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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Gene

NDUFB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Alternative name(s):
Complex I-B17
Short name:
CI-B17
NADH-ubiquinone oxidoreductase B17 subunit
Gene namesi
Name:NDUFB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165264.10
HGNCiHGNC:7701 NDUFB6
MIMi603322 gene
neXtProtiNX_O95139

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 86HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4712
OpenTargetsiENSG00000165264
PharmGKBiPA31512

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFB6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001188072 – 128NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei24N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95139
MaxQBiO95139
PaxDbiO95139
PeptideAtlasiO95139
PRIDEiO95139
ProteomicsDBi50658
TopDownProteomicsiO95139-1 [O95139-1]
O95139-2 [O95139-2]

PTM databases

iPTMnetiO95139
PhosphoSitePlusiO95139

Expressioni

Gene expression databases

BgeeiENSG00000165264 Expressed in 239 organ(s), highest expression level in myocardium
CleanExiHS_NDUFB6
ExpressionAtlasiO95139 baseline and differential
GenevisibleiO95139 HS

Organism-specific databases

HPAiHPA044001
HPA053334

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

BioGridi110792, 28 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO95139
IntActiO95139, 10 interactors
MINTiO95139
STRINGi9606.ENSP00000369176

Structurei

3D structure databases

ProteinModelPortaliO95139
SMRiO95139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB6 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4633 Eukaryota
ENOG4111RT5 LUCA
GeneTreeiENSGT00390000007535
HOGENOMiHOG000231724
HOVERGENiHBG006449
InParanoidiO95139
KOiK03962
OMAiPAWIIHY
OrthoDBiEOG091G0SHB
PhylomeDBiO95139
TreeFamiTF328587

Family and domain databases

InterProiView protein in InterPro
IPR019174 NADH_DH_b-subcmplx_su6
PANTHERiPTHR15083 PTHR15083, 1 hit
PfamiView protein in Pfam
PF09782 NDUF_B6, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95139-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGYTPDEKL RLQQLRELRR RWLKDQELSP REPVLPPQKM GPMEKFWNKF
60 70 80 90 100
LENKSPWRKM VHGVYKKSIF VFTHVLVPVW IIHYYMKYHV SEKPYGIVEK
110 120
KSRIFPGDTI LETGEVIPPM KEFPDQHH
Length:128
Mass (Da):15,489
Last modified:January 23, 2007 - v3
Checksum:iE8F419F5EB154D0B
GO
Isoform 2 (identifier: O95139-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-106: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):13,716
Checksum:iC5F9519567423E88
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZX2A0A087WZX2_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB6
97Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04523392 – 106Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035840 mRNA Translation: AAC68838.1
AF067167 mRNA Translation: AAD32451.1
CR456920 mRNA Translation: CAG33201.1
AK289702 mRNA Translation: BAF82391.1
AL353671 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58541.1
CH471071 Genomic DNA Translation: EAW58542.1
BC009801 mRNA Translation: AAH09801.1
BC029247 mRNA Translation: AAH29247.1
BI669356 mRNA No translation available.
CCDSiCCDS6528.1 [O95139-1]
CCDS6529.1 [O95139-2]
RefSeqiNP_002484.1, NM_002493.4 [O95139-1]
NP_877416.1, NM_182739.2 [O95139-2]
UniGeneiHs.493668

Genome annotation databases

EnsembliENST00000350021; ENSP00000297983; ENSG00000165264 [O95139-2]
ENST00000379847; ENSP00000369176; ENSG00000165264 [O95139-1]
GeneIDi4712
KEGGihsa:4712
UCSCiuc003zre.3 human [O95139-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035840 mRNA Translation: AAC68838.1
AF067167 mRNA Translation: AAD32451.1
CR456920 mRNA Translation: CAG33201.1
AK289702 mRNA Translation: BAF82391.1
AL353671 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58541.1
CH471071 Genomic DNA Translation: EAW58542.1
BC009801 mRNA Translation: AAH09801.1
BC029247 mRNA Translation: AAH29247.1
BI669356 mRNA No translation available.
CCDSiCCDS6528.1 [O95139-1]
CCDS6529.1 [O95139-2]
RefSeqiNP_002484.1, NM_002493.4 [O95139-1]
NP_877416.1, NM_182739.2 [O95139-2]
UniGeneiHs.493668

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70b1-128[»]
5XTDelectron microscopy3.70b1-128[»]
5XTHelectron microscopy3.90b3-126[»]
5XTIelectron microscopy17.40Bb/b3-126[»]
ProteinModelPortaliO95139
SMRiO95139
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110792, 28 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO95139
IntActiO95139, 10 interactors
MINTiO95139
STRINGi9606.ENSP00000369176

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

PTM databases

iPTMnetiO95139
PhosphoSitePlusiO95139

Polymorphism and mutation databases

BioMutaiNDUFB6

Proteomic databases

EPDiO95139
MaxQBiO95139
PaxDbiO95139
PeptideAtlasiO95139
PRIDEiO95139
ProteomicsDBi50658
TopDownProteomicsiO95139-1 [O95139-1]
O95139-2 [O95139-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350021; ENSP00000297983; ENSG00000165264 [O95139-2]
ENST00000379847; ENSP00000369176; ENSG00000165264 [O95139-1]
GeneIDi4712
KEGGihsa:4712
UCSCiuc003zre.3 human [O95139-1]

Organism-specific databases

CTDi4712
DisGeNETi4712
EuPathDBiHostDB:ENSG00000165264.10
GeneCardsiNDUFB6
HGNCiHGNC:7701 NDUFB6
HPAiHPA044001
HPA053334
MIMi603322 gene
neXtProtiNX_O95139
OpenTargetsiENSG00000165264
PharmGKBiPA31512
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4633 Eukaryota
ENOG4111RT5 LUCA
GeneTreeiENSGT00390000007535
HOGENOMiHOG000231724
HOVERGENiHBG006449
InParanoidiO95139
KOiK03962
OMAiPAWIIHY
OrthoDBiEOG091G0SHB
PhylomeDBiO95139
TreeFamiTF328587

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

GeneWikiiNDUFB6
GenomeRNAii4712
PROiPR:O95139
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165264 Expressed in 239 organ(s), highest expression level in myocardium
CleanExiHS_NDUFB6
ExpressionAtlasiO95139 baseline and differential
GenevisibleiO95139 HS

Family and domain databases

InterProiView protein in InterPro
IPR019174 NADH_DH_b-subcmplx_su6
PANTHERiPTHR15083 PTHR15083, 1 hit
PfamiView protein in Pfam
PF09782 NDUF_B6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB6_HUMAN
AccessioniPrimary (citable) accession number: O95139
Secondary accession number(s): A8K0Y7, Q5VYT2, Q6IB84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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