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Protein

Dual specificity protein phosphatase 14

Gene

DUSP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 14 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
MKP-1-like protein tyrosine phosphatase
Short name:
MKP-L
Mitogen-activated protein kinase phosphatase 6
Short name:
MAP kinase phosphatase 6
Short name:
MKP-6
Gene namesi
Name:DUSP14
Synonyms:MKP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000276023.4
HGNCiHGNC:17007 DUSP14
MIMi606618 gene
neXtProtiNX_O95147

Pathology & Biotechi

Organism-specific databases

DisGeNETi11072
OpenTargetsiENSG00000276023
PharmGKBiPA27523

Chemistry databases

ChEMBLiCHEMBL1764941

Polymorphism and mutation databases

BioMutaiDUSP14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948221 – 198Dual specificity protein phosphatase 14Add BLAST198

Proteomic databases

EPDiO95147
PaxDbiO95147
PeptideAtlasiO95147
PRIDEiO95147
ProteomicsDBi50661

PTM databases

DEPODiO95147
iPTMnetiO95147
PhosphoSitePlusiO95147

Expressioni

Gene expression databases

BgeeiENSG00000276023 Expressed in 189 organ(s), highest expression level in hair follicle
CleanExiHS_DUSP14
ExpressionAtlasiO95147 baseline and differential
GenevisibleiO95147 HS

Organism-specific databases

HPAiHPA019911

Interactioni

Subunit structurei

Interacts with CD28.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPERTQ8NA613EBI-3922653,EBI-741724

Protein-protein interaction databases

BioGridi116255, 75 interactors
IntActiO95147, 4 interactors
MINTiO95147
STRINGi9606.ENSP00000377910

Chemistry databases

BindingDBiO95147

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95147
SMRiO95147
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95147

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 156Tyrosine-protein phosphataseAdd BLAST66

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1718 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233766
HOVERGENiHBG051422
InParanoidiO95147
KOiK14165
OMAiQRYGPIE
OrthoDBiEOG091G0249
PhylomeDBiO95147
TreeFamiTF316009

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020420 Atypical_DUSP_famB
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01910 ADSPHPHTASEB
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

O95147-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA
60 70 80 90 100
RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV
110 120 130 140 150
SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP
160 170 180 190
NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLMPYWGI
Length:198
Mass (Da):22,255
Last modified:May 1, 1999 - v1
Checksum:i6AAFAE1B3A24F9AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038844 mRNA Translation: AAD02105.1
AF120032 mRNA Translation: AAF28861.1
BC000370 mRNA Translation: AAH00370.1
BC001894 mRNA Translation: AAH01894.1
BC004448 mRNA Translation: AAH04448.1
CCDSiCCDS11320.1
RefSeqiNP_008957.1, NM_007026.3
XP_005257034.1, XM_005256977.3
XP_011522536.1, XM_011524234.1
UniGeneiHs.91448

Genome annotation databases

EnsembliENST00000613659; ENSP00000484091; ENSG00000276023
ENST00000614294; ENSP00000478406; ENSG00000275932
ENST00000614411; ENSP00000477653; ENSG00000276023
ENST00000617516; ENSP00000478595; ENSG00000276023
ENST00000632468; ENSP00000487886; ENSG00000275932
ENST00000633870; ENSP00000488882; ENSG00000275932
GeneIDi11072
KEGGihsa:11072

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038844 mRNA Translation: AAD02105.1
AF120032 mRNA Translation: AAF28861.1
BC000370 mRNA Translation: AAH00370.1
BC001894 mRNA Translation: AAH01894.1
BC004448 mRNA Translation: AAH04448.1
CCDSiCCDS11320.1
RefSeqiNP_008957.1, NM_007026.3
XP_005257034.1, XM_005256977.3
XP_011522536.1, XM_011524234.1
UniGeneiHs.91448

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WGPX-ray1.88A/B2-191[»]
ProteinModelPortaliO95147
SMRiO95147
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116255, 75 interactors
IntActiO95147, 4 interactors
MINTiO95147
STRINGi9606.ENSP00000377910

Chemistry databases

BindingDBiO95147
ChEMBLiCHEMBL1764941

PTM databases

DEPODiO95147
iPTMnetiO95147
PhosphoSitePlusiO95147

Polymorphism and mutation databases

BioMutaiDUSP14

Proteomic databases

EPDiO95147
PaxDbiO95147
PeptideAtlasiO95147
PRIDEiO95147
ProteomicsDBi50661

Protocols and materials databases

DNASUi11072
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613659; ENSP00000484091; ENSG00000276023
ENST00000614294; ENSP00000478406; ENSG00000275932
ENST00000614411; ENSP00000477653; ENSG00000276023
ENST00000617516; ENSP00000478595; ENSG00000276023
ENST00000632468; ENSP00000487886; ENSG00000275932
ENST00000633870; ENSP00000488882; ENSG00000275932
GeneIDi11072
KEGGihsa:11072

Organism-specific databases

CTDi11072
DisGeNETi11072
EuPathDBiHostDB:ENSG00000276023.4
GeneCardsiDUSP14
HGNCiHGNC:17007 DUSP14
HPAiHPA019911
MIMi606618 gene
neXtProtiNX_O95147
OpenTargetsiENSG00000276023
PharmGKBiPA27523
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1718 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233766
HOVERGENiHBG051422
InParanoidiO95147
KOiK14165
OMAiQRYGPIE
OrthoDBiEOG091G0249
PhylomeDBiO95147
TreeFamiTF316009

Miscellaneous databases

ChiTaRSiDUSP14 human
EvolutionaryTraceiO95147
GenomeRNAii11072
PROiPR:O95147
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000276023 Expressed in 189 organ(s), highest expression level in hair follicle
CleanExiHS_DUSP14
ExpressionAtlasiO95147 baseline and differential
GenevisibleiO95147 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020420 Atypical_DUSP_famB
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01910 ADSPHPHTASEB
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS14_HUMAN
AccessioniPrimary (citable) accession number: O95147
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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