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UniProtKB - O95183 (VAMP5_HUMAN)

Entry version 166 (02 Dec 2020)
Sequence version 1 (01 May 1999)
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Protein

Vesicle-associated membrane protein 5

Gene

VAMP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei40 – 41(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Myogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95183

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle-associated membrane protein 5
Short name:
VAMP-5
Alternative name(s):
Myobrevin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VAMP5
ORF Names:HSPC191
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000168899.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:12646, VAMP5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607029, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95183

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei73 – 93Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini94 – 116VesicularSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10791

Open Targets

More...OpenTargetsi		ENSG00000168899

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37270

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95183, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VAMP5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002067331 – 116Vesicle-associated membrane protein 5Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95183

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95183

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95183

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95183

PeptideAtlas

More...PeptideAtlasi		O95183

PRoteomics IDEntifications database

More...PRIDEi		O95183

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50693

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95183

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O95183

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95183

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95183

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

During myogenesis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168899, Expressed in left adrenal gland and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95183, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95183, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168899, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O95183
With#Exp.IntAct
ABHD16A [O95870]3EBI-10191195,EBI-348517
AQP6 [Q13520]3EBI-10191195,EBI-13059134
ASGR2 - isoform 3 [P07307-3]3EBI-10191195,EBI-12808270
ATP6AP2 [O75787]3EBI-10191195,EBI-2512037
BIK [Q13323]3EBI-10191195,EBI-700794
CD53 [P19397]3EBI-10191195,EBI-6657396
CLDN5 [O00501]3EBI-10191195,EBI-18400628
CLDN7 [O95471]3EBI-10191195,EBI-740744
COMT [P21964]3EBI-10191195,EBI-372265
CPLX4 [Q7Z7G2]3EBI-10191195,EBI-18013275
CSE1L [P55060]2EBI-10191195,EBI-286709
CYB5R3 [P00387]3EBI-10191195,EBI-1046040
ELOVL4 [Q9GZR5]3EBI-10191195,EBI-18535450
ERGIC3 [Q9Y282]3EBI-10191195,EBI-781551
ERVFRD-1 [P60508]3EBI-10191195,EBI-17973325
FAM209A [Q5JX71]3EBI-10191195,EBI-18304435
FNDC9 [Q8TBE3]3EBI-10191195,EBI-12142257
GJA8 [P48165]3EBI-10191195,EBI-17458373
GORAB [Q5T7V8]3EBI-10191195,EBI-3917143
GPR152 [Q8TDT2]3EBI-10191195,EBI-13345167
GPX8 [Q8TED1]3EBI-10191195,EBI-11721746
GRAMD2B [Q96HH9]3EBI-10191195,EBI-2832937
HIBADH [P31937]3EBI-10191195,EBI-11427100
IL10RA [Q13651]3EBI-10191195,EBI-1031656
IL3RA [P26951]3EBI-10191195,EBI-1757512
IL7R [P16871]3EBI-10191195,EBI-80490
JAGN1 [Q8N5M9]3EBI-10191195,EBI-10266796
KIR2DL3 [P43628]3EBI-10191195,EBI-8632435
KIR3DL3 [Q8N743]3EBI-10191195,EBI-17272405
KLRC1 [P26715]3EBI-10191195,EBI-9018187
LGALS3BP [Q08380]2EBI-10191195,EBI-354956
LRRC25 [Q8N386]3EBI-10191195,EBI-11304917
MUC1 - isoform Y-LSP [P15941-11]3EBI-10191195,EBI-17263240
NCAPH2 - isoform 4 [Q6IBW4-4]3EBI-10191195,EBI-10247000
PANX1 [Q96RD7]3EBI-10191195,EBI-7037612
PVR [P15151]3EBI-10191195,EBI-3919694
REEP4 [Q9H6H4]3EBI-10191195,EBI-7545592
RETREG3 [Q86VR2]3EBI-10191195,EBI-10192441
SAR1A [Q9NR31]3EBI-10191195,EBI-3920694
SDC3 [A0A0S2Z4U3]3EBI-10191195,EBI-10204280
SEC11C [Q9BY50]3EBI-10191195,EBI-2855401
SLC14A2 [Q15849]3EBI-10191195,EBI-1573290
SLC18A1 - isoform 3 [P54219-3]3EBI-10191195,EBI-17595455
SLC39A2 [Q9NP94]3EBI-10191195,EBI-12898013
SNAP23 [A8K287]3EBI-10191195,EBI-10188497
SNAP29 [O95721]9EBI-10191195,EBI-490676
SORT1 [Q99523]3EBI-10191195,EBI-1057058
SPINT1 - isoform 2 [O43278-2]3EBI-10191195,EBI-12078338
STX16 [O14662]4EBI-10191195,EBI-2853548
STX16 - isoform E [O14662-5]3EBI-10191195,EBI-9089968
STX1A [Q16623]3EBI-10191195,EBI-712466
STX1B [P61266]3EBI-10191195,EBI-9071709
STX2 - isoform 1 [P32856-2]3EBI-10191195,EBI-11956649
STX4 [Q12846]7EBI-10191195,EBI-744942
STX5 [Q13190]4EBI-10191195,EBI-714206
STX8 [Q9UNK0]4EBI-10191195,EBI-727240
TAS2R5 [Q9NYW4]3EBI-10191195,EBI-17933167
TM4SF18 [Q96CE8]3EBI-10191195,EBI-13351685
TMCO5A [Q8N6Q1]3EBI-10191195,EBI-12821895
TMEM106C [Q9BVX2]3EBI-10191195,EBI-2821497
TMEM139 [Q8IV31]3EBI-10191195,EBI-7238458
TMEM14B [Q9NUH8]3EBI-10191195,EBI-8638294
TMEM45B [Q96B21]3EBI-10191195,EBI-3923061
TMEM52B [Q4KMG9]3EBI-10191195,EBI-18178701
TMEM86B [Q8N661]3EBI-10191195,EBI-2548832
TMPRSS2 - isoform 2 [O15393-2]3EBI-10191195,EBI-12345267
TMX2 [Q9Y320]3EBI-10191195,EBI-6447886
VSIG4 [Q9Y279]3EBI-10191195,EBI-903131
ZDHHC15 [Q96MV8]3EBI-10191195,EBI-12837904

