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Protein

Sphingosine 1-phosphate receptor 2

Gene

S1PR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).By similarity2 Publications

GO - Molecular functioni

  • G protein-coupled receptor activity Source: ProtInc
  • G protein-coupled receptor binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • lipid binding Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiO95136

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 2
Short name:
S1P receptor 2
Short name:
S1P2
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 5
Sphingosine 1-phosphate receptor Edg-5
Short name:
S1P receptor Edg-5
Gene namesi
Name:S1PR2
Synonyms:EDG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000267534.2
HGNCiHGNC:3169 S1PR2
MIMi605111 gene
neXtProtiNX_O95136

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 59Helical; Name=1By similarityAdd BLAST25
Topological domaini60 – 66CytoplasmicBy similarity7
Transmembranei67 – 95Helical; Name=2By similarityAdd BLAST29
Topological domaini96 – 109ExtracellularBy similarityAdd BLAST14
Transmembranei110 – 128Helical; Name=3By similarityAdd BLAST19
Topological domaini129 – 147CytoplasmicBy similarityAdd BLAST19
Transmembranei148 – 173Helical; Name=4By similarityAdd BLAST26
Topological domaini174 – 189ExtracellularBy similarityAdd BLAST16
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 233CytoplasmicBy similarityAdd BLAST23
Transmembranei234 – 255Helical; Name=6By similarityAdd BLAST22
Topological domaini256 – 271ExtracellularBy similarityAdd BLAST16
Transmembranei272 – 292Helical; Name=7By similarityAdd BLAST21
Topological domaini293 – 353CytoplasmicBy similarityAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 68 (DFNB68)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:610419
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076391108R → P in DFNB68. 1 PublicationCorresponds to variant dbSNP:rs869312749EnsemblClinVar.1
Natural variantiVAR_076392140Y → C in DFNB68. 1 PublicationCorresponds to variant dbSNP:rs869312750EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi9294
MalaCardsiS1PR2
MIMi610419 phenotype
OpenTargetsiENSG00000267534
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA162402353

Chemistry databases

ChEMBLiCHEMBL2955
GuidetoPHARMACOLOGYi276

Polymorphism and mutation databases

BioMutaiS1PR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694271 – 353Sphingosine 1-phosphate receptor 2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi305S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95136
PeptideAtlasiO95136
PRIDEiO95136
ProteomicsDBi50657

PTM databases

iPTMnetiO95136
PhosphoSitePlusiO95136

Expressioni

Gene expression databases

BgeeiENSG00000267534 Expressed in 179 organ(s), highest expression level in islet of Langerhans
CleanExiHS_S1PR2
ExpressionAtlasiO95136 baseline and differential
GenevisibleiO95136 HS

Organism-specific databases

HPAiHPA014255
HPA014307

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114708, 22 interactors
CORUMiO95136
DIPiDIP-60682N
IntActiO95136, 3 interactors
STRINGi9606.ENSP00000466933

Chemistry databases

BindingDBiO95136

Structurei

3D structure databases

ProteinModelPortaliO95136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHTX Eukaryota
ENOG41100F8 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiO95136
KOiK04292
OMAiDYACPVR
OrthoDBiEOG091G0DD4
PhylomeDBiO95136

Family and domain databases

CDDicd15347 7tmA_S1PR2_Edg5, 1 hit
InterProiView protein in InterPro
IPR004063 EDG5_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PANTHERiPTHR22750:SF17 PTHR22750:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01525 EDG5RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95136-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLYSEYLN PNKVQEHYNY TKETLETQET TSRQVASAFI VILCCAIVVE
60 70 80 90 100
NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGSVTLRL
110 120 130 140 150
TPVQWFAREG SAFITLSASV FSLLAIAIER HVAIAKVKLY GSDKSCRMLL
160 170 180 190 200
LIGASWLISL VLGGLPILGW NCLGHLEACS TVLPLYAKHY VLCVVTIFSI
210 220 230 240 250
ILLAIVALYV RIYCVVRSSH ADMAAPQTLA LLKTVTIVLG VFIVCWLPAF
260 270 280 290 300
SILLLDYACP VHSCPILYKA HYFFAVSTLN SLLNPVIYTW RSRDLRREVL
310 320 330 340 350
RPLQCWRPGV GVQGRRRGGT PGHHLLPLRS SSSLERGMHM PTSPTFLEGN

