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Protein

Aflatoxin B1 aldehyde reductase member 3

Gene

AKR7A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44NADP1 Publication1
Active sitei49Proton donorBy similarity1
Sitei77Lowers pKa of active site TyrBy similarity1
Binding sitei113SubstrateBy similarity1
Binding sitei169NADPBy similarity1
Binding sitei222NADP1 Publication1
Binding sitei232SubstrateBy similarity1
Binding sitei235SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi143 – 144NADP1 Publication2
Nucleotide bindingi198 – 208NADP1 PublicationAdd BLAST11
Nucleotide bindingi290 – 298NADP1 Publication9

GO - Molecular functioni

  • alditol:NADP+ 1-oxidoreductase activity Source: Ensembl
  • aldo-keto reductase (NADP) activity Source: Reactome
  • electron transfer activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-HSA-5423646 Aflatoxin activation and detoxification
SABIO-RKiO95154

Names & Taxonomyi

Protein namesi
Recommended name:
Aflatoxin B1 aldehyde reductase member 3 (EC:1.-.-.-)
Alternative name(s):
AFB1 aldehyde reductase 2
Short name:
AFB1-AR 2
Gene namesi
Name:AKR7A3
Synonyms:AFAR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162482.4
HGNCiHGNC:390 AKR7A3
MIMi608477 gene
neXtProtiNX_O95154

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162482
PharmGKBiPA24683

Polymorphism and mutation databases

BioMutaiAKR7A3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703781 – 331Aflatoxin B1 aldehyde reductase member 3Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei85PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95154
MaxQBiO95154
PaxDbiO95154
PeptideAtlasiO95154
PRIDEiO95154
ProteomicsDBi50669

PTM databases

iPTMnetiO95154
PhosphoSitePlusiO95154

Expressioni

Tissue specificityi

Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.2 Publications

Gene expression databases

BgeeiENSG00000162482 Expressed in 203 organ(s), highest expression level in body of stomach
CleanExiHS_AKR7A3
GenevisibleiO95154 HS

Organism-specific databases

HPAiHPA064638

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116626, 10 interactors
IntActiO95154, 8 interactors
STRINGi9606.ENSP00000355377

Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95154
SMRiO95154
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95154

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IDYD Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250286
HOVERGENiHBG050576
InParanoidiO95154
KOiK15303
OMAiLYNPLNR
OrthoDBiEOG091G0BTK
PhylomeDBiO95154
TreeFamiTF329173

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
SUPFAMiSSF51430 SSF51430, 1 hit

Sequencei

Sequence statusi: Complete.

O95154-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQLSRARP ATVLGAMEMG RRMDAPTSAA VTRAFLERGH TEIDTAFVYS
60 70 80 90 100
EGQSETILGG LGLRLGGSDC RVKIDTKAIP LFGNSLKPDS LRFQLETSLK
110 120 130 140 150
RLQCPRVDLF YLHMPDHSTP VEETLRACHQ LHQEGKFVEL GLSNYAAWEV
160 170 180 190 200
AEICTLCKSN GWILPTVYQG MYNAITRQVE TELFPCLRHF GLRFYAFNPL
210 220 230 240 250
AGGLLTGKYK YEDKNGKQPV GRFFGNTWAE MYRNRYWKEH HFEGIALVEK
260 270 280 290 300
ALQAAYGASA PSMTSATLRW MYHHSQLQGA HGDAVILGMS SLEQLEQNLA
310 320 330
AAEEGPLEPA VVDAFNQAWH LVTHECPNYF R
Length:331
Mass (Da):37,206
Last modified:February 21, 2001 - v2
Checksum:iB9C32C33C7102AB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51E → D in AAD02195 (PubMed:10383892).Curated1
Sequence conflicti247L → P in AAH42420 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017416138V → M2 PublicationsCorresponds to variant dbSNP:rs2231198Ensembl.1
Natural variantiVAR_017417215N → D3 PublicationsCorresponds to variant dbSNP:rs1738023Ensembl.1
Natural variantiVAR_017418323T → A3 PublicationsCorresponds to variant dbSNP:rs1738025Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040639 mRNA Translation: AAD02195.1
AJ271799 mRNA Translation: CAC81076.1
AL035413 Genomic DNA No translation available.
BC025709 mRNA Translation: AAH25709.1
BC031562 mRNA Translation: AAH31562.1
BC042420 mRNA Translation: AAH42420.2
CCDSiCCDS193.1
RefSeqiNP_036199.2, NM_012067.2
UniGeneiHs.6980

Genome annotation databases

EnsembliENST00000361640; ENSP00000355377; ENSG00000162482
GeneIDi22977
KEGGihsa:22977
UCSCiuc001bbv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040639 mRNA Translation: AAD02195.1
AJ271799 mRNA Translation: CAC81076.1
AL035413 Genomic DNA No translation available.
BC025709 mRNA Translation: AAH25709.1
BC031562 mRNA Translation: AAH31562.1
BC042420 mRNA Translation: AAH42420.2
CCDSiCCDS193.1
RefSeqiNP_036199.2, NM_012067.2
UniGeneiHs.6980

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CLPX-ray3.00A/B/C/D/E/F/G/H/I/J/K8-331[»]
ProteinModelPortaliO95154
SMRiO95154
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116626, 10 interactors
IntActiO95154, 8 interactors
STRINGi9606.ENSP00000355377

PTM databases

iPTMnetiO95154
PhosphoSitePlusiO95154

Polymorphism and mutation databases

BioMutaiAKR7A3

Proteomic databases

EPDiO95154
MaxQBiO95154
PaxDbiO95154
PeptideAtlasiO95154
PRIDEiO95154
ProteomicsDBi50669

Protocols and materials databases

DNASUi22977
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361640; ENSP00000355377; ENSG00000162482
GeneIDi22977
KEGGihsa:22977
UCSCiuc001bbv.2 human

Organism-specific databases

CTDi22977
EuPathDBiHostDB:ENSG00000162482.4
GeneCardsiAKR7A3
H-InvDBiHIX0000196
HGNCiHGNC:390 AKR7A3
HPAiHPA064638
MIMi608477 gene
neXtProtiNX_O95154
OpenTargetsiENSG00000162482
PharmGKBiPA24683
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDYD Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250286
HOVERGENiHBG050576
InParanoidiO95154
KOiK15303
OMAiLYNPLNR
OrthoDBiEOG091G0BTK
PhylomeDBiO95154
TreeFamiTF329173

Enzyme and pathway databases

ReactomeiR-HSA-5423646 Aflatoxin activation and detoxification
SABIO-RKiO95154

Miscellaneous databases

ChiTaRSiAKR7A3 human
EvolutionaryTraceiO95154
GenomeRNAii22977
PROiPR:O95154
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162482 Expressed in 203 organ(s), highest expression level in body of stomach
CleanExiHS_AKR7A3
GenevisibleiO95154 HS

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
SUPFAMiSSF51430 SSF51430, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARK73_HUMAN
AccessioniPrimary (citable) accession number: O95154
Secondary accession number(s): Q86SR4
, Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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