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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

Gene

NDUFB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Alternative name(s):
Complex I-AGGG
Short name:
CI-AGGG
NADH-ubiquinone oxidoreductase AGGG subunit
Gene namesi
Name:NDUFB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000090266.12
HGNCiHGNC:7697 NDUFB2
MIMi603838 gene
neXtProtiNX_O95178

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4708
OpenTargetsiENSG00000090266
PharmGKBiPA31503

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFB2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionCombined sources1 PublicationAdd BLAST33
ChainiPRO_000002004234 – 105NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialAdd BLAST72

Proteomic databases

EPDiO95178
MaxQBiO95178
PaxDbiO95178
PeptideAtlasiO95178
PRIDEiO95178
ProteomicsDBi50689
TopDownProteomicsiO95178

PTM databases

iPTMnetiO95178
PhosphoSitePlusiO95178

Expressioni

Gene expression databases

BgeeiENSG00000090266
CleanExiHS_NDUFB2
ExpressionAtlasiO95178 baseline and differential
GenevisibleiO95178 HS

Organism-specific databases

HPAiHPA051377

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

BioGridi110788, 1 interactor
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO95178
IntActiO95178, 2 interactors
STRINGi9606.ENSP00000247866

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70Y39-97[»]
5XTDelectron microscopy3.70Y39-97[»]
5XTHelectron microscopy3.90Y39-97[»]
5XTIelectron microscopy17.40BY/Y39-97[»]
ProteinModelPortaliO95178
SMRiO95178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB2 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410J0BK Eukaryota
ENOG41128HF LUCA
GeneTreeiENSGT00390000004044
HOGENOMiHOG000252974
HOVERGENiHBG006499
InParanoidiO95178
KOiK03958
OrthoDBiEOG091G0YSW
PhylomeDBiO95178
TreeFamiTF316619

Family and domain databases

InterProiView protein in InterPro
IPR026627 NDUFB2
PANTHERiPTHR15223 PTHR15223, 1 hit
PfamiView protein in Pfam
PF14813 NADH_B2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALTRLASF ARVGGRLFRS GCARTAGDGG VRHAGGGVHI EPRYRQFPQL
60 70 80 90 100
TRSQVFQSEF FSGLMWFWIL WRFWHDSEEV LGHFPYPDPS QWTDEELGIP

PDDED
Length:105
Mass (Da):12,058
Last modified:May 1, 1999 - v1
Checksum:i5698368608CDC16F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050639 mRNA Translation: AAD05428.1
AF067166 mRNA Translation: AAD32450.1
CR542121 mRNA Translation: CAG46918.1
BC001168 mRNA No translation available.
CCDSiCCDS5862.1
PIRiJE0384
RefSeqiNP_004537.1, NM_004546.2
UniGeneiHs.655788

Genome annotation databases

EnsembliENST00000247866; ENSP00000247866; ENSG00000090266
ENST00000465506; ENSP00000419357; ENSG00000090266
ENST00000476279; ENSP00000419087; ENSG00000090266
GeneIDi4708
KEGGihsa:4708
UCSCiuc003vwa.4 human

Similar proteinsi

Entry informationi

Entry nameiNDUB2_HUMAN
AccessioniPrimary (citable) accession number: O95178
Secondary accession number(s): Q6FGI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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