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UniProtKB - O95171 (SCEL_HUMAN)

Protein

Sciellin

Gene

SCEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: UniProtKB
  • epidermis development Source: UniProtKB
  • keratinocyte differentiation Source: UniProtKB
  • positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • response to mechanical stimulus Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sciellin
Gene namesi
Name:SCEL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000136155.16
HGNCiHGNC:10573 SCEL
MIMi604112 gene
neXtProtiNX_O95171

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8796
OpenTargetsiENSG00000136155
PharmGKBiPA34986

Polymorphism and mutation databases

BioMutaiSCEL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759031 – 688SciellinAdd BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83N6-acetyllysineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei389PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95171
MaxQBiO95171
PaxDbiO95171
PeptideAtlasiO95171
PRIDEiO95171
ProteomicsDBi50686
50687 [O95171-2]

PTM databases

GlyConnecti1724
iPTMnetiO95171
PhosphoSitePlusiO95171

Expressioni

Tissue specificityi

Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.

Gene expression databases

BgeeiENSG00000136155 Expressed in 118 organ(s), highest expression level in mouth mucosa
CleanExiHS_SCEL
ExpressionAtlasiO95171 baseline and differential
GenevisibleiO95171 HS

Organism-specific databases

HPAiHPA039737
HPA040154

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi114324, 12 interactors
IntActiO95171, 10 interactors
MINTiO95171
STRINGi9606.ENSP00000302579

Structurei

3D structure databases

ProteinModelPortaliO95171
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati251 – 2661Add BLAST16
Repeati267 – 2862Add BLAST20
Repeati287 – 3063Add BLAST20
Repeati307 – 3264Add BLAST20
Repeati327 – 3465Add BLAST20
Repeati347 – 3666Add BLAST20
Repeati367 – 3867Add BLAST20
Repeati387 – 4068Add BLAST20
Repeati407 – 4269Add BLAST20
Repeati427 – 44610Add BLAST20
Repeati447 – 46511Add BLAST19
Repeati466 – 48412Add BLAST19
Repeati485 – 50413Add BLAST20
Repeati505 – 52314Add BLAST19
Repeati524 – 54315Add BLAST20
Repeati544 – 56316Add BLAST20
Domaini619 – 685LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 56316 X approximate tandem repeatsAdd BLAST313

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGG Eukaryota
ENOG4111UEX LUCA
GeneTreeiENSGT00530000063872
HOGENOMiHOG000294069
HOVERGENiHBG023141
InParanoidiO95171
OMAiICPPKPG
OrthoDBiEOG091G09RH
PhylomeDBiO95171
TreeFamiTF335114

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95171-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNVTLRKMS PTGNEMKSTT QGTTRKQQDF HEVNKRRTFL QDNSWIKKRP 
        60         70         80         90        100
EEEKDENYGR VVLNRHNSHD ALDRKVNERD VPKATISRYS SDDTLDRISD 
       110        120        130        140        150
RNDAAKTYKA NTLDNQLTNR SMSMFRSLEV TKLQPGGSLN ANTSNTIAST 
       160        170        180        190        200
SATTPVKKKR QSWFPPPPPG YNASSSTGTR RREPGVHPPI PPKPSSPVSS 
       210        220        230        240        250
PNQLRQDNRQ IHPPKPGVYT ETNRSAERNI RSQDLDNIVK VATSLQRSDK 
       260        270        280        290        300
GEELDNLIKM NKSLNRNQGL DSLFRANPKV EEREKRAKSL ESLIYMSTRT 
       310        320        330        340        350
DKDGKGIQSL GSPIKVNQRT DKNEKGRQNL ESVAKVNARM NKTSRRSEDL 
       360        370        380        390        400
DNATEVNPKG HENTTGKKDL DGLIKVDPET NKNITRGQSL DNLIKVTPEV 
       410        420        430        440        450
KRSNQGSKDL NNFIKVYPGT EKSTEGGQSL DSLIKVTPER NRTNQGNQDL 
       460        470        480        490        500
ENLIKVIPSA NKSSEQGLDE HINVSPKAVK NTDGKQDLDK LIKVNPEIFT 
       510        520        530        540        550
NNQRNQDLAN LIKVNPAVIR NNQSQDLDNL IKVKPSALRN TNRDQNLENL 
       560        570        580        590        600
IEVNSHVSEN KNGSSNTGAK QAGPQDTVVY TRTYVENSKS PKDGYQENIS 
       610        620        630        640        650
GKYIQTVYST SDRSVIERDM CTYCRKPLGV ETKMILDELQ ICCHSTCFKC 
       660        670        680 
EICKQPLENL QAGDSIWIYR QTIHCEPCYS KIMAKWIP
Length:688
Mass (Da):77,552
Last modified:December 16, 2008 - v2
Checksum:iB97F62DD560B57C3
GO
Isoform 2 (identifier: O95171-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-251: RSQDLDNIVKVATSLQRSDKG → S

Show »
Length:668
Mass (Da):75,326
Checksum:i119DB006BB85EC13
GO
Isoform 3 (identifier: O95171-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-181: Missing.
     367-386: Missing.

