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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Gene

NDUFA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Alternative name(s):
Complex I-B9
Short name:
CI-B9
NADH-ubiquinone oxidoreductase B9 subunit
Gene namesi
Name:NDUFA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170906.15
HGNCiHGNC:7686 NDUFA3
MIMi603832 gene
neXtProtiNX_O95167

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170906
PharmGKBiPA31492

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFA3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001187932 – 84NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95167
PaxDbiO95167
PeptideAtlasiO95167
PRIDEiO95167
ProteomicsDBi50680
TopDownProteomicsiO95167

PTM databases

iPTMnetiO95167
PhosphoSitePlusiO95167

Expressioni

Gene expression databases

BgeeiENSG00000170906 Expressed in 229 organ(s), highest expression level in quadriceps femoris
CleanExiHS_NDUFA3
ExpressionAtlasiO95167 baseline and differential
GenevisibleiO95167 HS

Organism-specific databases

HPAiHPA046976

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

BioGridi110776, 29 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO95167
IntActiO95167, 20 interactors
MINTiO95167
STRINGi9606.ENSP00000398290

Structurei

3D structure databases

SMRiO95167
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA3 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J189 Eukaryota
ENOG411212S LUCA
GeneTreeiENSGT00390000004322
HOGENOMiHOG000015319
HOVERGENiHBG006495
InParanoidiO95167
KOiK03947
OMAiAVIMPMI
OrthoDBiEOG091G13PK
PhylomeDBiO95167
TreeFamiTF333021

Family and domain databases

InterProiView protein in InterPro
IPR026626 NDUFA3
PANTHERiPTHR15221 PTHR15221, 1 hit
PfamiView protein in Pfam
PF14987 NADHdh_A3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

O95167-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP
60 70 80
YNYPVPVRDD GNMPDVPSHP QDPQGPSLEW LKKL
Length:84
Mass (Da):9,279
Last modified:May 1, 1999 - v1
Checksum:i38B27A96D7A05D31
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6FGG4Q6FGG4_HUMAN
NADH dehydrogenase (Ubiquinone) 1 a...
NDUFA3 hCG_20947
84Annotation score:
A8MVM8A8MVM8_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA3
72Annotation score:
A8MYJ8A8MYJ8_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA3
81Annotation score:
H7C2R1H7C2R1_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA3
69Annotation score:
S4R3T6S4R3T6_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA3
73Annotation score:
S4R3I5S4R3I5_HUMAN
NADH dehydrogenase (Ubiquinone) 1 a...
NDUFA3 hCG_20947
41Annotation score:
F2Z2C6F2Z2C6_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA3
65Annotation score:
H7C0D7H7C0D7_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA3
34Annotation score:
A8MUI2A8MUI2_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA3
61Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03617562N → D in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044955 mRNA Translation: AAD05420.1
AF070653 mRNA Translation: AAD20959.1
BC022369 mRNA Translation: AAH22369.1
BC061644 mRNA Translation: AAH61644.1
CCDSiCCDS12877.1
PIRiJE0379
RefSeqiNP_004533.1, NM_004542.3
XP_016882322.1, XM_017026833.1
UniGeneiHs.198269

Genome annotation databases

EnsembliENST00000419113; ENSP00000398290; ENSG00000170906
ENST00000485876; ENSP00000418438; ENSG00000170906
ENST00000620289; ENSP00000477783; ENSG00000276061
ENST00000622523; ENSP00000483683; ENSG00000276061
GeneIDi4696
KEGGihsa:4696

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044955 mRNA Translation: AAD05420.1
AF070653 mRNA Translation: AAD20959.1
BC022369 mRNA Translation: AAH22369.1
BC061644 mRNA Translation: AAH61644.1
CCDSiCCDS12877.1
PIRiJE0379
RefSeqiNP_004533.1, NM_004542.3
XP_016882322.1, XM_017026833.1
UniGeneiHs.198269

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70U2-84[»]
5XTDelectron microscopy3.70U2-84[»]
5XTHelectron microscopy3.90U2-84[»]
5XTIelectron microscopy17.40BU/U2-84[»]
SMRiO95167
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110776, 29 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO95167
IntActiO95167, 20 interactors
MINTiO95167
STRINGi9606.ENSP00000398290

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

PTM databases

iPTMnetiO95167
PhosphoSitePlusiO95167

Polymorphism and mutation databases

BioMutaiNDUFA3

Proteomic databases

EPDiO95167
PaxDbiO95167
PeptideAtlasiO95167
PRIDEiO95167
ProteomicsDBi50680
TopDownProteomicsiO95167

Protocols and materials databases

DNASUi4696
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419113; ENSP00000398290; ENSG00000170906
ENST00000485876; ENSP00000418438; ENSG00000170906
ENST00000620289; ENSP00000477783; ENSG00000276061
ENST00000622523; ENSP00000483683; ENSG00000276061
GeneIDi4696
KEGGihsa:4696

Organism-specific databases

CTDi4696
EuPathDBiHostDB:ENSG00000170906.15
GeneCardsiNDUFA3
HGNCiHGNC:7686 NDUFA3
HPAiHPA046976
MIMi603832 gene
neXtProtiNX_O95167
OpenTargetsiENSG00000170906
PharmGKBiPA31492
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J189 Eukaryota
ENOG411212S LUCA
GeneTreeiENSGT00390000004322
HOGENOMiHOG000015319
HOVERGENiHBG006495
InParanoidiO95167
KOiK03947
OMAiAVIMPMI
OrthoDBiEOG091G13PK
PhylomeDBiO95167
TreeFamiTF333021

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSiNDUFA3 human
GenomeRNAii4696
PROiPR:O95167
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170906 Expressed in 229 organ(s), highest expression level in quadriceps femoris
CleanExiHS_NDUFA3
ExpressionAtlasiO95167 baseline and differential
GenevisibleiO95167 HS

Family and domain databases

InterProiView protein in InterPro
IPR026626 NDUFA3
PANTHERiPTHR15221 PTHR15221, 1 hit
PfamiView protein in Pfam
PF14987 NADHdh_A3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA3_HUMAN
AccessioniPrimary (citable) accession number: O95167
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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