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Protein

Ornithine decarboxylase antizyme 2

Gene

OAZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).By similarity1 Publication

GO - Molecular functioni

  • ornithine decarboxylase inhibitor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processPolyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-350562 Regulation of ornithine decarboxylase (ODC)

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 2
Short name:
AZ2
Short name:
ODC-Az 2
Gene namesi
Name:OAZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000180304.14
HGNCiHGNC:8096 OAZ2
MIMi604152 gene
neXtProtiNX_O95190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4947
OpenTargetsiENSG00000180304
PharmGKBiPA31885

Chemistry databases

DrugBankiDB00129 L-Ornithine

Polymorphism and mutation databases

BioMutaiOAZ2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208571 – 189Ornithine decarboxylase antizyme 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95190
PaxDbiO95190
PRIDEiO95190
ProteomicsDBi50696

PTM databases

PhosphoSitePlusiO95190

Expressioni

Gene expression databases

BgeeiENSG00000180304 Expressed in 236 organ(s), highest expression level in frontal cortex
CleanExiHS_OAZ2
ExpressionAtlasiO95190 baseline and differential
GenevisibleiO95190 HS

Organism-specific databases

HPAiHPA047694

Interactioni

Subunit structurei

Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240).By similarity1 Publication

Protein-protein interaction databases

BioGridi111001, 7 interactors
IntActiO95190, 1 interactor
STRINGi9606.ENSP00000463013

Structurei

3D structure databases

ProteinModelPortaliO95190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387 Eukaryota
ENOG4112791 LUCA
GeneTreeiENSGT00390000009476
HOGENOMiHOG000115253
HOVERGENiHBG007857
InParanoidiO95190
KOiK16613
OMAiFICFRKS
OrthoDBiEOG091G0SR0
PhylomeDBiO95190
TreeFamiTF314741

Family and domain databases

Gene3Di3.40.630.60, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR029916 ODC-AZ_2
IPR002993 ODC_AZ
IPR038581 ODC_AZ_sf
PANTHERiPTHR10279 PTHR10279, 1 hit
PTHR10279:SF6 PTHR10279:SF6, 1 hit
PfamiView protein in Pfam
PF02100 ODC_AZ, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS01337 ODC_AZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket
Note: A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95190-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD
60 70 80 90 100
PSLSALIYKD EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ
110 120 130 140 150
SLFVEIPDGL LADGSKEGLL ALLEFAEEKM KVNYVFICFR KGREDRAPLL
160 170 180
KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP LDQNLSDED
Length:189
Mass (Da):21,011
Last modified:May 1, 1999 - v1
Checksum:i66390D87EB30CB8F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLV9J3QLV9_HUMAN
Ornithine decarboxylase antizyme 2
OAZ2
60Annotation score:
J3KS80J3KS80_HUMAN
Ornithine decarboxylase antizyme 2
OAZ2
129Annotation score:
J3KRW5J3KRW5_HUMAN
Ornithine decarboxylase antizyme 2
OAZ2
136Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05042070P → L. Corresponds to variant dbSNP:rs3751534Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057297 mRNA Translation: AAD03265.1
CCDSiCCDS58372.1 [O95190-1]
RefSeqiNP_002528.1, NM_002537.3 [O95190-1]
UniGeneiHs.744924

Genome annotation databases

EnsembliENST00000326005; ENSP00000463013; ENSG00000180304 [O95190-1]
GeneIDi4947
KEGGihsa:4947
UCSCiuc002ano.3 human [O95190-1]

Keywords - Coding sequence diversityi

Polymorphism, Ribosomal frameshifting

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057297 mRNA Translation: AAD03265.1
CCDSiCCDS58372.1 [O95190-1]
RefSeqiNP_002528.1, NM_002537.3 [O95190-1]
UniGeneiHs.744924

3D structure databases

ProteinModelPortaliO95190
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111001, 7 interactors
IntActiO95190, 1 interactor
STRINGi9606.ENSP00000463013

Chemistry databases

DrugBankiDB00129 L-Ornithine

PTM databases

PhosphoSitePlusiO95190

Polymorphism and mutation databases

BioMutaiOAZ2

Proteomic databases

EPDiO95190
PaxDbiO95190
PRIDEiO95190
ProteomicsDBi50696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326005; ENSP00000463013; ENSG00000180304 [O95190-1]
GeneIDi4947
KEGGihsa:4947
UCSCiuc002ano.3 human [O95190-1]

Organism-specific databases

CTDi4947
DisGeNETi4947
EuPathDBiHostDB:ENSG00000180304.14
GeneCardsiOAZ2
H-InvDBiHIX0026777
HGNCiHGNC:8096 OAZ2
HPAiHPA047694
MIMi604152 gene
neXtProtiNX_O95190
OpenTargetsiENSG00000180304
PharmGKBiPA31885
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4387 Eukaryota
ENOG4112791 LUCA
GeneTreeiENSGT00390000009476
HOGENOMiHOG000115253
HOVERGENiHBG007857
InParanoidiO95190
KOiK16613
OMAiFICFRKS
OrthoDBiEOG091G0SR0
PhylomeDBiO95190
TreeFamiTF314741

Enzyme and pathway databases

ReactomeiR-HSA-350562 Regulation of ornithine decarboxylase (ODC)

Miscellaneous databases

ChiTaRSiOAZ2 human
GeneWikiiOAZ2
GenomeRNAii4947
PROiPR:O95190
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180304 Expressed in 236 organ(s), highest expression level in frontal cortex
CleanExiHS_OAZ2
ExpressionAtlasiO95190 baseline and differential
GenevisibleiO95190 HS

Family and domain databases

Gene3Di3.40.630.60, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR029916 ODC-AZ_2
IPR002993 ODC_AZ
IPR038581 ODC_AZ_sf
PANTHERiPTHR10279 PTHR10279, 1 hit
PTHR10279:SF6 PTHR10279:SF6, 1 hit
PfamiView protein in Pfam
PF02100 ODC_AZ, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS01337 ODC_AZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOAZ2_HUMAN
AccessioniPrimary (citable) accession number: O95190
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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