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UniProtKB - O95168 (NDUB4_HUMAN)

Entry version 178 (02 Jun 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Gene

NDUFB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS00843-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95168

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95168

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Alternative name(s):
Complex I-B15
Short name:
CI-B15
NADH-ubiquinone oxidoreductase B15 subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7699, NDUFB4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603840, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95168

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000065518.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 105HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000065518

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31510

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95168, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363065

Drug and drug target database

More...DrugBanki		DB00157, NADH

DrugCentral

More...DrugCentrali		O95168

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NDUFB4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188002 – 129NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei26PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95168

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95168

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95168

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95168

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95168

PeptideAtlas

More...PeptideAtlasi		O95168

PRoteomics IDEntifications database

More...PRIDEi		O95168

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50681 [O95168-1]
50682 [O95168-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O95168-1 [O95168-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95168

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95168

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95168

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000065518, Expressed in heart right ventricle and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95168, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95168, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000065518, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Complex I is composed of 45 different subunits.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110790, 60 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-577, Mitochondrial respiratory chain complex I

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95168

Protein interaction database and analysis system

More...IntActi		O95168, 34 interactors

Molecular INTeraction database

More...MINTi		O95168

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000184266

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O95168

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95168, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95168

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFB4 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S2HF, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007133

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_123402_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95168

Identification of Orthologs from Complete Genome Data

More...OMAi		PLFFWFY

Database of Orthologous Groups

More...OrthoDBi		1434967at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95168

TreeFam database of animal gene trees

More...TreeFami		TF328761

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009866, NADH_UbQ_OxRdtase_NDUFB4_su

The PANTHER Classification System

More...PANTHERi		PTHR15469, PTHR15469, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07225, NDUF_B4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95168-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFPKYKPSS LRTLPETLDP AEYNISPETR RAQAERLAIR AQLKREYLLQ 
        60         70         80         90        100
YNDPNRRGLI ENPALLRWAY ARTINVYPNF RPTPKNSLMG ALCGFGPLIF 
       110        120 
IYYIIKTERD RKEKLIQEGK LDRTFHLSY
Length:129
Mass (Da):15,209
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5060D0BF46FFF28
GO
Isoform 2 (identifier: O95168-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-129: DRKEKLIQEGKLDRTFHLSY → VSIQTRCLVFE

Show »
Length:120
Mass (Da):14,026
Checksum:i08BB084685E3098E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXQ9C9JXQ9_HUMAN
Complex I-B15
NDUFB4
80Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3P9F2Z3P9_HUMAN
Complex I-B15
NDUFB4
69Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042719110 – 129DRKEK…FHLSY → VSIQTRCLVFE in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF044957 mRNA Translation: AAD05421.1
AC126182 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79525.1
BC000855 mRNA Translation: AAH00855.1
BC070285 mRNA Translation: AAH70285.1
BC146885 mRNA Translation: AAI46886.1
BC146887 mRNA Translation: AAI46888.1
BC146927 mRNA Translation: AAI46928.1
BC146932 mRNA Translation: AAI46933.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2999.1 [O95168-1]
CCDS54630.1 [O95168-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JE0383

NCBI Reference Sequences

More...RefSeqi		NP_001161803.1, NM_001168331.1 [O95168-2]
NP_004538.2, NM_004547.5 [O95168-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000184266; ENSP00000184266; ENSG00000065518 [O95168-1]
ENST00000485064; ENSP00000419578; ENSG00000065518 [O95168-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4710

UCSC genome browser

More...UCSCi		uc003edt.4, human [O95168-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044957 mRNA Translation: AAD05421.1
AC126182 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79525.1
BC000855 mRNA Translation: AAH00855.1
BC070285 mRNA Translation: AAH70285.1
BC146885 mRNA Translation: AAI46886.1
BC146887 mRNA Translation: AAI46888.1
BC146927 mRNA Translation: AAI46928.1
BC146932 mRNA Translation: AAI46933.1
CCDSiCCDS2999.1 [O95168-1]
CCDS54630.1 [O95168-2]
PIRiJE0383
RefSeqiNP_001161803.1, NM_001168331.1 [O95168-2]
NP_004538.2, NM_004547.5 [O95168-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70o2-129[»]
5XTDelectron microscopy3.70o2-129[»]
5XTHelectron microscopy3.90o2-129[»]
5XTIelectron microscopy17.40Bo/o2-129[»]
SMRiO95168
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110790, 60 interactors
ComplexPortaliCPX-577, Mitochondrial respiratory chain complex I
CORUMiO95168
IntActiO95168, 34 interactors
MINTiO95168
STRINGi9606.ENSP00000184266

Chemistry databases

BindingDBiO95168
ChEMBLiCHEMBL2363065
DrugBankiDB00157, NADH
DrugCentraliO95168

PTM databases

iPTMnetiO95168
PhosphoSitePlusiO95168
SwissPalmiO95168

Genetic variation databases

BioMutaiNDUFB4

Proteomic databases

EPDiO95168
jPOSTiO95168
MassIVEiO95168
MaxQBiO95168
PaxDbiO95168
PeptideAtlasiO95168
PRIDEiO95168
ProteomicsDBi50681 [O95168-1]
50682 [O95168-2]
TopDownProteomicsiO95168-1 [O95168-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32798, 81 antibodies

The DNASU plasmid repository

More...DNASUi		4710

Genome annotation databases

EnsembliENST00000184266; ENSP00000184266; ENSG00000065518 [O95168-1]
ENST00000485064; ENSP00000419578; ENSG00000065518 [O95168-2]
GeneIDi4710
KEGGihsa:4710
UCSCiuc003edt.4, human [O95168-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4710

GeneCards: human genes, protein and diseases

More...GeneCardsi		NDUFB4
HGNCiHGNC:7699, NDUFB4
HPAiENSG00000065518, Tissue enhanced (skeletal)
MIMi603840, gene
neXtProtiNX_O95168
OpenTargetsiENSG00000065518
PharmGKBiPA31510
VEuPathDBiHostDB:ENSG00000065518.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S2HF, Eukaryota
GeneTreeiENSGT00390000007133
HOGENOMiCLU_123402_0_0_1
InParanoidiO95168
OMAiPLFFWFY
OrthoDBi1434967at2759
PhylomeDBiO95168
TreeFamiTF328761

Enzyme and pathway databases

BioCyciMetaCyc:HS00843-MONOMER
PathwayCommonsiO95168
ReactomeiR-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis
SIGNORiO95168

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4710, 384 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NDUFB4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4710
PharosiO95168, Tclin

Protein Ontology

More...PROi		PR:O95168
RNActiO95168, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000065518, Expressed in heart right ventricle and 250 other tissues
ExpressionAtlasiO95168, baseline and differential
GenevisibleiO95168, HS

Family and domain databases

InterProiView protein in InterPro
IPR009866, NADH_UbQ_OxRdtase_NDUFB4_su
PANTHERiPTHR15469, PTHR15469, 1 hit
PfamiView protein in Pfam
PF07225, NDUF_B4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDUB4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95168
Secondary accession number(s): B2RUY3, B9EJC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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