UniProtKB - O95183 (VAMP5_HUMAN)
Protein
Vesicle-associated membrane protein 5
Gene
VAMP5
Organism
Homo sapiens (Human)
Status
Functioni
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 40 – 41 | (Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)1 Publication | 2 |
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- Golgi to plasma membrane protein transport Source: GO_Central
- muscle organ development Source: ProtInc
- skeletal muscle tissue development Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Myogenesis |
Enzyme and pathway databases
PathwayCommonsi | O95183 |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle-associated membrane protein 5Short name: VAMP-5 Alternative name(s): Myobrevin |
Gene namesi | Name:VAMP5 ORF Names:HSPC191 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12646, VAMP5 |
MIMi | 607029, gene |
neXtProti | NX_O95183 |
VEuPathDBi | HostDB:ENSG00000168899.4 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane Curated; Single-pass type IV membrane protein Curated
Plasma membrane
- Cell membrane Curated; Single-pass type IV membrane protein Curated
Other locations
- Endomembrane system Curated; Single-pass type IV membrane protein Curated
Note: Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity).By similarity
Endosome
- late endosome Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: BHF-UCL
- cytoplasmic vesicle membrane Source: BHF-UCL
- integral component of organelle membrane Source: BHF-UCL
- intercalated disc Source: BHF-UCL
- perinuclear region of cytoplasm Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 72 | CytoplasmicSequence analysisAdd BLAST | 72 | |
Transmembranei | 73 – 93 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 94 – 116 | VesicularSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10791 |
OpenTargetsi | ENSG00000168899 |
PharmGKBi | PA37270 |
Miscellaneous databases
Pharosi | O95183, Tbio |
Genetic variation databases
BioMutai | VAMP5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206733 | 1 – 116 | Vesicle-associated membrane protein 5Add BLAST | 116 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineBy similarity | 1 | |
Modified residuei | 48 | PhosphoserineCombined sources | 1 | |
Modified residuei | 49 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O95183 |
jPOSTi | O95183 |
MassIVEi | O95183 |
PaxDbi | O95183 |
PeptideAtlasi | O95183 |
PRIDEi | O95183 |
ProteomicsDBi | 50693 |
PTM databases
iPTMneti | O95183 |
MetOSitei | O95183 |
PhosphoSitePlusi | O95183 |
SwissPalmi | O95183 |
Expressioni
Inductioni
During myogenesis.
Gene expression databases
Bgeei | ENSG00000168899, Expressed in left adrenal gland and 216 other tissues |
ExpressionAtlasi | O95183, baseline and differential |
Genevisiblei | O95183, HS |
Organism-specific databases
HPAi | ENSG00000168899, Low tissue specificity |
Interactioni
Binary interactionsi
O95183
Protein-protein interaction databases
BioGRIDi | 116007, 133 interactors |
IntActi | O95183, 135 interactors |
MINTi | O95183 |
STRINGi | 9606.ENSP00000305647 |
Miscellaneous databases
RNActi | O95183, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 65 | v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the synaptobrevin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0860, Eukaryota |
GeneTreei | ENSGT00730000111371 |
HOGENOMi | CLU_064620_4_2_1 |
InParanoidi | O95183 |
OMAi | WENKKMK |
OrthoDBi | 1607213at2759 |
PhylomeDBi | O95183 |
TreeFami | TF313666 |
Family and domain databases
CDDi | cd15872, R-SNARE_VAMP5, 1 hit |
InterProi | View protein in InterPro IPR001388, Synaptobrevin IPR042855, V_SNARE_CC IPR042166, Vamp5 IPR042581, VAMP5_R-SNARE |
PANTHERi | PTHR47462, PTHR47462, 1 hit |
Pfami | View protein in Pfam PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
PROSITEi | View protein in PROSITE PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
O95183-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST
60 70 80 90 100
FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS
110
SAPRTQDAGI ASGPGN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | T → M in AAF36111 (PubMed:11042152).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054825 mRNA Translation: AAC97473.1 AF077197 mRNA Translation: AAD26992.1 AF151025 mRNA Translation: AAF36111.1 BC017891 mRNA Translation: AAH17891.1 |
CCDSi | CCDS1980.1 |
RefSeqi | NP_006625.1, NM_006634.2 |
Genome annotation databases
Ensembli | ENST00000306384; ENSP00000305647; ENSG00000168899 |
GeneIDi | 10791 |
KEGGi | hsa:10791 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054825 mRNA Translation: AAC97473.1 AF077197 mRNA Translation: AAD26992.1 AF151025 mRNA Translation: AAF36111.1 BC017891 mRNA Translation: AAH17891.1 |
CCDSi | CCDS1980.1 |
RefSeqi | NP_006625.1, NM_006634.2 |
3D structure databases
SMRi | O95183 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116007, 133 interactors |
IntActi | O95183, 135 interactors |
MINTi | O95183 |
STRINGi | 9606.ENSP00000305647 |
PTM databases
iPTMneti | O95183 |
MetOSitei | O95183 |
PhosphoSitePlusi | O95183 |
SwissPalmi | O95183 |
Genetic variation databases
BioMutai | VAMP5 |
Proteomic databases
EPDi | O95183 |
jPOSTi | O95183 |
MassIVEi | O95183 |
PaxDbi | O95183 |
PeptideAtlasi | O95183 |
PRIDEi | O95183 |
ProteomicsDBi | 50693 |
Protocols and materials databases
Antibodypediai | 31895, 161 antibodies |
Genome annotation databases
Ensembli | ENST00000306384; ENSP00000305647; ENSG00000168899 |
GeneIDi | 10791 |
KEGGi | hsa:10791 |
Organism-specific databases
CTDi | 10791 |
DisGeNETi | 10791 |
GeneCardsi | VAMP5 |
HGNCi | HGNC:12646, VAMP5 |
HPAi | ENSG00000168899, Low tissue specificity |
MIMi | 607029, gene |
neXtProti | NX_O95183 |
OpenTargetsi | ENSG00000168899 |
PharmGKBi | PA37270 |
VEuPathDBi | HostDB:ENSG00000168899.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0860, Eukaryota |
GeneTreei | ENSGT00730000111371 |
HOGENOMi | CLU_064620_4_2_1 |
InParanoidi | O95183 |
OMAi | WENKKMK |
OrthoDBi | 1607213at2759 |
PhylomeDBi | O95183 |
TreeFami | TF313666 |
Enzyme and pathway databases
PathwayCommonsi | O95183 |
Miscellaneous databases
BioGRID-ORCSi | 10791, 3 hits in 882 CRISPR screens |
ChiTaRSi | VAMP5, human |
GenomeRNAii | 10791 |
Pharosi | O95183, Tbio |
PROi | PR:O95183 |
RNActi | O95183, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168899, Expressed in left adrenal gland and 216 other tissues |
ExpressionAtlasi | O95183, baseline and differential |
Genevisiblei | O95183, HS |
Family and domain databases
CDDi | cd15872, R-SNARE_VAMP5, 1 hit |
InterProi | View protein in InterPro IPR001388, Synaptobrevin IPR042855, V_SNARE_CC IPR042166, Vamp5 IPR042581, VAMP5_R-SNARE |
PANTHERi | PTHR47462, PTHR47462, 1 hit |
Pfami | View protein in Pfam PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
PROSITEi | View protein in PROSITE PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VAMP5_HUMAN | |
Accessioni | O95183Primary (citable) accession number: O95183 Secondary accession number(s): Q9P0T2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM