UniProtKB - O95163 (ELP1_HUMAN)

BLAST

>sp|O95163|ELP1_HUMAN Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3
MRNLKLFRTLEFRDIQGPGNPQCFSLRTEQGTVLIGSEHGLIEVDPVSREVKNEVSLVAE
GFLPEDGSGRIVGVQDLLDQESVCVATASGDVILCSLSTQQLECVGSVASGISVMSWSPD
QELVLLATGQQTLIMMTKDFEPILEQQIHQDDFGESKFITVGWGRKETQFHGSEGRQAAF
QMQMHESALPWDDHRPQVTWRGDGQFFAVSVVCPETGARKVRVWNREFALQSTSEPVAGL
GPALAWKPSGSLIASTQDKPNQQDIVFFEKNGLLHGHFTLPFLKDEVKVNDLLWNADSSV
LAVWLEDLQREESSIPKTCVQLWTVGNYHWYLKQSLSFSTCGKSKIVSLMWDPVTPYRLH
VLCQGWHYLAYDWHWTTDRSVGDNSSDLSNVAVIDGNRVLVTVFRQTVVPPPMCTYQLLF
PHPVNQVTFLAHPQKSNDLAVLDASNQISVYKCGDCPSADPTVKLGAVGGSGFKVCLRTP
HLEKRYKIQFENNEDQDVNPLKLGLLTWIEEDVFLAVSHSEFSPRSVIHHLTAASSEMDE
EHGQLNVSSSAAVDGVIISLCCNSKTKSVVLQLADGQIFKYLWESPSLAIKPWKNSGGFP
VRFPYPCTQTELAMIGEEECVLGLTDRCRFFINDIEVASNITSFAVYDEFLLLTTHSHTC
QCFCLRDASFKTLQAGLSSNHVSHGEVLRKVERGSRIVTVVPQDTKLVLQMPRGNLEVVH
HRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIYDHNPKVFLGNVETFIKQIDSVNHI
NLFFTELKEEDVTKTMYPAPVTSSVYLSRDPDGNKIDLVCDAMRAVMESINPHKYCLSIL
TSHVKKTTPELEIVLQKVHELQGNAPSDPDAVSAEEALKYLLHLVDVNELYDHSLGTYDF
DLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCGPEYFPE
CLNLIKDKNLYNEALKLYSPSSQQYQDISIAYGEHLMQEHMYEPAGLMFARCGAHEKALS
AFLTCGNWKQALCVAAQLNFTKDQLVGLGRTLAGKLVEQRKHIDAAMVLEECAQDYEEAV
LLLLEGAAWEEALRLVYKYNRLDIIETNVKPSILEAQKNYMAFLDSQTATFSRHKKRLLV
VRELKEQAQQAGLDDEVPHGQESDLFSETSSVVSGSEMSGKYSHSNSRISARSSKNRRKA
ERKKHSLKEGSPLEDLALLEALSEVVQNTENLKDEVYHILKVLFLFEFDEQGRELQKAFE
DTLQLMERSLPEIWTLTYQQNSATPVLGPNSTANSIMASYQQQKTSVPVLDAELFIPPKI
NRRTQWKLSLLD

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History
Entry version 172 (07 Nov 2018)
Sequence version 3 (25 Nov 2008)
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Protein

Elongator complex protein 1

Gene

ELP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

phosphorylase kinase regulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11818576

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

immune response
Source: ProtInc
Traceable author statementⁱ
- 9751059
positive regulation of cell migration Source: UniProtKB
protein-containing complex assembly
Source: ProtInc
Traceable author statementⁱ
- 9751059
protein phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 9751059
regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11818576
transcription elongation from RNA polymerase II promoter
Source: BHF-UCL
Traceable author statementⁱ
- 11714725
tRNA wobble uridine modification Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones
SignaLinkⁱ	O95163
SIGNORⁱ	O95163

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongator complex protein 1 Short name: ELP1 Alternative name(s): IkappaB kinase complex-associated protein Short name: IKK complex-associated protein p150
Gene namesⁱ	Name:ELP1Imported Synonyms:IKAP, IKBKAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000070061.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5959 ELP1
MIMⁱ	603722 gene
neXtProtⁱ	NX_O95163

