UniProtKB - O95159 (ZFPL1_HUMAN)

BLAST

>sp|O95159|ZFPL1_HUMAN Zinc finger protein-like 1 OS=Homo sapiens OX=9606 GN=ZFPL1 PE=1 SV=2
MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNIPL
ASRETTRLVCYDLFHWACLNERAAQLPRNTAPAGYQCPSCNGPIFPPTNLAGPVASALRE
KLATVNWARAGLGLPLIDEVVSPEPEPLNTSDFSDWSSFNASSTPGPEEVDSASAAPAFY
SQAPRPPASPGRPEQHTVIHMGNPEPLTHAPRKVYDTRDDDRTPGLHGDCDDDKYRRRPA
LGWLARLLRSRAGSRKRPLTLLQRAGLLLLLGLLGFLALLALMSRLGRAAADSDPNLDPL
MNPHIRVGPS

Align
Format
Add to basket Added to basket
History
Entry version 130 (07 Nov 2018)
Sequence version 2 (05 Jul 2004)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Zinc finger protein-like 1

Gene

ZFPL1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 43	B box-type; degenerateAdd BLAST		43
Zinc fingerⁱ	53 – 101	RING-type; degenerateAdd BLAST		49

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 9653652
zinc ion binding
Source: UniProtKB
Non-traceable author statementⁱ
- 9653652

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 9653652
vesicle-mediated transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Transport
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein-like 1 Alternative name(s): Zinc finger protein MCG4
Gene namesⁱ	Name:ZFPL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162300.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12868 ZFPL1
neXtProtⁱ	NX_O95159

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 266	CytoplasmicSequence analysisAdd BLAST	266
Transmembraneⁱ	267 – 287	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	288 – 310	LumenalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	27	C → A: Impairs the interaction with OLGA2/GM130 and cis-Golgi assembly. 1 Publication		1
Mutagenesisⁱ	53	C → A: Impairs the interaction with OLGA2/GM130 and cis-Golgi assembly. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162300
PharmGKBⁱ	PA37457

Polymorphism and mutation databases

BioMutaⁱ	ZFPL1

BioMutaⁱ

ZFPL1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056318	1 – 310	Zinc finger protein-like 1Add BLAST		310

Post-translational modificationⁱ

Phosphorylated.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95159
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95159
PaxDbⁱ	O95159
PeptideAtlas More...PeptideAtlasⁱ	O95159
PRIDEⁱ	O95159
ProteomicsDBⁱ	50676

PTM databases

iPTMnetⁱ	O95159
PhosphoSitePlusⁱ	O95159

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162300 Expressed in 212 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_ZFPL1
ExpressionAtlasⁱ	O95159 baseline and differential
Genevisibleⁱ	O95159 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014909 HPA017347

HPAⁱ

HPA014909
HPA017347

Interactionⁱ

Subunit structureⁱ

Interacts with GOLGA2/GM130.1 Publication

Protein-protein interaction databases

BioGridⁱ	113374, 27 interactors
IntActⁱ	O95159, 65 interactors
Molecular INTeraction database More...MINTⁱ	O95159
STRINGⁱ	9606.ENSP00000294258

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.

Sequence similaritiesⁱ

Belongs to the ZFPL1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 43	B box-type; degenerateAdd BLAST		43
Zinc fingerⁱ	53 – 101	RING-type; degenerateAdd BLAST		49

Keywords - Domainⁱ

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3970 Eukaryota ENOG410ZR2P LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009753
HOGENOMⁱ	HOG000031475
HOVERGENⁱ	HBG079377
InParanoidⁱ	O95159
OMAⁱ	LIIIMAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CGO
PhylomeDBⁱ	O95159
TreeFamⁱ	TF315090

Family and domain databases

InterProⁱ	View protein in InterPro IPR039043 ZFPL1
PANTHERⁱ	PTHR12981 PTHR12981, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

O95159-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN 
        60         70         80         90        100
PNCRLCNIPL ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC 
       110        120        130        140        150
NGPIFPPTNL AGPVASALRE KLATVNWARA GLGLPLIDEV VSPEPEPLNT 
       160        170        180        190        200
SDFSDWSSFN ASSTPGPEEV DSASAAPAFY SQAPRPPASP GRPEQHTVIH 
       210        220        230        240        250
MGNPEPLTHA PRKVYDTRDD DRTPGLHGDC DDDKYRRRPA LGWLARLLRS 
       260        270        280        290        300
RAGSRKRPLT LLQRAGLLLL LGLLGFLALL ALMSRLGRAA ADSDPNLDPL 
       310
MNPHIRVGPS

Length:310

Mass (Da):34,114

Last modified:July 5, 2004 - v2

Checksum:ⁱA12F1CA68A6E7F4F

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PNY1	E9PNY1_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	207	Annotation score:
E9PQ47	E9PQ47_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	188	Annotation score:
E9PQA5	E9PQA5_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	172	Annotation score:
E9PMQ3	E9PMQ3_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	109	Annotation score:
E9PJ47	E9PJ47_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	80	Annotation score:
E9PJX1	E9PJX1_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	65	Annotation score:
H0YCU8	H0YCU8_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	53	Annotation score:
A0A0G2JKQ6	A0A0G2JKQ6_HUMAN	Zinc finger protein-like 1 Zinc finger protein-like 1	ZFPL1	10	Annotation score:

