UniProtKB - O95154 (ARK73_HUMAN)

BLAST

>sp|O95154|ARK73_HUMAN Aflatoxin B1 aldehyde reductase member 3 OS=Homo sapiens OX=9606 GN=AKR7A3 PE=1 SV=2
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGG
LGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTP
VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVE
TELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEH
HFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA
AAEEGPLEPAVVDAFNQAWHLVTHECPNYFR

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History
Entry version 157 (07 Nov 2018)
Sequence version 2 (21 Feb 2001)
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Protein

Aflatoxin B1 aldehyde reductase member 3

Gene

AKR7A3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	44	NADP1 Publication	1
Active siteⁱ	49	Proton donorBy similarity	1
Siteⁱ	77	Lowers pKa of active site TyrBy similarity	1
Binding siteⁱ	113	SubstrateBy similarity	1
Binding siteⁱ	169	NADPBy similarity	1
Binding siteⁱ	222	NADP1 Publication	1
Binding siteⁱ	232	SubstrateBy similarity	1
Binding siteⁱ	235	SubstrateBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	143 – 144	NADP1 Publication	2
Nucleotide bindingⁱ	198 – 208	NADP1 PublicationAdd BLAST	11
Nucleotide bindingⁱ	290 – 298	NADP1 Publication	9

GO - Molecular functionⁱ

alditol:NADP+ 1-oxidoreductase activity Source: Ensembl
aldo-keto reductase (NADP) activity Source: Reactome
electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 10383892
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 25416956

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aflatoxin catabolic process Source: Ensembl
cellular aldehyde metabolic process
Source: ProtInc
Traceable author statementⁱ
- 10383892
xenobiotic metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD, NADP

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5423646 Aflatoxin activation and detoxification
SABIO-RKⁱ	O95154

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aflatoxin B1 aldehyde reductase member 3 (EC:1.-.-.-) Alternative name(s): AFB1 aldehyde reductase 2 Short name: AFB1-AR 2
Gene namesⁱ	Name:AKR7A3 Synonyms:AFAR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162482.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:390 AKR7A3
MIMⁱ	608477 gene
neXtProtⁱ	NX_O95154

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162482
PharmGKBⁱ	PA24683

Polymorphism and mutation databases

BioMutaⁱ	AKR7A3

BioMutaⁱ

AKR7A3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000070378	1 – 331	Aflatoxin B1 aldehyde reductase member 3Add BLAST		331

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	6	PhosphoserineBy similarity	1
Modified residueⁱ	85	PhosphoserineCombined sources	1
Modified residueⁱ	227	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95154
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95154
PaxDbⁱ	O95154
PeptideAtlas More...PeptideAtlasⁱ	O95154
PRIDEⁱ	O95154
ProteomicsDBⁱ	50669

PTM databases

iPTMnetⁱ	O95154
PhosphoSitePlusⁱ	O95154

Expressionⁱ

Tissue specificityⁱ

Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000162482 Expressed in 203 organ(s), highest expression level in body of stomach
CleanExⁱ	HS_AKR7A3
Genevisibleⁱ	O95154 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064638

HPAⁱ

HPA064638

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-748869,EBI-748869
AKR7A2	O43488	3	EBI-748869,EBI-748855
TERF2IP	Q9NYB0	2	EBI-748869,EBI-750109

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 25416956

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116626, 10 interactors
IntActⁱ	O95154, 8 interactors
STRINGⁱ	9606.ENSP00000355377

