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Protein

Snurportin-1

Gene

SNUPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.4 Publications

GO - Molecular functioni

  • nuclear import signal receptor activity Source: InterPro
  • RNA cap binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-191859 snRNP Assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Snurportin-1
Alternative name(s):
RNA U transporter 1
Gene namesi
Name:SNUPN
Synonyms:RNUT1, SPN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000169371.13
HGNCiHGNC:14245 SNUPN
MIMi607902 gene
neXtProtiNX_O95149

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27R → A: Abolishes interaction with KPNB1 and m3G-cap U1 snRNP import receptor activity. 1 Publication1
Mutagenesisi107W → A: Reduces binding to m3G-cap structure, interaction with XPO1 and snRNP import receptor activity. 2 Publications1
Mutagenesisi203 – 207FRFYW → A: Reduces binding to m3G-cap structure. 1 Publication5
Mutagenesisi276W → A: Reduces binding to m3G-cap structure, interaction with XPO1 and snRNP import receptor activity. 2 Publications1

Organism-specific databases

DisGeNETi10073
OpenTargetsiENSG00000169371
PharmGKBiPA34611

Chemistry databases

ChEMBLiCHEMBL3885569

Polymorphism and mutation databases

BioMutaiSNUPN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910711 – 360Snurportin-1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95149
MaxQBiO95149
PaxDbiO95149
PeptideAtlasiO95149
PRIDEiO95149
ProteomicsDBi50662

PTM databases

iPTMnetiO95149
PhosphoSitePlusiO95149

Expressioni

Gene expression databases

BgeeiENSG00000169371 Expressed in 104 organ(s), highest expression level in testis
CleanExiHS_SNUPN
ExpressionAtlasiO95149 baseline and differential
GenevisibleiO95149 HS

Organism-specific databases

HPAiCAB005004

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei105Interaction with m3G-cap structureCombined sources1 Publication1
Sitei144Interaction with m3G-cap structureCombined sources1 Publication1
Sitei276Interaction with m3G-cap structureCombined sources1 Publication1

Binary interactionsi

Protein-protein interaction databases

BioGridi115384, 31 interactors
ComplexPortaliCPX-1032 Importin complex, Snurportin variant
CORUMiO95149
DIPiDIP-48513N
ELMiO95149
IntActiO95149, 20 interactors
MINTiO95149
STRINGi9606.ENSP00000309831

Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95149
SMRiO95149
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95149

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 73IBBPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 159Necessary for interaction with XPO11 PublicationAdd BLAST159
Regioni1 – 65Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activity2 PublicationsAdd BLAST65
Regioni127 – 129Interaction with m3G-cap structureCombined sources1 Publication3
Regioni208 – 328Necessary for binding to the m3G-cap structure1 PublicationAdd BLAST121

Sequence similaritiesi

Belongs to the snurportin family.Curated

Phylogenomic databases

eggNOGiKOG3132 Eukaryota
ENOG410XQNJ LUCA
GeneTreeiENSGT00510000047494
HOGENOMiHOG000012990
HOVERGENiHBG053257
InParanoidiO95149
KOiK13151
OMAiYHRQTHY
OrthoDBiEOG091G0PL0
PhylomeDBiO95149
TreeFamiTF313108

Family and domain databases

InterProiView protein in InterPro
IPR002652 Importin-a_IBB
IPR017336 Snurportin-1
IPR024721 Snurportin-1_N
PANTHERiPTHR13403 PTHR13403, 1 hit
PfamiView protein in Pfam
PF11538 Snurportin1, 1 hit
PIRSFiPIRSF037955 Snurportin-1, 1 hit
PROSITEiView protein in PROSITE
PS51214 IBB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O95149-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL
60 70 80 90 100
QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN
110 120 130 140 150
QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN
160 170 180 190 200
RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ
210 220 230 240 250
TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF
260 270 280 290 300
PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD
310 320 330 340 350
YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS
360
PDHPGCLMEN
Length:360
Mass (Da):41,143
Last modified:May 1, 1999 - v1
Checksum:i50B456D1C23B4BA1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQR0H3BQR0_HUMAN
Snurportin-1
SNUPN
63Annotation score:
H3BSK1H3BSK1_HUMAN
Snurportin-1
SNUPN
136Annotation score:
H3BTA6H3BTA6_HUMAN
Snurportin-1
SNUPN
100Annotation score:
H3BRI5H3BRI5_HUMAN
Snurportin-1
SNUPN
209Annotation score:
H3BUB4H3BUB4_HUMAN
Snurportin-1
SNUPN
200Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039029 mRNA Translation: AAC70906.1
CR456811 mRNA Translation: CAG33092.1
AK289475 mRNA Translation: BAF82164.1
CH471136 Genomic DNA Translation: EAW99245.1
CH471136 Genomic DNA Translation: EAW99246.1
BC004203 mRNA Translation: AAH04203.1
CCDSiCCDS10281.1
RefSeqiNP_001036046.1, NM_001042581.1
NP_001036053.1, NM_001042588.1
NP_005692.1, NM_005701.3
UniGeneiHs.21577

