4_HUMAN | Leptin receptor overlapping transcr... | LEPROTL1 | 144 | Annotation score: | ||
E5RIL0 | E5RIL0_HUMAN | Leptin receptor overlapping transcr... | LEPROTL1 | 106 | Annotation score: | ||
E5RJS9 | E5RJS9_HUMAN | Leptin receptor overlapping transcr... | LEPROTL1 | 154 | Annotation score: | ||
H0YBC1 | H0YBC1_HUMAN | Leptin receptor overlapping transcr... | LEPROTL1 | 136 | Annotation score: | ||
E5RIQ0 | E5RIQ0_HUMAN | Leptin receptor overlapping transcr... | LEPROTL1 | 70 | Annotation score: | ||
A0A3B3IS19 | A0A3B3IS19_HUMAN | Leptin receptor overlapping transcr... | LEPROTL1 hCG_15463 | 155 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 123 | N → K in AAC98697 (PubMed:11342119).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046307 | 94 – 131 | IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063605 mRNA Translation: AAC98697.1 AY358674 mRNA Translation: AAQ89037.1 AC026979 Genomic DNA No translation available. AC044849 Genomic DNA No translation available. AL546441 mRNA No translation available. BC000642 mRNA Translation: AAH00642.1 |
CCDSi | CCDS47834.1 [O95214-2] CCDS6075.1 [O95214-1] |
RefSeqi | NP_001121680.1, NM_001128208.1 [O95214-2] NP_056159.2, NM_015344.2 [O95214-1] |
Genome annotation databases
Ensembli | ENST00000321250; ENSP00000314625; ENSG00000104660 ENST00000523116; ENSP00000428281; ENSG00000104660 [O95214-2] |
GeneIDi | 23484 |
KEGGi | hsa:23484 |
MANE-Selecti | ENST00000321250.13; ENSP00000314625.8; NM_015344.3; NP_056159.2 |
UCSCi | uc003xhx.3, human [O95214-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063605 mRNA Translation: AAC98697.1 AY358674 mRNA Translation: AAQ89037.1 AC026979 Genomic DNA No translation available. AC044849 Genomic DNA No translation available. AL546441 mRNA No translation available. BC000642 mRNA Translation: AAH00642.1 |
CCDSi | CCDS47834.1 [O95214-2] CCDS6075.1 [O95214-1] |
RefSeqi | NP_001121680.1, NM_001128208.1 [O95214-2] NP_056159.2, NM_015344.2 [O95214-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117042, 77 interactors |
IntActi | O95214, 75 interactors |
STRINGi | 9606.ENSP00000428281 |
PTM databases
SwissPalmi | O95214 |
Genetic variation databases
BioMutai | LEPROTL1 |
Proteomic databases
EPDi | O95214 |
jPOSTi | O95214 |
MassIVEi | O95214 |
MaxQBi | O95214 |
PaxDbi | O95214 |
PeptideAtlasi | O95214 |
PRIDEi | O95214 |
ProteomicsDBi | 20577 50721 [O95214-1] |
Protocols and materials databases
Antibodypediai | 63110, 26 antibodies from 10 providers |
DNASUi | 23484 |
Genome annotation databases
Ensembli | ENST00000321250; ENSP00000314625; ENSG00000104660 ENST00000523116; ENSP00000428281; ENSG00000104660 [O95214-2] |
GeneIDi | 23484 |
KEGGi | hsa:23484 |
MANE-Selecti | ENST00000321250.13; ENSP00000314625.8; NM_015344.3; NP_056159.2 |
UCSCi | uc003xhx.3, human [O95214-1] |
Organism-specific databases
CTDi | 23484 |
DisGeNETi | 23484 |
GeneCardsi | LEPROTL1 |
HGNCi | HGNC:6555, LEPROTL1 |
HPAi | ENSG00000104660, Low tissue specificity |
MIMi | 607338, gene |
neXtProti | NX_O95214 |
OpenTargetsi | ENSG00000104660 |
PharmGKBi | PA30334 |
VEuPathDBi | HostDB:ENSG00000104660 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2174, Eukaryota |
GeneTreei | ENSGT00390000006503 |
HOGENOMi | CLU_1577984_0_0_1 |
InParanoidi | O95214 |
OMAi | HSAVITW |
OrthoDBi | 1642378at2759 |
PhylomeDBi | O95214 |
TreeFami | TF313689 |
Enzyme and pathway databases
PathwayCommonsi | O95214 |
SignaLinki | O95214 |
Miscellaneous databases
BioGRID-ORCSi | 23484, 10 hits in 1046 CRISPR screens |
ChiTaRSi | LEPROTL1, human |
GenomeRNAii | 23484 |
Pharosi | O95214, Tdark |
PROi | PR:O95214 |
RNActi | O95214, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104660, Expressed in forebrain and 238 other tissues |
ExpressionAtlasi | O95214, baseline and differential |
Genevisiblei | O95214, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007262, Vps55/LEPROT |
PANTHERi | PTHR12050, PTHR12050, 1 hit |
Pfami | View protein in Pfam PF04133, Vps55, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LERL1_HUMAN | |
Accessioni | O95214Primary (citable) accession number: O95214 Secondary accession number(s): E9PHP8, Q9BW48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families