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Protein

Chondroitin sulfate proteoglycan 5

Gene

CSPG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.1 Publication

Miscellaneous

Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • growth factor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Growth regulation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 5
Alternative name(s):
Acidic leucine-rich EGF-like domain-containing brain protein
Neuroglycan C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSPG5
Synonyms:CALEB, NGC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000114646.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2467 CSPG5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606775 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95196

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 423ExtracellularSequence analysisAdd BLAST393
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 566CytoplasmicSequence analysisAdd BLAST122

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10675

Open Targets

More...
OpenTargetsi
ENSG00000114646

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26965

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSPG5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004215131 – 566Chondroitin sulfate proteoglycan 5Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi165O-linked (GalNAc...) serine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi374 ↔ 387By similarity
Disulfide bondi381 ↔ 397By similarity
Disulfide bondi399 ↔ 412By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei467PhosphoserineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei543PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity).By similarity
Phosphorylated; in intracellular and extracellular parts.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95196

PeptideAtlas

More...
PeptideAtlasi
O95196

PRoteomics IDEntifications database

More...
PRIDEi
O95196

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50697
50698 [O95196-2]
50699 [O95196-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
657

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95196

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95196

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
O95196

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to brain (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in brain of 3 months, 5 and 10-year-old individuals.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114646 Expressed in 147 organ(s), highest expression level in endothelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_CSPG5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95196 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95196 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049529
HPA067818
HPA071779

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GopcQ8BH603EBI-296349,EBI-296357From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115917, 7 interactors

Protein interaction database and analysis system

More...
IntActi
O95196, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95196

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95196

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini371 – 413EGF-likeAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni264 – 301Interaction with TNC and TNRBy similarityAdd BLAST38
Regioni442 – 460Interaction with GOPC1 PublicationAdd BLAST19

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJTR Eukaryota
ENOG410YF9F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000034270

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112020

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081361

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95196

KEGG Orthology (KO)

More...
KOi
K08116

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPTYPFQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05S8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95196

TreeFam database of animal gene trees

More...
TreeFami
TF338636

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010555 CSPG5_S_attach_dom
IPR009505 Neural_ProG_Cyt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06566 Chon_Sulph_att, 1 hit
PF06567 Neural_ProG_Cyt, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95196-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP
60 70 80 90 100
AWEPPANDTR EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW
110 120 130 140 150
LEADSPGLGG VTAEAGSGDA QALPATLQAP HEVLGQSIMP PAIPEATEAS
160 170 180 190 200
GPPSPTPGDK LSPASELPKE SPLEVWLNLG GSTPDPQGPE LTYPFQGTLE
210 220 230 240 250
PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD TEGETPSWSL
260 270 280 290 300
LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL
310 320 330 340 350
LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL
360 370 380 390 400
ASSENGTECR SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN
410 420 430 440 450
TQDYIWHKGM RCESIITDFQ VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL
460 470 480 490 500
KTENTKLRRT NKFRTPSELH NDNFSLSTIA EGSHPNVRKL CNTPRTSSPH
510 520 530 540 550
ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN SMSPKLEGGK
560
GDQADLDVNC LQNNLT
Length:566
Mass (Da):60,016
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD8DA045C1BE31E5
GO
Isoform 2 (identifier: O95196-2) [UniParc]FASTAAdd to basket
Also known as: CSPG5-I

The sequence of this isoform differs from the canonical sequence as follows:
     487-513: Missing.

Show »
Length:539
Mass (Da):56,983
Checksum:iBBD8B64B93091DDF
GO
Isoform 3 (identifier: O95196-3) [UniParc]FASTAAdd to basket
Also known as: CSPG5-II

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     487-513: Missing.

