Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chondroitin sulfate proteoglycan 5

Gene

CSPG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.1 Publication

Miscellaneous

Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Growth regulation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 5
Alternative name(s):
Acidic leucine-rich EGF-like domain-containing brain protein
Neuroglycan C
Gene namesi
Name:CSPG5
Synonyms:CALEB, NGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114646.9
HGNCiHGNC:2467 CSPG5
MIMi606775 gene
neXtProtiNX_O95196

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 423ExtracellularSequence analysisAdd BLAST393
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 566CytoplasmicSequence analysisAdd BLAST122

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10675
OpenTargetsiENSG00000114646
PharmGKBiPA26965

Polymorphism and mutation databases

BioMutaiCSPG5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004215131 – 566Chondroitin sulfate proteoglycan 5Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi165O-linked (GalNAc...) serine1 Publication1
Disulfide bondi374 ↔ 387By similarity
Disulfide bondi381 ↔ 397By similarity
Disulfide bondi399 ↔ 412By similarity
Modified residuei467PhosphoserineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei543PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity).By similarity
Phosphorylated; in intracellular and extracellular parts.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiO95196
PeptideAtlasiO95196
PRIDEiO95196
ProteomicsDBi50697
50698 [O95196-2]
50699 [O95196-3]

PTM databases

GlyConnecti657
iPTMnetiO95196
PhosphoSitePlusiO95196
UniCarbKBiO95196

Expressioni

Tissue specificityi

Restricted to brain (at protein level).1 Publication

Developmental stagei

Expressed in brain of 3 months, 5 and 10-year-old individuals.1 Publication

Gene expression databases

BgeeiENSG00000114646 Expressed in 147 organ(s), highest expression level in endothelial cell
CleanExiHS_CSPG5
ExpressionAtlasiO95196 baseline and differential
GenevisibleiO95196 HS

Organism-specific databases

HPAiHPA049529
HPA067818
HPA071779

Interactioni

Subunit structurei

Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GopcQ8BH603EBI-296349,EBI-296357From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115917, 7 interactors
IntActiO95196, 3 interactors
STRINGi9606.ENSP00000373244

Structurei

3D structure databases

ProteinModelPortaliO95196
SMRiO95196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini371 – 413EGF-likeAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni264 – 301Interaction with TNC and TNRBy similarityAdd BLAST38
Regioni442 – 460Interaction with GOPC1 PublicationAdd BLAST19

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJTR Eukaryota
ENOG410YF9F LUCA
GeneTreeiENSGT00440000034270
HOGENOMiHOG000112020
HOVERGENiHBG081361
InParanoidiO95196
KOiK08116
OMAiEPTYPFQ
OrthoDBiEOG091G05S8
PhylomeDBiO95196
TreeFamiTF338636

Family and domain databases

InterProiView protein in InterPro
IPR010555 CSPG5_S_attach_dom
IPR009505 Neural_ProG_Cyt
PfamiView protein in Pfam
PF06566 Chon_Sulph_att, 1 hit
PF06567 Neural_ProG_Cyt, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95196-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP
60 70 80 90 100
AWEPPANDTR EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW
110 120 130 140 150
LEADSPGLGG VTAEAGSGDA QALPATLQAP HEVLGQSIMP PAIPEATEAS
160 170 180 190 200
GPPSPTPGDK LSPASELPKE SPLEVWLNLG GSTPDPQGPE LTYPFQGTLE
210 220 230 240 250
PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD TEGETPSWSL
260 270 280 290 300
LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL
310 320 330 340 350
LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL
360 370 380 390 400
ASSENGTECR SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN
410 420 430 440 450
TQDYIWHKGM RCESIITDFQ VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL
460 470 480 490 500
KTENTKLRRT NKFRTPSELH NDNFSLSTIA EGSHPNVRKL CNTPRTSSPH
510 520 530 540 550
ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN SMSPKLEGGK
560
GDQADLDVNC LQNNLT
Length:566
Mass (Da):60,016
Last modified:May 5, 2009 - v3
Checksum:iDD8DA045C1BE31E5
GO
Isoform 2 (identifier: O95196-2) [UniParc]FASTAAdd to basket
Also known as: CSPG5-I

The sequence of this isoform differs from the canonical sequence as follows:
     487-513: Missing.

Show »
Length:539
Mass (Da):56,983
Checksum:iBBD8B64B93091DDF
GO
Isoform 3 (identifier: O95196-3) [UniParc]FASTAAdd to basket
Also known as: CSPG5-II

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     487-513: Missing.