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Neuropathy, hereditary sensory and autonomic, 3 (HSAN3)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN3 patients manifest a variety of symptoms such as alacrima, decreased taste, decreased sensitivity to pain and temperature, vasomotor instability, hypoactive or absent deep tendon reflexes, vomiting crises, and gastrointestinal dysfunction.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011327	696	R → P in HSAN3; mild phenotype; phosphorylation is reduced. 2 PublicationsCorresponds to variant dbSNP:rs137853022EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8518
GeneReviewsⁱ	IKBKAP
MalaCards human disease database More...MalaCardsⁱ	ELP1
MIMⁱ	223900 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000070061
Orphanetⁱ	1764 Familial dysautonomia
PharmGKBⁱ	PA29775

Polymorphism and mutation databases

BioMutaⁱ	IKBKAP

BioMutaⁱ

IKBKAP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084177	1 – 1332	Elongator complex protein 1Add BLAST		1332

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	471	PhosphoserineCombined sources	1
Modified residueⁱ	804	PhosphoserineCombined sources	1
Modified residueⁱ	867	PhosphoserineCombined sources	1
Modified residueⁱ	1171	PhosphoserineCombined sources	1
Modified residueⁱ	1174	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95163
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95163
PaxDbⁱ	O95163
PeptideAtlas More...PeptideAtlasⁱ	O95163
PRIDEⁱ	O95163
ProteomicsDBⁱ	50677

PTM databases

iPTMnetⁱ	O95163
PhosphoSitePlusⁱ	O95163

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000070061 Expressed in 229 organ(s), highest expression level in metanephros
CleanExⁱ	HS_IKBKAP
ExpressionAtlasⁱ	O95163 baseline and differential
Genevisibleⁱ	O95163 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB021340 HPA049677 HPA050686

HPAⁱ

CAB021340
HPA049677
HPA050686

Interactionⁱ

Subunit structureⁱ

Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ELP3	Q9H9T3	8	EBI-347559,EBI-355217
HTT	P42858	4	EBI-347559,EBI-466029
IRF4	Q15306	2	EBI-347559,EBI-751345

Protein-protein interaction databases

BioGridⁱ	114090, 76 interactors
ComplexPortalⁱ	CPX-1949 Elongator holoenzyme complex
CORUMⁱ	O95163
Database of interacting proteins More...DIPⁱ	DIP-27579N
IntActⁱ	O95163, 42 interactors
Molecular INTeraction database More...MINTⁱ	O95163
STRINGⁱ	9606.ENSP00000363779

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	723 – 734	Combined sources	12
Helixⁱ	738 – 747	Combined sources	10
Helixⁱ	754 – 757	Combined sources	4
Helixⁱ	760 – 763	Combined sources	4
Helixⁱ	767 – 773	Combined sources	7
Helixⁱ	777 – 786	Combined sources	10
Turnⁱ	792 – 796	Combined sources	5
Helixⁱ	815 – 830	Combined sources	16
Turnⁱ	832 – 835	Combined sources	4
Helixⁱ	836 – 844	Combined sources	9
Beta strandⁱ	846 – 848	Combined sources	3
Helixⁱ	851 – 860	Combined sources	10
Helixⁱ	868 – 870	Combined sources	3
Helixⁱ	874 – 882	Combined sources	9
Helixⁱ	887 – 894	Combined sources	8
Turnⁱ	895 – 897	Combined sources	3
Helixⁱ	900 – 908	Combined sources	9
Helixⁱ	918 – 924	Combined sources	7
Helixⁱ	929 – 939	Combined sources	11
Helixⁱ	943 – 950	Combined sources	8
Beta strandⁱ	955 – 957	Combined sources	3
Helixⁱ	958 – 967	Combined sources	10
Helixⁱ	971 – 975	Combined sources	5
Helixⁱ	983 – 997	Combined sources	15
Turnⁱ	998 – 1000	Combined sources	3
Helixⁱ	1002 – 1011	Combined sources	10
Helixⁱ	1015 – 1024	Combined sources	10
Helixⁱ	1028 – 1036	Combined sources	9
Turnⁱ	1037 – 1039	Combined sources	3
Helixⁱ	1042 – 1057	Combined sources	16
Turnⁱ	1058 – 1060	Combined sources	3
Helixⁱ	1062 – 1072	Combined sources	11
Helixⁱ	1076 – 1085	Combined sources	10
Helixⁱ	1089 – 1097	Combined sources	9
Turnⁱ	1098 – 1100	Combined sources	3
Helixⁱ	1103 – 1107	Combined sources	5
Helixⁱ	1109 – 1126	Combined sources	18
Turnⁱ	1127 – 1130	Combined sources	4
Helixⁱ	1233 – 1245	Combined sources	13
Helixⁱ	1249 – 1264	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	O95163
SMRⁱ	O95163
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ELP1/IKA1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1920 Eukaryota COG5290 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013344
HOVERGENⁱ	HBG019038
InParanoidⁱ	O95163
KEGG Orthology (KO) More...KOⁱ	K11373
OMAⁱ	KVRVWNR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01A5
PhylomeDBⁱ	O95163
TreeFamⁱ	TF300402

