UniProtKB - O95201 (ZN205_HUMAN)
Protein
Zinc finger protein 205
Gene
ZNF205
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 308 – 330 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 498 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 504 – 526 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of hydrogen peroxide biosynthetic process Source: BHF-UCL
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: BHF-UCL
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95201 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 205Alternative name(s): Zinc finger protein 210 |
Gene namesi | Name:ZNF205 Synonyms:ZNF210 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12996, ZNF205 |
MIMi | 603436, gene |
neXtProti | NX_O95201 |
VEuPathDBi | HostDB:ENSG00000122386.10 |
Subcellular locationi
Nucleus
- Nucleus Curated
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7755 |
OpenTargetsi | ENSG00000122386 |
PharmGKBi | PA37576 |
Miscellaneous databases
Pharosi | O95201, Tbio |
Genetic variation databases
BioMutai | ZNF205 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047451 | 1 – 554 | Zinc finger protein 205Add BLAST | 554 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 219 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 292 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O95201 |
jPOSTi | O95201 |
MassIVEi | O95201 |
MaxQBi | O95201 |
PaxDbi | O95201 |
PeptideAtlasi | O95201 |
PRIDEi | O95201 |
ProteomicsDBi | 50709 |
PTM databases
iPTMneti | O95201 |
PhosphoSitePlusi | O95201 |
Expressioni
Tissue specificityi
Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver, kidney and thymus.
Gene expression databases
Bgeei | ENSG00000122386, Expressed in tendon of biceps brachii and 221 other tissues |
ExpressionAtlasi | O95201, baseline and differential |
Genevisiblei | O95201, HS |
Organism-specific databases
HPAi | ENSG00000122386, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsO95201
Protein-protein interaction databases
BioGRIDi | 113539, 20 interactors |
IntActi | O95201, 17 interactors |
MINTi | O95201 |
STRINGi | 9606.ENSP00000480401 |
Miscellaneous databases
RNActi | O95201, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 193 | KRABPROSITE-ProRule annotationAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 308 – 330 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 498 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 504 – 526 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161865 |
HOGENOMi | CLU_002678_9_0_1 |
InParanoidi | O95201 |
OMAi | GDEKEWR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O95201 |
TreeFami | TF338003 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O95201-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSADGGGIQD TQDKETPPEV PDRGHPHQEM PSKLGEAVPS GDTQESLHIK
60 70 80 90 100
MEPEEPHSEG ASQEDGAQGA WGWAPLSHGS KEKALFLPGG ALPSPRIPVL
110 120 130 140 150
SREGRTRDRQ MAAALLTAWS QMPVTFEDVA LYLSREEWGR LDHTQQNFYR
160 170 180 190 200
DVLQKKNGLS LGFPFSRPFW APQAHGKGEA SGSSRQAGDE KEWRGACTGA
210 220 230 240 250
VEVGQRVQTS SVAALGNVKP FRTRAGRVQW GVPQCAQEAA CGRSSGPAKD
260 270 280 290 300
SGQPAEPDRT PDAAPPDPSP TEPQEYRVPE KPNEEEKGAP ESGEEGLAPD
310 320 330 340 350
SEVGRKSYRC EQCGKGFSWH SHLVTHRRTH TGEKPYACTD CGKRFGRSSH
360 370 380 390 400
LIQHQIIHTG EKPYTCPACR KSFSHHSTLI QHQRIHTGEK PYVCDRCAKR
410 420 430 440 450
FTRRSDLVTH QGTHTGAKPH KCPICAKCFT QSSALVTHQR THTGVKPYPC
460 470 480 490 500
PECGKCFSQR SNLIAHNRTH TGEKPYHCLD CGKSFSHSSH LTAHQRTHRG
510 520 530 540 550
VRPYACPLCG KSFSRRSNLH RHEKIHTTGP KALAMLMLGA AAAGALATPP
PAPT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L417 | I3L417_HUMAN | Zinc finger protein 205 | ZNF205 | 255 | Annotation score: | ||
