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UniProtKB - O95171 (SCEL_HUMAN)

Entry version 152 (10 Feb 2021)
Sequence version 2 (16 Dec 2008)
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Protein

Sciellin

Gene

SCEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95171

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sciellin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCEL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10573, SCEL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604112, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95171

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136155.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8796

Open Targets

More...OpenTargetsi		ENSG00000136155

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34986

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95171, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SCEL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759031 – 688SciellinAdd BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei83N6-acetyllysineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei389PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95171

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95171

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95171

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95171

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95171

PeptideAtlas

More...PeptideAtlasi		O95171

PRoteomics IDEntifications database

More...PRIDEi		O95171

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27081
50686 [O95171-1]
50687 [O95171-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1724, 5 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95171, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95171

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95171

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136155, Expressed in mouth mucosa and 132 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95171, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95171, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136155, Tissue enhanced (esophagus, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114324, 17 interactors

Protein interaction database and analysis system

More...IntActi		O95171, 15 interactors

Molecular INTeraction database

More...MINTi		O95171

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000302579

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95171, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati251 – 2661Add BLAST16
Repeati267 – 2862Add BLAST20
Repeati287 – 3063Add BLAST20
Repeati307 – 3264Add BLAST20
Repeati327 – 3465Add BLAST20
Repeati347 – 3666Add BLAST20
Repeati367 – 3867Add BLAST20
Repeati387 – 4068Add BLAST20
Repeati407 – 4269Add BLAST20
Repeati427 – 44610Add BLAST20
Repeati447 – 46511Add BLAST19
Repeati466 – 48412Add BLAST19
Repeati485 – 50413Add BLAST20
Repeati505 – 52314Add BLAST19
Repeati524 – 54315Add BLAST20
Repeati544 – 56316Add BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini619 – 685LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 56316 X approximate tandem repeatsAdd BLAST313

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1704, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_399516_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95171

Identification of Orthologs from Complete Genome Data

More...OMAi		GYNATPS

Database of Orthologous Groups

More...OrthoDBi		876581at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95171

TreeFam database of animal gene trees

More...TreeFami		TF335114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001781, Znf_LIM

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00132, LIM, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95171-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNVTLRKMS PTGNEMKSTT QGTTRKQQDF HEVNKRRTFL QDNSWIKKRP 
        60         70         80         90        100
EEEKDENYGR VVLNRHNSHD ALDRKVNERD VPKATISRYS SDDTLDRISD 
       110        120        130        140        150
RNDAAKTYKA NTLDNQLTNR SMSMFRSLEV TKLQPGGSLN ANTSNTIAST 
       160        170        180        190        200
SATTPVKKKR QSWFPPPPPG YNASSSTGTR RREPGVHPPI PPKPSSPVSS 
       210        220        230        240        250
PNQLRQDNRQ IHPPKPGVYT ETNRSAERNI RSQDLDNIVK VATSLQRSDK 
       260        270        280        290        300
GEELDNLIKM NKSLNRNQGL DSLFRANPKV EEREKRAKSL ESLIYMSTRT 
       310        320        330        340        350
DKDGKGIQSL GSPIKVNQRT DKNEKGRQNL ESVAKVNARM NKTSRRSEDL 
       360        370        380        390        400
DNATEVNPKG HENTTGKKDL DGLIKVDPET NKNITRGQSL DNLIKVTPEV 
       410        420        430        440        450
KRSNQGSKDL NNFIKVYPGT EKSTEGGQSL DSLIKVTPER NRTNQGNQDL 
       460        470        480        490        500
ENLIKVIPSA NKSSEQGLDE HINVSPKAVK NTDGKQDLDK LIKVNPEIFT 
       510        520        530        540        550
NNQRNQDLAN LIKVNPAVIR NNQSQDLDNL IKVKPSALRN TNRDQNLENL 
       560        570        580        590        600
IEVNSHVSEN KNGSSNTGAK QAGPQDTVVY TRTYVENSKS PKDGYQENIS 
       610        620        630        640        650
GKYIQTVYST SDRSVIERDM CTYCRKPLGV ETKMILDELQ ICCHSTCFKC 
       660        670        680 
EICKQPLENL QAGDSIWIYR QTIHCEPCYS KIMAKWIP
Length:688
Mass (Da):77,552
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB97F62DD560B57C3
GO
Isoform 2 (identifier: O95171-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-251: RSQDLDNIVKVATSLQRSDKG → S

Show »
Length:668
Mass (Da):75,326
Checksum:i119DB006BB85EC13
GO
Isoform 3 (identifier: O95171-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-181: Missing.
     367-386: Missing.