TVV
Length:353
Mass (Da):38,867
Last modified:November 7, 2003 - v2
Checksum:i8E37084284ABF7E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113F → S in AAC98919 (PubMed:10617617).Curated1
Sequence conflicti318G → V in AAC98919 (PubMed:10617617).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076391108R → P in DFNB68. 1 PublicationCorresponds to variant dbSNP:rs869312749EnsemblClinVar.1
Natural variantiVAR_076392140Y → C in DFNB68. 1 PublicationCorresponds to variant dbSNP:rs869312750EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034780 mRNA Translation: AAC98919.1
AY262688 Genomic DNA Translation: AAP20652.1
BC069598 mRNA Translation: AAH69598.1
CCDSiCCDS12229.1
RefSeqiNP_004221.3, NM_004230.3
UniGeneiHs.655405

Genome annotation databases

EnsembliENST00000590320; ENSP00000466933; ENSG00000267534
ENST00000646641; ENSP00000496438; ENSG00000267534
GeneIDi9294
KEGGihsa:9294
UCSCiuc002mnl.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034780 mRNA Translation: AAC98919.1
AY262688 Genomic DNA Translation: AAP20652.1
BC069598 mRNA Translation: AAH69598.1
CCDSiCCDS12229.1
RefSeqiNP_004221.3, NM_004230.3
UniGeneiHs.655405

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZTImodel-A1-353[»]
ProteinModelPortaliO95136
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114708, 22 interactors
CORUMiO95136
DIPiDIP-60682N
IntActiO95136, 3 interactors
STRINGi9606.ENSP00000466933

Chemistry databases

BindingDBiO95136
ChEMBLiCHEMBL2955
GuidetoPHARMACOLOGYi276

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95136
PhosphoSitePlusiO95136

Polymorphism and mutation databases

BioMutaiS1PR2

Proteomic databases

PaxDbiO95136
PeptideAtlasiO95136
PRIDEiO95136
ProteomicsDBi50657

Protocols and materials databases

DNASUi9294
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590320; ENSP00000466933; ENSG00000267534
ENST00000646641; ENSP00000496438; ENSG00000267534
GeneIDi9294
KEGGihsa:9294
UCSCiuc002mnl.3 human

Organism-specific databases

CTDi9294
DisGeNETi9294
EuPathDBiHostDB:ENSG00000267534.2
GeneCardsiS1PR2
HGNCiHGNC:3169 S1PR2
HPAiHPA014255
HPA014307
MalaCardsiS1PR2
MIMi605111 gene
610419 phenotype
neXtProtiNX_O95136
OpenTargetsiENSG00000267534
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA162402353
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHTX Eukaryota
ENOG41100F8 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiO95136
KOiK04292
OMAiDYACPVR
OrthoDBiEOG091G0DD4
PhylomeDBiO95136

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiO95136

Miscellaneous databases

ChiTaRSiS1PR2 human
GeneWikiiS1PR2
GenomeRNAii9294
PROiPR:O95136
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000267534 Expressed in 179 organ(s), highest expression level in islet of Langerhans
CleanExiHS_S1PR2
ExpressionAtlasiO95136 baseline and differential
GenevisibleiO95136 HS

Family and domain databases

CDDicd15347 7tmA_S1PR2_Edg5, 1 hit
InterProiView protein in InterPro
IPR004063 EDG5_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PANTHERiPTHR22750:SF17 PTHR22750:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01525 EDG5RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR2_HUMAN
AccessioniPrimary (citable) accession number: O95136
Secondary accession number(s): Q86UN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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