Show »
Length:401
Mass (Da):43,621
Checksum:i9F0D31F21854FCEB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUT8A0A087WUT8_HUMAN
Chondroitin sulfate proteoglycan 5
CSPG5
477Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055089188G → V2 PublicationsCorresponds to variant dbSNP:rs3732530Ensembl.1
Natural variantiVAR_055090417T → P. Corresponds to variant dbSNP:rs34016925Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0157601 – 138Missing in isoform 3. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_015761487 – 513Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059274 mRNA Translation: AAC69612.1
AF461087 mRNA Translation: AAQ04774.1
AF461088 mRNA Translation: AAQ04775.1
AF461089 mRNA Translation: AAQ04776.1
AC099778 Genomic DNA No translation available.
AC112512 Genomic DNA No translation available.
CCDSiCCDS2757.1 [O95196-2]
CCDS56252.1 [O95196-3]
CCDS56253.1 [O95196-1]
RefSeqiNP_001193872.1, NM_001206943.1 [O95196-1]
NP_001193873.1, NM_001206944.1
NP_006565.2, NM_006574.3 [O95196-2]
UniGeneiHs.45127

Genome annotation databases

EnsembliENST00000264723; ENSP00000264723; ENSG00000114646 [O95196-2]
ENST00000383738; ENSP00000373244; ENSG00000114646 [O95196-1]
ENST00000456150; ENSP00000392096; ENSG00000114646 [O95196-3]
GeneIDi10675
KEGGihsa:10675
UCSCiuc003crn.4 human [O95196-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059274 mRNA Translation: AAC69612.1
AF461087 mRNA Translation: AAQ04774.1
AF461088 mRNA Translation: AAQ04775.1
AF461089 mRNA Translation: AAQ04776.1
AC099778 Genomic DNA No translation available.
AC112512 Genomic DNA No translation available.
CCDSiCCDS2757.1 [O95196-2]
CCDS56252.1 [O95196-3]
CCDS56253.1 [O95196-1]
RefSeqiNP_001193872.1, NM_001206943.1 [O95196-1]
NP_001193873.1, NM_001206944.1
NP_006565.2, NM_006574.3 [O95196-2]
UniGeneiHs.45127

3D structure databases

ProteinModelPortaliO95196
SMRiO95196
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115917, 7 interactors
IntActiO95196, 3 interactors
STRINGi9606.ENSP00000373244

PTM databases

GlyConnecti657
iPTMnetiO95196
PhosphoSitePlusiO95196
UniCarbKBiO95196

Polymorphism and mutation databases

BioMutaiCSPG5

Proteomic databases

PaxDbiO95196
PeptideAtlasiO95196
PRIDEiO95196
ProteomicsDBi50697
50698 [O95196-2]
50699 [O95196-3]

Protocols and materials databases

DNASUi10675
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264723; ENSP00000264723; ENSG00000114646 [O95196-2]
ENST00000383738; ENSP00000373244; ENSG00000114646 [O95196-1]
ENST00000456150; ENSP00000392096; ENSG00000114646 [O95196-3]
GeneIDi10675
KEGGihsa:10675
UCSCiuc003crn.4 human [O95196-1]

Organism-specific databases

CTDi10675
DisGeNETi10675
EuPathDBiHostDB:ENSG00000114646.9
GeneCardsiCSPG5
H-InvDBiHIX0003276
HGNCiHGNC:2467 CSPG5
HPAiHPA049529
HPA067818
HPA071779
MIMi606775 gene
neXtProtiNX_O95196
OpenTargetsiENSG00000114646
PharmGKBiPA26965
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTR Eukaryota
ENOG410YF9F LUCA
GeneTreeiENSGT00440000034270
HOGENOMiHOG000112020
HOVERGENiHBG081361
InParanoidiO95196
KOiK08116
OMAiEPTYPFQ
OrthoDBiEOG091G05S8
PhylomeDBiO95196
TreeFamiTF338636

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

Miscellaneous databases

ChiTaRSiCSPG5 human
GenomeRNAii10675
PROiPR:O95196
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114646 Expressed in 147 organ(s), highest expression level in endothelial cell
CleanExiHS_CSPG5
ExpressionAtlasiO95196 baseline and differential
GenevisibleiO95196 HS

Family and domain databases

InterProiView protein in InterPro
IPR010555 CSPG5_S_attach_dom
IPR009505 Neural_ProG_Cyt
PfamiView protein in Pfam
PF06566 Chon_Sulph_att, 1 hit
PF06567 Neural_ProG_Cyt, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSPG5_HUMAN
AccessioniPrimary (citable) accession number: O95196
Secondary accession number(s): Q71M39, Q71M40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again