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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Gene

NDUFA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Alternative name(s):
Complex I-B14.5a
Short name:
CI-B14.5a
NADH-ubiquinone oxidoreductase subunit B14.5a
Gene namesi
Name:NDUFA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000267855.5
HGNCiHGNC:7691 NDUFA7
MIMi602139 gene
neXtProtiNX_O95182

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000267855
PharmGKBiPA31497

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFA7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001188342 – 113NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei40N6-acetyllysineBy similarity1
Modified residuei96PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95182
MaxQBiO95182
PaxDbiO95182
PeptideAtlasiO95182
PRIDEiO95182
ProteomicsDBi50692
TopDownProteomicsiO95182

PTM databases

iPTMnetiO95182
PhosphoSitePlusiO95182

Expressioni

Gene expression databases

BgeeiENSG00000267855
CleanExiHS_NDUFA7
ExpressionAtlasiO95182 baseline and differential
GenevisibleiO95182 HS

Organism-specific databases

HPAiHPA059251
HPA071866

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

BioGridi110781, 83 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO95182
IntActiO95182, 33 interactors
MINTiO95182
STRINGi9606.ENSP00000470609

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Helixi54 – 57Combined sources4
Helixi60 – 62Combined sources3

3D structure databases

ProteinModelPortaliO95182
SMRiO95182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA7 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4630 Eukaryota
ENOG410XW5P LUCA
GeneTreeiENSGT00390000006553
HOVERGENiHBG002178
InParanoidiO95182
KOiK03951
OMAiPQPELPD
OrthoDBiEOG091G16YW
PhylomeDBiO95182
TreeFamiTF319126

Family and domain databases

InterProiView protein in InterPro
IPR009947 NADH-UbQ_OxRdtase_B14.5a_su
PANTHERiPTHR12485 PTHR12485, 1 hit
PfamiView protein in Pfam
PF07347 CI-B14_5a, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASATRLIQR LRNWASGHDL QGKLQLRYQE ISKRTQPPPK LPVGPSHKLS
60 70 80 90 100
NNYYCTRDGR RESVPPSIIM SSQKALVSGK PAESSAVAAT EKKAVTPAPP
110
IKRWELSSDQ PYL
Length:113
Mass (Da):12,551
Last modified:January 23, 2007 - v3
Checksum:i0B6BF051809B5E9E
GO

Sequence cautioni

The sequence AAC99399 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05058966P → A. Corresponds to variant dbSNP:rs2288415Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050637 mRNA Translation: AAD05427.1
AF054178 mRNA Translation: AAC99399.1 Different initiation.
BC003102 mRNA Translation: AAH03102.1
CCDSiCCDS42492.1
PIRiJE0380
RefSeqiNP_004992.2, NM_005001.4
UniGeneiHs.333427

Genome annotation databases

EnsembliENST00000301457; ENSP00000301457; ENSG00000267855
ENST00000593729; ENSP00000470962; ENSG00000267855
GeneIDi4701
KEGGihsa:4701
UCSCiuc002mjm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNDUA7_HUMAN
AccessioniPrimary (citable) accession number: O95182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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