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006849 Elp1 IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERⁱ	PTHR12747 PTHR12747, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04762 IKI3, 1 hit
PIRSFⁱ	PIRSF017233 IKAP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O95163-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MRNLKLFRTL EFRDIQGPGN PQCFSLRTEQ GTVLIGSEHG LIEVDPVSRE 
        60         70         80         90        100
VKNEVSLVAE GFLPEDGSGR IVGVQDLLDQ ESVCVATASG DVILCSLSTQ 
       110        120        130        140        150
QLECVGSVAS GISVMSWSPD QELVLLATGQ QTLIMMTKDF EPILEQQIHQ 
       160        170        180        190        200
DDFGESKFIT VGWGRKETQF HGSEGRQAAF QMQMHESALP WDDHRPQVTW 
       210        220        230        240        250
RGDGQFFAVS VVCPETGARK VRVWNREFAL QSTSEPVAGL GPALAWKPSG 
       260        270        280        290        300
SLIASTQDKP NQQDIVFFEK NGLLHGHFTL PFLKDEVKVN DLLWNADSSV 
       310        320        330        340        350
LAVWLEDLQR EESSIPKTCV QLWTVGNYHW YLKQSLSFST CGKSKIVSLM 
       360        370        380        390        400
WDPVTPYRLH VLCQGWHYLA YDWHWTTDRS VGDNSSDLSN VAVIDGNRVL 
       410        420        430        440        450
VTVFRQTVVP PPMCTYQLLF PHPVNQVTFL AHPQKSNDLA VLDASNQISV 
       460        470        480        490        500
YKCGDCPSAD PTVKLGAVGG SGFKVCLRTP HLEKRYKIQF ENNEDQDVNP 
       510        520        530        540        550
LKLGLLTWIE EDVFLAVSHS EFSPRSVIHH LTAASSEMDE EHGQLNVSSS 
       560        570        580        590        600
AAVDGVIISL CCNSKTKSVV LQLADGQIFK YLWESPSLAI KPWKNSGGFP 
       610        620        630        640        650
VRFPYPCTQT ELAMIGEEEC VLGLTDRCRF FINDIEVASN ITSFAVYDEF 
       660        670        680        690        700
LLLTTHSHTC QCFCLRDASF KTLQAGLSSN HVSHGEVLRK VERGSRIVTV 
       710        720        730        740        750
VPQDTKLVLQ MPRGNLEVVH HRALVLAQIR KWLDKLMFKE AFECMRKLRI 
       760        770        780        790        800
NLNLIYDHNP KVFLGNVETF IKQIDSVNHI NLFFTELKEE DVTKTMYPAP 
       810        820        830        840        850
VTSSVYLSRD PDGNKIDLVC DAMRAVMESI NPHKYCLSIL TSHVKKTTPE 
       860        870        880        890        900
LEIVLQKVHE LQGNAPSDPD AVSAEEALKY LLHLVDVNEL YDHSLGTYDF 
       910        920        930        940        950
DLVLMVAEKS QKDPKEYLPF LNTLKKMETN YQRFTIDKYL KRYEKAIGHL 
       960        970        980        990       1000
SKCGPEYFPE CLNLIKDKNL YNEALKLYSP SSQQYQDISI AYGEHLMQEH 
      1010       1020       1030       1040       1050
MYEPAGLMFA RCGAHEKALS AFLTCGNWKQ ALCVAAQLNF TKDQLVGLGR 
      1060       1070       1080       1090       1100
TLAGKLVEQR KHIDAAMVLE ECAQDYEEAV LLLLEGAAWE EALRLVYKYN 
      1110       1120       1130       1140       1150
RLDIIETNVK PSILEAQKNY MAFLDSQTAT FSRHKKRLLV VRELKEQAQQ 
      1160       1170       1180       1190       1200
AGLDDEVPHG QESDLFSETS SVVSGSEMSG KYSHSNSRIS ARSSKNRRKA 
      1210       1220       1230       1240       1250
ERKKHSLKEG SPLEDLALLE ALSEVVQNTE NLKDEVYHIL KVLFLFEFDE 
      1260       1270       1280       1290       1300
QGRELQKAFE DTLQLMERSL PEIWTLTYQQ NSATPVLGPN STANSIMASY 
      1310       1320       1330 
QQQKTSVPVL DAELFIPPKI NRRTQWKLSL LD

