UniProtKB - O95171 (SCEL_HUMAN)
Protein
Sciellin
Gene
SCEL
Organism
Homo sapiens (Human)
Status
Functioni
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- embryo development ending in birth or egg hatching Source: UniProtKB
- epidermis development Source: UniProtKB
- keratinocyte differentiation Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
- response to mechanical stimulus Source: BHF-UCL
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95171 |
Names & Taxonomyi
Protein namesi | Recommended name: Sciellin |
Gene namesi | Name:SCEL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10573, SCEL |
MIMi | 604112, gene |
neXtProti | NX_O95171 |
VEuPathDBi | HostDB:ENSG00000136155.16 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- cornified envelope Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8796 |
OpenTargetsi | ENSG00000136155 |
PharmGKBi | PA34986 |
Miscellaneous databases
Pharosi | O95171, Tbio |
Genetic variation databases
BioMutai | SCEL |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075903 | 1 – 688 | SciellinAdd BLAST | 688 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 83 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 289 | PhosphoserineBy similarity | 1 | |
Modified residuei | 389 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95171 |
jPOSTi | O95171 |
MassIVEi | O95171 |
MaxQBi | O95171 |
PaxDbi | O95171 |
PeptideAtlasi | O95171 |
PRIDEi | O95171 |
ProteomicsDBi | 27081 50686 [O95171-1] 50687 [O95171-2] |
PTM databases
GlyConnecti | 1724, 5 N-Linked glycans (1 site) |
GlyGeni | O95171, 1 site |
iPTMneti | O95171 |
PhosphoSitePlusi | O95171 |
Expressioni
Tissue specificityi
Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.
Gene expression databases
Bgeei | ENSG00000136155, Expressed in mouth mucosa and 132 other tissues |
ExpressionAtlasi | O95171, baseline and differential |
Genevisiblei | O95171, HS |
Organism-specific databases
HPAi | ENSG00000136155, Tissue enhanced (esophagus, skin, tongue) |
Interactioni
Binary interactionsi
Hide detailsO95171
Isoform 2 [O95171-2]
With | #Exp. | IntAct |
---|---|---|
NMI [Q13287] | 3 | EBI-12056699,EBI-372942 |
Protein-protein interaction databases
BioGRIDi | 114324, 17 interactors |
IntActi | O95171, 15 interactors |
MINTi | O95171 |
STRINGi | 9606.ENSP00000302579 |
Miscellaneous databases
RNActi | O95171, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 251 – 266 | 1Add BLAST | 16 | |
Repeati | 267 – 286 | 2Add BLAST | 20 | |
Repeati | 287 – 306 | 3Add BLAST | 20 | |
Repeati | 307 – 326 | 4Add BLAST | 20 | |
Repeati | 327 – 346 | 5Add BLAST | 20 | |
Repeati | 347 – 366 | 6Add BLAST | 20 | |
Repeati | 367 – 386 | 7Add BLAST | 20 | |
Repeati | 387 – 406 | 8Add BLAST | 20 | |
Repeati | 407 – 426 | 9Add BLAST | 20 | |
Repeati | 427 – 446 | 10Add BLAST | 20 | |
Repeati | 447 – 465 | 11Add BLAST | 19 | |
Repeati | 466 – 484 | 12Add BLAST | 19 | |
Repeati | 485 – 504 | 13Add BLAST | 20 | |
Repeati | 505 – 523 | 14Add BLAST | 19 | |
Repeati | 524 – 543 | 15Add BLAST | 20 | |
Repeati | 544 – 563 | 16Add BLAST | 20 | |
Domaini | 619 – 685 | LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 251 – 563 | 16 X approximate tandem repeatsAdd BLAST | 313 |