Sequence cautionⁱ

The sequence AAB86533 differs from that shown. Reason: Frameshift at positions 110, 114, 127, 156, 157 and 255.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	182	Q → R in AAB86533 (PubMed:9253601).Curated	1
Sequence conflictⁱ	182	Q → R in AAD08644 (Ref. 3) Curated	1
Sequence conflictⁱ	246	R → Q in AAB86533 (PubMed:9253601).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034472	218	R → Q. Corresponds to variant dbSNP:rs35251366Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001891 mRNA Translation: AAB86533.1 Frameshift. AF030291 mRNA Translation: AAF21634.1 AF043611 mRNA Translation: AAD08644.1 AK291964 mRNA Translation: BAF84653.1 AP003068 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74344.1 BC012530 mRNA Translation: AAH12530.1 BC012814 mRNA Translation: AAH12814.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8092.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006773.2, NM_006782.3
UniGeneⁱ	Hs.712317 Hs.98170

Genome annotation databases

Ensemblⁱ	ENST00000294258; ENSP00000294258; ENSG00000162300
GeneIDⁱ	7542
KEGGⁱ	hsa:7542
UCSC genome browser More...UCSCⁱ	uc001ocq.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95159	Zinc finger protein-like 1, isoform CRA_a		HUMAN		310	UniRef100_O95159

Protein	Similar proteins		Species	Score	Length	Source
O95159	Zinc finger protein-like 1		BOVIN		312	UniRef90_O95159
Zinc finger protein-like 1		MOUSE		310
Zinc finger protein-like 1, isoform CRA_a		HUMAN		310
zinc finger protein-like 1		Yangtze finless porpoise		345
zinc finger protein-like 1		DELLE		312
+120

Protein	Similar proteins		Species	Score	Length	Source
O95159	Zinc finger protein-like 1		BOVIN		312	UniRef50_O95159
Zinc finger protein-like 1		MOUSE		310
Zinc finger protein-like 1, isoform CRA_a		HUMAN		310
zinc finger protein-like 1		Yangtze finless porpoise		345
zinc finger protein-like 1		DELLE		312
+122

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001891 mRNA Translation: AAB86533.1 Frameshift. AF030291 mRNA Translation: AAF21634.1 AF043611 mRNA Translation: AAD08644.1 AK291964 mRNA Translation: BAF84653.1 AP003068 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74344.1 BC012530 mRNA Translation: AAH12530.1 BC012814 mRNA Translation: AAH12814.1
CCDSⁱ	CCDS8092.1
RefSeqⁱ	NP_006773.2, NM_006782.3
UniGeneⁱ	Hs.712317 Hs.98170

3D structure databases

ProteinModelPortalⁱ	O95159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113374, 27 interactors
IntActⁱ	O95159, 65 interactors
MINTⁱ	O95159
STRINGⁱ	9606.ENSP00000294258

PTM databases

iPTMnetⁱ	O95159
PhosphoSitePlusⁱ	O95159

Polymorphism and mutation databases

BioMutaⁱ	ZFPL1

BioMutaⁱ

ZFPL1

Proteomic databases

EPDⁱ	O95159
MaxQBⁱ	O95159
PaxDbⁱ	O95159
PeptideAtlasⁱ	O95159
PRIDEⁱ	O95159
ProteomicsDBⁱ	50676

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000294258; ENSP00000294258; ENSG00000162300
GeneIDⁱ	7542
KEGGⁱ	hsa:7542
UCSCⁱ	uc001ocq.2 human

Organism-specific databases

CTDⁱ	7542
EuPathDBⁱ	HostDB:ENSG00000162300.11
GeneCardsⁱ	ZFPL1
HGNCⁱ	HGNC:12868 ZFPL1
HPAⁱ	HPA014909 HPA017347
neXtProtⁱ	NX_O95159
OpenTargetsⁱ	ENSG00000162300
PharmGKBⁱ	PA37457
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3970 Eukaryota ENOG410ZR2P LUCA
GeneTreeⁱ	ENSGT00390000009753
HOGENOMⁱ	HOG000031475
HOVERGENⁱ	HBG079377
InParanoidⁱ	O95159
OMAⁱ	LIIIMAK
OrthoDBⁱ	EOG091G0CGO
PhylomeDBⁱ	O95159
TreeFamⁱ	TF315090

Miscellaneous databases

ChiTaRSⁱ	ZFPL1 human
GenomeRNAiⁱ	7542
Protein Ontology More...PROⁱ	PR:O95159

Gene expression databases

Bgeeⁱ	ENSG00000162300 Expressed in 212 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_ZFPL1
ExpressionAtlasⁱ	O95159 baseline and differential
Genevisibleⁱ	O95159 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039043 ZFPL1
PANTHERⁱ	PTHR12981 PTHR12981, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFPL1_HUMAN
Accessionⁱ	O95159Primary (citable) accession number: O95159 Secondary accession number(s): A8K7E9, O14616, Q9UID0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95159 (ZFPL1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger protein-like 1

ZFPL1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Golgi apparatus

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