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UniProtKB - O95159 (ZFPL1_HUMAN)
Protein
Zinc finger protein-like 1
Gene
ZFPL1
Organism
Homo sapiens (Human)
Status
Functioni
Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 43 | B box-type; degenerateAdd BLAST | 43 | |
Zinc fingeri | 53 – 101 | RING-type; degenerateAdd BLAST | 49 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- regulation of transcription, DNA-templated Source: UniProtKB
- vesicle-mediated transport Source: UniProtKB-KW
Keywordsi
Biological process | ER-Golgi transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95159 |
SignaLinki | O95159 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein-like 1Alternative name(s): Zinc finger protein MCG4 |
Gene namesi | Name:ZFPL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12868, ZFPL1 |
MIMi | 619397, gene |
neXtProti | NX_O95159 |
VEuPathDBi | HostDB:ENSG00000162300 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane 1 Publication; Single-pass membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleus Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 266 | CytoplasmicSequence analysisAdd BLAST | 266 | |
Transmembranei | 267 – 287 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 310 | LumenalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 27 | C → A: Impairs the interaction with OLGA2/GM130 and cis-Golgi assembly. 1 Publication | 1 | |
Mutagenesisi | 53 | C → A: Impairs the interaction with OLGA2/GM130 and cis-Golgi assembly. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7542 |
OpenTargetsi | ENSG00000162300 |
PharmGKBi | PA37457 |
Miscellaneous databases
Pharosi | O95159, Tbio |
Genetic variation databases
BioMutai | ZFPL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056318 | 1 – 310 | Zinc finger protein-like 1Add BLAST | 310 |
Post-translational modificationi
Phosphorylated.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O95159 |
jPOSTi | O95159 |
MassIVEi | O95159 |
MaxQBi | O95159 |
PaxDbi | O95159 |
PeptideAtlasi | O95159 |
PRIDEi | O95159 |
ProteomicsDBi | 50676 |
PTM databases
iPTMneti | O95159 |
PhosphoSitePlusi | O95159 |
SwissPalmi | O95159 |
Expressioni
Tissue specificityi
Expressed strongly in the exocrine pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000162300, Expressed in heart left ventricle and 226 other tissues |
ExpressionAtlasi | O95159, baseline and differential |
Genevisiblei | O95159, HS |
Organism-specific databases
HPAi | ENSG00000162300, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with GOLGA2/GM130.
1 PublicationBinary interactionsi
O95159
Protein-protein interaction databases
BioGRIDi | 113374, 446 interactors |
IntActi | O95159, 96 interactors |
MINTi | O95159 |
STRINGi | 9606.ENSP00000294258 |
Miscellaneous databases
RNActi | O95159, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 145 – 231 | DisorderedSequence analysisAdd BLAST | 87 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 147 – 169 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 211 – 231 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Domaini
The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
Sequence similaritiesi
Belongs to the ZFPL1 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 43 | B box-type; degenerateAdd BLAST | 43 | |
Zinc fingeri | 53 – 101 | RING-type; degenerateAdd BLAST | 49 |
Keywords - Domaini
Transmembrane, Transmembrane helix, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3970, Eukaryota |
GeneTreei | ENSGT00390000009753 |
HOGENOMi | CLU_075387_0_0_1 |
InParanoidi | O95159 |
OMAi | NHSKCIV |
OrthoDBi | 807302at2759 |
PhylomeDBi | O95159 |
TreeFami | TF315090 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR039043, ZFPL1 IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR12981, PTHR12981, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
O95159-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN
60 70 80 90 100
PNCRLCNIPL ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC
110 120 130 140 150
NGPIFPPTNL AGPVASALRE KLATVNWARA GLGLPLIDEV VSPEPEPLNT
160 170 180 190 200
SDFSDWSSFN ASSTPGPEEV DSASAAPAFY SQAPRPPASP GRPEQHTVIH
210 220 230 240 250
MGNPEPLTHA PRKVYDTRDD DRTPGLHGDC DDDKYRRRPA LGWLARLLRS
260 270 280 290 300
RAGSRKRPLT LLQRAGLLLL LGLLGFLALL ALMSRLGRAA ADSDPNLDPL
310
MNPHIRVGPS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PNY1 | E9PNY1_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 207 | Annotation score: | ||