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00530000063872 |
HOGENOMi | CLU_399516_0_0_1 |
InParanoidi | O95171 |
OMAi | GYNATPS |
OrthoDBi | 876581at2759 |
PhylomeDBi | O95171 |
TreeFami | TF335114 |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
SMARTi | View protein in SMART SM00132, LIM, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O95171-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNVTLRKMS PTGNEMKSTT QGTTRKQQDF HEVNKRRTFL QDNSWIKKRP
60 70 80 90 100
EEEKDENYGR VVLNRHNSHD ALDRKVNERD VPKATISRYS SDDTLDRISD
110 120 130 140 150
RNDAAKTYKA NTLDNQLTNR SMSMFRSLEV TKLQPGGSLN ANTSNTIAST
160 170 180 190 200
SATTPVKKKR QSWFPPPPPG YNASSSTGTR RREPGVHPPI PPKPSSPVSS
210 220 230 240 250
PNQLRQDNRQ IHPPKPGVYT ETNRSAERNI RSQDLDNIVK VATSLQRSDK
260 270 280 290 300
GEELDNLIKM NKSLNRNQGL DSLFRANPKV EEREKRAKSL ESLIYMSTRT
310 320 330 340 350
DKDGKGIQSL GSPIKVNQRT DKNEKGRQNL ESVAKVNARM NKTSRRSEDL
360 370 380 390 400
DNATEVNPKG HENTTGKKDL DGLIKVDPET NKNITRGQSL DNLIKVTPEV
410 420 430 440 450
KRSNQGSKDL NNFIKVYPGT EKSTEGGQSL DSLIKVTPER NRTNQGNQDL
460 470 480 490 500
ENLIKVIPSA NKSSEQGLDE HINVSPKAVK NTDGKQDLDK LIKVNPEIFT
510 520 530 540 550
NNQRNQDLAN LIKVNPAVIR NNQSQDLDNL IKVKPSALRN TNRDQNLENL
560 570 580 590 600
IEVNSHVSEN KNGSSNTGAK QAGPQDTVVY TRTYVENSKS PKDGYQENIS
610 620 630 640 650
GKYIQTVYST SDRSVIERDM CTYCRKPLGV ETKMILDELQ ICCHSTCFKC
660 670 680
EICKQPLENL QAGDSIWIYR QTIHCEPCYS KIMAKWIP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF2Z2X8 | F2Z2X8_HUMAN | Sciellin | SCEL | 283 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | R → G in BAH13533 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 124 | M → V in AAH47536 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 201 | P → T in AAH47536 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 337 | N → D in AAC78461 (PubMed:9813070).Curated | 1 | |
Sequence conflicti | 340 | M → T in AAC78461 (PubMed:9813070).Curated | 1 | |
Sequence conflicti | 680 | S → P in BAD96440 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047920 | 336 | V → L. Corresponds to variant dbSNP:rs34164479Ensembl. | 1 | |
Natural variantiVAR_047921 | 386 | R → K. Corresponds to variant dbSNP:rs2274016Ensembl. | 1 | |
Natural variantiVAR_047922 | 480 | K → R. Corresponds to variant dbSNP:rs8002725Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045288 | 160 – 181 | Missing in isoform 3. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_035980 | 231 – 251 | RSQDL…RSDKG → S in isoform 2. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_045289 | 367 – 386 | Missing in isoform 3. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045941 mRNA Translation: AAC78461.1 AK301659 mRNA Translation: BAH13533.1 AK222720 mRNA Translation: BAD96440.1 AL137140 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80568.1 CH471093 Genomic DNA Translation: EAW80569.1 BC047536 mRNA Translation: AAH47536.1 |
CCDSi | CCDS53877.1 [O95171-3] CCDS9458.1 [O95171-2] CCDS9459.1 [O95171-1] |
RefSeqi | NP_001154178.1, NM_001160706.1 [O95171-3] NP_003834.3, NM_003843.3 [O95171-2] NP_659001.2, NM_144777.2 [O95171-1] |
Genome annotation databases