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	11 – 15	Combined sources	5
Turnⁱ	20 – 22	Combined sources	3
Helixⁱ	25 – 36	Combined sources	12
Turnⁱ	37 – 39	Combined sources	3
Beta strandⁱ	42 – 44	Combined sources	3
Helixⁱ	49 – 52	Combined sources	4
Helixⁱ	53 – 59	Combined sources	7
Beta strandⁱ	67 – 69	Combined sources	3
Beta strandⁱ	73 – 78	Combined sources	6
Helixⁱ	88 – 102	Combined sources	15
Beta strandⁱ	107 – 112	Combined sources	6
Helixⁱ	121 – 133	Combined sources	13
Beta strandⁱ	136 – 144	Combined sources	9
Helixⁱ	147 – 160	Combined sources	14
Beta strandⁱ	165 – 171	Combined sources	7
Helixⁱ	178 – 180	Combined sources	3
Helixⁱ	183 – 190	Combined sources	8
Beta strandⁱ	193 – 197	Combined sources	5
Helixⁱ	201 – 206	Combined sources	6
Helixⁱ	211 – 214	Combined sources	4
Turnⁱ	215 – 217	Combined sources	3
Beta strandⁱ	220 – 226	Combined sources	7
Helixⁱ	229 – 236	Combined sources	8
Helixⁱ	239 – 256	Combined sources	18
Helixⁱ	257 – 259	Combined sources	3
Helixⁱ	263 – 274	Combined sources	12
Helixⁱ	279 – 281	Combined sources	3
Beta strandⁱ	284 – 287	Combined sources	4
Helixⁱ	292 – 303	Combined sources	12
Helixⁱ	309 – 322	Combined sources	14
Helixⁱ	323 – 325	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O95154
SMRⁱ	O95154
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O95154

EvolutionaryTraceⁱ

O95154

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IDYD Eukaryota COG0667 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074567
HOGENOMⁱ	HOG000250286
HOVERGENⁱ	HBG050576
InParanoidⁱ	O95154
KEGG Orthology (KO) More...KOⁱ	K15303
OMAⁱ	LYNPLNR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BTK
PhylomeDBⁱ	O95154
TreeFamⁱ	TF329173

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
SUPFAMⁱ	SSF51430 SSF51430, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95154-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRQLSRARP ATVLGAMEMG RRMDAPTSAA VTRAFLERGH TEIDTAFVYS 
        60         70         80         90        100
EGQSETILGG LGLRLGGSDC RVKIDTKAIP LFGNSLKPDS LRFQLETSLK 
       110        120        130        140        150
RLQCPRVDLF YLHMPDHSTP VEETLRACHQ LHQEGKFVEL GLSNYAAWEV 
       160        170        180        190        200
AEICTLCKSN GWILPTVYQG MYNAITRQVE TELFPCLRHF GLRFYAFNPL 
       210        220        230        240        250
AGGLLTGKYK YEDKNGKQPV GRFFGNTWAE MYRNRYWKEH HFEGIALVEK 
       260        270        280        290        300
ALQAAYGASA PSMTSATLRW MYHHSQLQGA HGDAVILGMS SLEQLEQNLA 
       310        320        330 
AAEEGPLEPA VVDAFNQAWH LVTHECPNYF R

Length:331

Mass (Da):37,206

Last modified:February 21, 2001 - v2

Checksum:ⁱB9C32C33C7102AB3

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	51	E → D in AAD02195 (PubMed:10383892).Curated		1
Sequence conflictⁱ	247	L → P in AAH42420 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017416	138	V → M2 PublicationsCorresponds to variant dbSNP:rs2231198Ensembl.	1
Natural variantⁱVAR_017417	215	N → D3 PublicationsCorresponds to variant dbSNP:rs1738023Ensembl.	1
Natural variantⁱVAR_017418	323	T → A3 PublicationsCorresponds to variant dbSNP:rs1738025Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF040639 mRNA Translation: AAD02195.1 AJ271799 mRNA Translation: CAC81076.1 AL035413 Genomic DNA No translation available. BC025709 mRNA Translation: AAH25709.1 BC031562 mRNA Translation: AAH31562.1 BC042420 mRNA Translation: AAH42420.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS193.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036199.2, NM_012067.2
UniGeneⁱ	Hs.6980

Genome annotation databases

Ensemblⁱ	ENST00000361640; ENSP00000355377; ENSG00000162482
GeneIDⁱ	22977
KEGGⁱ	hsa:22977
UCSC genome browser More...UCSCⁱ	uc001bbv.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95154	Aflatoxin B1 aldehyde reductase member 4		HUMAN		331	UniRef90_O95154
Uncharacterized protein		MACMU		331
Aldo-keto reductase family 7, member A2 (Aflatoxin aldehyde reductase)		PANTR		331
Uncharacterized protein		PAPAN		331
Uncharacterized protein		PANPA		331
+30