E9PQ47 | E9PQ47_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 188 | Annotation score: | ||
E9PQA5 | E9PQA5_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 172 | Annotation score: | ||
E9PMQ3 | E9PMQ3_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 109 | Annotation score: | ||
E9PJ47 | E9PJ47_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 80 | Annotation score: | ||
H0YCU8 | H0YCU8_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 53 | Annotation score: | ||
E9PJX1 | E9PJX1_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 65 | Annotation score: | ||
A0A0G2JKQ6 | A0A0G2JKQ6_HUMAN | Zinc finger protein-like 1 | ZFPL1 | 10 | Annotation score: |
Sequence cautioni
The sequence AAB86533 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 182 | Q → R in AAB86533 (PubMed:9253601).Curated | 1 | |
Sequence conflicti | 182 | Q → R in AAD08644 (Ref. 3) Curated | 1 | |
Sequence conflicti | 246 | R → Q in AAB86533 (PubMed:9253601).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034472 | 218 | R → Q. Corresponds to variant dbSNP:rs35251366Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF001891 mRNA Translation: AAB86533.1 Frameshift. AF030291 mRNA Translation: AAF21634.1 AF043611 mRNA Translation: AAD08644.1 AK291964 mRNA Translation: BAF84653.1 AP003068 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74344.1 BC012530 mRNA Translation: AAH12530.1 BC012814 mRNA Translation: AAH12814.1 |
CCDSi | CCDS8092.1 |
RefSeqi | NP_006773.2, NM_006782.3 |
Genome annotation databases
Ensembli | ENST00000294258; ENSP00000294258; ENSG00000162300 |
GeneIDi | 7542 |
KEGGi | hsa:7542 |
MANE-Selecti | ENST00000294258.8; ENSP00000294258.3; NM_006782.4; NP_006773.2 |
UCSCi | uc001ocq.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF001891 mRNA Translation: AAB86533.1 Frameshift. AF030291 mRNA Translation: AAF21634.1 AF043611 mRNA Translation: AAD08644.1 AK291964 mRNA Translation: BAF84653.1 AP003068 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74344.1 BC012530 mRNA Translation: AAH12530.1 BC012814 mRNA Translation: AAH12814.1 |
CCDSi | CCDS8092.1 |
RefSeqi | NP_006773.2, NM_006782.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113374, 446 interactors |
IntActi | O95159, 96 interactors |
MINTi | O95159 |
STRINGi | 9606.ENSP00000294258 |
PTM databases
iPTMneti | O95159 |
PhosphoSitePlusi | O95159 |
SwissPalmi | O95159 |
Genetic variation databases
BioMutai | ZFPL1 |
Proteomic databases
EPDi | O95159 |
jPOSTi | O95159 |
MassIVEi | O95159 |
MaxQBi | O95159 |
PaxDbi | O95159 |
PeptideAtlasi | O95159 |
PRIDEi | O95159 |
ProteomicsDBi | 50676 |
Protocols and materials databases
Antibodypediai | 2657, 108 antibodies from 20 providers |
DNASUi | 7542 |
Genome annotation databases
Ensembli | ENST00000294258; ENSP00000294258; ENSG00000162300 |
GeneIDi | 7542 |
KEGGi | hsa:7542 |
MANE-Selecti | ENST00000294258.8; ENSP00000294258.3; NM_006782.4; NP_006773.2 |
UCSCi | uc001ocq.2, human |
Organism-specific databases
CTDi | 7542 |
DisGeNETi | 7542 |
GeneCardsi | ZFPL1 |
HGNCi | HGNC:12868, ZFPL1 |
HPAi | ENSG00000162300, Low tissue specificity |
MIMi | 619397, gene |
neXtProti | NX_O95159 |
OpenTargetsi | ENSG00000162300 |
PharmGKBi | PA37457 |
VEuPathDBi | HostDB:ENSG00000162300 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3970, Eukaryota |
GeneTreei | ENSGT00390000009753 |
HOGENOMi | CLU_075387_0_0_1 |
InParanoidi | O95159 |
OMAi | NHSKCIV |
OrthoDBi | 807302at2759 |
PhylomeDBi | O95159 |
TreeFami | TF315090 |
Enzyme and pathway databases
PathwayCommonsi | O95159 |
SignaLinki | O95159 |
Miscellaneous databases
BioGRID-ORCSi | 7542, 12 hits in 1086 CRISPR screens |
ChiTaRSi | ZFPL1, human |
GenomeRNAii | 7542 |
Pharosi | O95159, Tbio |
PROi | PR:O95159 |
RNActi | O95159, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162300, Expressed in heart left ventricle and 226 other tissues |
ExpressionAtlasi | O95159, baseline and differential |
Genevisiblei | O95159, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR039043, ZFPL1 IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR12981, PTHR12981, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFPL1_HUMAN | |
Accessioni | O95159Primary (citable) accession number: O95159 Secondary accession number(s): A8K7E9, O14616, Q9UID0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families