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UniProtKB - O95159 (ZFPL1_HUMAN)

Entry version 144 (02 Dec 2020)
Sequence version 2 (05 Jul 2004)
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Protein

Zinc finger protein-like 1

Gene

ZFPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 43B box-type; degenerateAdd BLAST43
Zinc fingeri53 – 101RING-type; degenerateAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95159

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein-like 1
Alternative name(s):
Zinc finger protein MCG4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000162300.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:12868, ZFPL1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95159

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 266CytoplasmicSequence analysisAdd BLAST266
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 310LumenalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27C → A: Impairs the interaction with OLGA2/GM130 and cis-Golgi assembly. 1 Publication1
Mutagenesisi53C → A: Impairs the interaction with OLGA2/GM130 and cis-Golgi assembly. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7542

Open Targets

More...OpenTargetsi		ENSG00000162300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37457

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95159, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZFPL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000563181 – 310Zinc finger protein-like 1Add BLAST310

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95159

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95159

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95159

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95159

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95159

PeptideAtlas

More...PeptideAtlasi		O95159

PRoteomics IDEntifications database

More...PRIDEi		O95159

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50676

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95159

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95159

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95159

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in the exocrine pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162300, Expressed in heart left ventricle and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95159, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95159, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000162300, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GOLGA2/GM130.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O95159
With#Exp.IntAct
AHNAK2 - isoform 3 [Q8IVF2-3]3EBI-718439,EBI-12078468
BIK [Q13323]3EBI-718439,EBI-700794
BSND [Q8WZ55]3EBI-718439,EBI-7996695
CD3E [P07766]3EBI-718439,EBI-1211297
CGRRF1 [Q99675]3EBI-718439,EBI-2130213
CLEC10A [Q8IUN9]3EBI-718439,EBI-2873246
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-718439,EBI-11989440
CPLX4 [Q7Z7G2]3EBI-718439,EBI-18013275
CREB3L1 [Q96BA8]5EBI-718439,EBI-6942903
CYBRD1 [Q53TN4]3EBI-718439,EBI-8637742
EBP [Q15125]3EBI-718439,EBI-3915253
ELOVL4 [Q9GZR5]3EBI-718439,EBI-18535450
ERGIC3 [Q9Y282]3EBI-718439,EBI-781551
FAM209A [Q5JX71]3EBI-718439,EBI-18304435
FATE1 [Q969F0]3EBI-718439,EBI-743099
FKBP7 [Q9Y680]3EBI-718439,EBI-3918971
FKBP8 [Q14318]3EBI-718439,EBI-724839
FNDC9 [Q8TBE3]3EBI-718439,EBI-12142257
FRMD3 [A2A2Y4]3EBI-718439,EBI-6911547
GORAB [Q5T7V8]3EBI-718439,EBI-3917143
GPR42 [O15529]3EBI-718439,EBI-18076404
HIBADH [P31937]3EBI-718439,EBI-11427100
KASH5 [Q8N6L0]3EBI-718439,EBI-749265
KLRC1 [P26715]3EBI-718439,EBI-9018187
LDLRAD1 [Q5T700]3EBI-718439,EBI-10173166
LEUTX [A8MZ59]3EBI-718439,EBI-17490413
LIME1 [Q9H400]3EBI-718439,EBI-2830566
MFF - isoform 5 [Q9GZY8-5]3EBI-718439,EBI-11956541
MFSD14B [Q5SR56]3EBI-718439,EBI-373355
MGST3 [O14880]3EBI-718439,EBI-724754
MIP [P30301]3EBI-718439,EBI-8449636
MRM3 [Q9HC36]3EBI-718439,EBI-1045440
MRPS18B [Q9Y676]3EBI-718439,EBI-750085
MS4A3 [Q96HJ5]3EBI-718439,EBI-12806656
MTERF3 [Q96E29]3EBI-718439,EBI-7825321
PGRMC2 [O15173]3EBI-718439,EBI-1050125
PLEKHO1 [Q53GL0]3EBI-718439,EBI-949945
PVR [P15151]3EBI-718439,EBI-3919694
RELL2 [Q8NC24]3EBI-718439,EBI-10269209
SCN3B [Q9NY72]3EBI-718439,EBI-17247926
SGMS2 [Q8NHU3]3EBI-718439,EBI-10977284
SHISAL1 [Q3SXP7]3EBI-718439,EBI-18037857
SLC10A6 [Q3KNW5]3EBI-718439,EBI-18159983
SLC19A3 [Q9BZV2]3EBI-718439,EBI-3923779
SLC7A14 [Q8TBB6]3EBI-718439,EBI-5235586
SMIM3 [Q9BZL3]5EBI-718439,EBI-741850
SSMEM1 [Q8WWF3]3EBI-718439,EBI-17280858
STX1A [Q16623]3EBI-718439,EBI-712466
STX2 - isoform 1 [P32856-2]3EBI-718439,EBI-11956649
STX4 [Q12846]3EBI-718439,EBI-744942
SYAP1 [Q96A49]3EBI-718439,EBI-10770179
SYT1 [P21579]3EBI-718439,EBI-524909
TEX29 [Q8N6K0]3EBI-718439,EBI-19027521
TM4SF19 [Q96DZ7]3EBI-718439,EBI-6448756
TMEM106C [Q9BVX2]3EBI-718439,EBI-2821497
TMEM139 [Q8IV31]3EBI-718439,EBI-7238458
TMEM14B [Q9NUH8]3EBI-718439,EBI-8638294
TMEM237 - isoform 2 [Q96Q45-2]3EBI-718439,EBI-10982110
TMPRSS2 - isoform 2 [O15393-2]3EBI-718439,EBI-12345267
TSTD2 [Q5T7W7]3EBI-718439,EBI-8994397