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116007, 133 interactors

Protein interaction database and analysis system

More...IntActi		O95183, 134 interactors

Molecular INTeraction database

More...MINTi		O95183

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000305647

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95183, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95183

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 65v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0860, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111371

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_064620_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95183

Identification of Orthologs from Complete Genome Data

More...OMAi		WENKKMK

Database of Orthologous Groups

More...OrthoDBi		1607213at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95183

TreeFam database of animal gene trees

More...TreeFami		TF313666

Family and domain databases

Conserved Domains Database

More...CDDi		cd15872, R-SNARE_VAMP5, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001388, Synaptobrevin
IPR042855, V_SNARE_CC
IPR042166, Vamp5
IPR042581, VAMP5_R-SNARE

The PANTHER Classification System

More...PANTHERi		PTHR47462, PTHR47462, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00957, Synaptobrevin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00219, SYNAPTOBREVN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00417, SYNAPTOBREVIN, 1 hit
PS50892, V_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O95183-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST 
        60         70         80         90        100
FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS 
       110 
SAPRTQDAGI ASGPGN
Length:116
Mass (Da):12,805
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32A1F3B808A6016C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17T → M in AAF36111 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF054825 mRNA Translation: AAC97473.1
AF077197 mRNA Translation: AAD26992.1
AF151025 mRNA Translation: AAF36111.1
BC017891 mRNA Translation: AAH17891.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1980.1

NCBI Reference Sequences

More...RefSeqi		NP_006625.1, NM_006634.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306384; ENSP00000305647; ENSG00000168899

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10791

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054825 mRNA Translation: AAC97473.1
AF077197 mRNA Translation: AAD26992.1
AF151025 mRNA Translation: AAF36111.1
BC017891 mRNA Translation: AAH17891.1
CCDSiCCDS1980.1
RefSeqiNP_006625.1, NM_006634.2

3D structure databases

SMRiO95183
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116007, 133 interactors
IntActiO95183, 134 interactors
MINTiO95183
STRINGi9606.ENSP00000305647

PTM databases

iPTMnetiO95183
MetOSiteiO95183
PhosphoSitePlusiO95183
SwissPalmiO95183

Polymorphism and mutation databases

BioMutaiVAMP5

Proteomic databases

EPDiO95183
jPOSTiO95183
MassIVEiO95183
PaxDbiO95183
PeptideAtlasiO95183
PRIDEiO95183
ProteomicsDBi50693

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31895, 161 antibodies

Genome annotation databases

EnsembliENST00000306384; ENSP00000305647; ENSG00000168899
GeneIDi10791
KEGGihsa:10791

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10791
DisGeNETi10791
EuPathDBiHostDB:ENSG00000168899.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		VAMP5
HGNCiHGNC:12646, VAMP5
HPAiENSG00000168899, Low tissue specificity
MIMi607029, gene
neXtProtiNX_O95183
OpenTargetsiENSG00000168899
PharmGKBiPA37270

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0860, Eukaryota
GeneTreeiENSGT00730000111371
HOGENOMiCLU_064620_4_2_1
InParanoidiO95183
OMAiWENKKMK
OrthoDBi1607213at2759
PhylomeDBiO95183
TreeFamiTF313666

Enzyme and pathway databases

PathwayCommonsiO95183

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10791, 2 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VAMP5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10791
PharosiO95183, Tbio

Protein Ontology

More...PROi		PR:O95183
RNActiO95183, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168899, Expressed in left adrenal gland and 216 other tissues
ExpressionAtlasiO95183, baseline and differential
GenevisibleiO95183, HS

Family and domain databases

CDDicd15872, R-SNARE_VAMP5, 1 hit
InterProiView protein in InterPro
IPR001388, Synaptobrevin
IPR042855, V_SNARE_CC
IPR042166, Vamp5
IPR042581, VAMP5_R-SNARE
PANTHERiPTHR47462, PTHR47462, 1 hit
PfamiView protein in Pfam
PF00957, Synaptobrevin, 1 hit
PRINTSiPR00219, SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417, SYNAPTOBREVIN, 1 hit
PS50892, V_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVAMP5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95183
Secondary accession number(s): Q9P0T2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: December 2, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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