Show »
Length:646
Mass (Da):72,843
Checksum:iBDA3D0960363AEFC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2X8F2Z2X8_HUMAN
Sciellin
SCEL
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37R → G in BAH13533 (PubMed:14702039).Curated1
Sequence conflicti124M → V in AAH47536 (PubMed:15489334).Curated1
Sequence conflicti201P → T in AAH47536 (PubMed:15489334).Curated1
Sequence conflicti337N → D in AAC78461 (PubMed:9813070).Curated1
Sequence conflicti340M → T in AAC78461 (PubMed:9813070).Curated1
Sequence conflicti680S → P in BAD96440 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047920336V → L. Corresponds to variant dbSNP:rs34164479Ensembl.1
Natural variantiVAR_047921386R → K. Corresponds to variant dbSNP:rs2274016Ensembl.1
Natural variantiVAR_047922480K → R. Corresponds to variant dbSNP:rs8002725Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045288160 – 181Missing in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_035980231 – 251RSQDL…RSDKG → S in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_045289367 – 386Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF045941 mRNA Translation: AAC78461.1
AK301659 mRNA Translation: BAH13533.1
AK222720 mRNA Translation: BAD96440.1
AL137140 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80568.1
CH471093 Genomic DNA Translation: EAW80569.1
BC047536 mRNA Translation: AAH47536.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53877.1 [O95171-3]
CCDS9458.1 [O95171-2]
CCDS9459.1 [O95171-1]

NCBI Reference Sequences

More...RefSeqi		NP_001154178.1, NM_001160706.1 [O95171-3]
NP_003834.3, NM_003843.3 [O95171-2]
NP_659001.2, NM_144777.2 [O95171-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000349847; ENSP00000302579; ENSG00000136155 [O95171-1]
ENST00000377246; ENSP00000366454; ENSG00000136155 [O95171-2]
ENST00000535157; ENSP00000437895; ENSG00000136155 [O95171-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8796

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8796

UCSC genome browser

More...UCSCi		uc001vki.4, human [O95171-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045941 mRNA Translation: AAC78461.1
AK301659 mRNA Translation: BAH13533.1
AK222720 mRNA Translation: BAD96440.1
AL137140 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80568.1
CH471093 Genomic DNA Translation: EAW80569.1
BC047536 mRNA Translation: AAH47536.1
CCDSiCCDS53877.1 [O95171-3]
CCDS9458.1 [O95171-2]
CCDS9459.1 [O95171-1]
RefSeqiNP_001154178.1, NM_001160706.1 [O95171-3]
NP_003834.3, NM_003843.3 [O95171-2]
NP_659001.2, NM_144777.2 [O95171-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114324, 17 interactors
IntActiO95171, 15 interactors
MINTiO95171
STRINGi9606.ENSP00000302579

PTM databases

GlyConnecti1724, 5 N-Linked glycans (1 site)
GlyGeniO95171, 1 site
iPTMnetiO95171
PhosphoSitePlusiO95171

Genetic variation databases

BioMutaiSCEL

Proteomic databases

EPDiO95171
jPOSTiO95171
MassIVEiO95171
MaxQBiO95171
PaxDbiO95171
PeptideAtlasiO95171
PRIDEiO95171
ProteomicsDBi27081
50686 [O95171-1]
50687 [O95171-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24603, 150 antibodies

The DNASU plasmid repository

More...DNASUi		8796

Genome annotation databases

EnsembliENST00000349847; ENSP00000302579; ENSG00000136155 [O95171-1]
ENST00000377246; ENSP00000366454; ENSG00000136155 [O95171-2]
ENST00000535157; ENSP00000437895; ENSG00000136155 [O95171-3]
GeneIDi8796
KEGGihsa:8796
UCSCiuc001vki.4, human [O95171-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8796
DisGeNETi8796

GeneCards: human genes, protein and diseases

More...GeneCardsi		SCEL
HGNCiHGNC:10573, SCEL
HPAiENSG00000136155, Tissue enhanced (esophagus, skin, tongue)
MIMi604112, gene
neXtProtiNX_O95171
OpenTargetsiENSG00000136155
PharmGKBiPA34986
VEuPathDBiHostDB:ENSG00000136155.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1704, Eukaryota
GeneTreeiENSGT00530000063872
HOGENOMiCLU_399516_0_0_1
InParanoidiO95171
OMAiGYNATPS
OrthoDBi876581at2759
PhylomeDBiO95171
TreeFamiTF335114

Enzyme and pathway databases

PathwayCommonsiO95171

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8796, 3 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SCEL, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SCEL_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8796
PharosiO95171, Tbio

Protein Ontology

More...PROi		PR:O95171
RNActiO95171, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136155, Expressed in mouth mucosa and 132 other tissues
ExpressionAtlasiO95171, baseline and differential
GenevisibleiO95171, HS

Family and domain databases

InterProiView protein in InterPro
IPR001781, Znf_LIM
SMARTiView protein in SMART
SM00132, LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCEL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95171
Secondary accession number(s): B7Z797
, F5H651, Q53H61, Q5W0S8, Q5W0S9, Q86X00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 16, 2008
Last modified: February 10, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with genetic variants
    List of human entries with genetic variants
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