VAMP5

Functionⁱ

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	40 – 41	(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)1 Publication		2

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
Golgi to plasma membrane protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
muscle organ development
Source: ProtInc
Traceable author statementⁱ
- 9725904
skeletal muscle tissue development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Myogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vesicle-associated membrane protein 5 Short name: VAMP-5 Alternative name(s): Myobrevin
Gene namesⁱ	Name:VAMP5 ORF Names:HSPC191
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168899.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12646 VAMP5
MIMⁱ	607029 gene
neXtProtⁱ	NX_O95183

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 72	CytoplasmicSequence analysisAdd BLAST	72
Transmembraneⁱ	73 – 93	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	94 – 116	VesicularSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000168899
PharmGKBⁱ	PA37270

Polymorphism and mutation databases

BioMutaⁱ	VAMP5

BioMutaⁱ

VAMP5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206733	1 – 116	Vesicle-associated membrane protein 5Add BLAST		116

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	41	PhosphoserineBy similarity	1
Modified residueⁱ	48	PhosphoserineCombined sources	1
Modified residueⁱ	49	PhosphoserineCombined sources	1

Post-translational modificationⁱ

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95183
PaxDbⁱ	O95183
PeptideAtlas More...PeptideAtlasⁱ	O95183
PRIDEⁱ	O95183
ProteomicsDBⁱ	50693

PTM databases

iPTMnetⁱ	O95183
PhosphoSitePlusⁱ	O95183
SwissPalmⁱ	O95183

Expressionⁱ

Inductionⁱ

During myogenesis.

Gene expression databases

Bgeeⁱ	ENSG00000168899 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_VAMP5
ExpressionAtlasⁱ	O95183 baseline and differential
Genevisibleⁱ	O95183 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035082

HPAⁱ

HPA035082

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
SNAP23	A8K287	3	EBI-10191195,EBI-10188497
SNAP29	O95721	5	EBI-10191195,EBI-490676
STX16	O14662	3	EBI-10191195,EBI-2853548
STX4	Q12846	7	EBI-10191195,EBI-744942

Protein-protein interaction databases

BioGridⁱ	116007, 36 interactors
IntActⁱ	O95183, 54 interactors
Molecular INTeraction database More...MINTⁱ	O95183
STRINGⁱ	9606.ENSP00000305647

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95183
SMRⁱ	O95183
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 65	v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the synaptobrevin family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0860 Eukaryota COG5143 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111371
HOGENOMⁱ	HOG000042711
HOVERGENⁱ	HBG006675
InParanoidⁱ	O95183
KEGG Orthology (KO) More...KOⁱ	K08514
OMAⁱ	CQQQADE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZXR
PhylomeDBⁱ	O95183
TreeFamⁱ	TF313666

Family and domain databases

InterProⁱ	View protein in InterPro IPR001388 Synaptobrevin IPR016444 Synaptobrevin/VAMP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00957 Synaptobrevin, 1 hit
PIRSFⁱ	PIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
PROSITEⁱ	View protein in PROSITE PS00417 SYNAPTOBREVIN, 1 hit PS50892 V_SNARE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95183-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST 
        60         70         80         90        100
FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS 
       110 
SAPRTQDAGI ASGPGN

Length:116

Mass (Da):12,805

Last modified:May 1, 1999 - v1

Checksum:ⁱ32A1F3B808A6016C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	17	T → M in AAF36111 (PubMed:11042152).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF054825 mRNA Translation: AAC97473.1 AF077197 mRNA Translation: AAD26992.1 AF151025 mRNA Translation: AAF36111.1 BC017891 mRNA Translation: AAH17891.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1980.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006625.1, NM_006634.2
UniGeneⁱ	Hs.534373

Genome annotation databases

Ensemblⁱ	ENST00000306384; ENSP00000305647; ENSG00000168899
GeneIDⁱ	10791
KEGGⁱ	hsa:10791

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95183	HCG34604, isoform CRA_c		HUMAN		116	UniRef100_O95183

Protein	Similar proteins		Species	Score	Length	Source
O95183	HCG34604, isoform CRA_c		HUMAN		116	UniRef90_O95183
VAMP5 isoform 1		PANTR		116
Uncharacterized protein		PANPA		116
Uncharacterized protein		NOMLE		116
Vesicle associated membrane protein 5		GORGO		116
+1

Protein	Similar proteins		Species	Score	Length	Source
O95183	Vesicle-associated membrane protein 5		BOVIN		116	UniRef50_O95183
HCG34604, isoform CRA_c		HUMAN		116
Uncharacterized protein		NOMLE		116
VAMP5 isoform 1		PANTR		116
Uncharacterized protein		PANPA		116
+121

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF054825 mRNA Translation: AAC97473.1 AF077197 mRNA Translation: AAD26992.1 AF151025 mRNA Translation: AAF36111.1 BC017891 mRNA Translation: AAH17891.1
CCDSⁱ	CCDS1980.1
RefSeqⁱ	NP_006625.1, NM_006634.2
UniGeneⁱ	Hs.534373

3D structure databases

ProteinModelPortalⁱ	O95183
SMRⁱ	O95183
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116007, 36 interactors
IntActⁱ	O95183, 54 interactors
MINTⁱ	O95183
STRINGⁱ	9606.ENSP00000305647

PTM databases

iPTMnetⁱ	O95183
PhosphoSitePlusⁱ	O95183
SwissPalmⁱ	O95183

Polymorphism and mutation databases

BioMutaⁱ	VAMP5

BioMutaⁱ

VAMP5

Proteomic databases

EPDⁱ	O95183
PaxDbⁱ	O95183
PeptideAtlasⁱ	O95183
PRIDEⁱ	O95183
ProteomicsDBⁱ	50693

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000306384; ENSP00000305647; ENSG00000168899
GeneIDⁱ	10791
KEGGⁱ	hsa:10791

Organism-specific databases

CTDⁱ	10791
EuPathDBⁱ	HostDB:ENSG00000168899.4
GeneCardsⁱ	VAMP5
HGNCⁱ	HGNC:12646 VAMP5
HPAⁱ	HPA035082
MIMⁱ	607029 gene
neXtProtⁱ	NX_O95183
OpenTargetsⁱ	ENSG00000168899
PharmGKBⁱ	PA37270
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0860 Eukaryota COG5143 LUCA
GeneTreeⁱ	ENSGT00730000111371
HOGENOMⁱ	HOG000042711
HOVERGENⁱ	HBG006675
InParanoidⁱ	O95183
KOⁱ	K08514
OMAⁱ	CQQQADE
OrthoDBⁱ	EOG091G0ZXR
PhylomeDBⁱ	O95183
TreeFamⁱ	TF313666

Miscellaneous databases

ChiTaRSⁱ	VAMP5 human
GenomeRNAiⁱ	10791
Protein Ontology More...PROⁱ	PR:O95183
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168899 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_VAMP5
ExpressionAtlasⁱ	O95183 baseline and differential
Genevisibleⁱ	O95183 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001388 Synaptobrevin IPR016444 Synaptobrevin/VAMP
Pfamⁱ	View protein in Pfam PF00957 Synaptobrevin, 1 hit
PIRSFⁱ	PIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
PROSITEⁱ	View protein in PROSITE PS00417 SYNAPTOBREVIN, 1 hit PS50892 V_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VAMP5_HUMAN
Accessionⁱ	O95183Primary (citable) accession number: O95183 Secondary accession number(s): Q9P0T2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - O95183 (VAMP5_HUMAN)

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Vesicle-associated membrane protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Other locations

Endosome

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