Genome annotation databases

EnsembliENST00000308588; ENSP00000309831; ENSG00000169371
ENST00000564644; ENSP00000454852; ENSG00000169371
ENST00000564675; ENSP00000458053; ENSG00000169371
ENST00000567134; ENSP00000456224; ENSG00000169371
GeneIDi10073
KEGGihsa:10073
UCSCiuc002ban.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039029 mRNA Translation: AAC70906.1
CR456811 mRNA Translation: CAG33092.1
AK289475 mRNA Translation: BAF82164.1
CH471136 Genomic DNA Translation: EAW99245.1
CH471136 Genomic DNA Translation: EAW99246.1
BC004203 mRNA Translation: AAH04203.1
CCDSiCCDS10281.1
RefSeqiNP_001036046.1, NM_001042581.1
NP_001036053.1, NM_001042588.1
NP_005692.1, NM_005701.3
UniGeneiHs.21577

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XK5X-ray2.40A97-300[»]
2P8QX-ray2.35B25-64[»]
2Q5DX-ray3.20C/D25-64[»]
2QNAX-ray2.84B1-66[»]
3GB8X-ray2.90B1-328[»]
3GJXX-ray2.50B/E1-360[»]
3LWWX-ray3.15B/D25-64[»]
3NBYX-ray3.42B/E15-360[»]
3NBZX-ray2.80B/E15-360[»]
3NC0X-ray2.90B/E15-360[»]
5DISX-ray2.85C1-287[»]
ProteinModelPortaliO95149
SMRiO95149
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115384, 31 interactors
ComplexPortaliCPX-1032 Importin complex, Snurportin variant
CORUMiO95149
DIPiDIP-48513N
ELMiO95149
IntActiO95149, 20 interactors
MINTiO95149
STRINGi9606.ENSP00000309831

Chemistry databases

ChEMBLiCHEMBL3885569

PTM databases

iPTMnetiO95149
PhosphoSitePlusiO95149

Polymorphism and mutation databases

BioMutaiSNUPN

Proteomic databases

EPDiO95149
MaxQBiO95149
PaxDbiO95149
PeptideAtlasiO95149
PRIDEiO95149
ProteomicsDBi50662

Protocols and materials databases

DNASUi10073
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308588; ENSP00000309831; ENSG00000169371
ENST00000564644; ENSP00000454852; ENSG00000169371
ENST00000564675; ENSP00000458053; ENSG00000169371
ENST00000567134; ENSP00000456224; ENSG00000169371
GeneIDi10073
KEGGihsa:10073
UCSCiuc002ban.4 human

Organism-specific databases

CTDi10073
DisGeNETi10073
EuPathDBiHostDB:ENSG00000169371.13
GeneCardsiSNUPN
HGNCiHGNC:14245 SNUPN
HPAiCAB005004
MIMi607902 gene
neXtProtiNX_O95149
OpenTargetsiENSG00000169371
PharmGKBiPA34611
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3132 Eukaryota
ENOG410XQNJ LUCA
GeneTreeiENSGT00510000047494
HOGENOMiHOG000012990
HOVERGENiHBG053257
InParanoidiO95149
KOiK13151
OMAiYHRQTHY
OrthoDBiEOG091G0PL0
PhylomeDBiO95149
TreeFamiTF313108

Enzyme and pathway databases

ReactomeiR-HSA-191859 snRNP Assembly

Miscellaneous databases

ChiTaRSiSNUPN human
EvolutionaryTraceiO95149
GeneWikiiSNUPN
GenomeRNAii10073
PROiPR:O95149
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169371 Expressed in 104 organ(s), highest expression level in testis
CleanExiHS_SNUPN
ExpressionAtlasiO95149 baseline and differential
GenevisibleiO95149 HS

Family and domain databases

InterProiView protein in InterPro
IPR002652 Importin-a_IBB
IPR017336 Snurportin-1
IPR024721 Snurportin-1_N
PANTHERiPTHR13403 PTHR13403, 1 hit
PfamiView protein in Pfam
PF11538 Snurportin1, 1 hit
PIRSFiPIRSF037955 Snurportin-1, 1 hit
PROSITEiView protein in PROSITE
PS51214 IBB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPN1_HUMAN
AccessioniPrimary (citable) accession number: O95149
Secondary accession number(s): A6NE34, A8K0B0, D3DW76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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