Length:1,332

Mass (Da):150,254

Last modified:November 25, 2008 - v3

Checksum:ⁱ5BAC580433CC8641

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H2T0	F5H2T0_HUMAN	Elongator complex protein 1 Elongator complex protein 1	ELP1	983	Annotation score:
H0YDF3	H0YDF3_HUMAN	Elongator complex protein 1 Elongator complex protein 1	ELP1	346	Annotation score:

Sequence cautionⁱ

The sequence CAB43219 differs from that shown. Reason: Frameshift at position 1286.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	304	W → R in AAC64258 (PubMed:9751059).Curated	1
Sequence conflictⁱ	754	L → P in AAC64258 (PubMed:9751059).Curated	1
Sequence conflictⁱ	961	C → G in CAB43219 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1320	I → V in CAB43219 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047476	70	R → C. Corresponds to variant dbSNP:rs3737311EnsemblClinVar.	1
Natural variantⁱVAR_047477	182	M → K. Corresponds to variant dbSNP:rs10521092EnsemblClinVar.	1
Natural variantⁱVAR_047478	312	E → K1 PublicationCorresponds to variant dbSNP:rs1140064EnsemblClinVar.	1
Natural variantⁱVAR_047479	525	R → Q. Corresponds to variant dbSNP:rs838827EnsemblClinVar.	1
Natural variantⁱVAR_011327	696	R → P in HSAN3; mild phenotype; phosphorylation is reduced. 2 PublicationsCorresponds to variant dbSNP:rs137853022EnsemblClinVar.	1
Natural variantⁱVAR_047480	765	G → E. Corresponds to variant dbSNP:rs2230792EnsemblClinVar.	1
Natural variantⁱVAR_047481	816	I → L. Corresponds to variant dbSNP:rs2230793EnsemblClinVar.	1
Natural variantⁱVAR_047482	830	I → M. Corresponds to variant dbSNP:rs2230794EnsemblClinVar.	1
Natural variantⁱVAR_047483	848	T → N. Corresponds to variant dbSNP:rs10979599EnsemblClinVar.	1
Natural variantⁱVAR_047484	952	K → I. Corresponds to variant dbSNP:rs2230798EnsemblClinVar.	1
Natural variantⁱVAR_047485	1013	G → S. Corresponds to variant dbSNP:rs2230795EnsemblClinVar.	1
Natural variantⁱVAR_047486	1072	C → S2 PublicationsCorresponds to variant dbSNP:rs3204145EnsemblClinVar.	1
Natural variantⁱVAR_047487	1158	P → L1 PublicationCorresponds to variant dbSNP:rs1538660EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044195 mRNA Translation: AAC64258.1 AF153419 mRNA Translation: AAG43369.1 AK001641 mRNA Translation: BAG50955.1 AK289962 mRNA Translation: BAF82651.1 AL354797 Genomic DNA No translation available. AL359692 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW59027.1 AL049945 mRNA Translation: CAB43219.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6773.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305289.1, NM_001318360.1 NP_003631.2, NM_003640.4
UniGeneⁱ	Hs.494738

Genome annotation databases

Ensemblⁱ	ENST00000374647; ENSP00000363779; ENSG00000070061
GeneIDⁱ	8518
KEGGⁱ	hsa:8518
UCSC genome browser More...UCSCⁱ	uc004bdm.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95163	IKBKAP variant protein (Fragment)		HUMAN		1342	UniRef100_O95163
Elongator complex protein 1		HUMAN		983
cDNA FLJ12497 fis, clone NT2RM2001664, highly similar to IkappaB kinase complex-associated protein		HUMAN		406
cDNA FLJ14161 fis, clone NT2RM2001803, highly similar to IkappaB kinase complex-associated protein		HUMAN		537
UPI000387D681		HUMAN		1218

