Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicle-associated membrane protein 5

Gene

VAMP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei40 – 41(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)1 Publication2

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • Golgi to plasma membrane protein transport Source: GO_Central
  • muscle organ development Source: ProtInc
  • skeletal muscle tissue development Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 5
Short name:
VAMP-5
Alternative name(s):
Myobrevin
Gene namesi
Name:VAMP5
ORF Names:HSPC191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168899.4
HGNCiHGNC:12646 VAMP5
MIMi607029 gene
neXtProtiNX_O95183

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
Transmembranei73 – 93Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini94 – 116VesicularSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168899
PharmGKBiPA37270

Polymorphism and mutation databases

BioMutaiVAMP5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067331 – 116Vesicle-associated membrane protein 5Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1

Post-translational modificationi

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95183
PaxDbiO95183
PeptideAtlasiO95183
PRIDEiO95183
ProteomicsDBi50693

PTM databases

iPTMnetiO95183
PhosphoSitePlusiO95183
SwissPalmiO95183

Expressioni

Inductioni

During myogenesis.

Gene expression databases

BgeeiENSG00000168899 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExiHS_VAMP5
ExpressionAtlasiO95183 baseline and differential
GenevisibleiO95183 HS

Organism-specific databases

HPAiHPA035082

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi116007, 36 interactors
IntActiO95183, 54 interactors
MINTiO95183
STRINGi9606.ENSP00000305647

Structurei

3D structure databases

ProteinModelPortaliO95183
SMRiO95183
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 65v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00730000111371
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiO95183
KOiK08514
OMAiCQQQADE
OrthoDBiEOG091G0ZXR
PhylomeDBiO95183
TreeFamiTF313666

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

O95183-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST
60 70 80 90 100
FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS
110
SAPRTQDAGI ASGPGN
Length:116
Mass (Da):12,805
Last modified:May 1, 1999 - v1
Checksum:i32A1F3B808A6016C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17T → M in AAF36111 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054825 mRNA Translation: AAC97473.1
AF077197 mRNA Translation: AAD26992.1
AF151025 mRNA Translation: AAF36111.1
BC017891 mRNA Translation: AAH17891.1
CCDSiCCDS1980.1
RefSeqiNP_006625.1, NM_006634.2
UniGeneiHs.534373

Genome annotation databases

EnsembliENST00000306384; ENSP00000305647; ENSG00000168899
GeneIDi10791
KEGGihsa:10791

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054825 mRNA Translation: AAC97473.1
AF077197 mRNA Translation: AAD26992.1
AF151025 mRNA Translation: AAF36111.1
BC017891 mRNA Translation: AAH17891.1
CCDSiCCDS1980.1
RefSeqiNP_006625.1, NM_006634.2
UniGeneiHs.534373

3D structure databases

ProteinModelPortaliO95183
SMRiO95183
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116007, 36 interactors
IntActiO95183, 54 interactors
MINTiO95183
STRINGi9606.ENSP00000305647

PTM databases

iPTMnetiO95183
PhosphoSitePlusiO95183
SwissPalmiO95183

Polymorphism and mutation databases

BioMutaiVAMP5

Proteomic databases

EPDiO95183
PaxDbiO95183
PeptideAtlasiO95183
PRIDEiO95183
ProteomicsDBi50693

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306384; ENSP00000305647; ENSG00000168899
GeneIDi10791
KEGGihsa:10791

Organism-specific databases

CTDi10791
EuPathDBiHostDB:ENSG00000168899.4
GeneCardsiVAMP5
HGNCiHGNC:12646 VAMP5
HPAiHPA035082
MIMi607029 gene
neXtProtiNX_O95183
OpenTargetsiENSG00000168899
PharmGKBiPA37270
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00730000111371
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiO95183
KOiK08514
OMAiCQQQADE
OrthoDBiEOG091G0ZXR
PhylomeDBiO95183
TreeFamiTF313666

Miscellaneous databases

ChiTaRSiVAMP5 human
GenomeRNAii10791
PROiPR:O95183
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168899 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExiHS_VAMP5
ExpressionAtlasiO95183 baseline and differential
GenevisibleiO95183 HS

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP5_HUMAN
AccessioniPrimary (citable) accession number: O95183
Secondary accession number(s): Q9P0T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again