Ensembli | ENST00000349847; ENSP00000302579; ENSG00000136155 [O95171-1] ENST00000377246; ENSP00000366454; ENSG00000136155 [O95171-2] ENST00000535157; ENSP00000437895; ENSG00000136155 [O95171-3] |
GeneIDi | 8796 |
KEGGi | hsa:8796 |
UCSCi | uc001vki.4, human [O95171-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045941 mRNA Translation: AAC78461.1 AK301659 mRNA Translation: BAH13533.1 AK222720 mRNA Translation: BAD96440.1 AL137140 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80568.1 CH471093 Genomic DNA Translation: EAW80569.1 BC047536 mRNA Translation: AAH47536.1 |
CCDSi | CCDS53877.1 [O95171-3] CCDS9458.1 [O95171-2] CCDS9459.1 [O95171-1] |
RefSeqi | NP_001154178.1, NM_001160706.1 [O95171-3] NP_003834.3, NM_003843.3 [O95171-2] NP_659001.2, NM_144777.2 [O95171-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114324, 17 interactors |
IntActi | O95171, 15 interactors |
MINTi | O95171 |
STRINGi | 9606.ENSP00000302579 |
PTM databases
GlyConnecti | 1724, 5 N-Linked glycans (1 site) |
GlyGeni | O95171, 1 site |
iPTMneti | O95171 |
PhosphoSitePlusi | O95171 |
Genetic variation databases
BioMutai | SCEL |
Proteomic databases
EPDi | O95171 |
jPOSTi | O95171 |
MassIVEi | O95171 |
MaxQBi | O95171 |
PaxDbi | O95171 |
PeptideAtlasi | O95171 |
PRIDEi | O95171 |
ProteomicsDBi | 27081 50686 [O95171-1] 50687 [O95171-2] |
Protocols and materials databases
Antibodypediai | 24603, 150 antibodies |
DNASUi | 8796 |
Genome annotation databases
Ensembli | ENST00000349847; ENSP00000302579; ENSG00000136155 [O95171-1] ENST00000377246; ENSP00000366454; ENSG00000136155 [O95171-2] ENST00000535157; ENSP00000437895; ENSG00000136155 [O95171-3] |
GeneIDi | 8796 |
KEGGi | hsa:8796 |
UCSCi | uc001vki.4, human [O95171-1] |
Organism-specific databases
CTDi | 8796 |
DisGeNETi | 8796 |
GeneCardsi | SCEL |
HGNCi | HGNC:10573, SCEL |
HPAi | ENSG00000136155, Tissue enhanced (esophagus, skin, tongue) |
MIMi | 604112, gene |
neXtProti | NX_O95171 |
OpenTargetsi | ENSG00000136155 |
PharmGKBi | PA34986 |
VEuPathDBi | HostDB:ENSG00000136155.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1704, Eukaryota |
GeneTreei | ENSGT00530000063872 |
HOGENOMi | CLU_399516_0_0_1 |
InParanoidi | O95171 |
OMAi | GYNATPS |
OrthoDBi | 876581at2759 |
PhylomeDBi | O95171 |
TreeFami | TF335114 |
Enzyme and pathway databases
PathwayCommonsi | O95171 |
Miscellaneous databases
BioGRID-ORCSi | 8796, 3 hits in 867 CRISPR screens |
ChiTaRSi | SCEL, human |
GeneWikii | SCEL_(gene) |
GenomeRNAii | 8796 |
Pharosi | O95171, Tbio |
PROi | PR:O95171 |
RNActi | O95171, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136155, Expressed in mouth mucosa and 132 other tissues |
ExpressionAtlasi | O95171, baseline and differential |
Genevisiblei | O95171, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
SMARTi | View protein in SMART SM00132, LIM, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCEL_HUMAN | |
Accessioni | O95171Primary (citable) accession number: O95171 Secondary accession number(s): B7Z797 Q86X00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | December 16, 2008 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with genetic variants
List of human entries with genetic variants