Protein	Similar proteins		Species	Score	Length	Source
O95154	Aflatoxin B1 aldehyde reductase member 4		HUMAN		331	UniRef50_O95154
Aflatoxin B1 aldehyde reductase member 3	)	RAT		327
Uncharacterized protein		PAPAN		331
Uncharacterized protein		MACMU		331
Uncharacterized protein		CERAT		331
+181

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF040639 mRNA Translation: AAD02195.1 AJ271799 mRNA Translation: CAC81076.1 AL035413 Genomic DNA No translation available. BC025709 mRNA Translation: AAH25709.1 BC031562 mRNA Translation: AAH31562.1 BC042420 mRNA Translation: AAH42420.2
CCDSⁱ	CCDS193.1
RefSeqⁱ	NP_036199.2, NM_012067.2
UniGeneⁱ	Hs.6980

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CLP	X-ray	3.00	A/B/C/D/E/F/G/H/I/J/K	8-331	[»]
ProteinModelPortalⁱ	O95154
SMRⁱ	O95154
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116626, 10 interactors
IntActⁱ	O95154, 8 interactors
STRINGⁱ	9606.ENSP00000355377

PTM databases

iPTMnetⁱ	O95154
PhosphoSitePlusⁱ	O95154

Polymorphism and mutation databases

BioMutaⁱ	AKR7A3

BioMutaⁱ

AKR7A3

Proteomic databases

EPDⁱ	O95154
MaxQBⁱ	O95154
PaxDbⁱ	O95154
PeptideAtlasⁱ	O95154
PRIDEⁱ	O95154
ProteomicsDBⁱ	50669

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	22977
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361640; ENSP00000355377; ENSG00000162482
GeneIDⁱ	22977
KEGGⁱ	hsa:22977
UCSCⁱ	uc001bbv.2 human

Organism-specific databases

CTDⁱ	22977
EuPathDBⁱ	HostDB:ENSG00000162482.4
GeneCardsⁱ	AKR7A3
H-InvDBⁱ	HIX0000196
HGNCⁱ	HGNC:390 AKR7A3
HPAⁱ	HPA064638
MIMⁱ	608477 gene
neXtProtⁱ	NX_O95154
OpenTargetsⁱ	ENSG00000162482
PharmGKBⁱ	PA24683
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IDYD Eukaryota COG0667 LUCA
GeneTreeⁱ	ENSGT00550000074567
HOGENOMⁱ	HOG000250286
HOVERGENⁱ	HBG050576
InParanoidⁱ	O95154
KOⁱ	K15303
OMAⁱ	LYNPLNR
OrthoDBⁱ	EOG091G0BTK
PhylomeDBⁱ	O95154
TreeFamⁱ	TF329173

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5423646 Aflatoxin activation and detoxification
SABIO-RKⁱ	O95154

Miscellaneous databases

ChiTaRSⁱ	AKR7A3 human
EvolutionaryTraceⁱ	O95154
GenomeRNAiⁱ	22977
Protein Ontology More...PROⁱ	PR:O95154
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162482 Expressed in 203 organ(s), highest expression level in body of stomach
CleanExⁱ	HS_AKR7A3
Genevisibleⁱ	O95154 HS

Family and domain databases

CDDⁱ	cd06660 Aldo_ket_red, 1 hit
Gene3Dⁱ	3.20.20.100, 1 hit
InterProⁱ	View protein in InterPro IPR023210 NADP_OxRdtase_dom IPR036812 NADP_OxRdtase_dom_sf
Pfamⁱ	View protein in Pfam PF00248 Aldo_ket_red, 1 hit
SUPFAMⁱ	SSF51430 SSF51430, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARK73_HUMAN
Accessionⁱ	O95154Primary (citable) accession number: O95154 Secondary accession number(s): Q86SR4 , Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	February 21, 2001
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniParc

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UniRef

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Supporting data

UniProtKB - O95154 (ARK73_HUMAN)

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Aflatoxin B1 aldehyde reductase member 3

AKR7A3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