Show »
Length:401
Mass (Da):43,621
Checksum:i9F0D31F21854FCEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUT8A0A087WUT8_HUMAN
Chondroitin sulfate proteoglycan 5
CSPG5
477Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055089188G → V2 PublicationsCorresponds to variant dbSNP:rs3732530Ensembl.1
Natural variantiVAR_055090417T → P. Corresponds to variant dbSNP:rs34016925Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157601 – 138Missing in isoform 3. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_015761487 – 513Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF059274 mRNA Translation: AAC69612.1
AF461087 mRNA Translation: AAQ04774.1
AF461088 mRNA Translation: AAQ04775.1
AF461089 mRNA Translation: AAQ04776.1
AC099778 Genomic DNA No translation available.
AC112512 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2757.1 [O95196-2]
CCDS56252.1 [O95196-3]
CCDS56253.1 [O95196-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001193872.1, NM_001206943.1 [O95196-1]
NP_001193873.1, NM_001206944.1
NP_006565.2, NM_006574.3 [O95196-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.45127

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264723; ENSP00000264723; ENSG00000114646 [O95196-2]
ENST00000383738; ENSP00000373244; ENSG00000114646 [O95196-1]
ENST00000456150; ENSP00000392096; ENSG00000114646 [O95196-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10675

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10675

UCSC genome browser

More...
UCSCi
uc003crn.4 human [O95196-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059274 mRNA Translation: AAC69612.1
AF461087 mRNA Translation: AAQ04774.1
AF461088 mRNA Translation: AAQ04775.1
AF461089 mRNA Translation: AAQ04776.1
AC099778 Genomic DNA No translation available.
AC112512 Genomic DNA No translation available.
CCDSiCCDS2757.1 [O95196-2]
CCDS56252.1 [O95196-3]
CCDS56253.1 [O95196-1]
RefSeqiNP_001193872.1, NM_001206943.1 [O95196-1]
NP_001193873.1, NM_001206944.1
NP_006565.2, NM_006574.3 [O95196-2]
UniGeneiHs.45127

3D structure databases

ProteinModelPortaliO95196
SMRiO95196
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115917, 7 interactors
IntActiO95196, 3 interactors
STRINGi9606.ENSP00000373244

PTM databases

GlyConnecti657
iPTMnetiO95196
PhosphoSitePlusiO95196
UniCarbKBiO95196

Polymorphism and mutation databases

BioMutaiCSPG5

Proteomic databases

PaxDbiO95196
PeptideAtlasiO95196
PRIDEiO95196
ProteomicsDBi50697
50698 [O95196-2]
50699 [O95196-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10675
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264723; ENSP00000264723; ENSG00000114646 [O95196-2]
ENST00000383738; ENSP00000373244; ENSG00000114646 [O95196-1]
ENST00000456150; ENSP00000392096; ENSG00000114646 [O95196-3]
GeneIDi10675
KEGGihsa:10675
UCSCiuc003crn.4 human [O95196-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10675
DisGeNETi10675
EuPathDBiHostDB:ENSG00000114646.9

GeneCards: human genes, protein and diseases

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GeneCardsi
CSPG5

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0003276
HGNCiHGNC:2467 CSPG5
HPAiHPA049529
HPA067818
HPA071779
MIMi606775 gene
neXtProtiNX_O95196
OpenTargetsiENSG00000114646
PharmGKBiPA26965

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJTR Eukaryota
ENOG410YF9F LUCA
GeneTreeiENSGT00440000034270
HOGENOMiHOG000112020
HOVERGENiHBG081361
InParanoidiO95196
KOiK08116
OMAiEPTYPFQ
OrthoDBiEOG091G05S8
PhylomeDBiO95196
TreeFamiTF338636

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CSPG5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10675

Protein Ontology

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PROi
PR:O95196

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114646 Expressed in 147 organ(s), highest expression level in endothelial cell
CleanExiHS_CSPG5
ExpressionAtlasiO95196 baseline and differential
GenevisibleiO95196 HS

Family and domain databases

InterProiView protein in InterPro
IPR010555 CSPG5_S_attach_dom
IPR009505 Neural_ProG_Cyt
PfamiView protein in Pfam
PF06566 Chon_Sulph_att, 1 hit
PF06567 Neural_ProG_Cyt, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95196
Secondary accession number(s): Q71M39, Q71M40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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