Protein	Similar proteins		Species	Score	Length	Source
O95163	IKBKAP variant protein (Fragment)		HUMAN		1342	UniRef90_O95163
Elongator complex protein 1		PANTR		1332
Elongator complex protein 1		RHIBE		1332
Elongator complex protein 1		MACMU		1332
Elongator complex protein 1		COLAP		1332
+40

Protein	Similar proteins		Species	Score	Length	Source
O95163	Elongator complex protein 1		MOUSE		1333	UniRef50_O95163
Elongator complex protein 1		RAT		1331
Putative elongator complex protein 1		XENLA		1170
Elongator complex protein 1		RABIT		1333
IKBKAP variant protein (Fragment)		HUMAN		1342
+348

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044195 mRNA Translation: AAC64258.1 AF153419 mRNA Translation: AAG43369.1 AK001641 mRNA Translation: BAG50955.1 AK289962 mRNA Translation: BAF82651.1 AL354797 Genomic DNA No translation available. AL359692 Genomic DNA No translation available. CH471105 Genomic DNA Translation: EAW59027.1 AL049945 mRNA Translation: CAB43219.1 Frameshift.
CCDSⁱ	CCDS6773.1
RefSeqⁱ	NP_001305289.1, NM_001318360.1 NP_003631.2, NM_003640.4
UniGeneⁱ	Hs.494738

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5CQR	X-ray	3.02	A	715-1332	[»]
ProteinModelPortalⁱ	O95163
SMRⁱ	O95163
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114090, 76 interactors
ComplexPortalⁱ	CPX-1949 Elongator holoenzyme complex
CORUMⁱ	O95163
DIPⁱ	DIP-27579N
IntActⁱ	O95163, 42 interactors
MINTⁱ	O95163
STRINGⁱ	9606.ENSP00000363779

PTM databases

iPTMnetⁱ	O95163
PhosphoSitePlusⁱ	O95163

Polymorphism and mutation databases

BioMutaⁱ	IKBKAP

BioMutaⁱ

IKBKAP

Proteomic databases

EPDⁱ	O95163
MaxQBⁱ	O95163
PaxDbⁱ	O95163
PeptideAtlasⁱ	O95163
PRIDEⁱ	O95163
ProteomicsDBⁱ	50677

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374647; ENSP00000363779; ENSG00000070061
GeneIDⁱ	8518
KEGGⁱ	hsa:8518
UCSCⁱ	uc004bdm.5 human

Organism-specific databases

CTDⁱ	8518
DisGeNETⁱ	8518
EuPathDBⁱ	HostDB:ENSG00000070061.14
GeneCardsⁱ	ELP1
GeneReviewsⁱ	IKBKAP
HGNCⁱ	HGNC:5959 ELP1
HPAⁱ	CAB021340 HPA049677 HPA050686
MalaCardsⁱ	ELP1
MIMⁱ	223900 phenotype 603722 gene
neXtProtⁱ	NX_O95163
OpenTargetsⁱ	ENSG00000070061
Orphanetⁱ	1764 Familial dysautonomia
PharmGKBⁱ	PA29775
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1920 Eukaryota COG5290 LUCA
GeneTreeⁱ	ENSGT00390000013344
HOVERGENⁱ	HBG019038
InParanoidⁱ	O95163
KOⁱ	K11373
OMAⁱ	KVRVWNR
OrthoDBⁱ	EOG091G01A5
PhylomeDBⁱ	O95163
TreeFamⁱ	TF300402

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones
SignaLinkⁱ	O95163
SIGNORⁱ	O95163

Miscellaneous databases

ChiTaRSⁱ	IKBKAP human
GenomeRNAiⁱ	8518
Protein Ontology More...PROⁱ	PR:O95163
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000070061 Expressed in 229 organ(s), highest expression level in metanephros
CleanExⁱ	HS_IKBKAP
ExpressionAtlasⁱ	O95163 baseline and differential
Genevisibleⁱ	O95163 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006849 Elp1 IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERⁱ	PTHR12747 PTHR12747, 1 hit
Pfamⁱ	View protein in Pfam PF04762 IKI3, 1 hit
PIRSFⁱ	PIRSF017233 IKAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELP1_HUMAN
Accessionⁱ	O95163Primary (citable) accession number: O95163 Secondary accession number(s): Q5JSV2, Q9H327, Q9UG87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - O95163 (ELP1_HUMAN)

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Elongator complex protein 1

ELP1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Gene expression databases

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Secondary structure

3D structure databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