C9JEY6 | C9JEY6_HUMAN | Zinc finger protein 205 | ZNF205 | 278 | Annotation score: | ||
C9JS60 | C9JS60_HUMAN | Zinc finger protein 205 | ZNF205 | 118 | Annotation score: |
Sequence cautioni
The sequence AAC70007 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028798 | 43 | T → A1 PublicationCorresponds to variant dbSNP:rs909410Ensembl. | 1 | |
Natural variantiVAR_028799 | 255 | A → D. Corresponds to variant dbSNP:rs12445220Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF060865 mRNA Translation: AAC70007.1 Different initiation. AC108134 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85396.1 CH471112 Genomic DNA Translation: EAW85398.1 CH471112 Genomic DNA Translation: EAW85399.1 CH471112 Genomic DNA Translation: EAW85400.1 BC002810 mRNA Translation: AAH02810.1 |
CCDSi | CCDS10494.2 |
RefSeqi | NP_001035893.1, NM_001042428.1 NP_001265087.1, NM_001278158.1 NP_003447.2, NM_003456.2 XP_005255615.1, XM_005255558.2 |
Genome annotation databases
Ensembli | ENST00000219091; ENSP00000219091; ENSG00000122386 ENST00000382192; ENSP00000371627; ENSG00000122386 ENST00000620094; ENSP00000480401; ENSG00000122386 |
GeneIDi | 7755 |
KEGGi | hsa:7755 |
UCSCi | uc002cua.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF060865 mRNA Translation: AAC70007.1 Different initiation. AC108134 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85396.1 CH471112 Genomic DNA Translation: EAW85398.1 CH471112 Genomic DNA Translation: EAW85399.1 CH471112 Genomic DNA Translation: EAW85400.1 BC002810 mRNA Translation: AAH02810.1 |
CCDSi | CCDS10494.2 |
RefSeqi | NP_001035893.1, NM_001042428.1 NP_001265087.1, NM_001278158.1 NP_003447.2, NM_003456.2 XP_005255615.1, XM_005255558.2 |
3D structure databases
SMRi | O95201 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113539, 20 interactors |
IntActi | O95201, 17 interactors |
MINTi | O95201 |
STRINGi | 9606.ENSP00000480401 |
PTM databases
iPTMneti | O95201 |
PhosphoSitePlusi | O95201 |
Genetic variation databases
BioMutai | ZNF205 |
Proteomic databases
EPDi | O95201 |
jPOSTi | O95201 |
MassIVEi | O95201 |
MaxQBi | O95201 |
PaxDbi | O95201 |
PeptideAtlasi | O95201 |
PRIDEi | O95201 |
ProteomicsDBi | 50709 |
Protocols and materials databases
Antibodypediai | 822, 105 antibodies |
DNASUi | 7755 |
Genome annotation databases
Ensembli | ENST00000219091; ENSP00000219091; ENSG00000122386 ENST00000382192; ENSP00000371627; ENSG00000122386 ENST00000620094; ENSP00000480401; ENSG00000122386 |
GeneIDi | 7755 |
KEGGi | hsa:7755 |
UCSCi | uc002cua.4, human |
Organism-specific databases
CTDi | 7755 |
DisGeNETi | 7755 |
GeneCardsi | ZNF205 |
HGNCi | HGNC:12996, ZNF205 |
HPAi | ENSG00000122386, Low tissue specificity |
MIMi | 603436, gene |
neXtProti | NX_O95201 |
OpenTargetsi | ENSG00000122386 |
PharmGKBi | PA37576 |
VEuPathDBi | HostDB:ENSG00000122386.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161865 |
HOGENOMi | CLU_002678_9_0_1 |
InParanoidi | O95201 |
OMAi | GDEKEWR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O95201 |
TreeFami | TF338003 |
Enzyme and pathway databases
PathwayCommonsi | O95201 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 7755, 8 hits in 896 CRISPR screens |
ChiTaRSi | ZNF205, human |
GenomeRNAii | 7755 |
Pharosi | O95201, Tbio |
PROi | PR:O95201 |
RNActi | O95201, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122386, Expressed in tendon of biceps brachii and 221 other tissues |
ExpressionAtlasi | O95201, baseline and differential |
Genevisiblei | O95201, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN205_HUMAN | |
Accessioni | O95201Primary (citable) accession number: O95201 Secondary accession number(s): A8MZK0, D3DUB4, Q9BU95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families