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113374, 103 interactors

Protein interaction database and analysis system

More...IntActi		O95159, 90 interactors

Molecular INTeraction database

More...MINTi		O95159

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000294258

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95159, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZFPL1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 43B box-type; degenerateAdd BLAST43
Zinc fingeri53 – 101RING-type; degenerateAdd BLAST49

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3970, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009753

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_075387_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95159

Identification of Orthologs from Complete Genome Data

More...OMAi		SFDHDEN

Database of Orthologous Groups

More...OrthoDBi		807302at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95159

TreeFam database of animal gene trees

More...TreeFami		TF315090

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039043, ZFPL1

The PANTHER Classification System

More...PANTHERi		PTHR12981, PTHR12981, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

O95159-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN 
        60         70         80         90        100
PNCRLCNIPL ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC 
       110        120        130        140        150
NGPIFPPTNL AGPVASALRE KLATVNWARA GLGLPLIDEV VSPEPEPLNT 
       160        170        180        190        200
SDFSDWSSFN ASSTPGPEEV DSASAAPAFY SQAPRPPASP GRPEQHTVIH 
       210        220        230        240        250
MGNPEPLTHA PRKVYDTRDD DRTPGLHGDC DDDKYRRRPA LGWLARLLRS 
       260        270        280        290        300
RAGSRKRPLT LLQRAGLLLL LGLLGFLALL ALMSRLGRAA ADSDPNLDPL 
       310
MNPHIRVGPS
Length:310
Mass (Da):34,114
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA12F1CA68A6E7F4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNY1E9PNY1_HUMAN
Zinc finger protein-like 1
ZFPL1
207Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ47E9PQ47_HUMAN
Zinc finger protein-like 1
ZFPL1
188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQA5E9PQA5_HUMAN
Zinc finger protein-like 1
ZFPL1
172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMQ3E9PMQ3_HUMAN
Zinc finger protein-like 1
ZFPL1
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ47E9PJ47_HUMAN
Zinc finger protein-like 1
ZFPL1
80Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJX1E9PJX1_HUMAN
Zinc finger protein-like 1
ZFPL1
65Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCU8H0YCU8_HUMAN
Zinc finger protein-like 1
ZFPL1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JKQ6A0A0G2JKQ6_HUMAN
Zinc finger protein-like 1
ZFPL1
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB86533 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182Q → R in AAB86533 (PubMed:9253601).Curated1
Sequence conflicti182Q → R in AAD08644 (Ref. 3) Curated1
Sequence conflicti246R → Q in AAB86533 (PubMed:9253601).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034472218R → Q. Corresponds to variant dbSNP:rs35251366Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF001891 mRNA Translation: AAB86533.1 Frameshift.
AF030291 mRNA Translation: AAF21634.1
AF043611 mRNA Translation: AAD08644.1
AK291964 mRNA Translation: BAF84653.1
AP003068 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74344.1
BC012530 mRNA Translation: AAH12530.1
BC012814 mRNA Translation: AAH12814.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8092.1

NCBI Reference Sequences

More...RefSeqi		NP_006773.2, NM_006782.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000294258; ENSP00000294258; ENSG00000162300

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7542

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7542

UCSC genome browser

More...UCSCi		uc001ocq.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001891 mRNA Translation: AAB86533.1 Frameshift.
AF030291 mRNA Translation: AAF21634.1
AF043611 mRNA Translation: AAD08644.1
AK291964 mRNA Translation: BAF84653.1
AP003068 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74344.1
BC012530 mRNA Translation: AAH12530.1
BC012814 mRNA Translation: AAH12814.1
CCDSiCCDS8092.1
RefSeqiNP_006773.2, NM_006782.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi113374, 103 interactors
IntActiO95159, 90 interactors
MINTiO95159
STRINGi9606.ENSP00000294258

PTM databases

iPTMnetiO95159
PhosphoSitePlusiO95159
SwissPalmiO95159

Polymorphism and mutation databases

BioMutaiZFPL1

Proteomic databases

EPDiO95159
jPOSTiO95159
MassIVEiO95159
MaxQBiO95159
PaxDbiO95159
PeptideAtlasiO95159
PRIDEiO95159
ProteomicsDBi50676

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2657, 107 antibodies

Genome annotation databases

EnsembliENST00000294258; ENSP00000294258; ENSG00000162300
GeneIDi7542
KEGGihsa:7542
UCSCiuc001ocq.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7542
DisGeNETi7542
EuPathDBiHostDB:ENSG00000162300.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZFPL1
HGNCiHGNC:12868, ZFPL1
HPAiENSG00000162300, Low tissue specificity
neXtProtiNX_O95159
OpenTargetsiENSG00000162300
PharmGKBiPA37457

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3970, Eukaryota
GeneTreeiENSGT00390000009753
HOGENOMiCLU_075387_0_0_1
InParanoidiO95159
OMAiSFDHDEN
OrthoDBi807302at2759
PhylomeDBiO95159
TreeFamiTF315090

Enzyme and pathway databases

PathwayCommonsiO95159

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7542, 10 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZFPL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7542
PharosiO95159, Tbio

Protein Ontology

More...PROi		PR:O95159
RNActiO95159, protein

Gene expression databases

BgeeiENSG00000162300, Expressed in heart left ventricle and 225 other tissues
ExpressionAtlasiO95159, baseline and differential
GenevisibleiO95159, HS

Family and domain databases

InterProiView protein in InterPro
IPR039043, ZFPL1
PANTHERiPTHR12981, PTHR12981, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFPL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95159
Secondary accession number(s): A8K7E9, O14616, Q9UID0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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