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Protein

Ubiquitin-like protein 3

Gene

UBL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 3
Alternative name(s):
Membrane-anchored ubiquitin-fold protein
Short name:
HsMUB
Short name:
MUB
Protein HCG-1
Gene namesi
Name:UBL3
Synonyms:PNSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000122042.9
HGNCiHGNC:12504 UBL3
MIMi604711 gene
neXtProtiNX_O95164

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5412
OpenTargetsiENSG00000122042
PharmGKBiPA37151

Polymorphism and mutation databases

BioMutaiUBL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148621 – 114Ubiquitin-like protein 3Add BLAST114
PropeptideiPRO_0000248183115 – 117Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi113S-palmitoyl cysteine1 Publication1
Modified residuei114Cysteine methyl esterCurated1
Lipidationi114S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiO95164
MaxQBiO95164
PaxDbiO95164
PeptideAtlasiO95164
PRIDEiO95164
ProteomicsDBi50678

PTM databases

iPTMnetiO95164
PhosphoSitePlusiO95164
SwissPalmiO95164

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000122042 Expressed in 235 organ(s), highest expression level in caudate nucleus
CleanExiHS_UBL3
ExpressionAtlasiO95164 baseline and differential
GenevisibleiO95164 HS

Organism-specific databases

HPAiHPA053772
HPA058781

Interactioni

Protein-protein interaction databases

BioGridi111413, 6 interactors
IntActiO95164, 4 interactors
STRINGi9606.ENSP00000370055

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95164
SMRiO95164
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95164

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 88Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

eggNOGiENOG410IVZB Eukaryota
ENOG4111N2D LUCA
GeneTreeiENSGT00390000004952
HOGENOMiHOG000253908
HOVERGENiHBG054980
InParanoidiO95164
OMAiRFLHGSV
OrthoDBiEOG091G0VZB
PhylomeDBiO95164
TreeFamiTF314489

Family and domain databases

InterProiView protein in InterPro
IPR017000 MUB
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR040015 UBL3-like
IPR039540 UBL3-like_ubiquitin_dom
PANTHERiPTHR13169 PTHR13169, 1 hit
PfamiView protein in Pfam
PF13881 Rad60-SLD_2, 1 hit
PIRSFiPIRSF032572 MUB, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95164-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSNVPADMI NLRLILVSGK TKEFLFSPND SASDIAKHVY DNWPMDWEEE
60 70 80 90 100
QVSSPNILRL IYQGRFLHGN VTLGALKLPF GKTTVMHLVA RETLPEPNSQ
110
GQRNREKTGE SNCCVIL
Length:117
Mass (Da):13,157
Last modified:May 1, 1999 - v1
Checksum:i4EB1375D9C0B029F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10I → V in CAG38489 (Ref. 4) Curated1
Sequence conflicti28P → H in AAH44582 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044221 mRNA Translation: AAD02323.1
AL080177 mRNA Translation: CAB45762.1
AK311846 mRNA Translation: BAG34788.1
AK056580 mRNA Translation: BAG51754.1
CR533458 mRNA Translation: CAG38489.1
AL158193 Genomic DNA No translation available.
AL139188 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08446.1
BC044582 mRNA Translation: AAH44582.1
BC059385 mRNA Translation: AAH59385.1
CCDSiCCDS9334.1
PIRiT12498
RefSeqiNP_009037.1, NM_007106.3
UniGeneiHs.145575

Genome annotation databases

EnsembliENST00000380680; ENSP00000370055; ENSG00000122042
GeneIDi5412
KEGGihsa:5412
UCSCiuc001usp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044221 mRNA Translation: AAD02323.1
AL080177 mRNA Translation: CAB45762.1
AK311846 mRNA Translation: BAG34788.1
AK056580 mRNA Translation: BAG51754.1
CR533458 mRNA Translation: CAG38489.1
AL158193 Genomic DNA No translation available.
AL139188 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08446.1
BC044582 mRNA Translation: AAH44582.1
BC059385 mRNA Translation: AAH59385.1
CCDSiCCDS9334.1
PIRiT12498
RefSeqiNP_009037.1, NM_007106.3
UniGeneiHs.145575

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GOWNMR-A2-117[»]
ProteinModelPortaliO95164
SMRiO95164
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111413, 6 interactors
IntActiO95164, 4 interactors
STRINGi9606.ENSP00000370055

PTM databases

iPTMnetiO95164
PhosphoSitePlusiO95164
SwissPalmiO95164

Polymorphism and mutation databases

BioMutaiUBL3

Proteomic databases

EPDiO95164
MaxQBiO95164
PaxDbiO95164
PeptideAtlasiO95164
PRIDEiO95164
ProteomicsDBi50678

Protocols and materials databases

DNASUi5412
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380680; ENSP00000370055; ENSG00000122042
GeneIDi5412
KEGGihsa:5412
UCSCiuc001usp.4 human

Organism-specific databases

CTDi5412
DisGeNETi5412
EuPathDBiHostDB:ENSG00000122042.9
GeneCardsiUBL3
HGNCiHGNC:12504 UBL3
HPAiHPA053772
HPA058781
MIMi604711 gene
neXtProtiNX_O95164
OpenTargetsiENSG00000122042
PharmGKBiPA37151
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVZB Eukaryota
ENOG4111N2D LUCA
GeneTreeiENSGT00390000004952
HOGENOMiHOG000253908
HOVERGENiHBG054980
InParanoidiO95164
OMAiRFLHGSV
OrthoDBiEOG091G0VZB
PhylomeDBiO95164
TreeFamiTF314489

Miscellaneous databases

ChiTaRSiUBL3 human
EvolutionaryTraceiO95164
GeneWikiiUBL3
GenomeRNAii5412
PROiPR:O95164
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122042 Expressed in 235 organ(s), highest expression level in caudate nucleus
CleanExiHS_UBL3
ExpressionAtlasiO95164 baseline and differential
GenevisibleiO95164 HS

Family and domain databases

InterProiView protein in InterPro
IPR017000 MUB
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR040015 UBL3-like
IPR039540 UBL3-like_ubiquitin_dom
PANTHERiPTHR13169 PTHR13169, 1 hit
PfamiView protein in Pfam
PF13881 Rad60-SLD_2, 1 hit
PIRSFiPIRSF032572 MUB, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBL3_HUMAN
AccessioniPrimary (citable) accession number: O95164
Secondary accession number(s): B2R4J1
, Q5RL72, Q5VZS0, Q6FIG8, Q96SG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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