Note: No experimental confirmation available.
Show »
Length:646
Mass (Da):72,843
Checksum:iBDA3D0960363AEFC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2X8F2Z2X8_HUMAN
Sciellin
SCEL
283Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37R → G in BAH13533 (PubMed:14702039).Curated1
Sequence conflicti124M → V in AAH47536 (PubMed:15489334).Curated1
Sequence conflicti201P → T in AAH47536 (PubMed:15489334).Curated1
Sequence conflicti337N → D in AAC78461 (PubMed:9813070).Curated1
Sequence conflicti340M → T in AAC78461 (PubMed:9813070).Curated1
Sequence conflicti680S → P in BAD96440 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047920336V → L. Corresponds to variant dbSNP:rs34164479Ensembl.1
Natural variantiVAR_047921386R → K. Corresponds to variant dbSNP:rs2274016Ensembl.1
Natural variantiVAR_047922480K → R. Corresponds to variant dbSNP:rs8002725Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045288160 – 181Missing in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_035980231 – 251RSQDL…RSDKG → S in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_045289367 – 386Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045941 mRNA Translation: AAC78461.1
AK301659 mRNA Translation: BAH13533.1
AK222720 mRNA Translation: BAD96440.1
AL137140 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80568.1
CH471093 Genomic DNA Translation: EAW80569.1
BC047536 mRNA Translation: AAH47536.1
CCDSiCCDS53877.1 [O95171-3]
CCDS9458.1 [O95171-2]
CCDS9459.1 [O95171-1]
RefSeqiNP_001154178.1, NM_001160706.1 [O95171-3]
NP_003834.3, NM_003843.3 [O95171-2]
NP_659001.2, NM_144777.2 [O95171-1]
UniGeneiHs.534699

Genome annotation databases

EnsembliENST00000349847; ENSP00000302579; ENSG00000136155 [O95171-1]
ENST00000377246; ENSP00000366454; ENSG00000136155 [O95171-2]
ENST00000535157; ENSP00000437895; ENSG00000136155 [O95171-3]
GeneIDi8796
KEGGihsa:8796
UCSCiuc001vki.4 human [O95171-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045941 mRNA Translation: AAC78461.1
AK301659 mRNA Translation: BAH13533.1
AK222720 mRNA Translation: BAD96440.1
AL137140 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80568.1
CH471093 Genomic DNA Translation: EAW80569.1
BC047536 mRNA Translation: AAH47536.1
CCDSiCCDS53877.1 [O95171-3]
CCDS9458.1 [O95171-2]
CCDS9459.1 [O95171-1]
RefSeqiNP_001154178.1, NM_001160706.1 [O95171-3]
NP_003834.3, NM_003843.3 [O95171-2]
NP_659001.2, NM_144777.2 [O95171-1]
UniGeneiHs.534699

3D structure databases

ProteinModelPortaliO95171
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114324, 12 interactors
IntActiO95171, 10 interactors
MINTiO95171
STRINGi9606.ENSP00000302579

PTM databases

GlyConnecti1724
iPTMnetiO95171
PhosphoSitePlusiO95171

Polymorphism and mutation databases

BioMutaiSCEL

Proteomic databases

EPDiO95171
MaxQBiO95171
PaxDbiO95171
PeptideAtlasiO95171
PRIDEiO95171
ProteomicsDBi50686
50687 [O95171-2]

Protocols and materials databases

DNASUi8796
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349847; ENSP00000302579; ENSG00000136155 [O95171-1]
ENST00000377246; ENSP00000366454; ENSG00000136155 [O95171-2]
ENST00000535157; ENSP00000437895; ENSG00000136155 [O95171-3]
GeneIDi8796
KEGGihsa:8796
UCSCiuc001vki.4 human [O95171-1]

Organism-specific databases

CTDi8796
DisGeNETi8796
EuPathDBiHostDB:ENSG00000136155.16
GeneCardsiSCEL
HGNCiHGNC:10573 SCEL
HPAiHPA039737
HPA040154
MIMi604112 gene
neXtProtiNX_O95171
OpenTargetsiENSG00000136155
PharmGKBiPA34986
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGG Eukaryota
ENOG4111UEX LUCA
GeneTreeiENSGT00530000063872
HOGENOMiHOG000294069
HOVERGENiHBG023141
InParanoidiO95171
OMAiICPPKPG
OrthoDBiEOG091G09RH
PhylomeDBiO95171
TreeFamiTF335114

Miscellaneous databases

ChiTaRSiSCEL human
GeneWikiiSCEL_(gene)
GenomeRNAii8796
PROiPR:O95171
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136155 Expressed in 118 organ(s), highest expression level in mouth mucosa
CleanExiHS_SCEL
ExpressionAtlasiO95171 baseline and differential
GenevisibleiO95171 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCEL_HUMAN
AccessioniPrimary (citable) accession number: O95171
Secondary accession number(s): B7Z797
, F5H651, Q53H61, Q5W0S8, Q5W0S9, Q86X00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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